Endogenous Tim-1 (Kim-1) promotes T-cell responses and cell-mediated injury in experimental crescentic glomerulonephritis

Kidney International

Volumn 81, Issue 9, 2012, Pages 844-855

  Nozaki, Yuji ^a,b   Nikolic Paterson, David J ^b   Snelgrove, Sarah L ^a   Akiba, Hisaya ^c   Yagita, Hideo ^c   Holdsworth, Stephen R ^a,b   Kitching, A Richard ^a,b  

^a MONASH UNIVERSITY   (Australia)

^b MONASH MEDICAL CENTRE   (Australia)

^c JUNTENDO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

anti GBM disease; glomerulonephritis; immunology; lymphocytes

Indexed keywords

CASPASE 3; GLOBULIN; INTERLEUKIN 10; KI 67 ANTIGEN; KIDNEY INJURY MOLECULE 1; MESSENGER RNA; STROMAL INTERACTION MOLECULE 1; TRANSCRIPTION FACTOR FOXP3;

APOPTOSIS; ARTICLE; CD4+ T LYMPHOCYTE; GLOMERULUS BASEMENT MEMBRANE; HUMAN; IMMUNE RESPONSE; IMMUNE SYSTEM; IN VIVO STUDY; KIDNEY INJURY; KIDNEY PROXIMAL TUBULE; LYMPHOCYTE PROLIFERATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAPIDLY PROGRESSIVE GLOMERULONEPHRITIS; T LYMPHOCYTE; TH1 CELL; TH17 CELL;

EID: 84859758970     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1038/ki.2011.424     Document Type: Article

References (43)

