Interleukin-4 deficiency enhances Th1 responses and crescentic glomerulonephritis in mice

Kidney International

Volumn 53, Issue 1, 1998, Pages 112-118

  Kitching, A Richard ^a   Tipping, Peter G ^a   Mutch, David A ^a   Huang, Xiao R U ^a   Holdsworth, Stephen R ^a  

^a MONASH UNIVERSITY   (Australia)

Author keywords

Crescentic glomerulonephrits; Glomerulonephritis; Interleukin 4 deficiency; T helper cell

Indexed keywords

INTERLEUKIN 4;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELLULAR IMMUNITY; DELAYED HYPERSENSITIVITY; FIBRIN DEPOSITION; GLOMERULONEPHRITIS; HELPER CELL; HYPOTHESIS; LYMPHOCYTIC INFILTRATION; MACROPHAGE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

EID: 0031888579     PISSN: 00852538     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1755.1998.00733.x     Document Type: Article

References (29)

1. NEALE TJ, TIPPING PG, CARSON SD, HOLDSWORTH SR: Participation of cell-mediated immunity in deposition of fibrin in glomerulonephritis. Lancet 2:421-424, 1988
2. BOLTON WK, INNES DJ JR, STURGILL BC, KAISER DL: T-cells and macrophages in rapidly progressive glomerulonephritis: Clinicopathologic correlations. Kidney Int 32:869-876, 1987
3. HUANG XR, HOLDSWORTH SR, TIPPING PG: Evidence for delayed type hypersensitivity mechanisms in glomerular crescent formation. Kidney Int 46:69-78, 1994
4. HUANG XR, TIPPING PG, LI S, HOLDSWORTH SR: Th1 responsiveness to nephritogenic antigens determines susceptibility to crescentic glomerulonephritis in mice. Kidney Int 51:94-103, 1997
5. FONG TA, MOSMANN TR: The role of IFN-gamma in delayed-type hypersensitivity mediated by Th1 clones. J Immunol 143:2887-2893, 1989
6. CHER DJ, MOSMANN TR: Two types of murine helper T cell clone. II. Delayed-type hypersensitivity is mediated by TH1 clones. J Immunol 138:3688-3694, 1987
7. MOSMANN TR, COFFMAN RL: TH1 and TH2 cells: Different patterns of lymphokine secretion lead to different functional properties. Annu Rev Immunol 7:145-173, 1989
8. SEDER RA, PAUL WE: Acquisition of lymphokine-producing phenotype by CD4+ T cells. Annu Rev Immunol 12:635-673, 1994
9. MANETTI R, GEROSA F, GIUDIZI MG, BIAGIOTTI R, PARRONCHI P, PICCINNI MP, SAMPOGNARO S, MAGGI E, ROMAGNANI S, TRINCHIERI G: Interleukin 12 induces stable priming for interferon gamma (IFN-gamma) production during differentiation of human T helper (Th) cells and transient IFN-gamma production in established Th2 cell clones. J Exp Med 179:1273-1283, 1994
10. SEDER RA, PAUL WE, DAVIS MM, FAZEKAS DE ST GROTH B: The presence of interleukin 4 during in vitro priming determines the lymphokine-producing potential of CD4+ T cells from T cell receptor transgenic mice. J Exp Med 176:1091-1098, 1992
11. KELSO A: Th1 and Th2 subsets: Paradigms lost? Immunol Today 16:374-379, 1995
12. KOPF M, LE GROS G, BACHMANN M, LAMERS MC, BLUETHMANN H, KOHLER G: Disruption of the murine IL-4 gene blocks Th2 cytokine responses. Nature 362:245-248, 1993
13. TIPPING PG, HUANG, XR, BERNDT MC, HOLDSWORTH SR: A role for P selectin in complement-independent neutrophil-mediated glomerular injury. Kidney Int 46:79-88, 1994
