메뉴 건너뛰기




Volumn 499, Issue 1, 2012, Pages 25-36

Molecular cloning, bacterial expression and promoter analysis of squalene synthase from Withania somnifera (L.) Dunal

Author keywords

Promoter; SDS PAGE; Squalene synthase; Withaferin a; Withania somnifera; Withanolides

Indexed keywords

COMPLEMENTARY DNA; FARNESYL DIPHOSPHATE; JASMONIC ACID METHYL ESTER; POLYPEPTIDE; SALICYLIC ACID; SQUALENE SYNTHASE; WITHAFERIN A;

EID: 84859748263     PISSN: 03781119     EISSN: 18790038     Source Type: Journal    
DOI: 10.1016/j.gene.2012.03.004     Document Type: Article
Times cited : (76)

References (54)
  • 1
    • 12044254693 scopus 로고
    • Enzymatic cyclization of squalene and oxidosqualene to sterols and triterpenes
    • Abe I., Rohmer M., Prestwich G.D. Enzymatic cyclization of squalene and oxidosqualene to sterols and triterpenes. Chem. Rev. 1993, 93:2189-2206.
    • (1993) Chem. Rev. , vol.93 , pp. 2189-2206
    • Abe, I.1    Rohmer, M.2    Prestwich, G.D.3
  • 2
    • 0033779271 scopus 로고    scopus 로고
    • Hypoglycemic, diuretic and hypocholesterolemic effect of winter cherry (Withania somnifera) root
    • Andallu B., Radhika B. Hypoglycemic, diuretic and hypocholesterolemic effect of winter cherry (Withania somnifera) root. Indian J. Exp. Biol. 2000, 38:607-609.
    • (2000) Indian J. Exp. Biol. , vol.38 , pp. 607-609
    • Andallu, B.1    Radhika, B.2
  • 4
    • 79960266099 scopus 로고    scopus 로고
    • Drought, salt and wounding stress induce the expression of the plasma membrane intrinsic protein 1 gene in poplar (Populus alba×P. tremula var. glandulosa)
    • Bae E.K., Lee H., Lee J.S., Noh E.W. Drought, salt and wounding stress induce the expression of the plasma membrane intrinsic protein 1 gene in poplar (Populus alba×P. tremula var. glandulosa). Gene 2011, 483:43-48.
    • (2011) Gene , vol.483 , pp. 43-48
    • Bae, E.K.1    Lee, H.2    Lee, J.S.3    Noh, E.W.4
  • 5
    • 0031418908 scopus 로고    scopus 로고
    • Antioxidant activity of glycowithanolides from Withania somnifera
    • Bhattacharya S.K., Satyan K.S., Ghosal S. Antioxidant activity of glycowithanolides from Withania somnifera. Indian J. Exp. Biol. 1997, 35:236-239.
    • (1997) Indian J. Exp. Biol. , vol.35 , pp. 236-239
    • Bhattacharya, S.K.1    Satyan, K.S.2    Ghosal, S.3
  • 6
    • 77954219423 scopus 로고    scopus 로고
    • Comprehensive metabolic fingerprinting of Withania somnifera leaf and root extracts
    • Chatterjee S., et al. Comprehensive metabolic fingerprinting of Withania somnifera leaf and root extracts. Phytochemistry 2010, 71:1085-1094.
    • (2010) Phytochemistry , vol.71 , pp. 1085-1094
    • Chatterjee, S.1
  • 7
    • 70349981456 scopus 로고    scopus 로고
    • Metabolic clustering of a core collection of Indian ginseng Withania somnifera Dunal through DNA, isoenzyme, polypeptide and withanolide profile diversity
    • Chaurasiya N.D., Sangwan R.S., Misra L.N., Tuli R., Sangwan N.S. Metabolic clustering of a core collection of Indian ginseng Withania somnifera Dunal through DNA, isoenzyme, polypeptide and withanolide profile diversity. Fitoterapia 2009, 80:496-505.