1. Tipping PG, Neale TJ, Holdsworth SR. T lymphocyte participation in antibody-induced experimental glomerulonephritis. Kidney Int 1985; 27: 530-537. (Pubitemid 15076760)
2. Huang XR, Tipping PG, Apostolopoulos J et al. Mechanisms of T cell-induced glomerular injury in anti-glomerular basement membrane (GBM) glomerulonephritis in rats. Clin Exp Immunol 1997; 109: 134-142. (Pubitemid 27293895)
3. Huang XR, Holdsworth SR, Tipping PG. Evidence for delayed type hypersensitivity mechanisms in glomerular crescent formation. Kidney Int 1994; 46: 69-78. (Pubitemid 24210437)
4. Kitching AR, Tipping PG, Huang XR et al. Interleukin-4 and interleukin-10 attenuate established crescentic glomerulonephritis in mice. Kidney Int 1997; 52: 52-59. (Pubitemid 27321814)
5. Kitching AR, Tipping PG, Mutch DA et al. Interleukin-4 deficiency enhances Th1 responses and crescentic glomerulonephritis in mice. Kidney Int 1998; 53: 112-118. (Pubitemid 28066909)
6. Kitching AR, Tipping PG, Timoshanko JR et al. Endogenous interleukin-10 regulates Th1 responses that induce crescentic glomerulonephritis. Kidney Int 2000; 57: 518-525. (Pubitemid 30430643)
7. Ooi JD, Snelgrove SL, Engel DR et al. Endogenous foxp3(+) T-regulatory cells suppress anti-glomerular basement membrane nephritis. Kidney Int 2011; 79: 977-986.
8. Tipping PG, Huang XR, Qi MY et al. Crescentic glomerulonephritis in CD4-and CD8-deficient mice-requirement for CD4 but not CD8 cells. Am J Pathol 1998; 152: 1541-1548. (Pubitemid 28275012)
9. Li S, Holdsworth SR, Tipping PG. Antibody independent crescentic glomerulonephritis in m chain deficient mice. Kidney Int 1997; 51: 672-678. (Pubitemid 27157950)
10. Meyers JH, Sabatos CA, Chakravarti S et al. The TIM gene family regulates autoimmune and allergic diseases. Trends Mol Med 2005; 11: 362-369. (Pubitemid 41080577)
11. Kuchroo VK, Umetsu DT, DeKruyff RH et al. The TIM gene family: emerging roles in immunity and disease. Nat Rev Immunol 2003; 3: 454-462. (Pubitemid 37339185)
12. Chae SC, Park YR, Song JH et al. The polymorphisms of Tim-1 promoter region are associated with rheumatoid arthritis in a Korean population. Immunogenetics 2005; 56: 696-701.
13. Gao PS, Mathias RA, Plunkett B et al. Genetic variants of the T-cell immunoglobulin mucin 1 but not the T-cell immunoglobulin mucin 3 gene are associated with asthma in an African American population. J Allergy Clin Immunol 2005; 115: 982-988. (Pubitemid 40616212)
14. Umetsu SE, Lee WL, McIntire JJ et al. TIM-1 induces T cell activation and inhibits the development of peripheral tolerance. Nat Immunol 2005; 6: 447-454. (Pubitemid 41716757)
15. Meyers JH, Chakravarti S, Schlesinger D et al. TIM-4 is the ligand for TIM-1, and the TIM-1-TIM-4 interaction regulates T cell proliferation. Nat Immunol 2005; 6: 455-464. (Pubitemid 41716758)
16. Mariat C, Degauque N, Balasubramanian S et al. Tim-1 signaling substitutes for conventional signal 1 and requires costimulation to induce T cell proliferation. J Immunol 2009; 182: 1379-1385.
17. Ichimura T, Bonventre JV, Bailly V et al. Kidney injury molecule-1 (KIM-1), a putative epithelial cell adhesion molecule containing a novel immunoglobulin domain, is up-regulated in renal cells after injury. J Biol Chem 1998; 273: 4135-4142. (Pubitemid 28103282)
18. Ichimura T, Hung CC, Yang SA et al. Kidney injury molecule-1: a tissue and urinary biomarker for nephrotoxicant-induced renal injury. Am J Physiol Renal Physiol 2004; 286: F552-F563. (Pubitemid 38233650)
19. Van Timmeren MM, Bakker SJ, Vaidya VS et al. Tubular kidney injury molecule-1 in protein-overload nephropathy. Am J Physiol Renal Physiol 2006; 291: F456-F464. (Pubitemid 44148135)
20. Ichimura T, Asseldonk EJ, Humphreys BD et al. Kidney injury molecule-1 is a phosphatidylserine receptor that confers a phagocytic phenotype on epithelial cells. J Clin Invest 2008; 118: 1657-1668. (Pubitemid 351632370)
21. Xiao S, Najafian N, Reddy J et al. Differential engagement of Tim-1 during activation can positively or negatively costimulate T cell expansion and effector function. J Exp Med 2007; 204: 1691-1702. (Pubitemid 47048034)
