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Volumn 19, Issue 3, 2012, Pages 260-270

The effects of dexamethasone treatment in early gestation on hypothalamic-pituitary-adrenal responses and gene expression at 7 months of postnatal age in sheep

Author keywords

dexamethasone; fetal programming; hypothalamic pituitary adrenal; steroidogenic enzymes

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE 2; 3BETA HYDROXY DELTA5 STEROID DEHYDROGENASE; ARGIPRESSIN; CORTICOTROPIN; CORTICOTROPIN RECEPTOR; CORTICOTROPIN RELEASING FACTOR; DEXAMETHASONE; GLUCOCORTICOID RECEPTOR; HYDROCORTISONE; MESSENGER RNA; MINERALOCORTICOID RECEPTOR; PROOPIOMELANOCORTIN; PROPROTEIN CONVERTASE 1; PROPROTEIN CONVERTASE 2; STEROIDOGENIC ACUTE REGULATORY PROTEIN;

EID: 84859823655     PISSN: 19337191     EISSN: 19337205     Source Type: Journal    
DOI: 10.1177/1933719111418374     Document Type: Article
Times cited : (15)

References (54)
  • 1
    • 0033709493 scopus 로고    scopus 로고
    • Endocrine and paracrine regulation of birth at term and preterm 1
    • Challis JRG, Matthews SG, Gibb W, Lye SJ. Endocrine and paracrine regulation of birth at term and preterm 1. Endocr Rev. 2000;21(5):514-550.
    • (2000) Endocr Rev , vol.21 , Issue.5 , pp. 514-550
    • Challis, J.R.G.1    Matthews, S.G.2    Gibb, W.3    Lye, S.J.4
  • 4
    • 0034115174 scopus 로고    scopus 로고
    • Effects of repeated maternal betamethasone administration on growth and hypothalamic-pituitary-adrenal function of the ovine fetus at term
    • Sloboda DM, Newnham JP. Effects of repeated maternal betamethasone administration on growth and hypothalamic-pituitary-adrenal function of the ovine fetus at term. J Endocrinol. 2000;165(1):79-91. (Pubitemid 30210568)
    • (2000) Journal of Endocrinology , vol.165 , Issue.1 , pp. 79-91
    • Sloboda, D.M.1    Newnham, J.P.2    Challis, J.R.G.3
  • 6
    • 0036150161 scopus 로고    scopus 로고
    • The effect of prenatal betamethasone administration on postnatal ovine hypothalamic-pituitary-adrenal function
    • DOI 10.1677/joe.0.1720071
    • Sloboda DM, Moss TJ, Gurrin LC, Newnham JP. The effect of prenatal betamethasone administration on postnatal ovine hypothalamic-pituitary-adrenal function. J Endocrinol. 2002;172(1):71-81. (Pubitemid 34082946)
    • (2002) Journal of Endocrinology , vol.172 , Issue.1 , pp. 71-81
    • Sloboda, D.M.1    Moss, T.J.2    Gurrin, L.C.3    Newnham, J.P.4    Challis, J.R.G.5
  • 7
    • 17844406864 scopus 로고    scopus 로고
    • Synthetic glucocorticoids: Antenatal administration and long-term implications
    • DOI 10.2174/1381612053507873
    • Sloboda DM, Challis JRG, Moss TJM, Newnham JP. Synthetic glucocorticoids: antenatal administration and long-term implications. Curr Pharm Des. 2005;11(11):1459-1472. (Pubitemid 40590194)
    • (2005) Current Pharmaceutical Design , vol.11 , Issue.11 , pp. 1459-1472
    • Sloboda, D.M.1    Challis, J.R.G.2    Moss, T.J.M.3    Newnham, J.P.4
  • 8
    • 25144511377 scopus 로고    scopus 로고
    • Hepatic glucose regulation and metabolism in adult sheep: Effects of prenatal betamethasone
    • Sloboda DM, Moss TJM, Li S, et al. Hepatic glucose regulation and metabolism in adult sheep: effects of prenatal betamethasone. Am J Physiol Endocrinol Metab. 2005;289(4):721-728.
