Protection of Staphylococcus aureus-infected septic mice by suppression of early acute inflammation and enhanced antimicrobial activity by ginsan

FEMS Immunology and Medical Microbiology

Volumn 46, Issue 2, 2006, Pages 187-197

  Ahn, Ji Yeon ^a,b   Song, Jie Young ^a   Yun, Yeon Sook ^a   Jeong, Gajin ^b   Choi, In Soo ^c,d  

^a Korea Institute of Radiation and Medical Science   (South Korea)

^b Seoul National University   (South Korea)

^c Konkuk University   (South Korea)

^d Konkuk University   (South Korea)

Author keywords

Antibacterial activity; Inflammation; Panax ginseng; Sepsis; Staphylococcus aureus

Indexed keywords

CYTOKINE; ETOPOSIDE; GAMMA INTERFERON; GINSENG EXTRACT; INTERLEUKIN 12; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 6; MYELOID DIFFERENTIATION FACTOR 88; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 9; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBACTERIAL ACTIVITY; ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERIUM CULTURE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOWN REGULATION; IMMUNITY; IN VIVO STUDY; INFLAMMATION; MACROPHAGE; MALE; MONOCYTE; MOUSE; NONHUMAN; PERITONEUM MACROPHAGE; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEPSIS; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS INFECTION;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; ANTI-BACTERIAL AGENTS; CELL LINE; CYTOKINES; DOWN-REGULATION; HUMANS; INFLAMMATION; MACROPHAGES; MALE; MICE; MICE, INBRED BALB C; PANAX; PHAGOCYTOSIS; PHYTOTHERAPY; PLANT EXTRACTS; POLYSACCHARIDES; SEPSIS; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS AUREUS;

EID: 33645056430     PISSN: 09288244     EISSN: 1574695X     Source Type: Journal    
DOI: 10.1111/j.1574-695X.2005.00021.x     Document Type: Article

References (37)

