Total chemical synthesis and NMR characterization of the glycopeptide tx5a, a heavily post-translationally modified conotoxin, reveals that the glycan structure is α-D-Gal-(1→3)-α-D-GalNAc

European Journal of Biochemistry

Volumn 271, Issue 23-24, 2004, Pages 4939-4949

  Kang, James ^a   Low, William ^a   Norberg, Thomas ^b   Meisenhelder, Jill ^a   Hansson, Karin ^c   Stenflo, Johan ^c   Zhou, Guo Ping ^d,e   Imperial, Julita ^f   Olivera, Baldomero M ^f   Rigby, Alan C ^d,e   Craig, A Grey ^a  

^a SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^b SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES   (Sweden)

^c LUND UNIVERSITY   (Sweden)

^d HARVARD MEDICAL SCHOOL   (United States)

^e MARINE BIOLOGICAL LABORATORY   (United States)

^f UNIVERSITY OF UTAH   (United States)

Author keywords

Conus textile; Glycopeptide synthesis

Indexed keywords

4 CARBOXYGLUTAMIC ACID; 9 FLUORENYLMETHOXYCARBONYLTHREONINE; ANTIGEN; CONOTOXIN; CYSTEINE; DISACCHARIDE; GALACTOSE; GLYCAN; GLYCOPEPTIDE; GLYCOPEPTIDE TX5A; HYDROXYPROLINE; N ACETYLGALACTOSAMINE; T ANTIGEN; THREONINE; TRYPTOPHAN; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; HYPERACTIVITY; MASS SPECTROMETRY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; PROTEIN PROCESSING; PROTON NUCLEAR MAGNETIC RESONANCE; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SNAIL; SPASTICITY; STEREOCHEMISTRY;

CARBOHYDRATE SEQUENCE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CONOTOXINS; HYDROLYSIS; MOLECULAR SEQUENCE DATA; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN PROCESSING, POST-TRANSLATIONAL; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

CONUS TEXTILE; GASTROPODA;

EID: 19944428385     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1432-1033.2004.04464.x     Document Type: Article

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