Targeted gene inactivation of calpain-1 suppresses cortical degeneration due to traumatic brain injury and neuronal apoptosis induced by oxidative stress

Journal of Biological Chemistry

Volumn 287, Issue 16, 2012, Pages 13182-13193

  Yamada, Kaori H ^a,b   Kozlowski, Dorothy A ^c   Seidl, Stacey E ^c   Lance, Steven ^c   Wieschhaus, Adam J ^a,b   Sundivakkam, Premanand ^b   Tiruppathi, Chinnaswamy ^b   Chishti, Imran ^b   Herman, Ira M ^a   Kuchay, Shafi M ^b   Chishti, Athar H ^a,b  

^a TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF ILLINOIS   (United States)

^c DEPAUL UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS-INDUCING FACTORS; BIOCHEMICAL ANALYSIS; CALPAINS; CASPASE-3 ACTIVATION; CELL-DEATH PATHWAYS; CYSTEINE PROTEASE; EXTRACELLULAR; GENE INACTIVATION; IN-VIVO; KNOCK OUTS; MITOCHONDRIAL MEMBRANES; MODEL SYSTEM; MOUSE MODELS; NEURODEGENERATIVE DISORDERS; NEURONAL APOPTOSIS; RODENT MODELS; TRAUMATIC BRAIN INJURIES; WILD TYPES;

ACTIVATION ANALYSIS; AMINO ACIDS; BRAIN; CELL MEMBRANES; ENZYME ACTIVITY; FACTOR ANALYSIS; GENES; MAMMALS; MITOCHONDRIA; OXIDATIVE STRESS;

CELL DEATH;

CALCIUM ION; CALPAIN 1; CALPAIN 2; CASPASE 3;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN CONTUSION; BRAIN DEGENERATION; CALCIUM TRANSPORT; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INDUCTION; FEMALE; GENE FUNCTION; GENE INACTIVATION; GENE TARGETING; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NERVE CELL NECROSIS; NEUROCHEMISTRY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; TRAUMATIC BRAIN INJURY;

ANIMALS; APOPTOSIS; APOPTOSIS INDUCING FACTOR; BRAIN INJURIES; CALCIUM; CALPAIN; CASPASE 3; DISEASE MODELS, ANIMAL; FEMALE; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MITOCHONDRIAL MEMBRANES; NERVE DEGENERATION; NEURONS; OXIDATIVE STRESS; RNA, SMALL INTERFERING;

MUS; RODENTIA;

EID: 84859748670     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.302612     Document Type: Article

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