    • (2005) Am J Physiol Endocrinol Metab , vol.289 , Issue.4 , pp. 721-728
    • Sloboda, D.M.1    Moss, T.J.M.2    Li, S.3
  • 11
    • 43849100270 scopus 로고    scopus 로고
    • Expression of glucocorticoid receptor, mineralocorticoid receptor, and 11{beta}-hydroxysteroid dehydrogenase 1 and 2 in the fetal and postnatal ovine hippocampus: Ontogeny and effects of prenatal glucocorticoid exposure
    • DOI 10.1677/JOE-07-0375
    • Sloboda DM, Moss TJM, Li S, Matthews SG, Challis JRG, Newnham JP. Expression of glucocorticoid receptor, mineralocorticoid receptor, and 11 {beta}-hydroxysteroid dehydrogenase 1 and 2 in the fetal and postnatal ovine hippocampus: ontogeny and effects of prenatal glucocorticoid exposure. J Endocrinol. 2008;197(2):213-220. (Pubitemid 351696234)
    • (2008) Journal of Endocrinology , vol.197 , Issue.2 , pp. 213-220
    • Sloboda, D.M.1    Moss, T.J.M.2    Li, S.3    Matthews, S.G.4    Challis, J.R.G.5    Newnham, J.P.6
  • 12
    • 0021691461 scopus 로고
    • Prenatal treatment of congenital adrenal hyperplasia resulting from 21-hydroxylase deficiency
    • DOI 10.1016/S0022-3476(84)80310-8
    • David M, Forest MG. Prenatal treatment of congenital adrenal hyperplasia resulting from 21-hydroxylase deficiency. J Pediatr. 1984;105(5):799-803. (Pubitemid 15206715)
    • (1984) Journal of Pediatrics , vol.105 , Issue.5 , pp. 799-803
    • David, M.1    Forest, M.G.2
  • 13
    • 0025105235 scopus 로고
    • Prenatal treatment of congenital adrenal hyperplasia due to 21-hydroxylase deficiency
    • Pang SY, Pollack MS, Marshall RN, Immken L. Prenatal treatment of congenital adrenal hyperplasia due to 21-hydroxylase deficiency. N Engl J Med. 1990;322(2):111-115. (Pubitemid 20023869)
    • (1990) New England Journal of Medicine , vol.322 , Issue.2 , pp. 111-115
    • Pang, S.1    Pollack, M.S.2    Marshall, R.N.3    Immken, L.4
  • 14
    • 0027523996 scopus 로고
    • Prenatal dexamethasone treatment in pregnancies at risk for congenital adrenal hyperplasia due to 21-hydroxylase deficiency: Effect on midgestational amniotic fluid steroid levels
    • DOI 10.1210/jc.76.1.117
    • Dorr HG, Sippell WG. Prenatal dexamethasone treatment in pregnancies at risk for congenital adrenal hyperplasia due to 21-hydroxylase deficiency: effect on midgestational amniotic fluid steroid levels. J Clin Endocrinol Metab. 1993;76(1):117-120. (Pubitemid 23027564)
    • (1993) Journal of Clinical Endocrinology and Metabolism , vol.76 , Issue.1 , pp. 117-120
    • Dorr, H.G.1    Sippell, W.G.2
  • 15
    • 34249097377 scopus 로고    scopus 로고
    • Cognitive functions in children at risk for congenital adrenal hyperplasia treated prenatally with dexamethasone
    • Hirvikoski T, Nordenström A, Lindholm T, et al. Cognitive functions in children at risk for congenital adrenal hyperplasia treated prenatally with dexamethasone. Obstet Gynecol Surv 2007;62:382-384.
