RNA interference of PARG could inhibit the metastatic potency of colon carcinoma cells via PI3-kinase/Akt pathway

Cellular Physiology and Biochemistry

Volumn 29, Issue 3-4, 2012, Pages 361-372

  Li, Qiaozhuan ^a   Li, Ming ^a   Wang, Ya Lan ^a   Fauzee, Nilufer Jasmine Selimah ^a   Yang, Yi ^a   Pan, Juan ^a   Yang, Lian ^a   Lazar, Alexander ^b  

^a CHONGQING MEDICAL UNIVERSITY   (China)

^b UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

Metastasis; MMP2; MMP9; NF B; PARG; PARP; PI3K Akt pathway; shRNA

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; POLY(ADENOSINE DIPHOSPHATE RIBOSE); POLY(ADENOSINE DIPHOSPHATE RIBOSE)GLYCOHYDROLASE; POLY(ADENOSINE DIPHOSPHATE RIBOSE)POLYMERASE 1; POLYNUCLEOTIDE; PYRROLIDINE DITHIOCARBAMATE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL ADHESION; CELL INVASION; CELL MIGRATION; COLON CARCINOMA; CONTROLLED STUDY; FEMALE; GEL MOBILITY SHIFT ASSAY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LIVER METASTASIS; METASTASIS INHIBITION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RNA INTERFERENCE; SIGNAL TRANSDUCTION;

MURINAE;

EID: 84859892610     PISSN: 10158987     EISSN: 14219778     Source Type: Journal    
DOI: 10.1159/000338491     Document Type: Article

References (39)

