Ginsenoside Rd attenuates early oxidative damage and sequential inflammatory response after transient focal ischemia in rats

Neurochemistry International

Volumn 58, Issue 3, 2011, Pages 391-398

  Ye, Ruidong ^a   Yang, Qianzi ^a   Kong, Xiangwei ^b   Han, Junliang ^a   Zhang, Xiao ^a   Zhang, Yunxia ^a   Li, Ping ^a   Liu, Juanfang ^a   Shi, Ming ^a   Xiong, Lize ^b   Zhao, Gang ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Ginsenoside Rd; Neuroprotection; Oxidative stress; Stroke

Indexed keywords

4 HYDROXYNONENAL; 8 HYDROXYDEOXYGUANOSINE; ADVANCED GLYCATION END PRODUCT; CARBONYL DERIVATIVE; CYCLOOXYGENASE 2; FREE RADICAL; GINSENOSIDE RD; INDUCIBLE NITRIC OXIDE SYNTHASE; MALONALDEHYDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; ARTICLE; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; CELL ACTIVATION; CONTROLLED STUDY; DNA DAMAGE; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; INFLAMMATION; LIPID PEROXIDATION; LONG TERM CARE; MALE; MICRODIALYSIS; MICROGLIA; MIDDLE CEREBRAL ARTERY OCCLUSION; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN CARBONYLATION; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; STROKE; TREATMENT OUTCOME;

ANIMALS; ANTIOXIDANTS; BRAIN INFARCTION; BRAIN ISCHEMIA; DISEASE MODELS, ANIMAL; GINSENOSIDES; MALE; NEUROPROTECTIVE AGENTS; OXIDATIVE STRESS; PANAX; RATS; RATS, SPRAGUE-DAWLEY;

PANAX GINSENG; RATTUS;

EID: 79951577369     PISSN: 01970186     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuint.2010.12.015     Document Type: Article

References (35)

