메뉴 건너뛰기




Volumn 5, Issue 12, 2008, Pages 1313-1321

Erythropoiesis-stimulating protein delivery in providing erythropoiesis and neuroprotection

Author keywords

Blood brain (retina) barrier; Drug delivery system; Erythropoiesis; Erythropoietin; Fusion protein; Glycoengineering; Microencapsulation; Nano micro particles; Neuroprotection; PEGylation

Indexed keywords

ANGIOPEPTIN; APTAMER; COPOLYMER; DIMER; DIPALMITOYLPHOSPHATIDYLCHOLINE; DOXORUBICIN; DRUG CARRIER; ERYTHROPOIETIN; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HUMAN GROWTH HORMONE; HYALURONIC ACID; IMMUNOGLOBULIN FC FRAGMENT; INTERFERON; LEUPLIN DEPOT; LEUPRORELIN; LIPOSOME; MACROGOL; MONOMER; NOVEL ERYTHROPOIESIS STIMULATING PROTEIN; PEGINTERFERON; PEGINTERFERON ALPHA2A; PEGINTERFERON ALPHA2B; PHYTOSTEROL; POLYGLACTIN; POLYLACTIC ACID; POLYLYSINE; POLYMER; POLYSACCHARIDE; POLYSORBATE 20; RECOMBINANT ERYTHROPOIETIN; REPOTIN; SOMATULINE DEPOT; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 58149186702     PISSN: 17425247     EISSN: None     Source Type: Journal    
DOI: 10.1517/17425240802544159     Document Type: Review
Times cited : (11)

References (73)
  • 2
    • 0024270999 scopus 로고
    • Glycosylation at specific sites of erythropoietin is essential for biosynthesis, secretion, and biological function
    • Dube S, Fisher JW, Powell JS. Glycosylation at specific sites of erythropoietin is essential for biosynthesis, secretion, and biological function. J Biol Chem 1988;263:17516-21
    • (1988) J Biol Chem , vol.263 , pp. 17516-17521
    • Dube, S.1    Fisher, J.W.2    Powell, J.S.3
  • 3
    • 0031026905 scopus 로고    scopus 로고
    • Mapping of the active site of recombinant human erythropoietin
    • Elliott S, Lorenzini T, Chang D, et al. Mapping of the active site of recombinant human erythropoietin. Blood 1997;89:493-502
    • (1997) Blood , vol.89 , pp. 493-502
    • Elliott, S.1    Lorenzini, T.2    Chang, D.3
  • 4
    • 0031972657 scopus 로고    scopus 로고
    • Epoetin alfa and bera differ in their erythropoietin isoform compositions and biological properties
    • Storring PL, Tiplady RJ, Gaines Das RE, et al. Epoetin alfa and bera differ in their erythropoietin isoform compositions and biological properties. Br J Haematol 1998;100:79-89
    • (1998) Br J Haematol , vol.100 , pp. 79-89
    • Storring, P.L.1    Tiplady, R.J.2    Gaines Das, R.E.3
  • 5
    • 36049007201 scopus 로고    scopus 로고
    • Recombinant EPO production - points the nephrologist should know
    • Jelkmann W. Recombinant EPO production - points the nephrologist should know. Nephrol Dial Transplant 2007;22:2749-53
    • (2007) Nephrol Dial Transplant , vol.22 , pp. 2749-2753
    • Jelkmann, W.1
  • 6
    • 12244272391 scopus 로고    scopus 로고
    • Enhancement of therapeutic protein in vivo activities through glycoengineering
    • Elliott S, Lorenzini T, Asher S, et al. Enhancement of therapeutic protein in vivo activities through glycoengineering. Nat Biotechnol 2003;21:414-21
    • (2003) Nat Biotechnol , vol.21 , pp. 414-421
    • Elliott, S.1    Lorenzini, T.2    Asher, S.3
  • 8
    • 34548675154 scopus 로고    scopus 로고
    • Erythropoietin: A candidate neuroprotective agent in the treatment of glaucoma
    • Tsai JC, Song BJ, Wu L, et al. Erythropoietin: a candidate neuroprotective agent in the treatment of glaucoma. J Glaucoma 2007;16:567-71
    • (2007) J Glaucoma , vol.16 , pp. 567-571
    • Tsai, J.C.1    Song, B.J.2    Wu, L.3
  • 9
    • 26444572335 scopus 로고    scopus 로고
    • Erythropoietin is neuro protective, improves functional recovery, and reduces neuronal apoptosis and inflammation in a rodent model of experimental closed head injury
    • Yatsiv I, Grigoriadis N, Simeonidou C, et al. Erythropoietin is neuro protective, improves functional recovery, and reduces neuronal apoptosis and inflammation in a rodent model of experimental closed head injury FASEB J 2005;19:1701-3