    • (2009) Fitoterapia , vol.80 , pp. 496-505
    • Chaurasiya, N.D.1    Sangwan, R.S.2    Misra, L.N.3    Tuli, R.4    Sangwan, N.S.5
  • 8
    • 79955876007 scopus 로고    scopus 로고
    • Auxin stimulates DWARF4 expression and brassinosteroid biosynthesis in Arabidopsis
    • Chung Y., et al. Auxin stimulates DWARF4 expression and brassinosteroid biosynthesis in Arabidopsis. Plant J. 2011, 66:564-578.
    • (2011) Plant J. , vol.66 , pp. 564-578
    • Chung, Y.1
  • 10
    • 0036227280 scopus 로고    scopus 로고
    • Effect of Withania somnifera on CTL activity
    • Davis L., Kuttan G. Effect of Withania somnifera on CTL activity. J. Exp. Clin. Cancer Res. 2002, 21:115-118.
    • (2002) J. Exp. Clin. Cancer Res. , vol.21 , pp. 115-118
    • Davis, L.1    Kuttan, G.2
  • 11
    • 0032518190 scopus 로고    scopus 로고
    • Molecular characterization of tobacco squalene synthase and regulation in response to fungal elicitor
    • Devarenne T.P., Shin D.H., Back K., Yin S., Chappell J. Molecular characterization of tobacco squalene synthase and regulation in response to fungal elicitor. Arch. Biochem. Biophys. 1998, 349:205-215.
    • (1998) Arch. Biochem. Biophys. , vol.349 , pp. 205-215
    • Devarenne, T.P.1    Shin, D.H.2    Back, K.3    Yin, S.4    Chappell, J.5
  • 12
    • 0035984066 scopus 로고    scopus 로고
    • Regulation of squalene synthase, a key enzyme of sterol biosynthesis, in tobacco
    • Devarenne T.P., Ghosh A., Chappell J. Regulation of squalene synthase, a key enzyme of sterol biosynthesis, in tobacco. Plant Physiol. 2002, 129:1096-1106.
    • (2002) Plant Physiol. , vol.129 , pp. 1096-1106
    • Devarenne, T.P.1    Ghosh, A.2    Chappell, J.3
  • 13
    • 80051953435 scopus 로고    scopus 로고
    • Use of ISSR and RAPD markers to facilitate molecular characterization of Withania germplasm - a repository of a pharmaceutically active metabolites
    • Dhar R.S., Lattoo S.K., Kumar A., Qazi G.N. Use of ISSR and RAPD markers to facilitate molecular characterization of Withania germplasm - a repository of a pharmaceutically active metabolites. J. Plant Biol. 2008, 35(2):107-113.
    • (2008) J. Plant Biol. , vol.35 , Issue.2 , pp. 107-113
    • Dhar, R.S.1    Lattoo, S.K.2    Kumar, A.3    Qazi, G.N.4
  • 14
    • 33748927523 scopus 로고    scopus 로고
    • Phytochemical and genetic analysis in selected chemotypes of Withania somnifera
    • Dhar R.S., et al. Phytochemical and genetic analysis in selected chemotypes of Withania somnifera. Phytochemistry 2006, 67:2269-2276.
    • (2006) Phytochemistry , vol.67 , pp. 2269-2276
    • Dhar, R.S.1
  • 15
    • 0030614169 scopus 로고    scopus 로고
    • Salicylic acid and disease resistance in plants
    • Durner J., Shah J., Kessig D.F. Salicylic acid and disease resistance in plants. Trends Plant Sci. 1997, 2:266-274.
    • (1997) Trends Plant Sci. , vol.2 , pp. 266-274
    • Durner, J.1    Shah, J.2    Kessig, D.F.3
  • 16
    • 0000461280 scopus 로고
    • Confidence limit on phylogenies: an approach using the bootstrap
    • Felsenstein J. Confidence limit on phylogenies: an approach using the bootstrap. Evolution 1985, 39:783-791.
    • (1985) Evolution , vol.39 , pp. 783-791
    • Felsenstein, J.1
  • 18
    • 0029595442 scopus 로고
    • SOPMA: significant improvement in protein secondary structure prediction by consensus prediction from multiple alignments
    • Geourjon C., Deleage G. SOPMA: significant improvement in protein secondary structure prediction by consensus prediction from multiple alignments. Comput. Appl. Biosci. 1995, 11:681-684.
