Protective effects of N-acetylcysteine amide (NACA) on gentamicin-induced apoptosis in LLC-PK1 cells

Renal Failure

Volumn 34, Issue 4, 2012, Pages 487-494

  Gong, Xuezhong ^a,b   Celsi, Gianni ^a   Carlsson, Katarina ^a   Norgren, Svante ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b LINYI PEOPLE'S HOSPITAL   (China)

Author keywords

Apoptosis; Gentamicin induced nephrotoxicity; Inducible nitric oxide synthase; N acetylcysteine amide; P38 mitogen activated protein kinase

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; AMINOGUANIDINE; CELL DNA; GENTAMICIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; MITOGEN ACTIVATED PROTEIN KINASE P38; N ACETYLCYSTEINE AMIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BAX; PROTEIN BCL 2; SCAVENGER; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL PROTECTION; CELL STRAIN; CELL STRUCTURE; CONTROLLED STUDY; CYTOTOXICITY; DNA CONTENT; DNA DETERMINATION; DOSE RESPONSE; DRUG EFFECT; ENZYME INDUCTION; NEPHROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; RENAL PROTECTION; SIGNAL TRANSDUCTION;

ACETYLCYSTEINE; ACUTE KIDNEY INJURY; ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BLOTTING, WESTERN; CELL SURVIVAL; CELLS, CULTURED; DISEASE MODELS, ANIMAL; DNA; FLOW CYTOMETRY; FREE RADICAL SCAVENGERS; GENE EXPRESSION REGULATION; GENTAMICINS; LLC-PK1 CELLS; NF-KAPPA B; NITRIC OXIDE SYNTHASE TYPE II; P38 MITOGEN-ACTIVATED PROTEIN KINASES; POLYMERASE CHAIN REACTION; PROTO-ONCOGENE PROTEINS C-BCL-2; SIGNAL TRANSDUCTION; SWINE;

EID: 84859595863     PISSN: 0886022X     EISSN: 15256049     Source Type: Journal    
DOI: 10.3109/0886022X.2012.655684     Document Type: Article

References (25)

