Ciglitazone induces caspase-independent apoptosis via p38-dependent AIF nuclear translocation in renal epithelial cells

Toxicology

Volumn 244, Issue 1, 2008, Pages 13-24

  Kwon, Chae Hwa ^a   Yoon, Chang Soo ^a   Kim, Yong Keun ^a  

^a Pusan National University School of Medicine   (South Korea)

Author keywords

AIF; Apoptosis; Caspase independent apoptosis; Ciglitazone; MAPK; Mitochondrial membrane potential; PPAR agonists; Renal epithelial cells

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; APOPTOSIS INDUCING FACTOR; CASPASE 3; CASPASE 3 INHIBITOR; CIGLITAZONE; CIPROFIBRATE; MITOGEN ACTIVATED PROTEIN KINASE P38; TROGLITAZONE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DEATH; CELL VIABILITY; CONTROLLED STUDY; ENZYME ACTIVATION; GENE TRANSLOCATION; KIDNEY EPITHELIUM; MEMBRANE DEPOLARIZATION; NONHUMAN; OPOSSUM; PRIORITY JOURNAL;

ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; APOPTOSIS; APOPTOSIS INDUCING FACTOR; BLOTTING, WESTERN; CELL LINE; CELL NUCLEUS; CELL SURVIVAL; CHROMANS; CLOFIBRIC ACID; DOSE-RESPONSE RELATIONSHIP, DRUG; EPITHELIAL CELLS; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; G1 PHASE; IMIDAZOLES; KIDNEY TUBULES; MEMBRANE POTENTIAL, MITOCHONDRIAL; OPOSSUMS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PPAR GAMMA; PYRIDINES; THIAZOLIDINEDIONES;

DIDELPHIDAE;

EID: 37549025332     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2007.10.019     Document Type: Article

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