Demonstration of renin mRNA, angiotensinogen mRNA, and angiotensin converting enzyme mRNA expression in the human eye: Evidence for an intraocular renin-angiotensin system

British Journal of Ophthalmology

Volumn 80, Issue 2, 1996, Pages 159-163

  Wagner, Jürgen ^a   Danser, A H Jan ^b,e   Derkx, Frans H M ^b   De Jong, Paulus T V M ^b   Paul, Martin ^a   Mullins, John J ^c   Schalekamp, Maarten A D H ^b   Ganten, Detlev ^d  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b ERASMUS MEDICAL CENTER   (Netherlands)

^c INSTITUTE OF FOOD RESEARCH   (United Kingdom)

^d MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^e ERASMUS UNIVERSITY ROTTERDAM   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN; ANGIOTENSINOGEN; DIPEPTIDYL CARBOXYPEPTIDASE; MESSENGER RNA; RENIN;

ADULT; AGED; ARTICLE; CHOROID; CLINICAL ARTICLE; DIABETES MELLITUS; DIABETIC RETINOPATHY; FEMALE; GENE EXPRESSION; HUMAN; HUMAN TISSUE; MALE; PIGMENT EPITHELIUM; PRIORITY JOURNAL; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; RETINA; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; VITREOUS BODY;

EID: 0030040965     PISSN: 00071161     EISSN: None     Source Type: Journal    
DOI: 10.1136/bjo.80.2.159     Document Type: Article

References (31)

