-
2
-
-
0029967424
-
Sheep cloned by nuclear transfer from a cultured cell line.
-
Campbell KHS, McWhir J, Ritchie WA, Wilmut I. Sheep cloned by nuclear transfer from a cultured cell line. Nature 1996, 380:64-66.
-
(1996)
Nature
, vol.380
, pp. 64-66
-
-
Campbell, K.H.S.1
McWhir, J.2
Ritchie, W.A.3
Wilmut, I.4
-
3
-
-
33747195353
-
Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors.
-
Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 2006, 126:663-676.
-
(2006)
Cell
, vol.126
, pp. 663-676
-
-
Takahashi, K.1
Yamanaka, S.2
-
4
-
-
71449125977
-
Forcing cells to change lineages.
-
Graf T, Enver T. Forcing cells to change lineages. Nature 2009, 462:587-594.
-
(2009)
Nature
, vol.462
, pp. 587-594
-
-
Graf, T.1
Enver, T.2
-
5
-
-
0023663888
-
Expression of a single transfected cDNA converts fibroblasts to myoblasts.
-
Davis RL, Weintraub H, Lassar AB. Expression of a single transfected cDNA converts fibroblasts to myoblasts. Cell 1987, 51:987-1000.
-
(1987)
Cell
, vol.51
, pp. 987-1000
-
-
Davis, R.L.1
Weintraub, H.2
Lassar, A.B.3
-
6
-
-
0346888544
-
Lmo2 and Scl/Tal1 convert non-axial mesoderm into haemangioblasts which differentiate into endothelial cells in the absence of Gata1.
-
Gering M, Yamada Y, Rabbitts TH, Patient RK. Lmo2 and Scl/Tal1 convert non-axial mesoderm into haemangioblasts which differentiate into endothelial cells in the absence of Gata1. Development 2003, 130:6187-6199.
-
(2003)
Development
, vol.130
, pp. 6187-6199
-
-
Gering, M.1
Yamada, Y.2
Rabbitts, T.H.3
Patient, R.K.4
-
7
-
-
0037099497
-
Transcription factor-mediated lineage switching reveals plasticity in primary committed progenitor cells.
-
Heyworth C, Pearson S, May G, Enver T. Transcription factor-mediated lineage switching reveals plasticity in primary committed progenitor cells. EMBO J 2002, 21:3770-3781.
-
(2002)
EMBO J
, vol.21
, pp. 3770-3781
-
-
Heyworth, C.1
Pearson, S.2
May, G.3
Enver, T.4
-
8
-
-
65349097905
-
Stem cell states, fates, and the rules of attraction.
-
Enver T, Pera M, Peterson C, Andrews PW. Stem cell states, fates, and the rules of attraction. Cell Stem Cell 2009, 4:387-397.
-
(2009)
Cell Stem Cell
, vol.4
, pp. 387-397
-
-
Enver, T.1
Pera, M.2
Peterson, C.3
Andrews, P.W.4
-
9
-
-
58549117664
-
Transcriptional regulatory networks in haematopoiesis.
-
Miranda-Saavedra D, Gottgens B. Transcriptional regulatory networks in haematopoiesis. Curr Opin Genet Dev 2008, 18:530-535.
-
(2008)
Curr Opin Genet Dev
, vol.18
, pp. 530-535
-
-
Miranda-Saavedra, D.1
Gottgens, B.2
-
10
-
-
78650362376
-
Emerging properties of animal gene regulatory networks.
-
Davidson EH. Emerging properties of animal gene regulatory networks. Nature 2010, 468:911-920.
-
(2010)
Nature
, vol.468
, pp. 911-920
-
-
Davidson, E.H.1
-
11
-
-
71149089027
-
Network design principles from the sea urchin embryo.
-
Davidson EH. Network design principles from the sea urchin embryo. Curr Opin Genet Dev 2009, 19:535-540.
-
(2009)
Curr Opin Genet Dev
, vol.19
, pp. 535-540
-
-
Davidson, E.H.1
-
12
-
-
79960901603
-
Reconstructing regulatory network transitions.
-
Petricka JJ, Benfey PN. Reconstructing regulatory network transitions. Trends Cell Biol 2011, 21:442-451.
-
(2011)
Trends Cell Biol
, vol.21
, pp. 442-451
-
-
Petricka, J.J.1
Benfey, P.N.2
-
13
-
-
77954842706
-
Gene regulatory networks governing haematopoietic stem cell development and identity.
-
Pimanda JE, Gottgens B. Gene regulatory networks governing haematopoietic stem cell development and identity. Int J Dev Biol 2010, 54:1201-1211.
-
(2010)
Int J Dev Biol
, vol.54
, pp. 1201-1211
-
-
Pimanda, J.E.1
Gottgens, B.2
-
14
-
-
34249079154
-
Network motifs: theory and experimental approaches.
-
Alon U. Network motifs: theory and experimental approaches. Nat Rev Genet 2007, 8:450-461.
-
(2007)
Nat Rev Genet
, vol.8
, pp. 450-461
-
-
Alon, U.1
-
15
-
-
39349096526
-
Hematopoiesis: an evolving paradigm for stem cell biology.
-
Orkin SH, Zon LI. Hematopoiesis: an evolving paradigm for stem cell biology. Cell 2008, 132:631-644.
-
(2008)
Cell
, vol.132
, pp. 631-644
-
-
Orkin, S.H.1
Zon, L.I.2
-
16
-
-
52649097448
-
The immunological genome project: networks of gene expression in immune cells.
-
Heng TSP, Painter MW, Elpek K, Lukacs-Kornek V, Mauermann N, Turley SJ, Koller D, Kim FS, Wagers AJ, Asinovski N, et al. The immunological genome project: networks of gene expression in immune cells. Nat Immunol 2008, 9:1091-1094.
-
(2008)
Nat Immunol
, vol.9
, pp. 1091-1094
-
-
Heng, T.S.P.1
Painter, M.W.2
Elpek, K.3
Lukacs-Kornek, V.4
Mauermann, N.5
Turley, S.J.6
Koller, D.7
Kim, F.S.8
Wagers, A.J.9
Asinovski, N.10
-
17
-
-
33746617272
-
Hematopoietic stem cells: the paradigmatic tissue-specific stem cell.
