Hepcidin expression in patients with acute leukaemia

European Journal of Clinical Investigation

Volumn 42, Issue 5, 2012, Pages 517-525

  Cheng, Pan Pan ^a   Sun, Zhen Zhen ^b   Jiang, Fang ^b   Tang, Yue Ting ^b   Jiao, Xiao Yang ^b  

^a JINING MEDICAL UNIVERSITY   (China)

^b THE FIRST AFFILIATED HOSPITAL OF SHANTOU UNIVERSITY MEDICAL COLLEGE   (China)

Author keywords

Acute leukaemia; Erythropoiesis; Hepcidin; Iron; Soluble transferrin receptor

Indexed keywords

ERYTHROPOIETIN; FERRITIN; HEMOGLOBIN; HEPCIDIN; INTERLEUKIN 6; IRON; TRANSFERRIN RECEPTOR;

ACUTE LEUKEMIA; ADULT; ARTICLE; BLAST CELL; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATIONAL STUDY; ERYTHROCYTE; ERYTHROPOIESIS; FEMALE; HEMATOLOGICAL PARAMETERS; HEMOGLOBIN BLOOD LEVEL; HUMAN; INFLAMMATION; IRON STORAGE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; REMISSION;

ADULT; ANTIMICROBIAL CATIONIC PEPTIDES; ERYTHROPOIESIS; ERYTHROPOIETIN; FEMALE; FERRITINS; HUMANS; INTERLEUKIN-6; LEUKEMIA; MALE; MIDDLE AGED; RECEPTORS, TRANSFERRIN; STATISTICS AS TOPIC; TRANSFERRIN; YOUNG ADULT;

EID: 84859717011     PISSN: 00142972     EISSN: 13652362     Source Type: Journal    
DOI: 10.1111/j.1365-2362.2011.02608.x     Document Type: Article

References (32)

1. Nemeth E, Tuttle MS, Powelson J, Vaughn MB, Donovan A, Ward DM et al. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science 2004;306:2090-3.
2. Ganz T. Hepcidin and its role in regulating systemic iron metabolism. Hematology Am Soc Hematol Educ Program 2006;29-35:507.
3. Kemna EH, Tjalsma H, Willems HL, Swinkels DW. Hepcidin: from discovery to differential diagnosis. Haematologica 2008;93:90-7.
4. Andrews NC. Forging a field: the golden age of iron biology. Blood 2008;112:219-30.
5. Nemeth E, Ganz T. Hepcidin and iron-loading anemias. Haematologica 2006;91:727-32.
6. Darshan D, Anderson GJ. Interacting signals in the control of hepcidin expression. Biometals 2009;22:77-87.
7. Nemeth E. Iron regulation and erythropoiesis. Curr Opin Hematol 2008;15:169-75.
8. Theurl I, Mattle V, Seifert M, Mariani M, Marth C, Weiss G. Dysregulated monocyte iron homeostasis and erythropoietin formation in patients with anemia of chronic disease. Blood 2006;107:4142-8.
9. Nicolas G, Bennoun M, Porteu A, Mativet S, Beaumont C, Grandchamp B et al. Severe iron deficiency anemia in transgenic mice expressing liver hepcidin. Proc Natl Acad Sci U S A 2002;99:4596-601.
10. Sham RL, Phatak PD, Nemeth E, Ganz T. Hereditary hemochromatosis due to resistance to hepcidin: high hepcidin concentrations in a family with C326S ferroportin mutation. Blood 2009;114:493-4.
11. Kearney SL, Nemeth E, Neufeld EJ, Thapa D, Ganz T, Weinstein DA et al. Urinary hepcidin in congenital chronic anemias. Pediatr Blood Cancer 2007;48:57-63.
12. Kattamis A, Papassotiriou I, Palaiologou D, Apostolakou F, Galani A, Ladis V et al. The effects of erythropoetic activity and iron burden on hepcidin expression in patients with thalassemia major. Haematologica 2006;91:809-12.
13. Cheng PP, Jiao XY, Wang XH, Lin JH, Cai YM. Hepcidin expression in anemia of chronic disease and concomitant iron-deficiency anemia. Clin Exp Med 2011;11:33-42.
14. Huang H, Constante M, Layoun A, Santos MM. Contribution of STAT3 and SMAD4 pathways to the regulation of hepcidin by opposing stimuli. Blood 2009;113:3593-9.
15. Origa R, Galanello R, Ganz T, Giagu N, Maccioni L, Faa G et al. Liver iron concentrations and urinary hepcidin in beta-thalassemia. Haematologica 2007;92:583-8.
16. Pak M, Lopez MA, Gabayan V, Ganz T, Rivera S. Suppression of hepcidin during anemia requires erythropoietic activity. Blood 2006;108:3730-5.
17. Pinto JP, Ribeiro S, Pontes H, Thowfeequ S, Tosh D, Carvalho F et al. Erythropoietin mediates hepcidin expression in hepatocytes through EPOR signaling and regulation of C/EBPalpha. Blood 2008;111:5727-33.
18. Wrighting DM, Andrews NC. Iron homeostasis and erythropoiesis. Curr Top Dev Biol 2008;82:141-67.
19. Corazza F, Beguin Y, Bergmann P, Andre M, Ferster A, Devalck C et al. Anemia in children with cancer is associated with decreased erythropoietic activity and not with inadequate erythropoietin production. Blood 1998;92:1793-8.
20. Porter JB. Practical management of iron overload. Br J Haematol 2001;115:239-52.
21. Nicolas G, Chauvet C, Viatte L, Danan JL, Bigard X, Devaux I et al. The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation. J Clin Invest 2002;110:1037-44.
22. Fleming RE. Iron and inflammation: cross-talk between pathways regulating hepcidin. J Mol Med 2008;86:491-4.
23. Trikha M, Corringham R, Klein B, Rossi JF. Targeted anti-interleukin-6 monoclonal antibody therapy for cancer: a review of the rationale and clinical evidence. Clin Cancer Res 2003;9:4653-65.
24. Zacharski LR, Ornstein DL, Woloshin S, Schwartz LM. Association of age, sex, and race with body iron stores in adults: analysis of NHANES III data. Am Heart J 2000;140:98-104.
25. You SA, Wang Q. Ferritin in atherosclerosis. Clin Chim Acta 2005;357:1-16.
26. Roy CN, Andrews NC. Anemia of inflammation: the hepcidin link. Curr Opin Hematol 2005;12:107-11.
27. Cavill I, Auerbach M, Bailie GR, Barrett-Lee P, Beguin Y, Kaltwasser P et al. Iron and the anaemia of chronic disease: a review and strategic recommendations. Curr Med Res Opin 2006;22:731-7.
28. Hedenus M, Birgegard G, Nasman P, Ahlberg L, Karlsson T, Lauri B et al. Addition of intravenous iron to epoetin beta increases hemoglobin response and decreases epoetin dose requirement in anemic patients with lymphoproliferative malignancies: a randomized multicenter study. Leukemia 2007;21:627-32.
29. Phiri KS, Calis JC, Kachala D, Borgstein E, Waluza J, Bates I et al. Improved method for assessing iron stores in the bone marrow. J Clin Pathol 2009;62:685-9.
30. Bottomley SS. Secondary iron overload disorders. Semin Hematol 1998;35:77-86.
31. Beutler E, Hoffbrand AV, Cook JD. Iron deficiency and overload. Hematology Am Soc Hematol Educ Program 2003;1:40-61.
32. Stone RM, DeAngelo DJ. Screens, iron, and leukemia. Blood 2009;114:2857-8.