The TIM-1:TIM-4 pathway enhances renal ischemia-reperfusion injury

Journal of the American Society of Nephrology

Volumn 22, Issue 3, 2011, Pages 484-495

  Rong, Song ^a   Park, Joon Keun ^a   Kirsch, Torsten ^a   Yagita, Hideo ^b   Akiba, Hisaya ^b   Boenisch, Olaf ^c   Haller, Hermann ^a   Najafian, Nader ^c   Habicht, Antje ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b JUNTENDO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MONOCLONAL ANTIBODY; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TISSUE INHIBITOR OF METALLOPROTEINASE 4;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRUSH BORDER; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE PRODUCTION; KIDNEY INJURY; KIDNEY ISCHEMIA; KIDNEY TUBULE NECROSIS; MACROPHAGE; MALE; MOUSE; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; REPERFUSION INJURY;

EID: 79952333501     PISSN: 10466673     EISSN: 15333450     Source Type: Journal    
DOI: 10.1681/ASN.2010030321     Document Type: Article

References (52)

1. Peeters P, Terryn W, Vanholder R, Lameire N: Delayed graft function in renal transplantation. Curr Opin Crit Care 10: 489-498, 2004 (Pubitemid 39620199)
2. Gueler F, Gwinner W, Schwarz A, Haller H: Long-term effects of acute ischemia and reperfusion injury. Kidney Int 66: 523-527, 2004 (Pubitemid 38981991)
3. Perico N, Cattaneo D, Sayegh MH, Remuzzi G: Delayed graft function in kidney transplantation. Lancet 364: 1814-1827, 2004
4. Bonventre JV: Pathophysiology of ischemic acute renal failure. Inflammation, lung-kidney cross-talk, and biomarkers. Contrib Nephrol 144:19-30, 2004
5. Fiorina P, Ansari MJ, Jurewicz M, Barry M, Ricchiuti V, Smith RN, Shea S, Means TK, Auchincloss H, Jr., Luster AD, Sayegh MH, Abdi R: Role of CXC chemokine receptor 3 pathway in renal ischemic injury. J Am Soc Nephrol 17: 716-723, 2006
6. Devalaraja-Narashimha K, Singaravelu K, Padanilam BJ: Poly(ADPribose) polymerase-mediated cell injury in acute renal failure. Pharmacol Res 52: 44-59, 2005 (Pubitemid 40725599)
7. Bonventre JV, Zuk A: Ischemic acute renal failure: An inflammatory disease? Kidney Int 66: 480-485, 2004 (Pubitemid 38981982)
8. Rabb H, O'Meara YM, Maderna P, Coleman P, Brady HR: Leukocytes, cell adhesion molecules and ischemic acute renal failure. Kidney Int 51: 1463-1468, 1997 (Pubitemid 27239898)
9. Rabb H: The T cell as a bridge between innate and adaptive immune systems: Implications for the kidney. Kidney Int 61: 1935-1946, 2002
10. De Greef KE, Ysebaert DK, Dauwe S, Persy V, Vercauteren SR, Mey D, De Broe ME: Anti-B7-1 blocks mononuclear cell adherence in vasa recta after ischemia. Kidney Int 60: 1415-1427, 2001 (Pubitemid 32960035)
11. Burne MJ, Daniels F, El Ghandour A, Mauiyyedi S, Colvin RB, O'Donnell MP, Rabb H: Identification of the CD4(+) T cell as a major pathogenic factor in ischemic acute renal failure. J Clin Invest 108: 1283-1290, 2001 (Pubitemid 33107755)
12. Friedewald JJ, Rabb H: Inflammatory cells in ischemic acute renal failure. Kidney Int 66: 486-491, 2004 (Pubitemid 38981983)