1. Davidovich L, Vodenicharov M, Affar EB, Poirier GG: Importance of Poly(ADP-ribose) glycohydrolase in the control of poly(ADP-ribose) metabolism. Exp Cell Res 2001;268:7-13. (Pubitemid 32678855)
2. de Murcia G, de Murcia JM: Poly(ADPribose) polymerase: a molecular nicksensor. Trends Biochem Sci 1994;19:172-176.
3. Shall S, de Murcia G: Poly(ADP-ribose) polymerase-1: what have we learned from the deficient mouse model? Mutat Res 2000;460:1-15. (Pubitemid 30365046)
4. Hong SJ, Dawson TM, Dawson VL: Nuclear and mitochondrial conversations in cell death: PARP-1 and AIF signaling.Trends Pharmacol Sci 2004;25:259-264. (Pubitemid 38553828)
5. Jagtap P, Szabo C: Poly(ADP-ribose) polymerase and the therapeutic effects of its inhibitors. Nat Rev Drug Discov 2005;4:421-440. (Pubitemid 40704125)
6. Schreiber V, Dantzer F, Ame JC, de Murcia G: Poly(ADP-ribose): novel functions for an old molecule. Nat Rev Mol Cell Biol 2006;4:517-528. (Pubitemid 44036457)
7. Cuzzocrea S, Riley DP, Caputi AP, Salvemini D: Antioxidant therapy: a new pharmacological approach in shock, inflammation, and ischemia/reperfusion injury. Pharmacol Rev 2001;53:135-159. (Pubitemid 32173112)
8. Li J, Zhang J: Pharmaceutical compositions containing poly(ADP-ribose) glycohydrolase inhibitors for inhibiting or decreasing free radical-induced cellular energy depletion, cell damage or cell death. WO 2000;00025787.
9. Di Paola R, Genovese T, Caputi AP, Threadgill M, Thiemermann C, Cuzzocrea S: Beneficial effects of 5- aminoisoquinolinone, a novel, potent, water-soluble, inhibitor of poly (ADPribose) polymerase, in a rat model of splanchnic artery occlusion and reperfusion. Eur J Pharmacol 2004;492:203-210. (Pubitemid 38721373)
10. Genovese T, Di Paola R, Catalano P, Li JH, Xu W, Massuda E, Caputi AP, Zhang J, Cuzzocrea S: Treatment with a novel poly(ADP- ribose) glycohydrolase inhibitor reduces development of septic shock-like syndrome induced by zymosan in mice. Crit Care Med 2004;32:1365-1374. (Pubitemid 38738594)
11. Virag L, Szabo C: The therapeutic potential of poly (ADP-ribose) polimerase inhibitors. Pharmacol Rev 2003;54:375-429.
12. Cuzzocrea S, Di Paola R, Mazzon E, Cortes U, Genovese T, Muiá C, Li W, Xu W, Li JH, Zhang J, Wang ZQ: PARG activity mediates intestinal injury induced by splanchnic artery occlusion and reperfusion. FASEB J 2005;19:558-566. (Pubitemid 40471247)
13. Pálfi A, Tóth A, Kulcsár G, Hantó K, Deres P, Bartha E, Halmosi R, Szabados E, Czopf L, Kálai T, Hideg K, Sümegi B, Tóth K: The role of Akt and Mitogen- Activated Protein Kinase Systems in the Protective Effect of Poly(ADP-Ribose) Polymerase Inhibition in Langendorff Perfused and in Isoproterenol-Damaged Rat Hearts. J Pharmacol Exp Ther 2005;315:273-282. (Pubitemid 41380521)
14. Veres B, Radnai B, Gallyas F Jr, Varbiro G, Berente Z, Osz E, Sumegi B: Regulation of Kinase Cascades and Transcripition Factors by a Poly(ADPRibose) Polymerase-1 Inhibitor, 4- Hydroxyquinazoline, in Lipopolysaccharide- Induced Inflammation in Mice. J Pharmacol Exp Ther 2004;310:247-255. (Pubitemid 38812718)
15. Guha M, Mackman N: The phosphatidylinositol 3-kinase-Akt pathway limits LPS activation of signaling pathways and expressing of inflammatory mediators in human monocytic cells. J Biol Chem 2002;277:32124-32132. (Pubitemid 34969025)
16. Li M, Wang Y: Effect of PARP inhibition on invasiveness of mouse colon carcinoma cell line. J Sun Yat-Sen Univ (Med Sci) 2008;29:388-392.
17. Qin Y, Wang Y, Li Y: Effect of Poly(ADP-ribose)polymerase inhibition on liver metastasis of mouse colorectal carcinoma CT26 cell line in vivo. J Fourth Mil Med Univ 2008;29:1621-1624.
18. Erdélyi K, Kiss A, Bakondi E, Bai P, Szabó C, Gergely P, Erdödi F, Virag L: Gallotannin Inhibits the Expression ofChemokines and Inflammatory Cytokines in A549 Cells. Mol Pharmacol 2005;68:895-904. (Pubitemid 41206046)
19. Wu X, Zeng H, Zhang X, Zhao Y, Sha H, Ge X, Zhang M, Gao X, Xu Q: Phosphatase of Regenerating Liver-3 Promotes Motility and Metastasis of Mouse Melanoma Cells. Am J Pathol 2004;164:2039-2054. (Pubitemid 38669352)
20. Arai A, Nosaka Y, Kohsaka H, Miyasaka N, Miura O: CrkL activates integrinmediated hematopoietic cell adhesion through the guanine nucleotide exchange factor C3G. Blood 1999;93:3713-3722. (Pubitemid 29249818)