    • (1995) Comput. Appl. Biosci. , vol.11 , pp. 681-684
    • Geourjon, C.1    Deleage, G.2
  • 19
    • 0024429671 scopus 로고
    • Immunomodulatory and CNS effects of sitoindosides IX and X, two new glycosides from Withania somnifera
    • Ghosal S., et al. Immunomodulatory and CNS effects of sitoindosides IX and X, two new glycosides from Withania somnifera. Phytother. Res. 1989, 3:201-206.
    • (1989) Phytother. Res. , vol.3 , pp. 201-206
    • Ghosal, S.1
  • 20
    • 0032846404 scopus 로고    scopus 로고
    • Molecular cloning and characterization of two cDNAs for Glycyrrhiza glabra squalene synthase
    • Hayashi H., Hirota A., Hiraoka N., Ikeshiro Y. Molecular cloning and characterization of two cDNAs for Glycyrrhiza glabra squalene synthase. Biol. Pharm. Bull. 1999, 22:947-950.
    • (1999) Biol. Pharm. Bull. , vol.22 , pp. 947-950
    • Hayashi, H.1    Hirota, A.2    Hiraoka, N.3    Ikeshiro, Y.4
  • 21
    • 0032918558 scopus 로고    scopus 로고
    • "Plant cis-acting regulatory DNA elements" (PLACE) database
    • Higo K., Ugawa Y., Iwamoto M., Korenaga T. "Plant cis-acting regulatory DNA elements" (PLACE) database. Nucleic Acid Res. 1999, 27(1):297-300.
    • (1999) Nucleic Acid Res. , vol.27 , Issue.1 , pp. 297-300
    • Higo, K.1    Ugawa, Y.2    Iwamoto, M.3    Korenaga, T.4
  • 22
    • 84863735338 scopus 로고    scopus 로고
    • Molecular cloning and characterization of the promoter of SmGGPPs and its expression pattern in Salvia miltiorrhiza
    • Hua W., Song J., Li C., Wang Z. Molecular cloning and characterization of the promoter of SmGGPPs and its expression pattern in Salvia miltiorrhiza. Mol. Biol. Rep. 2011, 10.1007/s11033-011-1388-8.
    • (2011) Mol. Biol. Rep.
    • Hua, W.1    Song, J.2    Li, C.3    Wang, Z.4
  • 23
    • 34548477866 scopus 로고    scopus 로고
    • Screening of indigenous Palestinian medicinal plants for potential anti-inflammatory and cytotoxic activity
    • Kaileh M., Berghe W.V., Boone E., Essawi T., Haegeman G. Screening of indigenous Palestinian medicinal plants for potential anti-inflammatory and cytotoxic activity. J. Ethnopharmacol. 2007, 113:510-516.
    • (2007) J. Ethnopharmacol. , vol.113 , pp. 510-516
    • Kaileh, M.1    Berghe, W.V.2    Boone, E.3    Essawi, T.4    Haegeman, G.5
  • 24
    • 79251597651 scopus 로고    scopus 로고
    • Gene regulation patterns in triterpene biosynthetic pathway driven by overexpression of squalene synthase and methyl jasmonate elicitation in Bupleurum falcatum
    • Kim Y.S., Cho J.H., Park S., Han J.Y., Back K., Choi Y.E. Gene regulation patterns in triterpene biosynthetic pathway driven by overexpression of squalene synthase and methyl jasmonate elicitation in Bupleurum falcatum. Planta 2011, 233:343-355.
    • (2011) Planta , vol.233 , pp. 343-355
    • Kim, Y.S.1    Cho, J.H.2    Park, S.3    Han, J.Y.4    Back, K.5    Choi, Y.E.6
  • 25
    • 73949113574 scopus 로고    scopus 로고
    • Notch-1 inhibition by Withaferin-A: a therapeutic target against colon carcinogenesis
    • Koduru S., Kumar R., Srinivasan S., Evers M.B., Damodaran C. Notch-1 inhibition by Withaferin-A: a therapeutic target against colon carcinogenesis. Mol. Cancer Ther. 2010, 9:202-210.