-
Bryder D, Rossi DJ, Weissman IL. Hematopoietic stem cells: the paradigmatic tissue-specific stem cell. Am J Pathol 2006, 169:338-346.
-
(2006)
Am J Pathol
, vol.169
, pp. 338-346
-
-
Bryder, D.1
Rossi, D.J.2
Weissman, I.L.3
-
18
-
-
72949096573
-
From genes to cells to tissues-modelling the haematopoietic system.
-
Foster SD, Oram SH, Wilson NK, Gottgens B. From genes to cells to tissues-modelling the haematopoietic system. Mol Biosyst 2009, 5:1413-1420.
-
(2009)
Mol Biosyst
, vol.5
, pp. 1413-1420
-
-
Foster, S.D.1
Oram, S.H.2
Wilson, N.K.3
Gottgens, B.4
-
19
-
-
74049165069
-
Ontogeny of haematopoiesis: recent advances and open questions.
-
Ottersbach K, Smith A, Wood A, Gottgens B. Ontogeny of haematopoiesis: recent advances and open questions. Br J Haematol 2010, 148:343-355.
-
(2010)
Br J Haematol
, vol.148
, pp. 343-355
-
-
Ottersbach, K.1
Smith, A.2
Wood, A.3
Gottgens, B.4
-
20
-
-
0030911358
-
Purification of primitive human hematopoietic cells capable of repopulating immune-deficient mice.
-
Bhatia M, Wang JCY, Kapp U, Bonnet D, Dick JE. Purification of primitive human hematopoietic cells capable of repopulating immune-deficient mice. Proc Natl Acad Sci U S A 1997, 94:5320-5325.
-
(1997)
Proc Natl Acad Sci U S A
, vol.94
, pp. 5320-5325
-
-
Bhatia, M.1
Wang, J.C.Y.2
Kapp, U.3
Bonnet, D.4
Dick, J.E.5
-
21
-
-
0029796633
-
Long-term lymphohematopoietic reconstitution by a single CD34-low/negative hematopoietic stem cell.
-
Osawa M, Hanada K-I, Hamada H, Nakauchi H. Long-term lymphohematopoietic reconstitution by a single CD34-low/negative hematopoietic stem cell. Science 1996, 273:242-245.
-
(1996)
Science
, vol.273
, pp. 242-245
-
-
Osawa, M.1
Hanada, K.-I.2
Hamada, H.3
Nakauchi, H.4
-
22
-
-
79960106880
-
Isolation of single human hematopoietic stem cells capable of long-term multilineage engraftment.
-
Notta F, Doulatov S, Laurenti E, Poeppl A, Jurisica I, Dick JE. Isolation of single human hematopoietic stem cells capable of long-term multilineage engraftment. Science 2011, 333:218-221.
-
(2011)
Science
, vol.333
, pp. 218-221
-
-
Notta, F.1
Doulatov, S.2
Laurenti, E.3
Poeppl, A.4
Jurisica, I.5
Dick, J.E.6
-
23
-
-
30044434743
-
Embryonic stem cell-derived hematopoietic stem cells.
-
Wang Y, Yates F, Naveiras O, Ernst P, Daley GQ. Embryonic stem cell-derived hematopoietic stem cells. Proc Natl Acad Sci U S A 2005, 102:19081-19086.
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 19081-19086
-
-
Wang, Y.1
Yates, F.2
Naveiras, O.3
Ernst, P.4
Daley, G.Q.5
-
24
-
-
22044453432
-
Control of self-renewal and differentiation of hematopoietic stem cells: HOXB4 on the threshold.
-
Klump H, Schiedlmeier B, Baum C. Control of self-renewal and differentiation of hematopoietic stem cells: HOXB4 on the threshold. Ann N Y Acad Sci 2005, 1044:6-15.
-
(2005)
Ann N Y Acad Sci
, vol.1044
, pp. 6-15
-
-
Klump, H.1
Schiedlmeier, B.2
Baum, C.3
-
25
-
-
71649102823
-
Autologous blood cell therapies from pluripotent stem cells.
-
Lengerke C, Daley GQ. Autologous blood cell therapies from pluripotent stem cells. Blood Rev 2010, 24:27-37.
-
(2010)
Blood Rev
, vol.24
, pp. 27-37
-
-
Lengerke, C.1
Daley, G.Q.2
-
26
-
-
0023922373
-
Purification and characterization of mouse hematopoietic stem cells.
-
Spangrude GJ, Heimfeld S, Weissman IL. Purification and characterization of mouse hematopoietic stem cells. Science 1988, 241:58-62.
-
(1988)
Science
, vol.241
, pp. 58-62
-
-
Spangrude, G.J.1
Heimfeld, S.2
Weissman, I.L.3
-
27
-
-
0026500983
-
Evidence that hematopoietic stem cells express mouse c-kit but do not depend on steel factor for their generation.
-
Ikuta K, Weissman IL. Evidence that hematopoietic stem cells express mouse c-kit but do not depend on steel factor for their generation. Proc Natl Acad Sci U S A 1992, 89:1502-1506.
-
(1992)
Proc Natl Acad Sci U S A
, vol.89
, pp. 1502-1506
-
-
Ikuta, K.1
Weissman, I.L.2
-
28
-
-
0028907847
-
Murine hematopoietic stem and progenitor cells: I. Enrichment and biologic characterization.
-
Li CL, Johnson GR. Murine hematopoietic stem and progenitor cells: I. Enrichment and biologic characterization. Blood 1995, 85:1472-1479.
-
(1995)
Blood
, vol.85
, pp. 1472-1479
-
-
Li, C.L.1
Johnson, G.R.2
-
29
-
-
0026041826
-
Enrichment and characterization of murine hematopoietic stem cells that express c-kit molecule.
-
Okada S, Nakauchi H, Nagayoshi K, Nishikawa S, Miura Y, Suda T. Enrichment and characterization of murine hematopoietic stem cells that express c-kit molecule. Blood 1991, 78:1706-1712.