21. Li Cai, Threadgill MD, Wang YL, Ming Li: Effect of Poly (ADP-ribose) Polymerase-1 Inhibition on the proliferation of Murine Colon Carcinoma CT26 Cells. Pathol Oncol Res 2009;15:323-328.
22. Garcia S, Bodano A, Gonzalez A, Forteza J, Gomez-Reino JJ, Conde C: Partial protection against collagen antibodyinduced arthritis in PARP-1 deficient mice. Arthritis Res Ther 2006;8:R14-22.
23. García S, Bodaño A, Pablos JL, Gómez- Reino JJ, Conde C: Poly(ADPribose) polymerase inhibition reduces tumor neceosis factor-induced inflammatory response in rheumatoid synovial fibroblasts. Ann Rheum Dis 2008;67:631-637. (Pubitemid 351571926)
24. Cuzzocrea S, Genovese T, Mazzon E, Crisafulli C, Min W, Di Paola R, Muia C, Li JH, Esposito E, Bramanti P, Xu W, Massuda E, Zhang J, Wang ZQ: Poly(ADP-Ribose) Glycohydrolase Activity Mediates Post-Traumatic Inflammatory Reaction after Experimental Spinal Cord Trauma. J Pharmacol Exp Ther 2006;319:127-138. (Pubitemid 44455117)
25. Frizzell KM, Gamble MJ, Berrocal JG, Zhang T, Krishnakumar R, Cen Y, Sauve AA, Kraus WL: Global analysis of transcriptional regulation by poly(ADPribose) polymerase-1 and poly(ADPribose) glycohydrolase in MCF-7 human breast cancer cells. J Biol Chem 2009;284:33926-33938.
26. Erdélyi K, Bai P, Kovács I, Szabó E, Mocsár G, Kakuk A, Szabó C, Gergely P, Virág L: Dual role of poly(ADP-ribose) glycohydrolase in the regulation of cell death in oxidatively stressed A549 cells. FASEB 2009;23:3553-3563.
27. Li B, Cheung PY, Wang X, Tsao SW, Ling MT, Wong YC, Cheung AL: Id-1 activation of PI3K/Akt/NF-êB signaling pathway and its significance in promoting survival of esophageal cancer cells. Carcinogenesis 2007;28:2313-2320. (Pubitemid 350111589)
28. Lin L, Li J, Wang YL, Lin X: Relationship of PARG with PARP, VEGF and b-FGF in colorectal carcinoma. Chin J Cancer Res 2009;21:135-141.
29. Hao LX, Wang YL, Cai Li, Li YY: Inhibitory effect of 5- aminoisoquinolinone on PARP activity in colon carcinoma cell line HT-26. Chin J Cancer Res 2007;26:566-571.
30. Karin M, Cao Y, Greten FR, Li ZW: NF- êB in cancer from innocent bystander to major culprit. Nat Rev Cancer 2002;2:301-310. (Pubitemid 37328783)
31. Kovacs K, Toth A, Deres P, Kalai T, Hideg K, Gallyas F Jr, Sumegi B: Critical role of PI3-kinase/Akt activation in the PARP inhibitor induced heart function recovery during ischemia-reperfusion. Biochem Pharmacol 2006;71:441-452. (Pubitemid 43077078)
32. Tapodi A, Debreceni B, Hanto K, Bognar Z, Wittmann I, Gallyas F Jr, Varbiro G, Sumegi B: Pivotal role of Akt activation in mitochondrial protection and cell survival by poly(ADPribose) polymerase-1 inhibition in oxidative stress. J Biol Chem2005;280:35767-35775.
33. Bar-shaiM, Carmeli E, Reznick AZ: The role of NF-êB in protein breakdown in immobilization, aging, and exercise from basic processes to promotion of health. Ann NY Acad Sci 2005;1057:431-447. (Pubitemid 43211651)
34. Cai D, Frantz JD, Tawa NE, Melendez PA, Oh B-C, Lidov HGW, Hasselgren PO, Frontera WR, Lee J, Glass DJ, Shoelson SE: IKKâ-NF-êB activation causes severe muscle wasting in mice. Cell 2004;119:285-298. (Pubitemid 39360909)
35. Li M, Treadgill MD, Wang YL, Li C, Xiao L: Poly(ADP-Ribose) Polymerase Inhibition Down-Regulates Expression of Metastasis-Related Genes in CT26 Colon Carcinoma Cells. Pathobiology 2009;76:108-116.
36. Xian L, Guang-jie D, Wang YL, Fauzee NJ: Expressions of Poly (ADP-ribose) Glycohydrolase and membrane Type a Matrix Metalloproteinase (MT1-MMP) in Colorectal Carcinoma. Chin J Cancer Res 2010;22:186-193.
37. Bushdid PB, Chen CL, Brantley DM, Yull F, Raghow R, Kerr LD, Barnett JV: NF- êB mediates signal regulation of msx-1 expression. Dev Biol 2001;237:107-115. (Pubitemid 32844309)
38. Fauzee NJS, Pan J, Wang YL: PARP and PARG Inhibitors-New Therapeutic Targets in Cancer Treatment. Pathol Oncol Res 2010;16:469-478.
39. Asano T, Yao Y, Zhu J, Li D, Abbruzzese JL, Reddy SA: The PI 3-kinase/Akt signaling pathway is activated due to aberrant Pten expression and targets transcription factors NF-kappaB and c- Myc in pancreatic cancer cells. Oncogene 2004;23:8571-8580 (Pubitemid 39576463)