    • (2010) Mol. Cancer Ther. , vol.9 , pp. 202-210
    • Koduru, S.1    Kumar, R.2    Srinivasan, S.3    Evers, M.B.4    Damodaran, C.5
  • 26
    • 84155180843 scopus 로고    scopus 로고
    • A comprehensive analysis of fifteen genes of steviol glycosides biosynthesis pathway in Stevia rebaudiana (Bertoni)
    • Kumar H., Kaul K., Bajpai-Gupta S., Kaul V.K., Kumar S. A comprehensive analysis of fifteen genes of steviol glycosides biosynthesis pathway in Stevia rebaudiana (Bertoni). Gene 2012, 492:276-284.
    • (2012) Gene , vol.492 , pp. 276-284
    • Kumar, H.1    Kaul, K.2    Bajpai-Gupta, S.3    Kaul, V.K.4    Kumar, S.5
  • 27
    • 0029759225 scopus 로고    scopus 로고
    • Use of Withania somnifera Dunal as an adjuvant during radiation therapy
    • Kuttan G. Use of Withania somnifera Dunal as an adjuvant during radiation therapy. Indian J. Exp. Biol. 1996, 34:854-856.
    • (1996) Indian J. Exp. Biol. , vol.34 , pp. 854-856
    • Kuttan, G.1
  • 28
    • 79956353743 scopus 로고    scopus 로고
    • Modulation of triterpene saponin production: in vitro cultures, elicitation, and metabolic engineering
    • Lambert E., Faizal A., Geelen D. Modulation of triterpene saponin production: in vitro cultures, elicitation, and metabolic engineering. Appl. Biochem. Biotechnol. 2011, 164(2):220-237.
    • (2011) Appl. Biochem. Biotechnol. , vol.164 , Issue.2 , pp. 220-237
    • Lambert, E.1    Faizal, A.2    Geelen, D.3
  • 29
    • 34250340035 scopus 로고    scopus 로고
    • Temporal sexual maturation and incremental stamina movement encourages mixed mating in Withania somnifera - an insurance for reproductive success
    • Lattoo S.K., Dhar R.S., Khan S., Bamotra S., Dhar A.K. Temporal sexual maturation and incremental stamina movement encourages mixed mating in Withania somnifera - an insurance for reproductive success. Curr. Sci. 2007, 22(10):1390-1399.
    • (2007) Curr. Sci. , vol.22 , Issue.10 , pp. 1390-1399
    • Lattoo, S.K.1    Dhar, R.S.2    Khan, S.3    Bamotra, S.4    Dhar, A.K.5
  • 30
    • 33748668268 scopus 로고    scopus 로고
    • Genetics and mechanism of induced male sterility in Andrographis paniculata (Burm. F.) Nees and its significance
    • Lattoo S.K., Khan S., Dhar A.K., Choudhary D.K., Gupta K.K., Sharma P.R. Genetics and mechanism of induced male sterility in Andrographis paniculata (Burm. F.) Nees and its significance. Curr. Sci. 2006, 91(4):515-519.
    • (2006) Curr. Sci. , vol.91 , Issue.4 , pp. 515-519
    • Lattoo, S.K.1    Khan, S.2    Dhar, A.K.3    Choudhary, D.K.4    Gupta, K.K.5    Sharma, P.R.6
  • 31
    • 84859766409 scopus 로고    scopus 로고
    • Development of hyper-productive hybrids through inter-varietal hybridisation for molecular analysis and metabolic pathway elucidation in Withania somnifera L. Dunal
    • Lattoo S.K., et al. Development of hyper-productive hybrids through inter-varietal hybridisation for molecular analysis and metabolic pathway elucidation in Withania somnifera L. Dunal. Proceedings 3 rd J & K State Science Congress, Feb 21-24 2009, 89.
    • (2009) Proceedings 3 rd J & K State Science Congress, Feb 21-24 , pp. 89
    • Lattoo, S.K.1
  • 32
    • 78149239365 scopus 로고    scopus 로고
    • Withaferin A inhibits activation of signal transducer and activator of transcription 3 in human breast cancer cells
    • Lee J., Hahm E.R., Singh S.V. Withaferin A inhibits activation of signal transducer and activator of transcription 3 in human breast cancer cells. Carcinogenesis 2010, 31(11):1991-1998.