1. El Mouedden M, Laurent G, Mingeot-Leclercq MP, Tulkens PM. Gentamicin-induced apoptosis in renal cell lines and embryonic rat fibroblasts. Toxicol Sci. 2000;56:229-239. (Pubitemid 30441483)
2. Martinez-Salgado C, Eleno N, Morales AI, Perez-Barriocanal F, Arevalo M, Lopez-Novoa JM. Gentamicin treatment induces simultaneous mesangial proliferation and apoptosis in rats. Kidney Int. 2004;65:2161-2171. (Pubitemid 38670002)
3. Yang TH, Young YH, Liu SH. EGb 761 (Ginkgo biloba) protects cochlear hair cells against ototoxicity induced by gentamicin via reducing reactive oxygen species and nitric oxide-related apoptosis. J Nutr Biochem. 2011;22(9):886-894.
4. Servais H, Jossin Y, Van Bambeke F, Tulkens PM, Mingeot-Leclercq MP. Gentamicin causes apoptosis at low concentrations in renal LLC-PK1 cells subjected to electroporation. Antimicrob Agents Chemother. 2006;50:1213-1221.
5. Juan SH, Chen CH, Hsu YH, et al. Tetramethylpyrazine protects rat renal tubular cell apoptosis induced by gentamicin. Nephrol Dial Transplant. 2007;22:732-739.
6. Cuzzocrea S, Mazzon E, Dugo L, et al. A role for superoxide in gentamicin-mediated nephropathy in rats. Eur J Pharmacol. 2002;450:67-76.
7. Reiter RJ, Tan DX, Sainz RM, Mayo JC, Lopez-Burillo S. Melatonin: Reducing the toxicity and increasing the efficacy of drugs. J Pharm Pharmacol. 2002;54:1299-1321. (Pubitemid 35174175)
8. Gong X, Celsi G, Carlsson K, Norgren S, Chen M. N-acetylcysteine amide protects renal proximal tubular epithelial cells against iohexol-induced apoptosis by blocking p38 MAPK and iNOS signaling. Am J Nephrol. 2010;31:178-188.
9. Polat A, Parlakpinar H, Tasdemir S, et al. Protective role of aminoguanidine on gentamicin-induced acute renal failure in rats. Acta Histochem. 2006;108:365-371. (Pubitemid 44584348)
10. Denamur S, Van Bambeke F, Mingeot-Leclercq MP, Tulkens PM. Apoptosis induced by aminoglycosides in LLC-PK1 cells: Comparative study of neomycin, gentamicin, amikacin, and isepamicin using electroporation. Antimicrob Agents Chemother. 2008;52:2236-2238. (Pubitemid 351758566)
11. Servais H, Van Der Smissen P, Thirion G, et al. Gentamicininduced apoptosis in LLC-PK1 cells: Involvement of lysosomes and mitochondria. Toxicol Appl Pharmacol. 2005;206: 321-333. (Pubitemid 41020674)
12. Santucci RA, Krieger JN. Gentamicin for the practicing urologist: Review of efficacy, single daily dosing and "switch" therapy. J Urol. 2000;163:1076-1084. (Pubitemid 30169366)
13. Gibbons CE, Maldonado-Perez D, Shah AN, Riccardi D, Ward DT. Calcium-sensing receptor antagonism or lithium treatment ameliorates aminoglycoside-induced cell death in renal epithelial cells. Biochim Biophys Acta. 2008;1782: 188-195.
14. Kwon CH, Yoon CS, Kim YK. Ciglitazone induces caspaseindependent apoptosis via p38-dependent AIF nuclear translocation in renal epithelial cells. Toxicology. 2008;244:13-24. (Pubitemid 50016621)
15. Volpini RA, Balbi AP, Costa RS, Coimbra TM. Increased expression of p38 mitogen-activated protein kinase is related to the acute renal lesions induced by gentamicin. Braz J Med Biol Res. 2006;39:817-823. (Pubitemid 43880941)
16. Ozbek E, Cekmen M, Ilbey YO, Simsek A, Polat EC, Somay A. Atorvastatin prevents gentamicin-induced renal damage in rats through the inhibition of p38-MAPK and NF-kappaB pathways. Ren Fail. 2009;31:382-392.
17. Rupesh KR, Priya AM, Sundarakrishnan B, Venkatesan R, Lakshmi BS, Jayachandran S. 2,2'-Bipyridyl based copper complexes down regulate expression of pro-inflammatory cytokines and suppress MAPKs in mitogen induced peripheral blood mononuclear cells. Eur J Med Chem. 2010;45: 2141-2146.
18. Kole L, Giri B, Manna SK, Pal B, Ghosh S. Biochanin-A, an isoflavon, showed anti-proliferative and anti-inflammatory activities through the inhibition of iNOS expression, p38-MAPK and ATF-2 phosphorylation and blocking NFkappaB nuclear translocation. Eur J Pharmacol. 2011;653: 8-15.
19. Liu H, BargoutiM, Zughaier S, et al. Osteoinductive LIM mineralization protein-1 suppresses activation of NF-kappaB and selectively regulates MAPK pathways in pre-osteoclasts. Bone. 2010;46:1328-1335.
20. Serbecic N, Beutelspacher SC. Anti-oxidative vitamins prevent lipid-peroxidation and apoptosis in corneal endothelial cells. Cell Tissue Res. 2005;320:465-475. (Pubitemid 40884148)
21. Jang SH, Lim JW, Kim H. Beta-carotene inhibits Helicobacter pylori-induced expression of inducible nitric oxide synthase and cyclooxygenase-2 in human gastric epithelial AGS cells. J Physiol Pharmacol. 2009;60(Suppl. 7):131-137.
22. Al-Majed AA, Mostafa AM, Al-Rikabi AC, Al-Shabanah OA. Protective effects of oral arabic gum administration on gentamicin-induced nephrotoxicity in rats. Pharmacol Res. 2002;46:445-451. (Pubitemid 35355746)
23. Ghatan S, Larner S, Kinoshita Y, et al. p38 MAP kinase mediates bax translocation in nitric oxide-induced apoptosis in neurons. J Cell Biol. 2000;150:335-347. (Pubitemid 30491357)
24. Vause CV, Durham PL. CGRP stimulation of iNOS and NO release from trigeminal ganglion glial cells involves mitogenactivated protein kinase pathways. J Neurochem. 2009;110: 811-821.
25. Kar S, Ukil A, Sharma G, Das PK. MAPK-directed phosphatases preferentially regulate pro-and anti-inflammatory cytokines in experimental visceral leishmaniasis: Involvement of distinct protein kinase C isoforms. J Leukoc Biol. 2010;88:9-20.