Disabling the mitotic spindle and tumor growth by targeting a cavity-induced allosteric site of survivin

Oncogene

Volumn 31, Issue 15, 2012, Pages 1938-1948

  Berezov, A ^a   Cai, Z ^a   Freudenberg, J A ^a   Zhang, H ^a   Cheng, X ^a   Thompson, T ^a   Murali, R ^a   Greene, M I ^a   Wang, Q ^b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b Samuel Oschin Comprehensive Cancer Institute   (United States)

Author keywords

cancer; mitosis; survivin; therapeutic

Indexed keywords

PROTEIN INHIBITOR; S 12; SURVIVIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING SITE; CANCER INHIBITION; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG TARGETING; FEMALE; HUMAN; HUMAN CELL; MITOSIS SPINDLE; MOUSE; NONHUMAN; PRIORITY JOURNAL; TUMOR;

ALLOSTERIC SITE; ANIMALS; BINDING SITES; CELL LINE, TUMOR; CELL SURVIVAL; DNA-BINDING PROTEINS; HUMANS; INHIBITOR OF APOPTOSIS PROTEINS; MICE; MICE, NUDE; MITOSIS; MITOTIC SPINDLE APPARATUS; NEOPLASM TRANSPLANTATION; NEOPLASMS; TRANSCRIPTION FACTORS;

EID: 84859758147     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2011.377     Document Type: Article

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