    • (2010) Carcinogenesis , vol.31 , Issue.11 , pp. 1991-1998
    • Lee, J.1    Hahm, E.R.2    Singh, S.V.3
  • 33
    • 1842847404 scopus 로고    scopus 로고
    • Cloning and expression of squalene synthase cDNA from hot pepper (Capsicum annuum L.)
    • Lee J.H., et al. Cloning and expression of squalene synthase cDNA from hot pepper (Capsicum annuum L.). Mol. Cells 2002, 13:436-443.
    • (2002) Mol. Cells , vol.13 , pp. 436-443
    • Lee, J.H.1
  • 34
    • 4644290998 scopus 로고    scopus 로고
    • Enhanced triterpene and phytosterol biosynthesis in Panax ginseng overexpressing squalene synthase gene
    • Lee M.H., Jeong J.H., Seo J.W., Shin C.G., Kim Y.S., In J.G. Enhanced triterpene and phytosterol biosynthesis in Panax ginseng overexpressing squalene synthase gene. Plant Cell Physiol. 2004, 45:976-984.
    • (2004) Plant Cell Physiol. , vol.45 , pp. 976-984
    • Lee, M.H.1    Jeong, J.H.2    Seo, J.W.3    Shin, C.G.4    Kim, Y.S.5    In, J.G.6
  • 35
    • 0036085047 scopus 로고    scopus 로고
    • PlantCARE, a database of plant cis-acting regulatory elements and a portal to tools for in silico analysis of promoter sequences
    • Lescot M., et al. PlantCARE, a database of plant cis-acting regulatory elements and a portal to tools for in silico analysis of promoter sequences. Nucleic Acids Res. 2002, 30:325-327.
    • (2002) Nucleic Acids Res. , vol.30 , pp. 325-327
    • Lescot, M.1
  • 36
    • 1642344588 scopus 로고    scopus 로고
    • Effect of Withania somnifera on B16F-10melanoma induced metastasis in mice
    • Leyon P.V., Kuttan G. Effect of Withania somnifera on B16F-10melanoma induced metastasis in mice. Phytother. Res. 2004, 18:118-122.
    • (2004) Phytother. Res. , vol.18 , pp. 118-122
    • Leyon, P.V.1    Kuttan, G.2
  • 37
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-delta delta C (T)) method
    • Livak K.J., Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-delta delta C (T)) method. Methods 2001, 25(4):402-408.
    • (2001) Methods , vol.25 , Issue.4 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 38
    • 0027487993 scopus 로고
    • Overexpression, purification, and kinetic characterization of a carboxyl-terminal-truncated yeast squalene synthetase
    • LoGrasso P.V., Soltis D.A., Boettcher B.R. Overexpression, purification, and kinetic characterization of a carboxyl-terminal-truncated yeast squalene synthetase. Arch. Biochem. Biophys. 1993, 307:193-199.
    • (1993) Arch. Biochem. Biophys. , vol.307 , pp. 193-199
    • LoGrasso, P.V.1    Soltis, D.A.2    Boettcher, B.R.3
  • 39
    • 34548348866 scopus 로고    scopus 로고
    • Purification and characterization of a novel glucosyltransferase specific to 27b-hydroxy steroidal lactones from Withania somnifera and its role in stress responses
    • Madina B.R., Sharma L.K., Chaturvedi P., Sangwan R.S., Tuli R. Purification and characterization of a novel glucosyltransferase specific to 27b-hydroxy steroidal lactones from Withania somnifera and its role in stress responses. Biochim. Biophys. Acta 2007, 1774:1199-1207.
    • (2007) Biochim. Biophys. Acta , vol.1774 , pp. 1199-1207
    • Madina, B.R.1    Sharma, L.K.2    Chaturvedi, P.3    Sangwan, R.S.4    Tuli, R.5
  • 40
    • 84855744068 scopus 로고    scopus 로고
    • Withaferin A induces apoptosis in human melanoma cells through generation of reactive oxygen species and down-regulation of Bcl-2
    • Mayola E., et al. Withaferin A induces apoptosis in human melanoma cells through generation of reactive oxygen species and down-regulation of Bcl-2. Apoptosis 2011, 10.1007/s10495-011-0625-x.