1. Danser AHJ, van den Dorpel MA, Deinum J, Derkx FHM, Franken AAM, Peperkamp E, et al. Renin, prorenin, and immunoreactive renin in vitreous fluid from eyes with and without diabetic retinopathy. J Clin Endocrinol Metab 1989; 68: 160-6.
2. Deinum J, Derkx FHM, Danser AHJ, Schalekamp MADH. Identification and quantification of renin and prorenin in the bovine eye. Endocrinology 1990; 126: 1673-82.
3. Sramek SJ, Wallow IHL, Day RP, Ehrlich EN. Ocular renin-angiotensin: immunohistochemical evidence for the presence of prorenin in eye tissue. Invest Ophthalmol Vis Sci 1988; 29: 1749-52.
4. Sramek SJ, Wallow IHL, Tewksbury DA, Brandt CR, Poulsen GL. An ocular renin-angiotensin system. Immunohistochemistry of angiotensinogen. Invest Ophthalmol Vis Sci 1992; 33: 1627-32.
5. Ferrari-Dileo G, Ryan JW, Rockwood EJ, Davis EB, Anderson DR. Angiotensin-converting enzyme in bovine, feline and human ocular tissues. Invest Ophthalmol Vis Sci 1988; 29: 876-81.
6. Weinreb RN, Sandman R, Ryder MI, Friberg TR. Angiotensin converting enzyme activity in human aqueous humor. Arch Ophthalmol 1985; 103: 34-6.
7. Danser AHJ, Derkx FHM, Admiraal PJJ, Deinum J, de Jong PTVM, Schalekamp MADH. Angiotensin levels in the eye. Invest Ophthalmol Vis Sci 1994; 35: 1008-18.
8. Kumar A, Rassoli A, Raizada MK. Angiotensinogen gene expression in neuronal and glial cells in primary cultures of rat brain. J Neurosci 1988; 19: 287-90.
9. Dzau VJ, Ingelfinger JR, Pratt RE. Regulation of tissue renin and angiotensin gene expressions. J Cardiovasc Pharmacol 1986;8(suppl 10):S11-6.
10. Paul M, Wagner J, Dzau VJ. Gene expression of the renin angiotensin systems in human tissues: quantitative analysis by the polymerase chain reaction. J Clin Invest 1993; 91: 2058-64.
11. Campbell DJ. Circulating and tissue angiotensin systems. J Clin Invest 1987; 79: 1-6.
12. Paul M, Bachmann J, Ganten D. The tissue renin-angiotensin systems in cardiovascular disease Trends Cardiovasc Med 1992; 2: 94-9.
13. Ferrari-Dileo G, Davis EB, Anderson DR. Angiotensin binding sites in bovine and human retinal blood vessels Invest Ophthalmol Vis Sci 1987; 28: 1747-51.
14. Rockwood EJ, Fantes F, Davis EB, Anderson DR. The response of retinal vasculature to angiotensin. Invest Ophthalmol Vis Sci 1987; 28: 676-82.
15. Constad WH, Fiore P, Samson C, Cinotti AA. Use of an angiotensin convening enzyme inhibitor in ocular hypertension and primary open-angle glaucoma. Am J Ophthalmol 1982; 105: 674-7.
16. Franken AAM, Derkx FHM, Man in't Veld AJ, Hop WCJ, van Rens GH, Peperkamp E, et al. High plasma prorenin in diabetes mellitus and its correlation with some complications. J Clin Endocrinol Metab 1990; 71: 1008-15.
17. Luetscher JA, Kraemer FB, Wilson DM, Schwartz HC, Bryer-Ash M. Increased plasma inactive renin in diabetes mellitus: a marker of microvascular complications. N Engl J Med 1985; 312: 1412-7.
18. Ariza A, Fernandes LA, Inagami T, Kim JH, Manuelidis EE. Renin in glioblastoma multiforme and its role in neovascularization. Am J Clin Pathol 1988; 90: 437-41.
19. Fernandez LA, Twickler J, Mead A. Neovascularization produced by angiotensin II. J Lab Clin Med 1985; 105: 141-5.
20. Auffray C, Rougeon F. Purification of mouse immunoglobulin heavy chain mRNAs from total myeloma tumor RNA. Eur J Biochem 1980; 107: 303-14.
21. Goedert M, Spillantini MG, Potier MC, Ulrich J, Crowther RA. Cloning and sequencing of the cDNA encoding an isoform of microtubule-associated protein tau containing four tandem repeats: differential expression of tau protein mRNAs in human brain. EMBO J 1989; 8: 393-9.
22. Kawasaki ES, Clark SS, Coyne MY, Smith SD, Champlin R, Witte ON, et al. Diagnosis of chronic myeloid and acute lymphocytic leukemias by detection of leukemia-specific mRNA sequences amplified in vitro. Proc Natl Acad Sci USA 1987; 85: 5698-702.
23. Wagner J, Paul M, Ganten D, Ritz E. Gene expression and quantification of components of the renin-angiotensin system from human renal biopsies by the polymerase chain reaction. J Am Soc Nephrol 1991; 2: 421 (abstract).
24. Hirsch AT, Talsness H, Schunkert H, Paul M, Dzau VJ. Tissue-specific activation of cardiac angiotensin converting enzyme in experimental heart failure. Circ Res 1991; 69: 475-82.
25. Cunha-Vaz J, Faria de Abreu JR, Campos AJ, Figo GM. Early breakdown of the blood-retinal barrier in diabetes. Br J Ophthalmol 1975; 59: 649-56.
26. Hermann K, Raizada MK, Sumners C, Philips MI. Presence of renin in primary neuronal and glial cells from rat brain. Brain Res 1987; 437: 205-13.
27. Berka JL, Stubbs AJ, Wang Z-M, Alcorn D, Campbell DJ, Skinner SL. Localisation of renin to Müller cells of the retina. J Hypertens 1994; 12 (suppl 3): S130 (abstract).
28. Kumar A, Rassoli A, Raizda MK. Angiotensinogen gene expression in neuronal and glial cells in primary cultures of rat brain. J Neurosci 1988; 19: 287-90.
29. Naftilan AJ, Zuo WM, Ingelfinger JR, Ryan TJ, Pratt RE, Dzau VJ. Localization and differential regulation of angiotensinogen mRNA expression in the vessel wall. J Clin Invest 1991; 87: 1300-11.
30. Paul M, Printz M, Harms E, Unger T, Lang RE, Ganten D. Localization of renin (EC 3.4.23) and converting enzyme (EC 3.4.15.1) in nerve endings of rat brain. Brain Res 1985; 334: 315-24.
31. Chai SY, Mendelsohn FAO, Paxinos G. Angiotensin converting enzyme in rat brain visualized by quantitative in vitro autoradiography. Neuroscience 1987; 20: 615-27.