Electrophysiological evaluation of sensory and motor pathways after incomplete unilateral spinal cord contusion: Laboratory investigation

Journal of Neurosurgery: Spine

Volumn 16, Issue 4, 2012, Pages 414-423

  Bazley, Faith A ^a   Hu, Charles ^a   Maybhate, Anil ^a   Pourmorteza, Amir ^a   Pashai, Nikta ^a   Thakor, Nitish V ^a   Kerr, Candace L ^b   All, Angelo H ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

Corticospinal tract; Motor evoked potential; Rat; Somatosensory evoked potential; Spinal cord injury; Unilateral contusion injury

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ELECTROPHYSIOLOGY; EVOKED SOMATOSENSORY RESPONSE; FEMALE; HINDLIMB; HISTOPATHOLOGY; LAMINECTOMY; MOTOR PERFORMANCE; NONHUMAN; PYRAMIDAL TRACT; RAT; SENSORY SYSTEM; SPINAL CORD CONTUSION; SPINAL CORD INJURY; TISSUE PRESERVATION; WHITE MATTER;

ANIMALS; AXONS; CONTUSIONS; EVOKED POTENTIALS, MOTOR; EVOKED POTENTIALS, SOMATOSENSORY; FORELIMB; FUNCTIONAL LATERALITY; HINDLIMB; MOTOR CORTEX; MOTOR NEURONS; NERVE REGENERATION; NEURAL PATHWAYS; NEURONAL PLASTICITY; RATS; SOMATOSENSORY CORTEX; SPINAL CORD INJURIES;

EID: 84859559849     PISSN: 15475654     EISSN: 15475646     Source Type: Journal    
DOI: 10.3171/2012.1.SPINE11684     Document Type: Article

References (56)