    • (2011) Apoptosis
    • Mayola, E.1
  • 41
    • 68649107171 scopus 로고    scopus 로고
    • Steroidal lactones from Withania somnifera, an ancient plant for novel medicine
    • Mirjalili M.H., Moyano E., Bonfil M., Cusido R.M., Palazon J. Steroidal lactones from Withania somnifera, an ancient plant for novel medicine. Molecules 2009, 14:2373-2393.
    • (2009) Molecules , vol.14 , pp. 2373-2393
    • Mirjalili, M.H.1    Moyano, E.2    Bonfil, M.3    Cusido, R.M.4    Palazon, J.5
  • 42
    • 77956469863 scopus 로고    scopus 로고
    • Withanolide D induces apoptosis in leukemia by targeting the activation of neutral sphingomyelinase-ceramide cascade mediated by synergistic activation of c-Jun N-terminal kinase and p38 mitogen-activated protein kinase
    • Mondal S., Mandal C., Sangwan R., Chandra S., Mandal C. Withanolide D induces apoptosis in leukemia by targeting the activation of neutral sphingomyelinase-ceramide cascade mediated by synergistic activation of c-Jun N-terminal kinase and p38 mitogen-activated protein kinase. Mol. Cancer 2010, 9:239.
    • (2010) Mol. Cancer , vol.9 , pp. 239
    • Mondal, S.1    Mandal, C.2    Sangwan, R.3    Chandra, S.4    Mandal, C.5
  • 43
    • 0034730724 scopus 로고    scopus 로고
    • Crystal structure of human squalene synthase. A key enzyme in cholesterol biosynthesis
    • Pandit J., et al. Crystal structure of human squalene synthase. A key enzyme in cholesterol biosynthesis. J. Biol. Chem. 2000, 275:30610-30617.
    • (2000) J. Biol. Chem. , vol.275 , pp. 30610-30617
    • Pandit, J.1
  • 44
    • 0027312026 scopus 로고
    • Conservation between human and fungal squalene synthetases: similarities in structure, function, and regulation
    • Robinson G.W., Tsay Y.H., Kienzle B.K., Smithmonroy C.A., Bishop R.W. Conservation between human and fungal squalene synthetases: similarities in structure, function, and regulation. Mol. Cell. Biol. 1993, 13:2706-2717.
    • (1993) Mol. Cell. Biol. , vol.13 , pp. 2706-2717
    • Robinson, G.W.1    Tsay, Y.H.2    Kienzle, B.K.3    Smithmonroy, C.A.4    Bishop, R.W.5
  • 45
    • 77950876064 scopus 로고    scopus 로고
    • Generation and analysis of expressed sequence tags from leaf and root of Withania somnifera (Ashwgandha)
    • Senthil K., Wasnik N.G., Kim Y.J., Yang D.C. Generation and analysis of expressed sequence tags from leaf and root of Withania somnifera (Ashwgandha). Mol. Biol. Rep. 2010, 37:893-902.
    • (2010) Mol. Biol. Rep. , vol.37 , pp. 893-902
    • Senthil, K.1    Wasnik, N.G.2    Kim, Y.J.3    Yang, D.C.4
  • 46
    • 17444400413 scopus 로고    scopus 로고
    • Overexpression of squalene synthase in Eleutherococcus senticosus increases phytosterol and triterpene accumulation
    • Seo J.W., Jeong J.H., Shin C.G., Lo S.C., Han S.S., Yu K.W. Overexpression of squalene synthase in Eleutherococcus senticosus increases phytosterol and triterpene accumulation. Phytochemistry 2005, 66:869-877.
