Strategies for the optimisation of in vivo experiments in accordance with the 3Rs philosophy

Regulatory Toxicology and Pharmacology

Volumn 63, Issue 1, 2012, Pages 140-154

  Madden, Judith C ^a   Hewitt, Mark ^a   Przybylak, Katarzyna ^a   Vandebriel, Rob J ^b   Piersma, Aldert H ^b   Cronin, Mark T D ^a  

^a LIVERPOOL JOHN MOORES UNIVERSITY   (United Kingdom)

^b NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

Author keywords

3Rs; In vivo assays; Optimisation; REACH; Reduction; Refinement; Replacement; Toxicity testing

Indexed keywords

ARTICLE; CARCINOGENICITY; CLINICAL PROTOCOL; DATA ANALYSIS; DEVELOPMENTAL TOXICITY; EMBRYOTOXICITY; EXPERIMENTAL ANIMAL; IN VIVO STUDY; MUTAGENICITY; NONHUMAN; PHILOSOPHY; PHILOSOPHY OF REDUCTION; PHILOSOPHY OF REFINEMENT; PHILOSOPHY OF REPLACEMENT; PRIORITY JOURNAL; PROCESS OPTIMIZATION; QUALITY CONTROL; SKIN SENSITIZATION; TOXICITY TESTING; TOXICOKINETICS; TOXICOLOGY;

ANIMAL TESTING ALTERNATIVES; ANIMALS; DATABASES, FACTUAL; DRUG TOXICITY; HUMANS; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; RISK ASSESSMENT; TOXICITY TESTS;

ANIMALIA;

EID: 84859631378     PISSN: 02732300     EISSN: 10960295     Source Type: Journal    
DOI: 10.1016/j.yrtph.2012.03.010     Document Type: Article

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