Investigating the relationship between in vitro-in vivo genotoxicity: Derivation of mechanistic QSAR models for in vivo liver genotoxicity and in vivo bone marrow micronucleus formation which encompass metabolism

Chemical Research in Toxicology

Volumn 25, Issue 2, 2012, Pages 277-296

  Mekenyan, Ovanes G ^a   Petkov, Petko I ^a   Kotov, Stefan V ^a   Stoeva, Stoyanka ^a   Kamenska, Verginia B ^a   Dimitrov, Sabcho D ^a   Honma, Masamitsu ^b   Hayashi, Makoto ^b,e   Benigni, Romualdo ^c   Donner, E Maria ^d   Patlewicz, Grace ^d  

^a ASSEN ZLATAROV UNIVERSITY   (Bulgaria)

^b NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

^c ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^d DUPONT COMPANY   (United States)

^e Biosafety Research Center Foods Drugs and Pesticides   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; COMPARATIVE STUDY; COMPUTER MODEL; CONTROLLED STUDY; GENOTOXICITY; IN VITRO STUDY; IN VIVO STUDY; LIVER TOXICITY; MAMMAL CELL; MICRONUCLEUS; QUANTITATIVE STRUCTURE ACTIVITY RELATION;

ANIMALS; BONE MARROW; CARCINOGENS; LIVER; MICE; MICRONUCLEI, CHROMOSOME-DEFECTIVE; MICRONUCLEUS TESTS; MODELS, BIOLOGICAL; MUTAGENS; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; RATS;

ANIMALIA; MAMMALIA;

EID: 84859743713     PISSN: 0893228X     EISSN: 15205010     Source Type: Journal    
DOI: 10.1021/tx200547s     Document Type: Article

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