    • (2005) Phytochemistry , vol.66 , pp. 869-877
    • Seo, J.W.1    Jeong, J.H.2    Shin, C.G.3    Lo, S.C.4    Han, S.S.5    Yu, K.W.6
  • 47
    • 0038468557 scopus 로고    scopus 로고
    • Two cis-acting elements necessary and sufficient for gibberellin-upregulated proteinase expression in rice seeds
    • Sutoh K., Yamauchi D. Two cis-acting elements necessary and sufficient for gibberellin-upregulated proteinase expression in rice seeds. Plant J. 2003, 34:635-645.
    • (2003) Plant J. , vol.34 , pp. 635-645
    • Sutoh, K.1    Yamauchi, D.2
  • 48
    • 0036959970 scopus 로고    scopus 로고
    • A genomics approach to the early stages of triterpene saponin biosynthesis in Medicago truncatula
    • Suzuki H., Achnine L., Xu R., Matsuda S.P.T., Dixon R.A. A genomics approach to the early stages of triterpene saponin biosynthesis in Medicago truncatula. Plant J. 2002, 32:1033-1048.
    • (2002) Plant J. , vol.32 , pp. 1033-1048
    • Suzuki, H.1    Achnine, L.2    Xu, R.3    Matsuda, S.P.T.4    Dixon, R.A.5
  • 49
    • 34547781750 scopus 로고    scopus 로고
    • MEGA4: molecular evolutionary genetics analysis (MEGA) software version 4.0
    • Tamura K., Dudley J., Nei M., Kumar S. MEGA4: molecular evolutionary genetics analysis (MEGA) software version 4.0. Mol. Biol. Evol. 2007, 24:1596-1599.
    • (2007) Mol. Biol. Evol. , vol.24 , pp. 1596-1599
    • Tamura, K.1    Dudley, J.2    Nei, M.3    Kumar, S.4
  • 50
    • 0030766822 scopus 로고    scopus 로고
    • Jasmonate signaled plant gene expression
    • Wasternack C., Parthier B. Jasmonate signaled plant gene expression. Trends Plant Sci. 1997, 2:302-307.
    • (1997) Trends Plant Sci. , vol.2 , pp. 302-307
    • Wasternack, C.1    Parthier, B.2
  • 51
    • 79952701908 scopus 로고    scopus 로고
    • Withaferin A enhances radiation-induced apoptosis in Caki cells through induction of reactive oxygen species, Bcl-2 downregulation and Akt inhibition
    • Yang E.S., Choi M.J., Kim J.H., Choi K.S., Kwon T.K. Withaferin A enhances radiation-induced apoptosis in Caki cells through induction of reactive oxygen species, Bcl-2 downregulation and Akt inhibition. Chem. Biol. Interact. 2011, 190(1):9-15.
    • (2011) Chem. Biol. Interact. , vol.190 , Issue.1 , pp. 9-15
    • Yang, E.S.1    Choi, M.J.2    Kim, J.H.3    Choi, K.S.4    Kwon, T.K.5
  • 52
    • 77955428907 scopus 로고    scopus 로고
    • Production of plant bioactive triterpenoid saponins: elicitation strategies and target genes to improve yields
    • Yendo A., de Costa F., Gosmann G., Fett-Neto A. Production of plant bioactive triterpenoid saponins: elicitation strategies and target genes to improve yields. Mol. Biotechnol. 2010, 46(1):94-104.
    • (2010) Mol. Biotechnol. , vol.46 , Issue.1 , pp. 94-104
    • Yendo, A.1    de Costa, F.2    Gosmann, G.3    Fett-Neto, A.4
  • 53
    • 39449115394 scopus 로고    scopus 로고
    • I-TASSER server for protein 3D structure prediction
    • Zhang Y. I-TASSER server for protein 3D structure prediction. BMC Bioinforma. 2008, 9:40.
    • (2008) BMC Bioinforma. , vol.9 , pp. 40
    • Zhang, Y.1
  • 54
    • 0030052102 scopus 로고    scopus 로고
    • Studies on the immunomodulatory effects of Ashwagandha
    • Ziauddin M., Phansalkar N., Patki P. Studies on the immunomodulatory effects of Ashwagandha. J. Ethnopharmacol. 1996, 50:69-76.
    • (1996) J. Ethnopharmacol. , vol.50 , pp. 69-76
    • Ziauddin, M.1    Phansalkar, N.2    Patki, P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.