The Antimalaria Agent Artemisinin Exerts Antiangiogenic Effects in Mouse Embryonic Stem Cell-Derived Embryoid Bodies

Laboratory Investigation

Volumn 83, Issue 11, 2003, Pages 1647-1655

  Wartenberg, Maria ^a   Wolf, Sandra ^a   Budde, Paula ^a   Grünheck, Frank ^a   Acker, Helmut ^b   Hescheler, Jürgen ^a   Wartenberg, Gerda ^a   Sauer, Heinrich ^a  

^a UNIVERSITY OF COLOGNE   (Germany)

^b MAX PLANCK INSTITUTE OF MOLECULAR PHYSIOLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TOCOPHEROL; ANTHRACYCLINE DERIVATIVE; ANTIMALARIAL AGENT; ARTEMISININ; CYTOSTATIC AGENT; DOXORUBICIN; GELATINASE A; GELATINASE B; HYPOXIA INDUCIBLE FACTOR 1ALPHA; INTERSTITIAL COLLAGENASE; LAMININ; MANNITOL; REACTIVE OXYGEN METABOLITE; SCAVENGER; VASCULOTROPIN;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER; CELL DIFFERENTIATION; CELL GROWTH; CONTROLLED STUDY; CYTOSTASIS; DOWN REGULATION; DRUG EFFECT; DRUG EFFICACY; DRUG PENETRATION; EMBRYO; EMBRYO CELL; EMBRYOID BODY; ENDOTHELIUM CELL; MOUSE; NONHUMAN; PERMEABILITY; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; ANTI-INFECTIVE AGENTS; ANTIMALARIALS; ARTEMISININS; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; DOXORUBICIN; EMBRYO; FREE RADICAL SCAVENGERS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; LAMININ; MATRIX METALLOPROTEINASES; MICE; NEOVASCULARIZATION, PATHOLOGIC; REACTIVE OXYGEN SPECIES; SESQUITERPENES; STEM CELLS; TRANSCRIPTION FACTORS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 0242413711     PISSN: 00236837     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.LAB.0000098424.38003.FF     Document Type: Article

References (33)