1. Abraham E Anzueto A Gutierrez G et al 1998 Double-blind randomised controlled trial of monoclonal antibody to human tumour necrosis factor in treatment of septic shock. NORASEPT II Study Group Lancet 351 929 933
2. Angus DC Linde-Zwirble WT Lidicker J Clermont G Carcillo J Pinsky MR 2001 Epidemiology of severe sepsis in the United States analysis of incidence, outcome, and associated costs of care Crit Care Med 29 1303 1310
3. Armstrong L Medford AR Uppington KM Robertson J Witherden IR Tetley TD Millar AB 2004 Expression of functional toll-like receptor-2 and -4 on alveolar epithelial cells Am J Respir Cell Mol Biol 31 241 245
4. Bachar O Adner M Uddman R Cardell LO 2004 Toll-like receptor stimulation induces airway hyper-responsiveness to bradykinin, an effect mediated by JNK and NF-kappa B signaling pathways Eur J Immunol 34 1196 1207
5. Bone RC 1994 Gram-positive organisms and sepsis Arch Intern Med 154 26 34
6. Calame W Douwes-Idema AE van den Barselaar MT van Furth R Mattie H 1994 Influence of cytostatic agents on the pulmonary defence of mice infected with Klebsiella pneumoniae and on the efficacy of treatment with ceftriaxone J Infect 29 53 66
7. Chabaud-Riou M Firestein GS 2004 Expression and activation of mitogen-activated protein kinase kinases-3 and -6 in rheumatoid arthritis Am J Pathol 164 177 184
8. Chen BC Chang YS Kang JC Hsu MJ Sheu JR Chen TL Teng CM Lin CH 2004 Peptidoglycan induces nuclear factor-kappab activation and cyclooxygenase-2 expression via Ras, Raf-1, and ERK in RAW 264.7 macrophages J Biol Chem 279 20889 20897
9. Cohen J 2002 The immunopathogenesis of sepsis Nature 420 885 891
10. Doherty GM Lange JR Langstein HN Alexander HR Buresh CM Norton JA 1992 Evidence for IFN-gamma as a mediator of the lethality of endotoxin and tumor necrosis factor-alpha J Immunol 149 1666 1670
11. Gogos CA Drosou E Bassaris HP Skoutelis A 2000 Pro- vs. Anti-inflammatory cytokine profile in patients with severe sepsis a marker for prognosis and future therapeutic options J Infect Dis 181 176 180
12. Harter L Mica L Stocker R Trentz O Keel M 2004 Increased expression of Toll-like receptor-2 and -4 on leukocytes from patients with sepsis Shock 22 403 409
13. Hultgren OH Stenson M Tarkowski A 2001 Role of IL-12 in Staphylococcus aureus-triggered arthritis and sepsis Arthritis Res 3 41 47
14. Joshi VD Kalvakolanu DV Hasday JD Hebel RJ Cross AS 2002 IL-18 levels and the outcome of innate immune response to lipopolysaccharide importance of a positive feedback loop with caspase-1 in IL-18 expression J Immunol 169 2536 2544
15. Kanangat S Bronze MS Meduri GU Postlethwaite A Stentz F Tolley E Schaberg D 2001 Enhanced extracellular growth of Staphylococcus aureus in the presence of selected linear peptide fragments of human interleukin (IL)-1beta and IL-1 receptor antagonist J Infect Dis 183 65 69
16. Kox WJ Volk T Kox SN Volk HD 2000 Immunomodulatory therapies in sepsis Intensive Care Med 26 Suppl 1 S124 128
17. Lee YS Chung IS Lee IR Kim KH Hong WS Yun YS 1997 Activation of multiple effector pathways of immune system by the antineoplastic immunostimulator acidic polysaccharide ginsan isolated from Panax ginseng Anticancer Res 17 323 331
18. Lim DS Bae KG Jung IS Kim CH Yun YS Song JY 2002 Anti-septicaemic effect of polysaccharide from Panax ginseng by macrophage activation J Infect 45 32 38
19. Marshall SA Wilke WW Pfaller MA Jones RN 1998 Staphylococcus aureus and coagulase-negative staphylococci from blood stream infections frequency of occurrence, antimicrobial susceptibility, and molecular (mecA) characterization of oxacillin resistance in the SCOPE program Diagn Microbiol Infect Dis 30 205 214
20. Meduri GU Kanangat S Stefan J Tolley E Schaberg D 1999 Cytokines IL-1beta, IL-6, and TNF-alpha enhance in vitro growth of bacteria Am J Respir Crit Care Med 160 961 967
21. O'Neill LA 2003 Therapeutic targeting of Toll-like receptors for inflammatory and infectious diseases Curr Opin Pharmacol 3 396 403
22. Onderdonk AB Cisneros RL Hinkson P Ostroff G 1992 Anti-infective effect of poly-beta 1-6-glucotriosyl-beta 1-3-glucopyranose glucan in vivo Infect Immun 60 1642 1647
23. Peiser L Gough PJ Kodama T Gordon S 2000 Macrophage class A scavenger receptor-mediated phagocytosis of Escherichia coli role of cell heterogeneity, microbial strain, and culture conditions in vitro Infect Immun 68 1953 1963
24. Puliti M von Hunolstein C Bistoni F Castronari R Orefici G Tissi L 2002 Role of macrophages in experimental group B streptococcal arthritis Cell Microbiol 4 691 700
25. Ramet M Manfruelli P Pearson A Mathey-Prevot B Ezekowitz RA 2002 Functional genomic analysis of phagocytosis and identification of a Drosophila receptor for E. coli Nature 416 644 648
26. Smith SR Calzetta A Bankowski J Kenworthy-Bott L Terminelli C 1993 Lipopolysaccharide-induced cytokine production and mortality in mice treated with Corynebacterium parvum J Leukoc Biol 54 23 29
27. Song ZJ Johansen HK Faber V Hoiby N 1997 Ginseng treatment enhances bacterial clearance and decreases lung pathology in athymic rats with chronic P. aeruginosa pneumonia APMIS 105 438 444
28. Song JY Han SK Son EH Pyo SN Yun YS Yi SY 2002 Induction of secretory and tumoricidal activities in peritoneal macrophages by ginsan Int Immunopharmacol 2 857 865
29. Ulloa L Ochani M Yang H Tanovic M Halperin D Yang R Czura CJ Fink MP Tracey KJ 2002 Ethyl pyruvate prevents lethality in mice with established lethal sepsis and systemic inflammation Proc Natl Acad Sci USA 99 12351 12356
30. Underhill DM Ozinsky A Smith KD Aderem A 1999 Toll-like receptor-2 mediates mycobacteria-induced proinflammatory signaling in macrophages Proc Natl Acad Sci USA 96 14459 14463
31. Veltrop MH Bancsi MJ Bertina RM Thompson J 2000 Role of monocytes in experimental Staphylococcus aureus endocarditis Infect Immun 68 4818 4821
32. Verdrengh M Tarkowski A 2000 Role of macrophages in Staphylococcus aureus-induced arthritis and sepsis Arthritis Rheum 43 2276 2282
33. Verhoef J Mattsson E 1995 The role of cytokines in gram-positive bacterial shock Trends Microbiol 3 136 140
34. Wang JE Jorgensen PF Almlof M Thiemermann C Foster SJ Aasen AO Solberg R 2000 Peptidoglycan and lipoteichoic acid from Staphylococcus aureus induce tumor necrosis factor alpha, interleukin 6 (IL-6), and IL-10 production in both T cells and monocytes in a human whole blood model Infect Immun 68 3965 3970
35. Wheeler AP Bernard GR 1999 Treating patients with severe sepsis N Engl J Med 340 207 214
36. Williams DL Ha T Li C Kalbfleisch JH Schweitzer J Vogt W Browder IW 2003 Modulation of tissue Toll-like receptor 2 and 4 during the early phases of polymicrobial sepsis correlates with mortality Crit Care Med 31 1808 1818
37. Yoshimura A Lien E Ingalls RR Tuomanen E Dziarski R Golenbock D 1999 Cutting edge recognition of Gram-positive bacterial cell wall components by the innate immune system occurs via Toll-like receptor 2 J Immunol 163 1 5