22. Lee HH, Meyer EH, Goya S et al. Apoptotic cells activate NKT cells through T cell Ig-like mucin-like-1 resulting in airway hyperreactivity. J Immunol 2010; 185: 5225-5235.
23. Summers SA, Steinmetz OM, Li M et al. Th1 and Th17 cells induce proliferative glomerulonephritis. J Am Soc Nephrol 2009; 20: 2518-2524.
24. Phoon RK, Kitching AR, Odobasic D et al. T-bet deficiency attenuates renal injury in experimental crescentic glomerulonephritis. J Am Soc Nephrol 2008; 19: 477-485. (Pubitemid 351355391)
25. Steinmetz OM, Summers SA, Gan PY et al. The Th17-defining transcription factor RORgt promotes glomerulonephritis. J Am Soc Nephrol 2011; 22: 472-483.
26. Panzer U, Steinmetz OM, Stahl RA et al. Kidney diseases and chemokines. Curr Drug Targets 2006; 7: 65-80.
27. Menke J, Zeller GC, Kikawada E et al. CXCL9, but not CXCL10, promotes CXCR3-dependent immune-mediated kidney disease. J Am Soc Nephrol 2008; 19: 1177-1189.
28. Turner JE, Paust HJ, Steinmetz OM et al. CCR6 recruits regulatory T cells and Th17 cells to the kidney in glomerulonephritis. J Am Soc Nephrol 2010; 21: 974-985.
29. Janssen U, Ostendorf T, Gaertner S et al. Improved survival and amelioration of nephrotoxic nephritis in intercellular adhesion molecule-1 knockout mice. J Am Soc Nephrol 1998; 9: 1805-1814. (Pubitemid 28443477)
30. Kawasaki K, Yaoita E, Yamamoto T et al. Antibodies against intercellular adhesion molecule-1 and lymphocyte function-associated antigen-1 prevent glomerular injury in rat experimental crescentic glomerulonephritis. J Immunol 1993; 150: 1074-1083. (Pubitemid 23133688)
31. Ueno T, Habicht A, Clarkson MR et al. The emerging role of T cell Ig mucin 1 in alloimmune responses in an experimental mouse transplant model. J Clin Invest 2008; 118: 742-751. (Pubitemid 351206562)
32. Freeman GJ, Casasnovas JM, Umetsu DT et al. TIM genes: a family of cell surface phosphatidylserine receptors that regulate innate and adaptive immunity. Immunol Rev 2010; 235: 172-189.
33. Ding Q, Yeung M, Camirand G et al. Regulatory B cells are identified by expression of TIM-1 and can be induced through TIM-1 ligation to promote tolerance in mice. J Clin Invest 2011; 121: 3645-3656.
34. Yamanishi Y, Kitaura J, Izawa K et al. TIM1 is an endogenous ligand for LMIR5/CD300b: LMIR5 deficiency ameliorates mouse kidney ischemia/reperfusion injury. J Exp Med 2010; 207: 1501-1511.
35. Rong S, Park JK, Kirsch T et al. The TIM-1:TIM-4 pathway enhances renal ischemia-reperfusion injury. J Am Soc Nephrol 2011; 22: 484-495.
36. Nozaki Y, Nikolic-Paterson DJ, Yagita H et al. Tim-1 promotes cisplatin nephrotoxicity. Am J Physiol Renal Physiol 2011; 301: F1098-F1104.
37. Kitching AR, Holdsworth SR, Tipping PG. IFN-g mediates crescent formation and cell-mediated immune injury in murine glomerulonephritis. J Am Soc Nephrol 1999; 10: 752-759. (Pubitemid 29149525)
38. Rangan GK, Pippin JW, Coombes JD et al. C5b-9 does not mediate chronic tubulointerstitial disease in the absence of proteinuria. Kidney Int 2005; 67: 492-503. (Pubitemid 40139841)
39. Ma FY, Liu J, Kitching AR et al. Targeting renal macrophage accumulation via c-fms kinase reduces tubular apoptosis but fails to modify progressive fibrosis in the obstructed rat kidney. Am J Physiol Renal Physiol 2009; 296: F177-F185.
40. Kitching AR, Turner AL, Wilson GR et al. IL-12p40 and IL-18 in crescentic glomerulonephritis: IL-12p40 is the Key Th1-defining cytokine chain, whereas IL-18 promotes local inflammation and leukocyte recruitment. J Am Soc Nephrol 2005; 16: 2023-2033. (Pubitemid 41716433)
41. Odobasic D, Kitching AR, Semple TJ et al. Glomerular expression of CD80 and CD86 is required for leukocyte accumulation and injury in crescentic glomerulonephritis. J Am Soc Nephrol 2005; 16: 2012-2022. (Pubitemid 41716432)
42. Odobasic D, Kitching AR, Semple TJ et al. Inducible co-stimulatory molecule ligand is protective during the induction and effector phases of crescentic glomerulonephritis. J Am Soc Nephrol 2006; 17: 1044-1053.
43. Tipping PG, Kitching AR, Huang XR et al. Immune modulation with interleukin-4 and interleukin-10 prevents crescent formation and glomerular injury in experimental glomerulonephritis. Eur J Immunol 1997; 27: 530-537. (Pubitemid 27085260)