    • (2005) FASEB J , vol.19 , pp. 1701-1703
    • Yatsiv, I.1    Grigoriadis, N.2    Simeonidou, C.3
  • 10
    • 34047261787 scopus 로고    scopus 로고
    • Erythropoietin promotes survival of retinal ganglion cells in DBA/2J glaucoma mice
    • Zhong L, Bradley J, Schubert W, et al. Erythropoietin promotes survival of retinal ganglion cells in DBA/2J glaucoma mice. Invest Ophthalmol Vis Sci 2007;48:1212-8
    • (2007) Invest Ophthalmol Vis Sci , vol.48 , pp. 1212-1218
    • Zhong, L.1    Bradley, J.2    Schubert, W.3
  • 11
    • 23944523376 scopus 로고    scopus 로고
    • Erythropoietin as a retinal angiogenic factor in proliferative diabetic retinopathy
    • Watanabe D, Suzuma K, Matsui S, et al. Erythropoietin as a retinal angiogenic factor in proliferative diabetic retinopathy. N Engl J Med 2005;353:782-92
    • (2005) N Engl J Med , vol.353 , pp. 782-792
    • Watanabe, D.1    Suzuma, K.2    Matsui, S.3
  • 12
    • 0033635054 scopus 로고    scopus 로고
    • Protein instability in poly(lactic-co-glycolic acid) microparticles
    • van de Weert M, Hennink WE, Jiskoot W. Protein instability in poly(lactic-co-glycolic acid) microparticles. Pharm Res 2000;17:1159-67
    • (2000) Pharm Res , vol.17 , pp. 1159-1167
    • van de Weert, M.1    Hennink, W.E.2    Jiskoot, W.3
  • 13
    • 0031398790 scopus 로고    scopus 로고
    • Microencapsulation of rh-erythropoietin, using biodegradable poty(D,L-lactide-co-glycolide) protein stability and the effects of stabilizing excipients
    • Michael M, Hans K, Gerhard W, er al. Microencapsulation of rh-erythropoietin, using biodegradable poty(D,L-lactide-co-glycolide) protein stability and the effects of stabilizing excipients. Eur J Pharm Biopharm 1997;43:29-36
    • (1997) Eur J Pharm Biopharm , vol.43 , pp. 29-36
    • Michael, M.1    Hans, K.2    Gerhard, W.3    er al4
  • 14
    • 0032078388 scopus 로고    scopus 로고
    • Recombinant human erythropoietin (rhEPO) loaded poty(lactide-co-glycolide) microspheres: Influence of the encapsulation technique and polymer purity on microsphere characteristics
    • Bittner B, Morlock M, Koll H, et al. Recombinant human erythropoietin (rhEPO) loaded poty(lactide-co-glycolide) microspheres: influence of the encapsulation technique and polymer purity on microsphere characteristics. Eur J Pharm Biopharm 1998;45:295-305
    • (1998) Eur J Pharm Biopharm , vol.45 , pp. 295-305
    • Bittner, B.1    Morlock, M.2    Koll, H.3
  • 15
    • 0032484233 scopus 로고    scopus 로고
    • Erythropoietin loaded microspheres prepared from biodegradable LPLG-PEO-LPLG triblock copolymers: Protein stabilization and in vitro release properties
    • Morlock M, Kissel T, Li YX, et al. Erythropoietin loaded microspheres prepared from biodegradable LPLG-PEO-LPLG triblock copolymers: protein stabilization and in vitro release properties. J Control Rel 1998;56:105-15
    • (1998) J Control Rel , vol.56 , pp. 105-115
    • Morlock, M.1    Kissel, T.2    Li, Y.X.3
  • 16
    • 0032915252 scopus 로고    scopus 로고
    • Pistel KF, Bittner B, Kott H, et al. Biodegradable recombinant human erythropoietin loaded microspheres prepared from linear and star-branched block copolymers: influence of encapsulation technique and polymer composition on particle characteristics. J Control Release 1999;59:309-25
    • Pistel KF, Bittner B, Kott H, et al. Biodegradable recombinant human erythropoietin loaded microspheres prepared from linear and star-branched block copolymers: influence of encapsulation technique and polymer composition on particle characteristics. J Control Release 1999;59:309-25
  • 17
    • 58149195222 scopus 로고    scopus 로고
    • Sustained-release composition of drugs encapsulated in microparticles of hyaluronic acid
    • US7276251B2;2007
    • Myung JK, Sun JK, Oh RK. Sustained-release composition of drugs encapsulated in microparticles of hyaluronic acid. US7276251B2;2007
