Enhanced epimerization of glycosylated amino acids during solid-phase peptide synthesis

Journal of the American Chemical Society

Volumn 134, Issue 14, 2012, Pages 6316-6325

  Zhang, Yalong ^a   Muthana, Saddam M ^a   Farnsworth, David ^a   Ludek, Olaf ^a   Adams, Kristie ^a   Barchi, Joseph J ^a   Gildersleeve, Jeffrey C ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BASIC RESEARCH; CLINICAL APPLICATION; EPIMERIZATION; FASTER RATES; GLYCOPEPTIDES; GLYCOSYLATED; MECHANISTIC STUDIES; O-LINKED; OVERALL RATE; PEPTIDE COUPLING; REACTION CONDITIONS; SOLID PHASE PEPTIDE SYNTHESIS; THERAPEUTIC COMPOUNDS;

AMINO ACIDS;

PEPTIDES;

AMINO ACID; COLLIDINE; GLYCOPEPTIDE; GLYCOPROTEIN; GLYCOSYLATED AMINO ACID; LEUCINE; MUCIN; PROLINE; SERINE; THREONINE; TN ANTIGEN; UNCLASSIFIED DRUG;

ARTICLE; CONFORMATION; CROSS COUPLING REACTION; EPIMER; EPIMERIZATION; GLYCOSYLATION; PEPTIDE SYNTHESIS; PROTON NUCLEAR MAGNETIC RESONANCE; REACTION TIME; SOLID PHASE SYNTHESIS;

AMINO ACIDS; ANTIGENS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; GLYCOPEPTIDES; GLYCOSYLATION; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, CHEMICAL; PEPTIDES; SOLID-PHASE SYNTHESIS TECHNIQUES; TIME FACTORS; VACCINES;

EID: 84859624519     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja212188r     Document Type: Article

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