    • (2007) Obstet Gynecol Surv , vol.62 , pp. 382-384
    • Hirvikoski, T.1    Nordenström, A.2    Lindholm, T.3
  • 16
    • 0036841532 scopus 로고    scopus 로고
    • Programming effects of short prenatal exposure to dexamethasone in sheep
    • DOI 10.1161/01.HYP.0000036455.62159.7E
    • Dodic M, Abouantoun T, O'Connor A, Wintour EM, Moritz KM. Programming effects of short prenatal exposure to dexamethasone in sheep. Hypertension. 2002;40(5):729-734. (Pubitemid 35278611)
    • (2002) Hypertension , vol.40 , Issue.5 , pp. 729-734
    • Dodic, M.1    Abouantoun, T.2    O'Connor, A.3    Wintour, E.M.4    Moritz, K.M.5
  • 17
    • 0036210390 scopus 로고    scopus 로고
    • Prolonged low-dose dexamethasone, in early gestation, has no long-term deleterious effect on normal ovine fetuses
    • DOI 10.1210/en.143.4.1159
    • Moritz K, Butkus A, Hantzis V, Peers A, Wintour EM, Dodic M. Prolonged low-dose dexamethasone, in early gestation, has no long-term deleterious effect on normal ovine fetuses. Endocrinology. 2002;143(4):1159-1165. (Pubitemid 34274342)
    • (2002) Endocrinology , vol.143 , Issue.4 , pp. 1159-1165
    • Moritz, K.1    Butkus, A.2    Hantzis, V.3    Peers, A.4    Wintour, E.M.5    Dodic, M.6
  • 19
    • 33644700108 scopus 로고    scopus 로고
    • Differential effects of prenatal exposure to dexamethasone or cortisol on circulatory control mechanisms mediated by angiotensin II in the central nervous system of adult sheep
    • DOI 10.1113/jphysiol.2005.102186
    • Dodic M, McAlinden AT, Jefferies AJ, et al. Differential effects of prenatal exposure to dexamethasone or cortisol on circulatory control mechanisms mediated by angiotensin II in the central nervous system of adult sheep. J Physiol. 2006;571(pt 3):651-660. (Pubitemid 43329553)
    • (2006) Journal of Physiology , vol.571 , Issue.3 , pp. 651-660
    • Dodic, M.1    McAlinden, A.T.2    Jefferies, A.J.3    Wintour, E.M.4    Cock, M.L.5    May, C.N.6    Evans, R.G.7    Moritz, K.M.8
  • 25
    • 0028276307 scopus 로고
    • Ontogeny of erythropoietin gene expression in the sheep fetus: Effect of dexamethasone at 60 days of gestation
    • Lim GB, Jeyaseelan K, Wintour EM. Ontogeny of erythropoietin gene expression in the sheep fetus: effect of dexamethasone at 60 days of gestation. Blood. 1994;84(2):460-466. (Pubitemid 24215945)
    • (1994) Blood , vol.84 , Issue.2 , pp. 460-466
    • Lim, G.B.1    Jeyaseelan, K.2    Wintour, E.M.3
  • 26
    • 0018824448 scopus 로고
    • The changing response pattern of sheep fetal adrenal cells throughout the course of gestation
    • Glickman JA, Challis JR. The changing response pattern of sheep fetal adrenal cells throughout the course of gestation. Endocrinology. 1980;106(5):1371-1376. (Pubitemid 10094431)
    • (1980) Endocrinology , vol.106 , Issue.5 , pp. 1371-1376
    • Glickman, J.A.1    Challis, J.R.G.2
  • 27
    • 71949119374 scopus 로고    scopus 로고
    • Effects of maternal dexamethasone treatment in early pregnancy on pituitary-adrenal axis in fetal sheep
    • Braun T, Li S, Sloboda DM, et al. Effects of maternal dexamethasone treatment in early pregnancy on pituitary-adrenal axis in fetal sheep. Endocrinology. 2009;150(12):5466-5477.
    • (2009) Endocrinology , vol.150 , Issue.12 , pp. 5466-5477
    • Braun, T.1    Li, S.2    Sloboda, D.M.3
  • 28
    • 0034833031 scopus 로고    scopus 로고
    • Programming effects in sheep of prenatal growth restriction and glucocorticoid exposure
    • Moss TJM, Sloboda DM, Gurrin LC, et al. Programming effects in sheep of prenatal growth restriction and glucocorticoid exposure. Am J Physiol Regul Integr Compar Physiol. 2001;281(3):960-970.
    • (2001) Am J Physiol Regul Integr Compar Physiol , vol.281 , Issue.3 , pp. 960-970
    • Moss, T.J.M.1    Sloboda, D.M.2    Gurrin, L.C.3
  • 30
    • 33645287671 scopus 로고    scopus 로고
    • Fetal exposure to excess glucocorticoid is unlikely to explain the effects of periconceptional undernutrition in sheep
    • Jaquiery AL, Oliver MH, Bloomfield FH. Fetal exposure to excess glucocorticoid is unlikely to explain the effects of periconceptional undernutrition in sheep. J Physiol. 2006;572(pt 1):109-118.