-
(1991)
Blood
, vol.78
, pp. 1706-1712
-
-
Okada, S.1
Nakauchi, H.2
Nagayoshi, K.3
Nishikawa, S.4
Miura, Y.5
Suda, T.6
-
30
-
-
0027268551
-
Purification and characterization of heterogeneous pluripotent hematopoietic stem cell populations expressing high levels of c-kit receptor.
-
Orlic D, Fischer R, Nishikawa S, Nienhuis AW, Bodine DM. Purification and characterization of heterogeneous pluripotent hematopoietic stem cell populations expressing high levels of c-kit receptor. Blood 1993, 82:762-770.
-
(1993)
Blood
, vol.82
, pp. 762-770
-
-
Orlic, D.1
Fischer, R.2
Nishikawa, S.3
Nienhuis, A.W.4
Bodine, D.M.5
-
31
-
-
79959919129
-
All hematopoietic cells develop from hematopoietic stem cells through Flk2/Flt3-positive progenitor cells.
-
Boyer Scott W, Schroeder Aaron V, Smith-Berdan S, Forsberg EC. All hematopoietic cells develop from hematopoietic stem cells through Flk2/Flt3-positive progenitor cells. Cell Stem Cell 2011, 9:64-73.
-
(2011)
Cell Stem Cell
, vol.9
, pp. 64-73
-
-
Boyer Scott, W.1
Schroeder Aaron, V.2
Smith-Berdan, S.3
Forsberg, E.C.4
-
32
-
-
80051606868
-
FLT3 expression initiates in fully multipotent mouse hematopoietic progenitor cells.
-
Buza-Vidas N, Woll P, Hultquist A, Duarte S, Lutteropp M, Bouriez-Jones T, Ferry H, Luc S, Jacobsen SEW. FLT3 expression initiates in fully multipotent mouse hematopoietic progenitor cells. Blood 2011, 118:1544-1548.
-
(2011)
Blood
, vol.118
, pp. 1544-1548
-
-
Buza-Vidas, N.1
Woll, P.2
Hultquist, A.3
Duarte, S.4
Lutteropp, M.5
Bouriez-Jones, T.6
Ferry, H.7
Luc, S.8
Jacobsen, S.E.W.9
-
33
-
-
0004328021
-
Chromosomal translocation in a human leukemic stem-cell line disrupts the T-cell antigen receptor delta-chain diversity region and results in a previously unreported fusion transcript.
-
Begley CG, Aplan PD, Davey MP, Nakahara K, Tchorz K, Kurtzberg J, Hershfield MS, Haynes BF, Cohen DI, Waldmann TA. Chromosomal translocation in a human leukemic stem-cell line disrupts the T-cell antigen receptor delta-chain diversity region and results in a previously unreported fusion transcript. Proc Natl Acad Sci U S A 1989, 86:2031-2035.
-
(1989)
Proc Natl Acad Sci U S A
, vol.86
, pp. 2031-2035
-
-
Begley, C.G.1
Aplan, P.D.2
Davey, M.P.3
Nakahara, K.4
Tchorz, K.5
Kurtzberg, J.6
Hershfield, M.S.7
Haynes, B.F.8
Cohen, D.I.9
Waldmann, T.A.10
-
34
-
-
0025746321
-
t(8;21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1.
-
Miyoshi H, Shimizu K, Kozu T, Maseki N, Kaneko Y, Ohki M. t(8;21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1. Proc Natl Acad Sci U S A 1991, 88:10431-10434.
-
(1991)
Proc Natl Acad Sci U S A
, vol.88
, pp. 10431-10434
-
-
Miyoshi, H.1
Shimizu, K.2
Kozu, T.3
Maseki, N.4
Kaneko, Y.5
Ohki, M.6
-
35
-
-
0027462484
-
Progression of interleukin-2 (IL-2)-dependent rat T cell lymphoma lines to IL-2-independent growth following activation of a gene (Gfi-1) encoding a novel zinc finger protein.
-
Gilks CB, Bear SE, Grimes HL, Tsichlis PN. Progression of interleukin-2 (IL-2)-dependent rat T cell lymphoma lines to IL-2-independent growth following activation of a gene (Gfi-1) encoding a novel zinc finger protein. Mol Cell Biol 1993, 13:1759-1768.
-
(1993)
Mol Cell Biol
, vol.13
, pp. 1759-1768
-
-
Gilks, C.B.1
Bear, S.E.2
Grimes, H.L.3
Tsichlis, P.N.4
-
36
-
-
0031895515
-
The Gfi-1B proto-oncoprotein represses p21WAF1 and inhibits myeloid cell differentiation.
-
Tong B, Grimes HL, Yang T-Y, Bear SE, Qin Z, Du K, El-Deiry WS, Tsichlis PN. The Gfi-1B proto-oncoprotein represses p21WAF1 and inhibits myeloid cell differentiation. Mol Cell Biol 1998, 18:2462-2473.
-
(1998)
Mol Cell Biol
, vol.18
, pp. 2462-2473
-
-
Tong, B.1
Grimes, H.L.2
Yang, T.-Y.3
Bear, S.E.4
Qin, Z.5
Du, K.6
El-Deiry, W.S.7
Tsichlis, P.N.8
-
38
-
-
0029121271
-
Absence of yolk sac hematopoiesis from mice with a targeted disruption of the scl gene.
-
Robb L, Lyons I, Li R, Hartley L, Köntgen F, Harvey RP, Metcalf D, Begley CG. Absence of yolk sac hematopoiesis from mice with a targeted disruption of the scl gene. Proc Natl Acad Sci U S A 1995, 92:7075-7079.
-
(1995)
Proc Natl Acad Sci U S A
, vol.92
, pp. 7075-7079
-
-
Robb, L.1
Lyons, I.2
Li, R.3
Hartley, L.4
Köntgen, F.5
Harvey, R.P.6
Metcalf, D.7
Begley, C.G.8
-
39
-
-
0028858855
-
Absence of blood formation in mice lacking the T-cell leukaemia oncoprotein tal-1/SCL.