1. S. Ashwal, B. Tone, H.R. Tian, D.J. Cole, and W.J. Pearce Core and penumbral nitric oxide synthase activity during cerebral ischemia and reperfusion Stroke 29 1998 1037 1047 (Pubitemid 28228169)
2. G. Bjelakovic, D. Nikolova, L.L. Gluud, R.G. Simonetti, and C. Gluud Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis JAMA 297 2007 842 857 (Pubitemid 46333949)
3. A. Chamorro Role of inflammation in stroke and atherothrombosis Cerebrovasc. Dis. 17 Suppl 3 2004 1 5 (Pubitemid 38134840)
4. J. Chen, Y. Li, L. Wang, Z. Zhang, D. Lu, M. Lu, and M. Chopp Therapeutic benefit of intravenous administration of bone marrow stromal cells after cerebral ischemia in rats Stroke 32 2001 1005 1011 (Pubitemid 32285175)
5. S.S. Choi, J.K. Lee, E.J. Han, K.J. Han, H.K. Lee, J. Lee, and H.W. Suh Effect of ginsenoside Rd on nitric oxide system induced by lipopolysaccharide plus TNF-alpha in C6 rat glioma cells Arch. Pharm. Res. 26 2003 375 382 (Pubitemid 43073825)
6. 2+ channels in vascular smooth muscle cells Eur. J. Pharmacol. 548 2006 129 136 (Pubitemid 44397016)
7. K. Hayakawa, K. Mishima, M. Nozako, M. Hazekawa, S. Mishima, M. Fujioka, K. Orito, N. Egashira, K. Iwasaki, and M. Fujiwara Delayed treatment with minocycline ameliorates neurologic impairment through activated microglia expressing a high-mobility group box1-inhibiting mechanism Stroke 39 2008 951 958 (Pubitemid 351619558)
8. K. Isayama, L.H. Pitts, and M.C. Nishimura Evaluation of 2,3,5-triphenyltetrazolium chloride staining to delineate rat brain infarcts Stroke 22 1991 1394 1398
9. J.J. Ley, L. Belayev, I. Saul, D.A. Becker, and M.D. Ginsberg Neuroprotective effect of STAZN, a novel azulenyl nitrone antioxidant, in focal cerebral ischemia in rats: dose-response and therapeutic window Brain Res. 1180 2007 101 110 (Pubitemid 350018730)
10. J. Li, W. Liu, S. Ding, W. Xu, Y. Guan, J.H. Zhang, and X. Sun Hyperbaric oxygen preconditioning induces tolerance against brain ischemia-reperfusion injury by upregulation of antioxidant enzymes in rats Brain Res. 1210 2008 223 229
11. X.Y. Li, J. Liang, Y.B. Tang, J.G. Zhou, and Y.Y. Guan Ginsenoside Rd prevents glutamate-induced apoptosis in rat cortical neurons Clin. Exp. Pharmacol. Physiol. 37 2010 199 204
12. X.Y. Lian, Z. Zhang, and J.L. Stringer Protective effects of ginseng components in a rodent model of neurodegeneration Ann. Neurol. 57 2005 642 648 (Pubitemid 40628852)
13. T.N. Lin, Y.Y. He, G. Wu, M. Khan, and C.Y. Hsu Effect of brain edema on infarct volume in a focal cerebral ischemia model in rats Stroke 24 1993 117 121 (Pubitemid 23014393)
14. W.M. Lin, Y.M. Zhang, R. Moldzio, and W.D. Rausch Ginsenoside Rd attenuates neuroinflammation of dopaminergic cells in culture J. Neural. Transm. Suppl. 2007 105 112
15. P. Lipton Ischemic cell death in brain neurons Physiol. Rev. 79 1999 1431 1568 (Pubitemid 29473320)
16. X. Liu, J. Xia, L. Wang, Y. Song, J. Yang, Y. Yan, H. Ren, and G. Zhao Efficacy and safety of ginsenoside-Rd for acute ischaemic stroke: a randomized, double-blind, placebo-controlled, phase II multicenter trial Eur. J. Neurol. 16 2009 569 575
17. Z.Q. Liu, X.Y. Luo, G.Z. Liu, Y.P. Chen, Z.C. Wang, and Y.X. Sun In vitro study of the relationship between the structure of ginsenoside and its antioxidative or prooxidative activity in free radical induced hemolysis of human erythrocytes J. Agric. Food Chem. 51 2003 2555 2558
18. M.V. Lopez, M.P. Cuadrado, O.M. Ruiz-Poveda, A.M. Del Fresno, and M.E. Accame Neuroprotective effect of individual ginsenosides on astrocytes primary culture Biochim. Biophys. Acta 1770 2007 1308 1316 (Pubitemid 47248059)
19. S. Nogawa, C. Forster, F. Zhang, M. Nagayama, M.E. Ross, and C. Iadecola Interaction between inducible nitric oxide synthase and cyclooxygenase-2 after cerebral ischemia Proc. Natl. Acad. Sci. U. S. A. 95 1998 10966 10971
20. W.R. Schabitz, R. Kollmar, M. Schwaninger, E. Juettler, J. Bardutzky, M.N. Scholzke, C. Sommer, and S. Schwab Neuroprotective effect of granulocyte colony-stimulating factor after focal cerebral ischemia Stroke 34 2003 745 751 (Pubitemid 36307405)
21. W. Tang, and G. Eisenbrand Chinese Drugs of Plant Origin: Chemistry, Pharmacology, and Use in Traditional and Modern Medicine 1992 Springer-Verlag Berlin/New York
22. P. Teismann, and B. Ferger The salicylate hydroxylation assay to measure hydroxyl free radicals induced by local application of glutamate in vivo or induced by the Fenton reaction in vitro Brain Res. Brain Res. Protoc. 5 2000 204 210 (Pubitemid 30210040)
23. Q. Wang, X. Gou, L. Xiong, W. Jin, S. Chen, L. Hou, and L. Xu Trans-activator of transcription-mediated delivery of NEP1-40 protein into brain has a neuroprotective effect against focal cerebral ischemic injury via inhibition of neuronal apoptosis Anesthesiology 108 2008 1071 1080
24. Q. Wang, Y. Peng, S. Chen, X. Gou, B. Hu, J. Du, Y. Lu, and L. Xiong Pretreatment with electroacupuncture induces rapid tolerance to focal cerebral ischemia through regulation of endocannabinoid system Stroke 40 2009 2157 2164
25. F. Yang, Z.R. Liu, J. Chen, S.J. Zhang, Q.Y. Quan, Y.G. Huang, and W. Jiang Roles of astrocytes and microglia in seizure-induced aberrant neurogenesis in the hippocampus of adult rats J. Neurosci. Res. 88 2010 519 529
26. L. Yang, Y. Deng, S. Xu, and X. Zeng In vivo pharmacokinetic and metabolism studies of ginsenoside Rd J. Chromatogr. B: Anal. Technol. Biomed. Life Sci. 854 2007 77 84 (Pubitemid 46962368)
27. Z.J. Yang, Y. Xie, G.M. Bosco, C. Chen, and E.M. Camporesi Hyperbaric oxygenation alleviates MCAO-induced brain injury and reduces hydroxyl radical formation and glutamate release Eur. J. Appl. Physiol. 108 2010 513 522
28. R. Ye, J. Han, X. Kong, L. Zhao, R. Cao, Z. Rao, and G. Zhao Protective effects of ginsenoside Rd on PC12 cells against hydrogen peroxide Biol. Pharm. Bull. 31 2008 1923 1927
29. R. Ye, N. Li, J. Han, X. Kong, R. Cao, Z. Rao, and G. Zhao Neuroprotective effects of ginsenoside Rd against oxygen-glucose deprivation in cultured hippocampal neurons Neurosci. Res. 64 2009 306 310
30. M.A. Yenari, L. Xu, X.N. Tang, Y. Qiao, and R.G. Giffard Microglia potentiate damage to blood-brain barrier constituents: improvement by minocycline in vivo and in vitro Stroke 37 2006 1087 1093
31. T. Yokozawa, Z.W. Liu, and E. Dong A study of ginsenoside-Rd in a renal ischemia-reperfusion model Nephron 78 1998 201 206 (Pubitemid 28054991)
32. T. Yokozawa, and S. Owada Effect of ginsenoside-Rd in cephaloridine-induced renal disorder Nephron 81 1999 200 207 (Pubitemid 29080432)
33. T. Yokozawa, A. Satoh, and E.J. Cho Ginsenoside-Rd attenuates oxidative damage related to aging in senescence-accelerated mice J. Pharm. Pharmacol. 56 2004 107 113 (Pubitemid 38195335)
34. X. Zeng, Y. Deng, Y. Feng, Y. Liu, L. Yang, Y. Huang, J. Sun, W. Liang, and Y. Guan Pharmacokinetics and safety of ginsenoside Rd following a single or multiple intravenous dose in healthy Chinese volunteers J. Clin. Pharmacol. 50 2010 285 292
35. N. Zhang, M. Komine-Kobayashi, R. Tanaka, M. Liu, Y. Mizuno, and T. Urabe Edaravone reduces early accumulation of oxidative products and sequential inflammatory responses after transient focal ischemia in mice brain Stroke 36 2005 2220 2225 (Pubitemid 41429250)