13. Chandraker A, Takada M, Nadeau KC, Peach R, Tilney NL, Sayegh MH: CD28-b7 blockade in organ dysfunction secondary to cold ischemia/reperfusion injury. Kidney Int 52: 1678-1684, 1997 (Pubitemid 28032075)
14. Yokota N, Burne-Taney M, Racusen L, Rabb H: Contrasting roles for STAT4 and STAT6 signal transduction pathways in murine renal ischemia-reperfusion injury. Am J Physiol Renal Physiol 285: F319-F325, 2003 (Pubitemid 36871205)
15. Meyers JH, Sabatos CA, Chakravarti S, Kuchroo VK: The TIM gene family regulates autoimmune and allergic diseases. Trends Mol Med 11: 362-369, 2005 (Pubitemid 41080577)
16. Kuchroo VK, Umetsu DT, DeKruyff RH, Freeman GJ: The TIM gene family: Emerging roles in immunity and disease. Nat Rev Immunol 3: 454-462, 2003 (Pubitemid 37339185)
17. Kaplan G, Totsuka A, Thompson P, Akatsuka T, Moritsugu Y, Feinstone SM: Identification of a surface glycoprotein on African green monkey kidney cells as a receptor for hepatitis A virus. Embo J 15: 4282-4296, 1996 (Pubitemid 26278711)
18. Ichimura T, Bonventre JV, Bailly V, Wei H, Hession CA, Cate RL, Sanicola M: Kidney injury molecule-1 (KIM-1), a putative epithelial cell adhesion molecule containing a novel immunoglobulin domain, is up-regulated in renal cells after injury. J Biol Chem 273: 4135-4142, 1998 (Pubitemid 28103282)
19. Feigelstock D, Thompson P, Mattoo P, Zhang Y, Kaplan GG: The human homolog of HAVcr-1 codes for a hepatitis A virus cellular receptor. J Virol 72: 6621-6628, 1998 (Pubitemid 28323979)
20. Han WK, Bailly V, Abichandani R, Thadhani R, Bonventre JV: Kidney Injury Molecule-1 (KIM-1): A novel biomarker for human renal proximal tubule injury. Kidney Int 62: 237-244, 2002 (Pubitemid 34754067)
21. Kobayashi N, Karisola P, Pena-Cruz V, Dorfman DM, Jinushi M, Umetsu SE, Butte MJ, Nagumo H, Chernova I, Zhu B, Sharpe AH, Ito S, Dranoff G, Kaplan GG, Casasnovas JM, Umetsu DT, Dekruyff RH, Freeman GJ: TIM-1 and TIM-4 glycoproteins bind phosphatidylserine and mediate uptake of apoptotic cells. Immunity 27: 927-940, 2007 (Pubitemid 50014866)
22. Ichimura T, Asseldonk EJ, Humphreys BD, Gunaratnam L, Duffield JS, Bonventre JV: Kidney injury molecule-1 is a phosphatidylserine receptor that confers a phagocytic phenotype on epithelial cells. J Clin Invest 118: 1657-1668, 2008 (Pubitemid 351632370)
23. Umetsu SE, Lee WL, McIntire JJ, Downey L, Sanjanwala B, Akbari O, Berry GJ, Nagumo H, Freeman GJ, Umetsu DT, DeKruyff RH: TIM-1 induces T cell activation and inhibits the development of peripheral tolerance. Nat Immunol 6: 447-454, 2005 (Pubitemid 41716757)
24. de Souza AJ, Oriss TB, O'Malley KJ, Ray A, Kane LP: T cell Ig and mucin 1 (TIM-1) is expressed on in vivo-activated T cells and provides a costimulatory signal for T cell activation. Proc Natl Acad Sci USA 102: 17113-17118, 2005 (Pubitemid 41692692)
25. Xiao S, Najafian N, Reddy J, Albin M, Zhu C, Jensen E, Imitola J, Korn T, Anderson AC, Zhang Z, Gutierrez C, Moll T, Sobel RA, Umetsu DT, Yagita H, Akiba H, Strom T, Sayegh MH, DeKruyff RH, Khoury SJ, Kuchroo VK: Differential engagement of Tim-1 during activation can positively or negatively costimulate T cell expansion and effector function. J Exp Med 204: 1691-1702, 2007 (Pubitemid 47048034)