-
Shivdasani RA, Mayer EL, Orkin SH. Absence of blood formation in mice lacking the T-cell leukaemia oncoprotein tal-1/SCL. Nature 1995, 373:432-434.
-
(1995)
Nature
, vol.373
, pp. 432-434
-
-
Shivdasani, R.A.1
Mayer, E.L.2
Orkin, S.H.3
-
40
-
-
0029918597
-
Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis.
-
Wang Q, Stacy T, Binder M, Marin-Padilla M, Sharpe AH, Speck NA. Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis. Proc Natl Acad Sci U S A 1996, 93:3444-3449.
-
(1996)
Proc Natl Acad Sci U S A
, vol.93
, pp. 3444-3449
-
-
Wang, Q.1
Stacy, T.2
Binder, M.3
Marin-Padilla, M.4
Sharpe, A.H.5
Speck, N.A.6
-
41
-
-
7244231429
-
Gfi-1 restricts proliferation and preserves functional integrity of haematopoietic stem cells.
-
Hock H, Hamblen MJ, Rooke HM, Schindler JW, Saleque S, Fujiwara Y, Orkin SH. Gfi-1 restricts proliferation and preserves functional integrity of haematopoietic stem cells. Nature 2004, 431:1002-1007.
-
(2004)
Nature
, vol.431
, pp. 1002-1007
-
-
Hock, H.1
Hamblen, M.J.2
Rooke, H.M.3
Schindler, J.W.4
Saleque, S.5
Fujiwara, Y.6
Orkin, S.H.7
-
42
-
-
8144220648
-
Transcription factor Gfi1 regulates self-renewal and engraftment of hematopoietic stem cells.
-
Zeng H, Yucel R, Kosan C, Klein-Hitpass L, Moroy T. Transcription factor Gfi1 regulates self-renewal and engraftment of hematopoietic stem cells. EMBO J 2004, 23:4116-4125.
-
(2004)
EMBO J
, vol.23
, pp. 4116-4125
-
-
Zeng, H.1
Yucel, R.2
Kosan, C.3
Klein-Hitpass, L.4
Moroy, T.5
-
43
-
-
0036467868
-
The zinc-finger proto-oncogene Gfi-1b is essential for development of the erythroid and megakaryocytic lineages.
-
Saleque S, Cameron S, Orkin SH. The zinc-finger proto-oncogene Gfi-1b is essential for development of the erythroid and megakaryocytic lineages. Genes Dev 2002, 16:301-306.
-
(2002)
Genes Dev
, vol.16
, pp. 301-306
-
-
Saleque, S.1
Cameron, S.2
Orkin, S.H.3
-
44
-
-
80052418667
-
Transcriptional regulation of haematopoietic transcription factors.
-
Wilson N, Calero-Nieto F, Ferreira R, Gottgens B. Transcriptional regulation of haematopoietic transcription factors. Stem Cell Res Ther 2011, 2:6.
-
(2011)
Stem Cell Res Ther
, vol.2
, pp. 6
-
-
Wilson, N.1
Calero-Nieto, F.2
Ferreira, R.3
Gottgens, B.4
-
45
-
-
84862833504
-
cis-Regulatory remodeling of the SCL locus during vertebrate evolution.
-
Gottgens B, Ferreira R, Sanchez M-J, Ishibashi S, Li J, Spensberger D, Lefevre P, Ottersbach K, Chapman M, Kinston S, et al. cis-Regulatory remodeling of the SCL locus during vertebrate evolution. Mol Cell Biol 2010, 30:5741-5751.
-
(2010)
Mol Cell Biol
, vol.30
, pp. 5741-5751
-
-
Gottgens, B.1
Ferreira, R.2
Sanchez, M.-J.3
Ishibashi, S.4
Li, J.5
Spensberger, D.6
Lefevre, P.7
Ottersbach, K.8
Chapman, M.9
Kinston, S.10
-
46
-
-
67349199007
-
Expression of the leukemia oncogene Lmo2 is controlled by an array of tissue-specific elements dispersed over 100 kb and bound by Tal1/Lmo2, Ets, and Gata factors.
-
Landry J-R, Bonadies N, Kinston S, Knezevic K, Wilson NK, Oram SH, Janes M, Piltz S, Hammett M, Carter J, et al. Expression of the leukemia oncogene Lmo2 is controlled by an array of tissue-specific elements dispersed over 100 kb and bound by Tal1/Lmo2, Ets, and Gata factors. Blood 2009, 113:5783-5792.
-
(2009)
Blood
, vol.113
, pp. 5783-5792
-
-
Landry, J.-R.1
Bonadies, N.2
Kinston, S.3
Knezevic, K.4
Wilson, N.K.5
Oram, S.H.6
Janes, M.7
Piltz, S.8
Hammett, M.9
Carter, J.10
-
47
-
-
27144469889
-
Fli1, Elf1, and Ets1 regulate the proximal promoter of the LMO2 gene in endothelial cells.
-
Landry J-R, Kinston S, Knezevic K, Donaldson IJ, Green AR, Göttgens B. Fli1, Elf1, and Ets1 regulate the proximal promoter of the LMO2 gene in endothelial cells. Blood 2005, 106:2680-2687.
-
(2005)
Blood
, vol.106
, pp. 2680-2687
-
-
Landry, J.-R.1
Kinston, S.2
Knezevic, K.3
Donaldson, I.J.4
Green, A.R.5
Göttgens, B.6
-
48
-
-
77955298571
-
Gfi1 expression is controlled by five distinct regulatory regions spread over 100 kilobases, with Scl/Tal1, Gata2, PU.1, Erg, Meis1, and Runx1 acting as upstream regulators in early hematopoietic cells.
-
Wilson NK, Timms RT, Kinston SJ, Cheng Y-H, Oram SH, Landry J-R, Mullender J, Ottersbach K, Gottgens B. Gfi1 expression is controlled by five distinct regulatory regions spread over 100 kilobases, with Scl/Tal1, Gata2, PU.1, Erg, Meis1, and Runx1 acting as upstream regulators in early hematopoietic cells. Mol Cell Biol 2010, 30:3853-3863.