    • Myung, J.K.1    Sun, J.K.2    Oh, R.K.3
  • 18
    • 15844426701 scopus 로고    scopus 로고
    • Importance of biologic follow-ons: Experience with EPO
    • Casadevall N, Rossert J. Importance of biologic follow-ons: experience with EPO. Best Pract Res Clin Haematol 2005;18:381-7
    • (2005) Best Pract Res Clin Haematol , vol.18 , pp. 381-387
    • Casadevall, N.1    Rossert, J.2
  • 19
    • 0141839165 scopus 로고    scopus 로고
    • Contribution of poly(amino acids) to advances in pharmaceutical biotechnology
    • Chiang CH, Yeh MK. Contribution of poly(amino acids) to advances in pharmaceutical biotechnology. Curr Pharm Biotechnol 2003;4:323-30
    • (2003) Curr Pharm Biotechnol , vol.4 , pp. 323-330
    • Chiang, C.H.1    Yeh, M.K.2
  • 20
    • 34248558723 scopus 로고    scopus 로고
    • The preparation of sustained release erythropoietin microparticle
    • Yeh MK, Chen JL, Chiang CH, et al. The preparation of sustained release erythropoietin microparticle. J Microencapsul 2007;24:82-93
    • (2007) J Microencapsul , vol.24 , pp. 82-93
    • Yeh, M.K.1    Chen, J.L.2    Chiang, C.H.3
  • 21
    • 2642655362 scopus 로고    scopus 로고
    • Composition for sustained release of non-aggregated erythropoietin
    • US5716644;
    • Stephen EZ, Paul AB, Howard B, et al. Composition for sustained release of non-aggregated erythropoietin. US5716644;1998
    • (1998)
    • Stephen, E.Z.1    Paul, A.B.2    Howard, B.3
  • 22
    • 0038518055 scopus 로고    scopus 로고
    • Herberger J, Murphy K, Munyakazi L, et al. Carbon dioxide extraction of residual solvents in poly(lactide-co-glycolide) microparticles. J Control Release 2003;90:181-95
    • Herberger J, Murphy K, Munyakazi L, et al. Carbon dioxide extraction of residual solvents in poly(lactide-co-glycolide) microparticles. J Control Release 2003;90:181-95
  • 23
    • 1542615793 scopus 로고    scopus 로고
    • Protein powders for encapsulation: A comparison of spray-freeze drying and spray drying of darbepoetin alfa
    • Nguyen XC, Herberger JD, Burke PA. Protein powders for encapsulation: a comparison of spray-freeze drying and spray drying of darbepoetin alfa. Pharm Res 2004;21:507-14
    • (2004) Pharm Res , vol.21 , pp. 507-514
    • Nguyen, X.C.1    Herberger, J.D.2    Burke, P.A.3
  • 24
    • 1542511345 scopus 로고    scopus 로고
    • Poly(lactide-co-glycolide) microsphere formulations of darbepoetin alfa: Spray drying is an alternative to encapsulation by spray-freeze drying
    • Burke PA, Klumb LA, Herberger JD, et al. Poly(lactide-co-glycolide) microsphere formulations of darbepoetin alfa: spray drying is an alternative to encapsulation by spray-freeze drying. Pharm Res 2004;21:500-6
    • (2004) Pharm Res , vol.21 , pp. 500-506
    • Burke, P.A.1    Klumb, L.A.2    Herberger, J.D.3
  • 25
    • 0031471038 scopus 로고    scopus 로고
    • Pharmacokinetic and pharmacological profiles of free and liposomal recombinant human erythropoietin after intravenous and subcutaneous administrations in rats
    • Moriya H, Maitani Y, Shimoda N, et al. Pharmacokinetic and pharmacological profiles of free and liposomal recombinant human erythropoietin after intravenous and subcutaneous administrations in rats. Pharm Res 1997;14:1621-8
    • (1997) Pharm Res , vol.14 , pp. 1621-1628
    • Moriya, H.1    Maitani, Y.2    Shimoda, N.3
  • 27
    • 7444236397 scopus 로고    scopus 로고
    • Tumor-targeted liposomes: Doxorubicin-loaded long-circulating liposomes modified with anti-cancer antibody
    • Lukyanov AN, Elbayoumi TA, Chakilam AR, et al. Tumor-targeted liposomes: doxorubicin-loaded long-circulating liposomes modified with anti-cancer antibody. J Control Rel 2004;100:135-44
    • (2004) J Control Rel , vol.100 , pp. 135-144
    • Lukyanov, A.N.1    Elbayoumi, T.A.2    Chakilam, A.R.3
  • 28
    • 7444223607 scopus 로고    scopus 로고
    • Nanoparticle-aptamer bioconjugates: A new approach for targeting prostate cancer cells
