Experimental investigation of cerebral contusion: Histopathological and immunohistochemical evaluation of dynamic cortical deformation

Journal of Neuropathology and Experimental Neurology

Volumn 58, Issue 2, 1999, Pages 153-164

  Shreiber, David I ^a   Bain, Allison C ^a   Ross, Douglas T ^b   Smith, Douglas H ^b   Gennarelli, T A ^b   McIntosh, Tracy K ^b   Meaney, David F ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Biomechanics; Brain injury; Cerebral contusion

Indexed keywords

GLIAL FIBRILLARY ACIDIC PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTOSIS; BRAIN CONTUSION; BRAIN CORTEX; BRAIN HEMORRHAGE; CAPSULA INTERNA; CONTROLLED STUDY; DEFORMITY; DISEASE SEVERITY; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; MALE; NERVE CELL NECROSIS; NERVE FIBER; NEUROFILAMENT; NONHUMAN; PRIORITY JOURNAL; RAT; VACUUM; WHITE MATTER;

EID: 0033026448     PISSN: 00223069     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005072-199902000-00005     Document Type: Article

References (33)

1. Adams JH, Graham DI. The pathology of blunt head injuries. In: Critchley M, O'Leary J, Jennet B, eds. Scientific Foundations of Neurology. Philadelphia: F.A. Davis Company, 1985
2. Adams JH, Graham DI, Scott G, Parker LS, Doyle D. Brain damage in fatal non-missile head injury. J Clin Pathol 1980;33:1132-45
3. Adams JH, Doyle D, Graham DI, et al. The contusion index: A reappraisal in human and experimental non-missile head injury. Neuropathol Appl Neurobiol 1985;11:299-308
4. Bullock R, Maxwell WL, Graham DI, Teasdale GM, Adams JH. Glial swelling following human cerebral contusion: An ultrastructural study. J Neurol Neurosurg Psychiatry 1991;54:427-34
5. Cervós-Navarro J, Lafuente JV. Traumatic brain injuries: Structural changes. J Neurol Sci 1991;102:S3-S14
6. Gennarelli TA. Animate models of human head injury [Review]. J Neurotrauma 1994;11:357-68
7. Smith D, Casey K, McIntosh T. Pharmacologic therapy for traumatic brain injury: Experimental approaches. New Horizons 1995; 3:562-72
8. McIntosh T, Smith D, Meaney D, Kotapka M, Gennarelli T, Graham D Neuropathological sequelae of traumatic brain injury: Relationship to neurochemical and biomechanical mechanisms [Review]. Lab Invest 1996;74:315-42
9. Mathew P, Graham DI, Bullock R, Maxwell W, McCulloch J, Teasdale G. Focal brain injury: Histological evidence of delayed inflammatory response in a new rodent model of focal cortical injury. Acta Neurochir (Wien) 1994;605:428-30
10. Mathew P, Bullock R, Teasdale G, McCulloch J. Changes in local microvascular permeability and in the effect of intervention with 21-aminosteroid (tirilazad) in a new experimental model of focal cortical injury in the rat. J Neurotrauma 1996;13:465-72
11. McIntosh TK, Vink R, Noble L, et al. Traumatic brain injury in the rat: Characterization of a lateral fluid-percussion model. Neuroscience 1989;28:233-44
12. Goodman JC, Cherian L, Bryan RMJ, Robertson CS. Lateral cortical impact injury in rats: Pathologic effects of varying cortical compression and impact velocity. J Neurotrauma 1994;11:587-97
13. Adams JH, Scott G, Parker LS, Graham DI, Doyle D. The contusion index: A quantitative approach to cerebral contusions in head injury. Neuropathol Appl Neurobiol 1980;6:319-24
14. Gennarelli TA, Thibault LE. Biomechanics of head injury. In: Wilkins R, Rangachary SS, eds. Neurosurgery. New York: McGraw-Hill, 1985:1531-36
15. Ommaya AK, Thibault LE, Bandak FA. Mechanisms of impact head injury. International J Impact Engineering 1994;15:535-60
16. Ross DT, Graham DI, Adams JH, Gennarelli TA. Correlation of neurofilament immunohistochemistry with silver staining of damaged axons following head injury in humans, sub-human primates, and rodents. (Abstract). Soc. of Neuroscience Abstracts. 1992:1088
17. Ross DT, Meaney DF, Sabol MK, Smith DH, Gennarelli TA. Distribution of forebrain diffuse axonal injury following inertial closed head injury in miniature swine. Exp Neurol 1994;126:291-99
18. Pappius, HM, Brain injury: New insights into neurotransmitter and receptor mechanisms. Neurochem Research, 1991;16(9):941-49
19. Eacott, MJ, Heywood CA. Perception and memory: Action and interaction. Crit Rev Neurobiol, 1995;9(4):311-29
20. Kuroda Y, Fujisawa H, Strebel S, Graham DI, Bullock R. Effect of neuroprotective N-methyl-D-aspartate antagonists on increased intracranial pressure: studies in the rat acute subdural hematoma model. Neurosurgery 1994;35:106-12
21. Duhaime AC, Gennarelli LM, Yachnis A. Acute subdural hematoma: Is the blood itself toxic? J Neurotrauma 1994;11:669-78
22. Graham DI, Adams JH, Nicoll JA, Maxwell WL, Gennarelli TA. The nature, distribution, and causes of traumatic brain injury, Brain Pathol. 1995;5(4):397-406
23. Meaney DF, Ross DT, Winklestein BA, et al. Modification of cortical impact brain injury model to produce axonal damage in the rat cerebral cortex. J Neurotrauma 1994;11:599-612
24. Ueno K, Melvin JW, Li L, Lighthall JW. Development of tissue level brain injury criteria by finite element analysis. J Neurotrauma 1995;12:695-706
25. Thibault LE, Meaney DF, Anderson BJ, Marmarou A. Biomechanical aspects of a fluid percussion model of brain injury. J Neurotrauma 1992;9:311-22
26. Shreiber DI, McIntosh TK, Meaney DF. Focal damage to the blood-brain barrier induced by dynamic displacement of the cortex (abstract). J Neurotrauma 1996;13:595.
27. Mathew P, Bullock R, Graham DI, Maxwell WL, Teasdale GM, McCulloch J. A new experimental model of contusion in the rat. Histopathological analysis and temporal patterns of cerebral blood flow disturbances. J Neurosurg 1996;85:860-70
28. Galford JE, McElhaney JH. A viscoelastic study of scalp, brain, and dura. J Biomech 1970;3:211-21
29. Bullock R, Zauner A, Myseros JS, Marmarou A, Woodward JJ, Young HF. Evidence for prolonged release of excitatory amino acids in severe head trauma. Relationship to clinical events. Ann NY Acad Sci 1995;765:290-97
30. Baker CJ, Moulton RJ, Macmillan VH, Shedlen PM. Excitatory amino acids in cerebrospinal fluid following traumatic brain injury in humans. J Neurosurg 1993;79(3):369-72
31. Choi D, Malucci-Gedde M, Kriegstein AR. Glutamate toxicity in cortical cell culture. J Neurosci 1987;7:357-68
32. Brown J, Baker AJ, Konasiewicz SJ, Moulton RJ. Clinical significance of CSF glutamate concentrations following severe traumatic brain injury in humans. J Neurotrauma 1998;15(4):253-63
33. Zhang L, Rzigalinski BA, Ellis EF, Satin LS. Reduction of voltage-dependent Mg2+ blockade of NMDA current in mechanically injured neurons. Science 1996;274:1921-23