-
(2010)
Mol Cell Biol
, vol.30
, pp. 3853-3863
-
-
Wilson, N.K.1
Timms, R.T.2
Kinston, S.J.3
Cheng, Y.-H.4
Oram, S.H.5
Landry, J.-R.6
Mullender, J.7
Ottersbach, K.8
Gottgens, B.9
-
49
-
-
20344385528
-
Transcriptional regulation of the SCL locus: identification of an enhancer that targets the primitive erythroid lineage in vivo.
-
Delabesse E, Ogilvy S, Chapman MA, Piltz SG, Gottgens B, Green AR. Transcriptional regulation of the SCL locus: identification of an enhancer that targets the primitive erythroid lineage in vivo. Mol Cell Biol 2005, 25:5215-5225.
-
(2005)
Mol Cell Biol
, vol.25
, pp. 5215-5225
-
-
Delabesse, E.1
Ogilvy, S.2
Chapman, M.A.3
Piltz, S.G.4
Gottgens, B.5
Green, A.R.6
-
50
-
-
2942526253
-
The scl +18/19 stem cell enhancer is not required for hematopoiesis: identification of a 5′ bifunctional hematopoietic-endothelial enhancer bound by Fli-1 and Elf-1.
-
Gottgens B, Broccardo C, Sanchez M-J, Deveaux S, Murphy G, Gothert JR, Kotsopoulou E, Kinston S, Delaney L, Piltz S, et al. The scl +18/19 stem cell enhancer is not required for hematopoiesis: identification of a 5′ bifunctional hematopoietic-endothelial enhancer bound by Fli-1 and Elf-1. Mol Cell Biol 2004, 24:1870-1883.
-
(2004)
Mol Cell Biol
, vol.24
, pp. 1870-1883
-
-
Gottgens, B.1
Broccardo, C.2
Sanchez, M.-J.3
Deveaux, S.4
Murphy, G.5
Gothert, J.R.6
Kotsopoulou, E.7
Kinston, S.8
Delaney, L.9
Piltz, S.10
-
51
-
-
27144453346
-
Transgenic analysis of the stem cell leukemia +19 stem cell enhancer in adult and embryonic hematopoietic and endothelial cells.
-
Silberstein L, Sánchez M-J, Socolovsky M, Liu Y, Hoffman G, Kinston S, Piltz S, Bowen M, Gambardella L, Green AR, et al. Transgenic analysis of the stem cell leukemia +19 stem cell enhancer in adult and embryonic hematopoietic and endothelial cells. Stem Cells 2005, 23:1378-1388.
-
(2005)
Stem Cells
, vol.23
, pp. 1378-1388
-
-
Silberstein, L.1
Sánchez, M.-J.2
Socolovsky, M.3
Liu, Y.4
Hoffman, G.5
Kinston, S.6
Piltz, S.7
Bowen, M.8
Gambardella, L.9
Green, A.R.10
-
52
-
-
0032582512
-
Transcriptional regulation of the stem cell leukemia gene by PU.1 and Elf-1.
-
Bockamp E-O, Fordham JL, Göttgens B, Murrell AM, Sanchez M-J, Green AR. Transcriptional regulation of the stem cell leukemia gene by PU.1 and Elf-1. J Biol Chem 1998, 273:29032-29042.
-
(1998)
J Biol Chem
, vol.273
, pp. 29032-29042
-
-
Bockamp, E.-O.1
Fordham, J.L.2
Göttgens, B.3
Murrell, A.M.4
Sanchez, M.-J.5
Green, A.R.6
-
53
-
-
15944401331
-
In vivo fate-tracing studies using the Scl stem cell enhancer: embryonic hematopoietic stem cells significantly contribute to adult hematopoiesis.
-
Göthert JR, Gustin SE, Hall MA, Green AR, Göttgens B, Izon DJ, Begley CG. In vivo fate-tracing studies using the Scl stem cell enhancer: embryonic hematopoietic stem cells significantly contribute to adult hematopoiesis. Blood 2005, 105:2724-2732.
-
(2005)
Blood
, vol.105
, pp. 2724-2732
-
-
Göthert, J.R.1
Gustin, S.E.2
Hall, M.A.3
Green, A.R.4
Göttgens, B.5
Izon, D.J.6
Begley, C.G.7
-
54
-
-
67149099806
-
The mouse Runx1 +23 hematopoietic stem cell enhancer confers hematopoietic specificity to both Runx1 promoters.
-
Bee T, Ashley ELK, Bickley SRB, Jarratt A, Li P-S, Sloane-Stanley J, Göttgens B, de Bruijn MFTR. The mouse Runx1 +23 hematopoietic stem cell enhancer confers hematopoietic specificity to both Runx1 promoters. Blood 2009, 113:5121-5124.
-
(2009)
Blood
, vol.113
, pp. 5121-5124
-
-
Bee, T.1
Ashley, E.L.K.2
Bickley, S.R.B.3
Jarratt, A.4
Li, P.-S.5
Sloane-Stanley, J.6
Göttgens, B.7
de Bruijn, M.F.T.R.8
-
55
-
-
38349165800
-
Runx1-mediated hematopoietic stem-cell emergence is controlled by a Gata/Ets/SCL-regulated enhancer.
-
Nottingham WT, Jarratt A, Burgess M, Speck CL, Cheng J-F, Prabhakar S, Rubin EM, Li P-S, Sloane-Stanley J, Kong-a-San J, et al. Runx1-mediated hematopoietic stem-cell emergence is controlled by a Gata/Ets/SCL-regulated enhancer. Blood 2007, 110:4188-4197.
-
(2007)
Blood
, vol.110
, pp. 4188-4197
-
-
Nottingham, W.T.1
Jarratt, A.2
Burgess, M.3
Speck, C.L.4
Cheng, J.-F.5
Prabhakar, S.6
Rubin, E.M.7
Li, P.-S.8
Sloane-Stanley, J.9
Kong-a-San, J.10
-
56
-
-
42449101777
-
Runx genes are direct targets of Scl/Tal1 in the yolk sac and fetal liver.