    • Farokhzad OC, Jon S, Khademhosseini A, et al. Nanoparticle-aptamer bioconjugates: a new approach for targeting prostate cancer cells. Cancer Res 2004;64:7668-72
    • (2004) Cancer Res , vol.64 , pp. 7668-7672
    • Farokhzad, O.C.1    Jon, S.2    Khademhosseini, A.3
  • 29
    • 17644399512 scopus 로고    scopus 로고
    • Pharmacokinetics and biodistribution of novel aptamer compositions
    • Healy JM, Lewis SD, Kurz M, et al. Pharmacokinetics and biodistribution of novel aptamer compositions. Pharm Res 2004;21:2234-46
    • (2004) Pharm Res , vol.21 , pp. 2234-2246
    • Healy, J.M.1    Lewis, S.D.2    Kurz, M.3
  • 30
    • 33646582037 scopus 로고    scopus 로고
    • Targeted nanoparticle-aptamer bioconjugates for cancer chemotherapy in vivo
    • Farokhzad OC, Cheng J, Teply BA, et al. Targeted nanoparticle-aptamer bioconjugates for cancer chemotherapy in vivo Proc Natl Acad Sci USA 2006;103:6315-20
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 6315-6320
    • Farokhzad, O.C.1    Cheng, J.2    Teply, B.A.3
  • 31
    • 0031038174 scopus 로고    scopus 로고
    • Erythropoietin receptor expression on human bone marrow erythroid precursor cells by a newly-devised quantitative flow-cytometric assay
    • Shinjo K, Takeshita A, Higuchi M, et al. Erythropoietin receptor expression on human bone marrow erythroid precursor cells by a newly-devised quantitative flow-cytometric assay. Br J Haematol 1997;96:551-8
    • (1997) Br J Haematol , vol.96 , pp. 551-558
    • Shinjo, K.1    Takeshita, A.2    Higuchi, M.3
  • 32
    • 33846918488 scopus 로고    scopus 로고
    • Pigment epithelium-derived factor protects retinal ganglion cells
    • Pang IH, Zeng H, Fleenor DL, et al. Pigment epithelium-derived factor protects retinal ganglion cells. BMC Neurosci 2007;8:11
    • (2007) BMC Neurosci , vol.8 , pp. 11
    • Pang, I.H.1    Zeng, H.2    Fleenor, D.L.3
  • 33
    • 1842556615 scopus 로고    scopus 로고
    • Erythropoietin receptor is expressed on adult rat dopaminergic neurons and erythropoietin is neurotrophic in cultured dopaminergic neuroblasts
    • Csete M, Rodriguez L, Wilcox M, et al. Erythropoietin receptor is expressed on adult rat dopaminergic neurons and erythropoietin is neurotrophic in cultured dopaminergic neuroblasts. Neurosci Lett 2004;359:124-6
    • (2004) Neurosci Lett , vol.359 , pp. 124-126
    • Csete, M.1    Rodriguez, L.2    Wilcox, M.3
  • 34
    • 33644875091 scopus 로고    scopus 로고
    • (Continuous Erythropoietin Receptor Activator): A new erythropoiesis-stimulating agent for the treatment of anemia
    • Macdougall IC. CERA (Continuous Erythropoietin Receptor Activator): a new erythropoiesis-stimulating agent for the treatment of anemia. Curr Hematol Rep 2005;4:436-40
    • (2005) Curr Hematol Rep , vol.4 , pp. 436-440
    • Macdougall, I.C.1
  • 35
    • 58149186619 scopus 로고    scopus 로고
    • Erythropoietin conjugates
    • US6340742B1;2002
    • Josef B, Bernd H, Hans PJ. Erythropoietin conjugates. US6340742B1;2002
    • Josef, B.1    Bernd, H.2    Hans, P.J.3
  • 36
    • 58149177315 scopus 로고    scopus 로고
    • Erythropoietin conjugates
    • US6583272B1;2003
    • Pascal SB. Erythropoietin conjugates. US6583272B1;2003
    • Pascal, S.B.1
  • 37
    • 15244357228 scopus 로고    scopus 로고
    • Mixed-effects modelling of the interspecies pharmacokinetic scaling of pegylated human erythropoietin
    • Jolling K, Perez Ruixo JJ, Hemeryck A, et al. Mixed-effects modelling of the interspecies pharmacokinetic scaling of pegylated human erythropoietin. Eur J Pharm Sci 2005;24:465-75
    • (2005) Eur J Pharm Sci , vol.24 , pp. 465-475
    • Jolling, K.1    Perez Ruixo, J.J.2    Hemeryck, A.3
  • 38
    • 33750973533 scopus 로고    scopus 로고
    • Macdougall IC, Robson R, Opatrna S, et al. Pharmacokinetics and pharmacodynamics of intravenous and subcutaneous continuous erythropoietin receptor activator (C.E.R.A.) in patients with chronic kidney disease. Clin J Am Soc Nephrol 2006;1:1211-5