1. 2 exposure. Lab Invest 77:533-539.
2. 2) increases the steady-state mRNA levels of collagenase/ MMP-1 in human dermal fibroblasts. Free Radic Biol Med 22:515-524.
3. Efferth T, Dunstan H, Sauerbrey A, Miyachi H, and Chitambar CR (2001). The anti-malarial artesunate is also active against cancer. Int J Oncol 18:767-773.
4. Efferth T, Olbrich A, and Bauer R (2002). mRNA expression profiles for the response of human tumor cell lines to the antimalarial drugs artesunate, arteether, and artemether. Biochem Pharmacol 64:617-623.
5. Gorlach A, Diebold I, Schini-Kerth VB, Berchner-Pfannschmidt U, Roth U, Brandes RP, Kietzmann T, and Busse R (2001). Thrombin activates the hypoxia-inducible factor-1 signaling pathway in vascular smooth muscle cells: Role of the p22(phox)-containing NADPH oxidase. Circ Res 89:47-54.
6. Harrison D, Griendling KK, Landmesser U, Hornig B, and Drexler H (2003). Role of oxidative stress in atherosclerosis. Am J Cardiol 91:7A-11A.
7. Haynes RK (2001). Artemisinin and derivatives: The future for malaria treatment? Curr Opin Infect Dis 14:719-726.
8. Heissig B, Hattori K, Friedrich M, Rafii S, and Werb Z (2003). Angiogenesis: Vascular remodeling of the extracellular matrix involves metalloproteinases. Curr Opin Hematol 10:136-141.
9. Huang LE, Arany Z, Livingston DM, and Bunn HF (1996). Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its alpha subunit. J Biol Chem 271:32253-32259.
10. Jefford CW (2001). Why artemisinin and certain synthetic peroxides are potent antimalarials: Implications for the mode of action. Curr Med Chem 8:1803-1826.
11. Mazure NM, Brahimi-Horn MC, and Pouyssegur J (2003). Protein kinases and the hypoxia-inducible factor-1, two switches in angiogenesis. Curr Pharm Des 9:531-541.
12. McGready R, Cho T, Keo NK, Thwai KL, Villegas L, Looareesuwan S, White NJ, and Nosten F (2001). Artemisinin antimalarials in pregnancy: A prospective treatment study of 539 episodes of multidrug-resistant Plasmodium falciparum. Clin Infect Dis 33:2009-2016.
13. Meshnick SR (1994). Free radicals and antioxidants. Lancet 344:1441-1442.
14. Meshnick SR, Taylor TE, and Kamchonwongpaisan S (1996). Artemisinin and the antimalarial endoperoxides: From herbal remedy to targeted chemotherapy. Microbiol Rev 60:301-315.
15. Molema G (2002). Tumor vasculature directed drug targeting: Applying new technologies and knowledge to the development of clinically relevant therapies. Pharm Res 19:1251-1258.
16. Molyneux CA, Glyn MC, and Ward BJ (2002). Oxidative stress and cardiac microvascular structure in ischemia and reperfusion: The protective effect of antioxidant vitamins. Microvasc Res 64:265-277.
17. Page EL, Robitaille GA, Pouyssegur J, and Richard DE (2002). Induction of hypoxia-inducible factor-1alpha by transcriptional and translational mechanisms. J Biol Chem 277:48403-48409.
18. Posner GH, Paik IH, Sur S, McRiner AJ, Borstnik K, Xie S, and Shapiro TA (2003). Orally active, antimalarial, anticancer, artemisinin-derived trioxane dimers with high stability and efficacy. J Med Chem 46:1060-1065.
19. Posner GH, Ploypradith P, Parker MH, O'Dowd H, Woo SH, Northrop J, Krasavin M, Dolan P, Kensler TW, Xie S, and Shapiro TA (1999). Antimalarial, antiproliferative, and antitumor activities of artemisinin-derived, chemically robust, trioxane dimers. J Med Chem 42:4275-4280.
20. Postma NS, Mommers EC, Eling WM, and Zuidema J (1996). Oxidative stress in malaria: Implications for prevention and therapy. Pharm World Sci 18:121-129.
21. 2-dependent ERK1/2 activation. J Biol Chem 276: 14264-14270.
22. Robert A, Dechy-Cabaret O, Cazelles J, and Meunier B (2002). From mechanistic studies on artemisinin derivatives to new modular antimalarial drugs. Acc Chem Res 35:167-174.
23. Sauer H, Gunther J, Hescheler J, and Wartenberg M (2000). Thalidomide inhibits angiogenesis in embryoid bodies by the generation of hydroxyl radicals. Am J Pathol 156:151-158.
24. Scott MD, Meshnick SR, Williams RA, Chiu DT, Pan HC, Lubin BH, and Kuypers FA (1989). Qinghaosu-mediated oxidation in normal and abnormal erythrocytes. J Lab Clin Med 114:401-406.
25. Seiler A, Visan A, Pohl I, Genschow E, Buesen R, and Spielmann H (2002). Improving the embryonic stem cell test (EST) by establishing molecular endpoints of tissue specific development using murine embryonic stem cells (D3 cells). ALTEX 2002, 19(Suppl 1):55-63.
26. Sobaniec-Lotowska ME and Sobaniec W (1996). Morphological features of encephalopathy after chronic administration of the antiepileptic drug valproate to rats: A transmission electron microscopic study of capillaries in the cerebellar cortex. Exp Toxicol Pathol 48:65-75.
27. Vargova L, Homola A, Zamecnik J, Tichy M, Benes V, and Sykova E (2003). Diffusion parameters of the extracellular space in human gliomas. Glia 42:77-88.
28. Vittet D, Prandini MH, Berthier R, Schweitzer A, Martin-Sisteron H, Uzan G, and Dejana E (1996). Embryonic stem cells differentiate in vitro to endothelial cells through successive maturation steps. Blood 88:3424-3431.
29. Wartenberg M, Budde P, De Marees M, Grunheck F, Tsang SY, Huang Y, Chen ZY, Hescheler J, and Sauer H (2003a). Inhibition of tumor-induced angiogenesis and matrix-metalloproteinase expression in confrontation cultures of embryoid bodies and tumor spheroids by plant ingredients used in traditional chinese medicine. Lab Invest 83:87-98.
30. Wartenberg M, Gunther J, Hescheler J, and Sauer H (1998a). The embryoid body as a novel in vitro assay system for antiangiogenic agents. Lab Invest 78:1301-1314.
31. Wartenberg M, Hescheler J, Acker H, Diedershagen H, and Sauer H (1998b). Doxorubicin distribution in multicellular prostate cancer spheroids evaluated by confocal laser scanning microscopy and the "optical probe technique." Cytometry 31:137-145.
32. Wartenberg M, Ling FC, Muschen M, Klein F, Acker H, Gassmann M, Petrat K, Putz V, Hescheler J, and Sauer H (2003b). Regulation of the multidrug resistance transporter P-glycoprotein in multicellular tumor spheroids by hypoxia-inducible factor (HIF-1) and reactive oxygen species. FASEB J 17:503-505.
33. Xu JH and Zhang YP (1996). (1996). Contragestational effects of dihydroartemisinin and artesunate. Yao Xue Xue Bao 31:657-661.