-
Landry J-R, Kinston S, Knezevic K, de Bruijn MFTR, Wilson N, Nottingham WT, Peitz M, Edenhofer F, Pimanda JE, Ottersbach K, et al. Runx genes are direct targets of Scl/Tal1 in the yolk sac and fetal liver. Blood 2008, 111:3005-3014.
-
(2008)
Blood
, vol.111
, pp. 3005-3014
-
-
Landry, J.-R.1
Kinston, S.2
Knezevic, K.3
de Bruijn, M.F.T.R.4
Wilson, N.5
Nottingham, W.T.6
Peitz, M.7
Edenhofer, F.8
Pimanda, J.E.9
Ottersbach, K.10
-
57
-
-
79955137160
-
A compendium of genome-wide hematopoietic transcription factor maps supports the identification of gene regulatory control mechanisms.
-
Hannah R, Joshi A, Wilson NK, Kinston S, Göttgens B. A compendium of genome-wide hematopoietic transcription factor maps supports the identification of gene regulatory control mechanisms. Exp Hematol 2011, 39:531-541.
-
(2011)
Exp Hematol
, vol.39
, pp. 531-541
-
-
Hannah, R.1
Joshi, A.2
Wilson, N.K.3
Kinston, S.4
Göttgens, B.5
-
58
-
-
14644412924
-
Genome-wide identification of cis-regulatory sequences controlling blood and endothelial development.
-
Donaldson IJ, Chapman M, Kinston S, Landry JR, Knezevic K, Piltz S, Buckley N, Green AR, Gottgens B. Genome-wide identification of cis-regulatory sequences controlling blood and endothelial development. Hum Mol Genet 2005, 14:595-601.
-
(2005)
Hum Mol Genet
, vol.14
, pp. 595-601
-
-
Donaldson, I.J.1
Chapman, M.2
Kinston, S.3
Landry, J.R.4
Knezevic, K.5
Piltz, S.6
Buckley, N.7
Green, A.R.8
Gottgens, B.9
-
59
-
-
36749094041
-
Gata2, Fli1, and Scl form a recursively wired gene-regulatory circuit during early hematopoietic development.
-
Pimanda JE, Ottersbach K, Knezevic K, Kinston S, Chan WY, Wilson NK, Landry JR, Wood AD, Kolb-Kokocinski A, Green AR, et al. Gata2, Fli1, and Scl form a recursively wired gene-regulatory circuit during early hematopoietic development. Proc Natl Acad Sci U S A 2007, 104:17692-17697.
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 17692-17697
-
-
Pimanda, J.E.1
Ottersbach, K.2
Knezevic, K.3
Kinston, S.4
Chan, W.Y.5
Wilson, N.K.6
Landry, J.R.7
Wood, A.D.8
Kolb-Kokocinski, A.9
Green, A.R.10
-
60
-
-
67049108075
-
The transcriptional program controlled by the stem cell leukemia gene Scl/Tal1 during early embryonic hematopoietic development.
-
Wilson NK, Miranda-Saavedra D, Kinston S, Bonadies N, Foster SD, Calero-Nieto F, Dawson MA, Donaldson IJ, Dumon S, Frampton J, et al. The transcriptional program controlled by the stem cell leukemia gene Scl/Tal1 during early embryonic hematopoietic development. Blood 2009, 113:5456-5465.
-
(2009)
Blood
, vol.113
, pp. 5456-5465
-
-
Wilson, N.K.1
Miranda-Saavedra, D.2
Kinston, S.3
Bonadies, N.4
Foster, S.D.5
Calero-Nieto, F.6
Dawson, M.A.7
Donaldson, I.J.8
Dumon, S.9
Frampton, J.10
-
61
-
-
0037174670
-
Network motifs: simple building blocks of complex networks.
-
Milo R, Shen-Orr S, Itzkovitz S, Kashtan N, Chklovskii D, Alon U. Network motifs: simple building blocks of complex networks. Science 2002, 298:824-827.
-
(2002)
Science
, vol.298
, pp. 824-827
-
-
Milo, R.1
Shen-Orr, S.2
Itzkovitz, S.3
Kashtan, N.4
Chklovskii, D.5
Alon, U.6
-
62
-
-
4344660909
-
ES02.01 transcriptional regulation of haematopoiesis.
-
Göttgens B. ES02.01 transcriptional regulation of haematopoiesis. Vox Sang 2004, 87:15-19.
-
(2004)
Vox Sang
, vol.87
, pp. 15-19
-
-
Göttgens, B.1
-
63
-
-
0032146794
-
PU.1 induces myeloid lineage commitment in multipotent hematopoietic progenitors.
-
Nerlov C, Graf T. PU.1 induces myeloid lineage commitment in multipotent hematopoietic progenitors. Genes Dev 1998, 12:2403-2412.
-
(1998)
Genes Dev
, vol.12
, pp. 2403-2412
-
-
Nerlov, C.1
Graf, T.2
-
64
-
-
0026489910
-
GATA-1 but not SCL induces megakaryocytic differentiation in an early myeloid line.
-
Visvader J, Elefanty AG, Strasser A, Adams J. GATA-1 but not SCL induces megakaryocytic differentiation in an early myeloid line. EMBO J 1992, 11:4557-4564.
-
(1992)
EMBO J
, vol.11
, pp. 4557-4564
-
-
Visvader, J.1
Elefanty, A.G.2
Strasser, A.3
Adams, J.4
-
65
-
-
34848883146
-
Reciprocal activation of GATA-1 and PU.1 marks initial specification of hematopoietic stem cells into myeloerythroid and myelolymphoid lineages.
-
Arinobu Y, Mizuno S-I, Chong Y, Shigematsu H, Iino T, Iwasaki H, Graf T, Mayfield R, Chan S, Kastner P, et al. Reciprocal activation of GATA-1 and PU.1 marks initial specification of hematopoietic stem cells into myeloerythroid and myelolymphoid lineages. Cell Stem Cell 2007, 1:416-427.