    • Macdougall IC, Robson R, Opatrna S, et al. Pharmacokinetics and pharmacodynamics of intravenous and subcutaneous continuous erythropoietin receptor activator (C.E.R.A.) in patients with chronic kidney disease. Clin J Am Soc Nephrol 2006;1:1211-5
  • 39
    • 0031055220 scopus 로고    scopus 로고
    • Comparative pharmacokinetics and antitumor efficacy of doxorubicin encapsulated in soybean-derived sterols and poly(ethylene glycol) liposomes in mice
    • Qi XR, Mai tani Y, Nagai T, et al. Comparative pharmacokinetics and antitumor efficacy of doxorubicin encapsulated in soybean-derived sterols and poly(ethylene glycol) liposomes in mice. Int J Pharm 1997;146:31-9
    • (1997) Int J Pharm , vol.146 , pp. 31-39
    • Qi, X.R.1    Mai tani, Y.2    Nagai, T.3
  • 40
    • 0032477808 scopus 로고    scopus 로고
    • Human erythropoietin dimers with markedly enhanced in vivo activity
    • Sytkowski AJ, Lunn ED, Davis KL, et al. Human erythropoietin dimers with markedly enhanced in vivo activity. Proc Natl Acad Sci USA 1998;95:1184-8
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 1184-1188
    • Sytkowski, A.J.1    Lunn, E.D.2    Davis, K.L.3
  • 41
    • 0033609857 scopus 로고    scopus 로고
    • An erythropoietin fusion protein comprised of identical repeating domains exhibits enhanced biological properties
    • Sytkowski AJ, Lunn ED, Risinger MA, et al. An erythropoietin fusion protein comprised of identical repeating domains exhibits enhanced biological properties. J Biol Chem 1999;274:24773-8
    • (1999) J Biol Chem , vol.274 , pp. 24773-24778
    • Sytkowski, A.J.1    Lunn, E.D.2    Risinger, M.A.3
  • 43
    • 0034061868 scopus 로고    scopus 로고
    • The fusion protein MEN 11303 (granulocyte-macrophage colony stimulating factor/erythropoietin) acts as a potent inducer of erythropoiesis
    • Battaglia A, Fattorossi A, Pierelli L, et al. The fusion protein MEN 11303 (granulocyte-macrophage colony stimulating factor/erythropoietin) acts as a potent inducer of erythropoiesis. Exp Hematol 2000;28:490-8
    • (2000) Exp Hematol , vol.28 , pp. 490-498
    • Battaglia, A.1    Fattorossi, A.2    Pierelli, L.3
  • 44
    • 58149180123 scopus 로고    scopus 로고
    • Lee DE, Oh MS, Chung BS, et al. Fusion protein having enhanced in vivo activity of erythropoietin. US7098318;2006
    • Lee DE, Oh MS, Chung BS, et al. Fusion protein having enhanced in vivo activity of erythropoietin. US7098318;2006
  • 45
    • 3042795848 scopus 로고    scopus 로고
    • Pulmonary delivery of an erythropoietin Fc fusion protein in non-human primates through an immunoglobulin transport pathway
    • Bitonti AJ, Dumont JA, Low SC, et al. Pulmonary delivery of an erythropoietin Fc fusion protein in non-human primates through an immunoglobulin transport pathway. Proc Natl Acad Sci USA 2004;101:9763-8
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 9763-9768
    • Bitonti, A.J.1    Dumont, J.A.2    Low, S.C.3
  • 46
    • 0034997401 scopus 로고    scopus 로고
    • Development and characterization of novel erythropoiesis stimulating protein (NESP)
    • Egrie JC, Browne JK. Development and characterization of novel erythropoiesis stimulating protein (NESP). Br J Cancer 2001;84(Suppl 1):3-10
    • (2001) Br J Cancer , vol.84 , Issue.SUPPL. 1 , pp. 3-10
    • Egrie, J.C.1    Browne, J.K.2
  • 47
    • 0032737391 scopus 로고    scopus 로고
    • Pharmacokinetics; of novel erythropoiesis stimulating protein compared with epoetin alfa in dialysis patients
    • Macdougall IC, Gray SJ, Elston O, et al. Pharmacokinetics; of novel erythropoiesis stimulating protein compared with epoetin alfa in dialysis patients. J Am Soc Nephrol 1999;10:2392-5
    • (1999) J Am Soc Nephrol , vol.10 , pp. 2392-2395
    • Macdougall, I.C.1    Gray, S.J.2    Elston, O.3
  • 48
    • 0028243124 scopus 로고