26. Ueno T, Habicht A, Clarkson MR, Albin MJ, Yamaura K, Boenisch O, Popoola J, Wang Y, Yagita H, Akiba H, Ansari MJ, Yang J, Turka LA, Rothstein DM, Padera RF, Najafian N, Sayegh MH: The emerging role of T cell Ig mucin 1 in alloimmune responses in an experimental mouse transplant model. J Clin Invest 118: 742-751, 2008 (Pubitemid 351206562)
27. Meyers JH, Chakravarti S, Schlesinger D, Illes Z, Waldner H, Umetsu SE, Kenny J, Zheng XX, Umetsu DT, DeKruyff RH, Strom TB, Kuchroo VK: TIM-4 is the ligand for TIM-1, and the TIM-1-TIM-4 interaction regulates T cell proliferation. Nat Immunol 6: 455-464, 2005 (Pubitemid 41716758)
28. Hein RM, Woods ML: TIM-1 regulates macrophage cytokine production and B7 family member expression. Immunol Lett 108: 103-108, 2007 (Pubitemid 44959063)
29. Thiemermann C, Patel NS, Kvale EO, Cockerill GW, Brown PA, Stewart KN, Cuzzocrea S, Britti D, Mota-Filipe H, Chatterjee PK: High density lipoprotein (HDL) reduces renal ischemia/reperfusion injury. J Am Soc Nephrol 14: 1833-1843, 2003
30. Chatterjee PK, Cuzzocrea S, Brown PA, Zacharowski K, Stewart KN, Mota-Filipe H, Thiemermann C: Tempol, a membrane-permeable radical scavenger, reduces oxidant stress-mediated renal dysfunction and injury in the rat. Kidney Int 58: 658-673, 2000 (Pubitemid 30620015)
31. Rutella S, Rumi C, Lucia MB, Barberi T, Puggioni PL, Lai M, Romano A, Cauda R, Leone G: Induction of CD69 antigen on normal CD4+ and CD8+ lymphocyte subsets and its relationship with the phenotype of responding T-cells. Cytometry 38: 95-101, 1999 (Pubitemid 29300332)
32. Day YJ, Huang L, Ye H, Li L, Linden J, Okusa MD: Renal ischemia-reperfusion injury and adenosine 2A receptor-mediated tissue protection: The role of CD4+ T cells and IFN-gamma. J Immunol 176:3108-3114, 2006
33. Rabb H, Daniels F, O'Donnell M, Haq M, Saba SR, Keane W, Tang WW: Pathophysiological role of T lymphocytes in renal ischemia-reperfusion injury in mice. Am J Physiol Renal Physiol 279: F525-F531, 2000
34. Zwacka RM, Zhang Y, Halldorson J, Schlossberg H, Dudus L, Engelhardt JF: CD4(+) T-lymphocytes mediate ischemia/reperfusion-induced inflammatory responses in mouse liver. J Clin Invest 100: 279-289, 1997 (Pubitemid 27349074)
35. Lai LW, Yong KC, Igarashi S, Lien YH: A sphingosine-1-phosphate type 1 receptor agonist inhibits the early T-cell transient following renal ischemia-reperfusion injury. Kidney Int 71: 1223-1231, 2007 (Pubitemid 46884247)
36. Suleiman M, Cury PM, Pestana JO, Burdmann EA, Bueno V: FTY720 prevents renal T-cell infiltration after ischemia/reperfusion injury. Transplant Proc 37: 373-374, 2005
37. Huang Y, Rabb H, Womer KL: Ischemia-reperfusion and immediate T cell responses. Cell Immunol 248: 4-11, 2007 (Pubitemid 350101454)
38. Ascon DB, Lopez-Briones S, Liu M, Ascon M, Savransky V, Colvin RB, Soloski MJ, Rabb H: Phenotypic and functional characterization of kidney-infiltrating lymphocytes in renal ischemia reperfusion injury. J Immunol 177: 3380-3387, 2006 (Pubitemid 44277858)