-
(2007)
Cell Stem Cell
, vol.1
, pp. 416-427
-
-
Arinobu, Y.1
Mizuno, S.-I.2
Chong, Y.3
Shigematsu, H.4
Iino, T.5
Iwasaki, H.6
Graf, T.7
Mayfield, R.8
Chan, S.9
Kastner, P.10
-
66
-
-
59149091124
-
Computational modeling of the hematopoietic erythroid-myeloid switch reveals insights into cooperativity, priming, and irreversibility.
-
Chickarmane V, Enver T, Peterson C. Computational modeling of the hematopoietic erythroid-myeloid switch reveals insights into cooperativity, priming, and irreversibility. PLoS Comput Biol 2009, 5:e1000268.
-
(2009)
PLoS Comput Biol
, vol.5
-
-
Chickarmane, V.1
Enver, T.2
Peterson, C.3
-
67
-
-
18444415449
-
Establishing the transcriptional programme for blood: the SCL stem cell enhancer is regulated by a multiprotein complex containing Ets and GATA factors.
-
Gottgens B, Nastos A, Kinston S, Piltz S, Delabesse ECM, Stanley M, Sanchez M-J, Ciau-Uitz A, Patient R, Green AR. Establishing the transcriptional programme for blood: the SCL stem cell enhancer is regulated by a multiprotein complex containing Ets and GATA factors. EMBO J 2002, 21:3039-3050.
-
(2002)
EMBO J
, vol.21
, pp. 3039-3050
-
-
Gottgens, B.1
Nastos, A.2
Kinston, S.3
Piltz, S.4
Delabesse, E.C.M.5
Stanley, M.6
Sanchez, M.-J.7
Ciau-Uitz, A.8
Patient, R.9
Green, A.R.10
-
68
-
-
79952762446
-
The gata1/pu.1 lineage fate paradigm varies between blood populations and is modulated by tif1[γ].
-
Monteiro R, Pouget C, Patient R. The gata1/pu.1 lineage fate paradigm varies between blood populations and is modulated by tif1[γ]. EMBO J 2011, 30:1093-1103.
-
(2011)
EMBO J
, vol.30
, pp. 1093-1103
-
-
Monteiro, R.1
Pouget, C.2
Patient, R.3
-
69
-
-
23344452957
-
GATA motifs regulate early hematopoietic lineage-specific expression of the Gata2 gene.
-
Kobayashi-Osaki M, Ohneda O, Suzuki N, Minegishi N, Yokomizo T, Takahashi S, Lim K-C, Engel JD, Yamamoto M. GATA motifs regulate early hematopoietic lineage-specific expression of the Gata2 gene. Mol Cell Biol 2005, 25:7005-7020.
-
(2005)
Mol Cell Biol
, vol.25
, pp. 7005-7020
-
-
Kobayashi-Osaki, M.1
Ohneda, O.2
Suzuki, N.3
Minegishi, N.4
Yokomizo, T.5
Takahashi, S.6
Lim, K.-C.7
Engel, J.D.8
Yamamoto, M.9
-
70
-
-
77955502318
-
Modeling reveals bistability and low-pass filtering in the network module determining blood stem cell fate.
-
Narula J, Smith AM, Gottgens B, Igoshin OA. Modeling reveals bistability and low-pass filtering in the network module determining blood stem cell fate. PLoS Comput Biol 2010, 6:e1000771.
-
(2010)
PLoS Comput Biol
, vol.6
-
-
Narula, J.1
Smith, A.M.2
Gottgens, B.3
Igoshin, O.A.4
-
71
-
-
0034717335
-
Regulation of B lymphocyte and macrophage development by graded expression of PU.1.
-
DeKoter RP, Singh H. Regulation of B lymphocyte and macrophage development by graded expression of PU.1. Science 2000, 288:1439-1441.
-
(2000)
Science
, vol.288
, pp. 1439-1441
-
-
DeKoter, R.P.1
Singh, H.2
-
72
-
-
0036193609
-
Constitutive expression of PU.1 in fetal hematopoietic progenitors blocks T cell development at the pro-T cell stage.
-
Anderson MK, Weiss AH, Hernandez-Hoyos Dionne G, Rothenberg CJ. EV Constitutive expression of PU.1 in fetal hematopoietic progenitors blocks T cell development at the pro-T cell stage. Immunity 2002, 16:285-296.
-
(2002)
Immunity
, vol.16
, pp. 285-296
-
-
Anderson, M.K.1
Weiss, A.H.2
Hernandez-Hoyos Dionne, G.3
Rothenberg, C.E.4
-
73
-
-
0037244284
-
Intrinsic requirement for zinc finger transcription factor Gfi-1 in neutrophil differentiation.
-
Hock H, Hamblen MJ, Rooke HM, Traver D, Bronson RT, Cameron S, Orkin SH. Intrinsic requirement for zinc finger transcription factor Gfi-1 in neutrophil differentiation. Immunity 2003, 18:109-120.
-
(2003)
Immunity
, vol.18
, pp. 109-120
-
-
Hock, H.1
Hamblen, M.J.2
Rooke, H.M.3
Traver, D.4
Bronson, R.T.5
Cameron, S.6
Orkin, S.H.7
-
74
-
-
17644443312
-
The transcriptional repressor Gfi1 affects development of early, uncommitted c-kit+ T cell progenitors and CD4/CD8 lineage decision in the thymus.
-
Yücel R, Karsunky H, Klein-Hitpass L, Möröy T. The transcriptional repressor Gfi1 affects development of early, uncommitted c-kit+ T cell progenitors and CD4/CD8 lineage decision in the thymus. J Exp Med 2003, 197:831-844.
-
(2003)
J Exp Med
, vol.197
, pp. 831-844
-
-
Yücel, R.1
Karsunky, H.2
Klein-Hitpass, L.3
Möröy, T.4
-
75
-
-
70349728484
-
A recurrent network involving the transcription factors PU.1 and Gfi1 orchestrates innate and adaptive immune cell fates.
-
Spooner CJ, Cheng JX, Pujadas E, Laslo P, Singh H. A recurrent network involving the transcription factors PU.1 and Gfi1 orchestrates innate and adaptive immune cell fates. Immunity 2009, 31:576-586.