    • Immunocytochemical analyses of distributions of Na, K-ATPase and GLUT1, insulin and transferrin receptors in the developing retinal pigment epithelial cells
    • Sugasawa K, Deguchi J, Okami T, et al. Immunocytochemical analyses of distributions of Na, K-ATPase and GLUT1, insulin and transferrin receptors in the developing retinal pigment epithelial cells. Cell Struct Funct 1994;19:21-8
    • (1994) Cell Struct Funct , vol.19 , pp. 21-28
    • Sugasawa, K.1    Deguchi, J.2    Okami, T.3
  • 49
    • 0030755944 scopus 로고    scopus 로고
    • A new function for the LDL receptor: Transcytosis of LDL across the blood-brain barrier
    • Dehouck B, Fenart L, Dehouck MP, et al. A new function for the LDL receptor: transcytosis of LDL across the blood-brain barrier. J Cell Biol 1997;138:877-89
    • (1997) J Cell Biol , vol.138 , pp. 877-889
    • Dehouck, B.1    Fenart, L.2    Dehouck, M.P.3
  • 50
    • 0033996507 scopus 로고    scopus 로고
    • Transport across the primate blood-brain barrier of a genetically engineered chimeric monoclonal antibody to the human insulin receptor
    • Coloma MJ, Lee HJ, Kurihara A, et al. Transport across the primate blood-brain barrier of a genetically engineered chimeric monoclonal antibody to the human insulin receptor. Pharm Res 2000;17:266-74
    • (2000) Pharm Res , vol.17 , pp. 266-274
    • Coloma, M.J.1    Lee, H.J.2    Kurihara, A.3
  • 51
    • 33947686655 scopus 로고    scopus 로고
    • Fusion antibody for Alzheimer's disease with bidirectional transport across the blood-brain barrier and abeta fibril disaggregation
    • Boado RJ, Zhang Y, Xia CF, et al. Fusion antibody for Alzheimer's disease with bidirectional transport across the blood-brain barrier and abeta fibril disaggregation. Bioconjug Chem 2007;18:447-55
    • (2007) Bioconjug Chem , vol.18 , pp. 447-455
    • Boado, R.J.1    Zhang, Y.2    Xia, C.F.3
  • 52
    • 0028279458 scopus 로고
    • Transport of human recombinant brain-derived neurotrophic factor (BDNF) through the rat blood brain barrier in vivo using vector-mediated peptide drug delivery
    • Pardridge WM, Kang YS, Buciak JL. Transport of human recombinant brain-derived neurotrophic factor (BDNF) through the rat blood brain barrier in vivo using vector-mediated peptide drug delivery. Pharm Res 1994;11:738-46
    • (1994) Pharm Res , vol.11 , pp. 738-746
    • Pardridge, W.M.1    Kang, Y.S.2    Buciak, J.L.3
  • 53
    • 0034691050 scopus 로고    scopus 로고
    • Noninvasive gene targeting to the brain
    • Shi N, Pardridge WM. Noninvasive gene targeting to the brain. Proc Natl Acad Sci USA 2000;97:7567-72
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 7567-7572
    • Shi, N.1    Pardridge, W.M.2
  • 54
    • 19444377842 scopus 로고    scopus 로고
    • Erythropoietin prevents long-term sensorimotor deficits and brain injury following neonatal hypoxia-ischemia in rats
    • Spandou E, Papadopoulou Z, Soubasi V, et al. Erythropoietin prevents long-term sensorimotor deficits and brain injury following neonatal hypoxia-ischemia in rats. Brain Res 2005;1045:22-30
    • (2005) Brain Res , vol.1045 , pp. 22-30
    • Spandou, E.1    Papadopoulou, Z.2    Soubasi, V.3
  • 55
    • 3042688444 scopus 로고    scopus 로고
    • Treatment of stroke with erythropoietin enhances neurogenesis and angiogenesis and improves neurological function in rats
    • Wang L, Zhang Z, Wang Y, et al. Treatment of stroke with erythropoietin enhances neurogenesis and angiogenesis and improves neurological function in rats. Stroke 2004;35:1732-7
    • (2004) Stroke , vol.35 , pp. 1732-1737
    • Wang, L.1    Zhang, Z.2    Wang, Y.3
  • 56
    • 17444398206 scopus 로고    scopus 로고
    • Erythropoietin protects primary hippocampal neurons increasing the expression of brain-derived neurotrophic factor
    • Viviani B, Bartesaghi S, Corsini E, et al. Erythropoietin protects primary hippocampal neurons increasing the expression of brain-derived neurotrophic factor. J Neurochem 2005;93:412-21