    • (2006) J Physiol , vol.572 , Issue.PART 1 , pp. 109-118
    • Jaquiery, A.L.1    Oliver, M.H.2    Bloomfield, F.H.3
  • 31
    • 0020073609 scopus 로고
    • Ontogeny and regulation of corticosteroid binding globulin capacity in plasma of fetal and newborn lambs
    • Ballard PL, Kitterman JA, Bland RD, et al. Ontogeny and regulation of corticosteroid binding globulin capacity in plasma of fetal and newborn lambs. Endocrinology. 1982;110(2):359-366. (Pubitemid 12162923)
    • (1982) Endocrinology , vol.110 , Issue.2 , pp. 359-366
    • Ballard, P.L.1    Kitterman, J.A.2    Bland, R.D.3
  • 32
    • 0021967677 scopus 로고
    • Possible role of cortisol in the stimulation of cortisol-binding capacity in the plasma of fetal sheep
    • Challis JR, Nancekievill EA, Lye SJ. Possible role of cortisol in the stimulation of cortisol-binding capacity in the plasma of fetal sheep. Endocrinology. 1985;116(3):1139-1144. (Pubitemid 15136975)
    • (1985) Endocrinology , vol.116 , Issue.3 , pp. 1139-1144
    • Challis, J.R.G.1    Nancekievill, E.A.2    Lye, S.J.3
  • 34
    • 0025768637 scopus 로고
    • Cellular localization of corticotropin releasing factor mRNA in the ovine brain
    • Matthews SG, Heavens RP, Sirinathsingji DJS. Cellular localization of corticotropin releasing factor mRNA in the ovine brain. Brain Res Mol Brain Res. 1991;11(2):171-176.
    • (1991) Brain Res Mol Brain Res , vol.11 , Issue.2 , pp. 171-176
    • Matthews, S.G.1    Heavens, R.P.2    Sirinathsingji, D.J.S.3
  • 35
    • 0028869498 scopus 로고
    • Regulation of CRH and AVP mRNA in the developing ovine hypothalamus: Effects of stress and glucocorticoids
    • Matthews SG, Challis JR. Regulation of CRH and AVP mRNA in the developing ovine hypothalamus: effects of stress and glucocorticoids. Am J Physiol. 1995;268(6 pt 1):1096-1107.
    • (1995) Am J Physiol , vol.268 , Issue.6 PART 1 , pp. 1096-1107
    • Matthews, S.G.1    Challis, J.R.2
  • 36
    • 0026605914 scopus 로고
    • Characterization of an ovine glucocorticoid receptor cDNA and developmental changes in its mRNA levels in the fetal sheep hypothalamus, pituitary gland and adrenal
    • Yang K, Hammond GL, Challis JR. Characterization of an ovine glucocorticoid receptor cDNA and developmental changes in its mRNA levels in the fetal sheep hypothalamus, pituitary gland and adrenal. J Mol Endocrinol 1992;8(2):173-180.
    • (1992) J Mol Endocrinol , vol.8 , Issue.2 , pp. 173-180
    • Yang, K.1    Hammond, G.L.2    Challis, J.R.3
  • 37
    • 0028063337 scopus 로고
    • Developmental changes in the distribution of pro-opiomelanocortin and prolactin mRNA in the pituitary of the ovine fetus and lamb
    • Matthews SG, Han X, Lu F, Challis JR. Developmental changes in the distribution of pro-opiomelanocortin and prolactin mRNA in the pituitary of the ovine fetus and lamb. J Mol Endocrinol. 1994;13(2):175-185. (Pubitemid 24318654)
    • (1994) Journal of Molecular Endocrinology , vol.13 , Issue.2 , pp. 175-185
    • Matthews, S.G.1    Han, X.2    Lu, F.3    Challis, J.R.G.4
  • 38
  • 39
    • 0026672940 scopus 로고
    • The cDNA structure of the porcine pro-hormone convertase PC 2 and the comparative processing by PC 1 and PC 2 of the N-terminal glycopeptide segment of porcine POMC
    • Seidah NG, Fournier H, Boileau G, Benjannet S, Rondeau N, Chretien M. The cDNA structure of the porcine pro-hormone convertase PC 2 and the comparative processing by PC 1 and PC 2 of the N-terminal glycopeptide segment of porcine POMC. FEBS Lett. 1992;310(3):235-239.