-
(2009)
Immunity
, vol.31
, pp. 576-586
-
-
Spooner, C.J.1
Cheng, J.X.2
Pujadas, E.3
Laslo, P.4
Singh, H.5
-
76
-
-
34848873739
-
C/EBPα induces PU.1 and interacts with AP-1 and NF-κB to regulate myeloid development.
-
Friedman AD. C/EBPα induces PU.1 and interacts with AP-1 and NF-κB to regulate myeloid development. Blood Cells Mol Dis 2007, 39:340-343.
-
(2007)
Blood Cells Mol Dis
, vol.39
, pp. 340-343
-
-
Friedman, A.D.1
-
77
-
-
2542455620
-
Stepwise reprogramming of B cells into macrophages.
-
Xie H, Ye M, Feng R, Graf T. Stepwise reprogramming of B cells into macrophages. Cell 2004, 117:663-676.
-
(2004)
Cell
, vol.117
, pp. 663-676
-
-
Xie, H.1
Ye, M.2
Feng, R.3
Graf, T.4
-
78
-
-
0030006070
-
Clonal selection and learning in the antibody system.
-
Rajewsky K. Clonal selection and learning in the antibody system. Nature 1996, 381:751-758.
-
(1996)
Nature
, vol.381
, pp. 751-758
-
-
Rajewsky, K.1
-
79
-
-
33747133955
-
Graded expression of interferon regulatory factor-4 coordinates isotype switching with plasma cell differentiation.
-
Sciammas R, Shaffer AL, Schatz JH, Zhao H, Staudt LM, Singh H. Graded expression of interferon regulatory factor-4 coordinates isotype switching with plasma cell differentiation. Immunity 2006, 25:225-236.
-
(2006)
Immunity
, vol.25
, pp. 225-236
-
-
Sciammas, R.1
Shaffer, A.L.2
Schatz, J.H.3
Zhao, H.4
Staudt, L.M.5
Singh, H.6
-
80
-
-
79957566441
-
An incoherent regulatory network architecture that orchestrates B cell diversification in response to antigen signaling.
-
Sciammas R, Li Y, Warmflash A, Song Y, Dinner AR, Singh H. An incoherent regulatory network architecture that orchestrates B cell diversification in response to antigen signaling. Mol Syst Biol 2011, 7.
-
(2011)
Mol Syst Biol
, vol.7
-
-
Sciammas, R.1
Li, Y.2
Warmflash, A.3
Song, Y.4
Dinner, A.R.5
Singh, H.6
-
81
-
-
77649264807
-
Functional cis-regulatory genomics for systems biology.
-
Nam J, Dong P, Tarpine R, Istrail S, Davidson EH. Functional cis-regulatory genomics for systems biology. Proc Natl Acad Sci U S A 2010, 107:3930-3935.
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, pp. 3930-3935
-
-
Nam, J.1
Dong, P.2
Tarpine, R.3
Istrail, S.4
Davidson, E.H.5
-
82
-
-
67651111994
-
Early chromatin unfolding by RUNX1: a molecular explanation for differential requirements during specification versus maintenance of the hematopoietic gene expression program.
-
Hoogenkamp M, Lichtinger M, Krysinska H, Lancrin C, Clarke D, Williamson A, Mazzarella L, Ingram R, Jorgensen H, Fisher A, et al. Early chromatin unfolding by RUNX1: a molecular explanation for differential requirements during specification versus maintenance of the hematopoietic gene expression program. Blood 2009, 114:299-309.
-
(2009)
Blood
, vol.114
, pp. 299-309
-
-
Hoogenkamp, M.1
Lichtinger, M.2
Krysinska, H.3
Lancrin, C.4
Clarke, D.5
Williamson, A.6
Mazzarella, L.7
Ingram, R.8
Jorgensen, H.9
Fisher, A.10
-
83
-
-
60149110371
-
The haemangioblast generates haematopoietic cells through a haemogenic endothelium stage.
-
Lancrin C, Sroczynska P, Stephenson C, Allen T, Kouskoff V, Lacaud G. The haemangioblast generates haematopoietic cells through a haemogenic endothelium stage. Nature 2009, 457:892-895.
-
(2009)
Nature
, vol.457
, pp. 892-895
-
-
Lancrin, C.1
Sroczynska, P.2
Stephenson, C.3
Allen, T.4
Kouskoff, V.5
Lacaud, G.6
-
84
-
-
37549052500
-
PU.1 is a major downstream target of AML1 (RUNX1) in adult mouse hematopoiesis.
-
Huang G, Zhang P, Hirai H, Elf S, Yan X, Chen Z, Koschmieder S, Okuno Y, Dayaram T, Growney JD, et al. PU.1 is a major downstream target of AML1 (RUNX1) in adult mouse hematopoiesis. Nat Genet 2008, 40:51-60.
-
(2008)
Nat Genet
, vol.40
, pp. 51-60
-
-
Huang, G.1
Zhang, P.2
Hirai, H.3
Elf, S.4
Yan, X.5
Chen, Z.6
Koschmieder, S.7
Okuno, Y.8
Dayaram, T.9
Growney, J.D.10
-
85
-
-
79955883317
-
Genome-wide analysis of simultaneous GATA1/2, RUNX1, FLI1, and SCL binding in megakaryocytes identifies hematopoietic regulators.
-
Tijssen Marloes R, Cvejic A, Joshi A, Hannah Rebecca L, Ferreira R, Forrai A, Bellissimo DC, Oram SH, Smethurst PA, Wilson NK, et al. Genome-wide analysis of simultaneous GATA1/2, RUNX1, FLI1, and SCL binding in megakaryocytes identifies hematopoietic regulators. Dev Cell 2011, 20:597-609.
-
(2011)
Dev Cell
, vol.20
, pp. 597-609
-
-
Tijssen Marloes, R.1
Cvejic, A.2
Joshi, A.3
Hannah Rebecca, L.4
Ferreira, R.5
Forrai, A.6
Bellissimo, D.C.7
Oram, S.H.8
Smethurst, P.A.9
Wilson, N.K.10
|