    • (2005) J Neurochem , vol.93 , pp. 412-421
    • Viviani, B.1    Bartesaghi, S.2    Corsini, E.3
  • 57
    • 3843124229 scopus 로고    scopus 로고
    • A novel role for an established player: Anemia drug erythropoietin for the treatment of cerebral hypoxia/ ischemia
    • Ehrenreich H, Timner W, Siren AL. A novel role for an established player: anemia drug erythropoietin for the treatment of cerebral hypoxia/ ischemia. Transfus Apher Sci 2004;31:39-44
    • (2004) Transfus Apher Sci , vol.31 , pp. 39-44
    • Ehrenreich, H.1    Timner, W.2    Siren, A.L.3
  • 58
    • 0036850611 scopus 로고    scopus 로고
    • Erythropoietin is involved in growth and angiogenesis in malignant tumours of female reproductive organs
    • Yasuda Y, Fujita Y, Masuda S, et al. Erythropoietin is involved in growth and angiogenesis in malignant tumours of female reproductive organs. Carcinogenesis 2002;23:1797-805
    • (2002) Carcinogenesis , vol.23 , pp. 1797-1805
    • Yasuda, Y.1    Fujita, Y.2    Masuda, S.3
  • 59
    • 0037479926 scopus 로고    scopus 로고
    • Erythropoietin regulates tumour growth of human malignancies
    • Yasuda Y, Fujita Y, Matsuo T, et al. Erythropoietin regulates tumour growth of human malignancies. Carcinogenesis 2003;24:1021-9
    • (2003) Carcinogenesis , vol.24 , pp. 1021-1029
    • Yasuda, Y.1    Fujita, Y.2    Matsuo, T.3
  • 60
    • 0031901771 scopus 로고    scopus 로고
    • Combined use of carboxyl-directed protein pegylation and vector-mediated blood-brain barrier drug delivery system optimizes brain uptake of brain-derived neurotrophic factor following intravenous administration
    • Pardridge WM, Wu D, Sakane T. Combined use of carboxyl-directed protein pegylation and vector-mediated blood-brain barrier drug delivery system optimizes brain uptake of brain-derived neurotrophic factor following intravenous administration. Pharm Res 1998;15:576-82
    • (1998) Pharm Res , vol.15 , pp. 576-582
    • Pardridge, W.M.1    Wu, D.2    Sakane, T.3
  • 61
    • 11244264537 scopus 로고    scopus 로고
    • PEGylated immunoliposomes directed against brain astrocytes
    • Chekhonin VP, Zhirkov YA, Gurina OI, et al. PEGylated immunoliposomes directed against brain astrocytes. Drug Deliv 2005;12:1-6
    • (2005) Drug Deliv , vol.12 , pp. 1-6
    • Chekhonin, V.P.1    Zhirkov, Y.A.2    Gurina, O.I.3
  • 62
    • 0033673170 scopus 로고    scopus 로고
    • Establishment and functional characterization of an in vitro model of the blood-brain barrier, comprising a co-culture of brain capillary endothelial cells and astrocytes
    • Gaillard PJ, Voorwinden LH, Nielsen JL, et al. Establishment and functional characterization of an in vitro model of the blood-brain barrier, comprising a co-culture of brain capillary endothelial cells and astrocytes. Eur J Pharm Sci 2001;12:215-22
    • (2001) Eur J Pharm Sci , vol.12 , pp. 215-222
    • Gaillard, P.J.1    Voorwinden, L.H.2    Nielsen, J.L.3
  • 63
    • 0033534638 scopus 로고    scopus 로고
    • Rat retinal ganglion cells culture enriched with the magnetic cell sorter
    • Shoge K, Mishima HK, Mukai S, et al. Rat retinal ganglion cells culture enriched with the magnetic cell sorter. Neurosci Lett 1999;259:111-4
    • (1999) Neurosci Lett , vol.259 , pp. 111-114
    • Shoge, K.1    Mishima, H.K.2    Mukai, S.3
  • 64
    • 0030636320 scopus 로고    scopus 로고
    • Erythropoietin receptor is expressed in rat hippocampal and cerebral cortical neurons, and erythropoietin prevents in vitro glutamate-induced neuronal death
    • Morishita E, Masuda S, Nagao M, et al. Erythropoietin receptor is expressed in rat hippocampal and cerebral cortical neurons, and erythropoietin prevents in vitro glutamate-induced neuronal death. Neuroscience 1997;76:105-16
    • (1997) Neuroscience , vol.76 , pp. 105-116
    • Morishita, E.1    Masuda, S.2    Nagao, M.3
  • 65
    • 0842346110 scopus 로고    scopus 로고
    • Development of an in vitro blood-brain barrier model - cytotoxicity of mercury and aluminum
    • Toimela T, Maenpaa H, Mannerstrom M, et al. Development of an in vitro blood-brain barrier model - cytotoxicity of mercury and aluminum. Toxicol Appl Pharmacol 2004;195:73-82
    • (2004) Toxicol Appl Pharmacol , vol.195 , pp. 73-82
    • Toimela, T.1    Maenpaa, H.2    Mannerstrom, M.3
  • 66
    • 0036678821 scopus 로고    scopus 로고
    • Erythropoietin administration protects retinal neurons from acute ischemia-reperfusion injury
    • Junk AK, Mammis A, Savitz SI, et al. Erythropoietin administration protects retinal neurons from acute ischemia-reperfusion injury. Proc Natl Acad Sci USA 2002;99:10659-64
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 10659-10664
    • Junk, A.K.1    Mammis, A.2    Savitz, S.I.3
  • 67
    • 33847687265 scopus 로고    scopus 로고
    • Erythropoietin delays disease onset in an amyotrophic lateral sclerosis model
    • Grunfeld JF, Barhum Y, Blondheim N, et al. Erythropoietin delays disease onset in an amyotrophic lateral sclerosis model. Exp Neurol 2007;204:260-3
    • (2007) Exp Neurol , vol.204 , pp. 260-263
    • Grunfeld, J.F.1    Barhum, Y.2    Blondheim, N.3
  • 68
    • 0034641710 scopus 로고    scopus 로고
    • Erythropoietin crosses the blood-brain barrier to protect against experimental brain injury
    • Brines ML, Ghezzi P, Keenan S, et al. Erythropoietin crosses the blood-brain barrier to protect against experimental brain injury. Proc Natl Acad Sci USA 2000;97:10526-31
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 10526-10531
    • Brines, M.L.1    Ghezzi, P.2    Keenan, S.3
  • 69
    • 13844251822 scopus 로고    scopus 로고
    • Erythropoietin treatment improves neurological functional recovery in EAE mice
    • Zhang J, Li Y, Cui Y, et al. Erythropoietin treatment improves neurological functional recovery in EAE mice. Brain Res 2005;1034:34-9
    • (2005) Brain Res , vol.1034 , pp. 34-39
    • Zhang, J.1    Li, Y.2    Cui, Y.3
  • 70
    • 0035957426 scopus 로고    scopus 로고
    • Erythropoietin prevents neuronal apoptosis after cerebral ischemia and metabolic stress
    • Siren AL, Frarelli M, Brines M, et al. Erythropoietin prevents neuronal apoptosis after cerebral ischemia and metabolic stress. Proc Natl Acad Sci USA 2001;98:4044-9
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 4044-4049
    • Siren, A.L.1    Frarelli, M.2    Brines, M.3
  • 71
    • 2442658142 scopus 로고    scopus 로고
    • Effect of erythropoietin axotomy-induced apoptosis in rat retinal ganglion cells
    • Weishaupt JH, Rohde G, Polking E, et al. Effect of erythropoietin axotomy-induced apoptosis in rat retinal ganglion cells. Invest Ophthalmol Vis Sci 2004;45:1514-22
    • (2004) Invest Ophthalmol Vis Sci , vol.45 , pp. 1514-1522
    • Weishaupt, J.H.1    Rohde, G.2    Polking, E.3
  • 72
    • 0035793485 scopus 로고    scopus 로고
    • Genc S, Kuralay F, Genc K, et al. Erythropoietin exerts neuroprotection in 1-methyl-4-phenyl-1,2,3, 6-tetrahydropyridine-treated C57/BL mice via increasing nitric oxide production. Neurosci Lett 2001;298:139-41
    • Genc S, Kuralay F, Genc K, et al. Erythropoietin exerts neuroprotection in 1-methyl-4-phenyl-1,2,3, 6-tetrahydropyridine-treated C57/BL mice via increasing nitric oxide production. Neurosci Lett 2001;298:139-41
  • 73
    • 34247862145 scopus 로고    scopus 로고
    • Intrastriatal administration of erythropoietin protects dopaminergic neurons and improves neurobehavioral outcome in a rat model of Parkinson's disease
    • Xue YQ, Zhao LR, Guo WP, et al. Intrastriatal administration of erythropoietin protects dopaminergic neurons and improves neurobehavioral outcome in a rat model of Parkinson's disease. Neuroscience 2007;146:1245-58
    • (2007) Neuroscience , vol.146 , pp. 1245-1258
    • Xue, Y.Q.1    Zhao, L.R.2    Guo, W.P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.