    • (1992) FEBS Lett , vol.310 , Issue.3 , pp. 235-239
    • Seidah, N.G.1    Fournier, H.2    Boileau, G.3    Benjannet, S.4    Rondeau, N.5    Chretien, M.6
  • 40
    • 0024788274 scopus 로고
    • 4 isomerase
    • DOI 10.1016/0014-5793(89)81516-9
    • Zhao HF, Simard J, Labrie C, Breton N, Rheaume E. Molecular cloning, cDNA structure and predicted amino acid sequence of bovine 3 beta-hydroxy-5-ene steroid dehydrogenase/delta 5-delta 4 isomerase. FEBS Lett. 1989;259(1):153-157. (Pubitemid 20009968)
    • (1989) FEBS Letters , vol.259 , Issue.1 , pp. 153-157
    • Zhao, H.-F.1    Simard, J.2    Labrie, C.3    Breton, N.4    Rheaume, E.5    Luu-The, V.6    Labrie, F.7
  • 42
    • 0033859787 scopus 로고    scopus 로고
    • Temporal expression of prostaglandin H synthase type 2 (PGHS-2) and P450(C17) in ovine placentomes with the natural onset of labour
    • DOI 10.1053/plac.1999.0503
    • Gyomory S, Gupta S, Lye SJ, Gibb W, Labrie F, Challis JRG. Temporal expression of prostaglandin H synthase type 2 (PGHS-2) and P45OC17 in ovine placentomes with the natural onset of labour. Placenta. 2000;21(5-6):478-486. (Pubitemid 30608591)
    • (2000) Placenta , vol.21 , Issue.5-6 , pp. 478-486
    • Gyomorey, S.1    Gupta, S.2    Lye, S.J.3    Gibb, W.4    Labrie, F.5    Challis, J.R.G.6
  • 43
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem. 1976;72:248-254.
    • (1976) Anal Biochem , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 44
    • 0035740132 scopus 로고    scopus 로고
    • Prenatal dexamethasone treatment of fetuses at risk for congenital adrenal hyperplasia: Benefits and concerns
    • DOI 10.1053/siny.2001.0071
    • Ritzén EM. Prenatal dexamethasone treatment of fetuses at risk for congenital adrenal hyperplasia: benefits and concerns. Semin Neonatol. 2001;6(4):357-362. (Pubitemid 34586855)
    • (2001) Seminars in Neonatology , vol.6 , Issue.4 , pp. 357-362
    • Ritzen, E.M.1
  • 45
    • 0035740401 scopus 로고    scopus 로고
    • Antenatal glucocorticoids and growth: Single versus multiple doses in animal and human studies
    • DOI 10.1053/siny.2001.0064
    • Newnham JP, Moss TJ. Antenatal glucocorticoids and growth: single versus multiple doses in animal and human studies. Semin Neonatol. 2001;6(4):285-292. (Pubitemid 34586848)
    • (2001) Seminars in Neonatology , vol.6 , Issue.4 , pp. 285-292
    • Newnham, J.P.1    Moss, T.J.2
  • 46
    • 0036160931 scopus 로고    scopus 로고
    • Lung function, arterial pressure and growth in sheep during early postnatal life following single and repeated prenatal corticosteroid treatments
    • DOI 10.1016/S0378-3782(01)00227-4, PII S0378378201002274
    • Moss TJ, Harding R, Newnham JP. Lung function, arterial pressure and growth in sheep during early postnatal life following single and repeated prenatal corticosteroid treatments. Early Hum Dev. 2002;66(1):11-24. (Pubitemid 34123284)
    • (2002) Early Human Development , vol.66 , Issue.1 , pp. 11-24
    • Moss, T.J.M.1    Harding, R.2    Newnham, J.P.3
  • 47
    • 0027059094 scopus 로고
    • Corticotrophin-releasing factors in the hypothalamus of the developing fetal sheep
    • Currie IS, Brooks AN. Corticotrophin-releasing factors in the hypothalamus of the developing fetal sheep. J Dev Physiol. 1992;17(5):241-246. (Pubitemid 23050445)
    • (1992) Journal of Developmental Physiology , vol.17 , Issue.5 , pp. 241-246
    • Currie, I.S.1    Brooks, A.N.2
  • 48
    • 0024392441 scopus 로고
    • Plasma concentrations of adrenocorticotropin-related peptides in lambs injected with ovine corticotropin releasing factor or vasopressin
    • Pradier P, Tournaire C, Dalle M, Delost P. Plasma concentrations of adrenocorticotropin-related peptides in lambs injected with ovine corticotropin releasing factor or vasopressin. J Dev Physiol. 1989;11(2):103-109. (Pubitemid 19199853)
    • (1989) Journal of Developmental Physiology , vol.11 , Issue.2 , pp. 103-109
    • Pradier, P.1    Tournaire, C.2    Dalle, M.3    Delost, P.4
  • 49
    • 0028169316 scopus 로고
    • Regulation of ovine fetal pituitary function by corticotrophin-releasing hormone, arginine vasopressin and cortisol in vitro
    • Lu F, Yang K. Regulation of ovine fetal pituitary function by corticotrophin-releasing hormone, arginine vasopressin and cortisol in vitro. J Endocrinol. 1994;143(1):199-208. (Pubitemid 2143203)
    • (1994) Journal of Endocrinology , vol.143 , Issue.1 , pp. 199-208
    • Lu, F.1    Yang, K.2    Challis, J.R.G.3
  • 50
    • 0031029827 scopus 로고    scopus 로고
    • Activational effects of gonadal steroids on hypothalamo-pituitary-adrenal regulation in the rat disclosed by response to dexamethasone suppression
    • Almeida OF, Canoine V, Ali S, Holsboer F, Patchev VK. Activational effects of gonadal steroids on hypothalamo-pituitary-adrenal regulation in the rat disclosed by response to dexamethasone suppression. J Neuroendocrinol. 1997;9(2):129-134. (Pubitemid 27060119)
    • (1997) Journal of Neuroendocrinology , vol.9 , Issue.2 , pp. 129-134
    • Almeida, O.F.X.1    Canoine, V.2    Ali, S.3    Holsboer, F.4    Patchev, V.K.5
  • 51
    • 0035084148 scopus 로고    scopus 로고
    • Glucocorticoid regulation of human and ovine parturition: The relationship between fetal hypothalamic-pituitary-adrenal axis activation and intrauterine prostaglandin production
    • Whittle WL, Patel FA, Alfaidy N, et al. Glucocorticoid regulation of human and ovine parturition: the relationship between fetal hypothalamic- pituitary-adrenal axis activation and intrauterine prostaglandin production. Biol Reprod. 2001;64(4):1019-1032. (Pubitemid 32239171)
    • (2001) Biology of Reproduction , vol.64 , Issue.4 , pp. 1019-1032
    • Whittle, W.L.1    Patel, F.A.2    Alfaidy, N.3    Holloway, A.C.4    Fraser, M.5    Gyomorey, S.6    Lye, S.J.7    Gibb, W.8    Challis, J.R.G.9
  • 52
    • 0031031519 scopus 로고    scopus 로고
    • Cellular localization of the prohormone convertases in the hypothalamic paraventricular and supraoptic nuclei: Selective regulation of PC1 in corticotrophin-releasing hormone parvocellular neurons mediated by glucocorticoids
    • Dong W, Seidel B, Marcinkiewicz M, Chretien M, Seidah NG, Day R. Cellular localization of the prohormone convertases in the hypothalamic paraventricular and supraoptic nuclei: selective regulation of PC1 in corticotrophin-releasing hormone parvocellular neurons mediated by glucocorticoids. J Neurosci. 1997;17(2):563-575. (Pubitemid 27024569)
    • (1997) Journal of Neuroscience , vol.17 , Issue.2 , pp. 563-575
    • Dong, W.1    Seidel, B.2    Marcinkiewicz, M.3    Chretien, M.4    Seidah, N.G.5    Day, R.6
  • 53
    • 77954890700 scopus 로고    scopus 로고
    • Epigenetic changes in the hypothalamic proopiomelanocortin and glucocorticoid receptor genes in the ovine fetus after periconceptional undernutrition
    • Stevens A, Begum G, Cook A, et al. Epigenetic changes in the hypothalamic proopiomelanocortin and glucocorticoid receptor genes in the ovine fetus after periconceptional undernutrition. Endocrinology. 2010;151(8):3652-3664.
    • (2010) Endocrinology , vol.151 , Issue.8 , pp. 3652-3664
    • Stevens, A.1    Begum, G.2    Cook, A.3
  • 54
    • 70450214713 scopus 로고    scopus 로고
    • Do alterations in placental 11beta-hydroxysteroid dehydrogenase (11betaHSD) activities explain differences in fetal hypothalamic-pituitary- adrenal (HPA) function following periconceptional undernutrition or twinning in sheep?
    • Connor KL, Challis JR, van Zijl P, et al. Do alterations in placental 11beta-hydroxysteroid dehydrogenase (11betaHSD) activities explain differences in fetal hypothalamic-pituitary-adrenal (HPA) function following periconceptional undernutrition or twinning in sheep? Reprod Sci. 2009;16(12):1201-1212.
    • (2009) Reprod Sci , vol.16 , Issue.12 , pp. 1201-1212
    • Connor, K.L.1    Challis, J.R.2    Van Zijl, P.3


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