39. Rodriguez-Pena A, Garcia-Criado FJ, Eleno N, Arevalo M, Lopez-Novoa JM: Intrarenal administration of molsidomine, a molecule releasing nitric oxide, reduces renal ischemia-reperfusion injury in rats. Am J Transplant 4: 1605-1613, 2004 (Pubitemid 39312294)
40. Uchida Y, Ke B, Freitas MC, Ji H, Zhao D, Benjamin ER, Najafian N, Yagita H, Akiba H, Busuttil RW, Kupiec-Weglinski JW: The emerging role of T cell immunoglobulin mucin-1 in the mechanism of liver ischemia and reperfusion injury in the mouse. Hepatology 51: 1363-1372, 2009
41. Lieberthal W, Fuhro R, Andry CC, Rennke H, Abernathy VE, Koh JS, Valeri R, Levine JS: Rapamycin impairs recovery from acute renal failure: Role of cell-cycle arrest and apoptosis of tubular cells. Am J Physiol Renal Physiol 281: F693-F706, 2001
42. Kelly KJ, Plotkin Z, Dagher PC: Guanosine supplementation reduces apoptosis and protects renal function in the setting of ischemic injury. J Clin Invest 108: 1291-1298, 2001 (Pubitemid 33107756)
43. Daemen MA, van 't Veer C, Denecker G, Heemskerk VH, Wolfs TG, Clauss M, Vandenabeele P, Buurman WA: Inhibition of apoptosis induced by ischemia-reperfusion prevents inflammation. J Clin Invest 104: 541-549, 1999
44. Lorz C, Ortiz A, Justo P, Gonzalez-Cuadrado S, Duque N, Gomez- Guerrero C, Egido J: Proapoptotic Fas ligand is expressed by normal kidney tubular epithelium and injured glomeruli. J Am Soc Nephrol 11: 1266-1277, 2000 (Pubitemid 30416223)
45. Jo SK, Yun SY, Chang KH, Cha DR, Cho WY, Kim HK, Won NH: Alpha-MSH decreases apoptosis in ischaemic acute renal failure in rats: Possible mechanism of this beneficial effect. Nephrol Dial Transplant 16: 1583-1591, 2001 (Pubitemid 32750449)
46. Feldenberg LR, Thevananther S, del Rio M, de Leon M, Devarajan P: Partial ATP depletion induces Fas- and caspase-mediated apoptosis in MDCK cells. Am J Physiol 276: F837-F846, 1999 (Pubitemid 29323557)
47. Meldrum KK, Meldrum DR, Hile KL, Yerkes EB, Ayala A, Cain MP, Rink RC, Casale AJ, Kaefer MA: p38 MAPK mediates renal tubular cell TNF-alpha production and TNF-alpha-dependent apoptosis during simulated ischemia. Am J Physiol Cell Physiol 281: C563-C570, 2001
48. Meldrum KK, Meldrum DR, Meng X, Ao L, Harken AH: TNF-alpha-dependent bilateral renal injury is induced by unilateral renal ischemiareperfusion. Am J Physiol Heart Circ Physiol 282: H540-H546, 2002 (Pubitemid 34654977)
49. Miyanishi M, Tada K, Koike M, Uchiyama Y, Kitamura T, Nagata S: Identification of Tim4 as a phosphatidylserine receptor. Nature 450: 435-439, 2007 (Pubitemid 350126753)
50. Burne-Taney MJ, Ascon DB, Daniels F, Racusen L, Baldwin W, Rabb H: B cell deficiency confers protection from renal ischemia reperfusion injury. J Immunol 171: 3210-3215, 2003 (Pubitemid 37093547)
51. Burne-Taney MJ, Yokota-Ikeda N, Rabb H: Effects of combined T- and B-cell deficiency on murine ischemia reperfusion injury. Am J Transplant 5: 1186-1193, 2005 (Pubitemid 40839406)
52. Park P, Haas M, Cunningham PN, Bao L, Alexander JJ, Quigg, RJ: Injury in renal ischemia-reperfusion is independent from immunoglobulins and T lymphocytes. Am J Physiol Renal Physiol 282: F352-F357, 2002 (Pubitemid 34654567)