14. TIPPING PG, HUANG XR, BERNDT MC, HOLDSWORTH SR: P-selectin directs T lymphocyte mediated injury in delayed type hypersensitivity responses: Studies in glomerulonephritis and cutaneous delayed type hypersensitivity. Eur J Immunol 26:454-460, 1996
15. BRADFORD MM: A rapid and sensitive method for quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254, 1976
16. STILMANT MM, BOLTON WK, STURGILL BC, COUSER WG: Crescentic glomerulonephritis without immune deposits: Clinicopathologic features. Kidney Int 15:184-195, 1979
17. LI S, HOLDSWORTH SR, TIPPING PG: Antibody independent crescentic glomerulonephritis in μ chain deficient mice. Kidney Int 51:672-678, 1997
18. BOLTON WK, TUCKER FL, STURGILL BC: New avian model of experimental glomerulonephritis consistent with mediation by cellular immunity. Nonhumorally mediated glomerulonephritis in chickens. J Clin Invest 73:1263-1276, 1984
19. TIPPING PG, KITCHING AR, HUANG XR, MUTCH DA, HOLDSWORTH SR: Immune modulation with interleukin-4 and interleukin-10 prevents crescent formation and glomerular injury in experimental glomerulonephritis. Eur J Immunol 27:530-537, 1997
20. MANETTI R, PARRONCHI P, GIUDIZI MG, PICCINNI MP, MAGGI E, TRINCHIERI, G, ROMAGNANI S: Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells. J Exp Med 177:1199-1204, 1993
21. LAWRENCE RA, ALLEN JE, GREGORY WF, KOPF M, MAIZELS RM: Infection of IL-4-deficient mice with the parasitic nematode Brugia malayi demonstrates that host resistance is not dependent on a T helper 2-dominated immune response. J Immunol 154:5995-6001, 1995
22. GERMANN T, BONGARTZ M, DLUGONSKA H, HESS H, SCHMITT E, KOLBE L, KOLSCH E, PODLASKI FJ, GATELY MK, RUDE E: Interleukin-12 profoundly up-regulates the synthesis of antigen-specific complement-fixing IgG2a, IgG2b and IgG3 antibody subclasses in vivo. Eur J Immunol 25:823-829, 1995
23. KUHN R, RAJEWSKY K, MULLER W: Generation and analysis of interleukin-4 deficient mice. Science 254:707-710, 1991
24. VON DER WEID T, KOPF M, KOHLER G, LANGHORNE J: The immune response to Plasmodium chabaudi malaria in interleukin-4-deficient mice. Eur J Immunol 24:2285-2293, 1994
25. GAUTAM S, TEBO JM, HAMILTON TA: IL-4 suppresses cytokine gene expression induced by IFN-gamma and/or IL-2 in murine peritoneal macrophages. J Immunol 148:1725-1730, 1992
26. APPELBERG R, ORME IM, PINTO DE SOUSA MI, SILVA MT: In vitro effects of interleukin-4 on interferon-gamma-induced macrophage activation. Immunology 76:553-559, 1992
27. LIEW FY, LI Y, SEVERN A, MILLOTT S, SCHMIDT J, SALTER M, MONCADA S: A possible novel pathway of regulation by murine T helper type-2 (Th2) cells of a Th1 cell activity via the modulation of the induction of nitric oxide synthase on macrophages. Eur J Immunol 21:2489-2494, 1991
28. RAMANI M, OLLIVIER V, TERNISIEN C, VU T, ELBIM C, HAKIM J, DE PROST D: Interleukin 4 prevents the induction of tissue factor mRNA in human monocytes in response to LPS or PMA stimulation. Br J Haematol 85:462-468, 1993
29. KATOH T, LAKKIS FG, MAKITA N, BADR KF: Co-regulated expression of glomerular 12/15-lipoxygenase and interleukin-4 mRNAs in rat nephrotoxic nephritis. Kidney Int 46:341-349, 1994