1. Agrawal G, Iyer S, All AH: A comparative study of recording procedures for motor evoked potential signals. Conf Proc IEEE Eng Med Biol Soc 2009:2086-2089, 2009
2. Agrawal G, Kerr C, Thakor NV, All AH: Characterization of graded multicenter animal spinal cord injury study contusion spinal cord injury using somatosensory-evoked potentials. Spine (Phila Pa 1976) 35:1122-1127, 2010
3. Agrawal G, Sherman D, Maybhate A, Gorelik M, Kerr DA, Thakor NV, et al: Slope analysis of somatosensory evoked potentials in spinal cord injury for detecting contusion injury and focal demyelination. J Clin Neurosci 17:1159-1164, 2010
4. Agrawal G, Thakor NV, All AH: Evoked potential versus behavior to detect minor insult to the spinal cord in a rat model. J Clin Neurosci 16:1052-1055, 2009
5. All AH, Agrawal G, Walczak P, Maybhate A, Bulte JW, Kerr DA: Evoked potential and behavioral outcomes for experimental autoimmune encephalomyelitis in Lewis rats. Neurol Sci 31:595-601, 2010
6. All AH, Walczak P, Agrawal G, Gorelik M, Lee C, Thakor NV, et al: Effect of MOG sensitization on somatosensory evoked potential in Lewis rats. J Neurol Sci 284:81-89, 2009
7. Anderson KD, Gunawan A, Steward O: Quantitative assessment of forelimb motor function after cervical spinal cord injury in rats: relationship to the corticospinal tract. Exp Neurol 194:161-174, 2005 (Pubitemid 40719752)
8. Anderson KD, Sharp KG, Steward O: Bilateral cervical contusion spinal cord injury in rats. Exp Neurol 220:9-22, 2009
9. Bareyre FM, Kerschensteiner M, Misgeld T, Sanes JR: Transgenic labeling of the corticospinal tract for monitoring axonal responses to spinal cord injury. Nat Med 11:1355-1360, 2005 (Pubitemid 41752918)
10. Bareyre FM, Kerschensteiner M, Raineteau O, Mettenleiter TC, Weinmann O, Schwab ME: The injured spinal cord spontaneously forms a new intraspinal circuit in adult rats. Nat Neurosci 7:269-277, 2004 (Pubitemid 38280451)
11. Basso DM, Beattie MS, Bresnahan JC: Graded histological and locomotor outcomes after spinal cord contusion using the NYU weight-drop device versus transection. Exp Neurol 139:244- 256, 1996
12. Basso DM, Beattie MS, Bresnahan JC: A sensitive and reliable locomotor rating scale for open field testing in rats. J Neurotrauma 12:1-21, 1995
13. Bazley FA, All AH, Thakor NV, Kerr C, Maybhate A: Plasticity associated changes in cortical somatosensory evoked potentials following spinal cord injury in rats, in: Engineering in Medicine and Biology Society, EMBC, 2011, Annual International Conference of the IEEE. New York: IEEE, 2011, pp 2005-2008 (http://ieeexplore.ieee.org/stamp/stamp. jsp?tp=&arnumber=6090564) [Accessed January 6, 2012]
14. Carmel JB, Berrol LJ, Brus-Ramer M, Martin JH: Chronic electrical stimulation of the intact corticospinal system after unilateral injury restores skilled locomotor control and promotes spinal axon outgrowth. J Neurosci 30:10918-10926, 2010
15. Cho SR, Kim YR, Kang HS, Yim SH, Park CI, Min YH, et al: Functional recovery after the transplantation of neurally differentiated mesenchymal stem cells derived from bone barrow in a rat model of spinal cord injury. Cell Transplant 18:1359-1368, 2009
16. Erceg S, Ronaghi M, Oria M, Roselló MG, Aragó MAP, Lopez MG, et al: Transplanted oligodendrocytes and motoneuron progenitors generated from human embryonic stem cells promote locomotor recovery after spinal cord transection. Stem Cells 28:1541-1549, 2010
17. Fehlings MG, Tator CH, Linden RD: The relationships among the severity of spinal cord injury, motor and somatosensory evoked potentials and spinal cord blood flow. Electroencephalogr Clin Neurophysiol 74:241-259, 1989 (Pubitemid 19164308)
18. Fehlings MG, Tator CH, Linden RD, Piper IR: Motor and somatosensory evoked potentials recorded from the rat. Electroencephalogr Clin Neurophysiol 69:65-78, 1988 (Pubitemid 18023229)
19. Fouad K, Pedersen V, Schwab ME, Brösamle C: Cervical sprouting of corticospinal fibers after thoracic spinal cord injury accompanies shifts in evoked motor responses. Curr Biol 11:1766-1770, 2001 (Pubitemid 33092164)
20. Garcia RM, Qureshi SA, Cassinelli EH, Biro CL, Furey CG, Bohlman HH: Detection of postoperative neurologic deficits using somatosensory-evoked potentials alone during posterior cervical laminoplasty. Spine J 10:890-895, 2010
21. Gensel JC, Tovar CA, Hamers FPT, Deibert RJ, Beattie MS, Bresnahan JC: Behavioral and histological characterization of unilateral cervical spinal cord contusion injury in rats. J Neurotrauma 23:36-54, 2006 (Pubitemid 43191085)
22. Ghosh A, Haiss F, Sydekum E, Schneider R, Gullo M, Wyss MT, et al: Rewiring of hindlimb corticospinal neurons after spinal cord injury. Nat Neurosci 13:97-104, 2010
23. Girgis J, Merrett D, Kirkland S, Metz GA, Verge V, Fouad K: Reaching training in rats with spinal cord injury promotes plasticity and task specific recovery. Brain 130:2993-3003, 2007 (Pubitemid 350033978)
24. Hu R, Zhou J, Luo C, Lin J, Wang X, Li X, et al: Glial scar and neuroregeneration: histological, functional, and magnetic resonance imaging analysis in chronic spinal cord injury. Laboratory investigation. J Neurosurg Spine 13:169-180, 2010
25. Iannotti C, Ping Zhang Y, Shields CB, Han Y, Burke DA, Xu XM: A neuroprotective role of glial cell line-derived neurotrophic factor following moderate spinal cord contusion injury. Exp Neurol 189:317-332, 2004 (Pubitemid 39232071)
26. Iyer B, Maybhate A, Presacco A, All AH: Multi-limb acquisition of motor evoked potentials and its application in spinal cord injury. J Neurosci Methods 193:210-216, 2010
27. Kaas JH, Qi HX, Burish MJ, Gharbawie OA, Onifer SM, Massey JM: Cortical and subcortical plasticity in the brains of humans, primates, and rats after damage to sensory afferents in the dorsal columns of the spinal cord. Exp Neurol 209:407-416, 2008 (Pubitemid 351174131)
28. Kerr CL, Letzen BS, Hill CM, Agrawal G, Thakor NV, Sterneckert JL, et al: Efficient differentiation of human embryonic stem cells into oligodendrocyte progenitors for application in a rat contusion model of spinal cord injury. Int J Neurosci 120:305-313, 2010
29. Klapka N, Hermanns S, Straten G, Masanneck C, Duis S, Hamers FP, et al: Suppression of fibrous scarring in spinal cord injury of rat promotes long-distance regeneration of corticospinal tract axons, rescue of primary motoneurons in somatosensory cortex and significant functional recovery. Eur J Neurosci 22:3047-3058, 2005 (Pubitemid 43001988)
30. Krajacic A, Weishaupt N, Girgis J, Tetzlaff W, Fouad K: Training- induced plasticity in rats with cervical spinal cord injury: effects and side effects. Behav Brain Res 214:323-331, 2010
31. