Insights into substrate specificity and metal activation of mammalian tetrahedral aspartyl aminopeptidase

Journal of Biological Chemistry

Volumn 287, Issue 16, 2012, Pages 13356-13370

  Chen, Yuanyuan ^a   Farquhar, Erik R ^a   Chance, Mark R ^a   Palczewski, Krzysztof ^a   Kiser, Philip D ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACIDIC RESIDUES; ACTIVE SITE; AMINO PEPTIDASE; BIOINORGANIC CHEMISTRY; DIVALENT CATION; ELECTRON MICROSCOPY ANALYSIS; ENZYMATIC ACTIVITIES; KEY ENZYMES; METAL-BINDING SITES; N-TERMINALS; NEURON FUNCTIONS; PEPTIDE SUBSTRATES; SIGNALING PEPTIDES; SINGLE PARTICLE; STRUCTURAL BASIS; STRUCTURAL DATA; SUBSTRATE SPECIFICITY; TETRAHEDRAL COMPLEXES; ZINC IONS;

BINDING SITES; ELECTRON MICROSCOPY; ENZYMES; MAMMALS; MANGANESE; PEPTIDES; PHYSIOLOGY; STRUCTURAL ANALYSIS; X RAY ABSORPTION SPECTROSCOPY; X RAY CRYSTALLOGRAPHY; ZINC;

SUBSTRATES;

ANGIOTENSIN DERIVATIVE; ASPARTYL AMINOPEPTIDASE; CALCIUM; COBALT; IMIDAZOLE; MAGNESIUM; MANGANESE; ZINC;

ARTICLE; BINDING SITE; COMPLEX FORMATION; CONTROLLED STUDY; COW; ELECTRON MICROSCOPY; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME PURIFICATION; ENZYME REGULATION; ENZYME SPECIFICITY; ENZYME STRUCTURE; MOLECULAR BIOLOGY; NONHUMAN; NUCLEOTIDE SEQUENCE; PLASTICITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; X RAY ABSORPTION SPECTROSCOPY; X RAY CRYSTALLOGRAPHY;

ANIMALS; CATALYTIC DOMAIN; CATTLE; CHELATING AGENTS; CRYSTALLOGRAPHY, X-RAY; ENZYME ACTIVATION; GLUTAMYL AMINOPEPTIDASE; MAMMALS; MANGANESE; METALS; PROTEIN SORTING SIGNALS; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; RETINA; SUBSTRATE SPECIFICITY;

MAMMALIA;

EID: 84859771335     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.347518     Document Type: Article

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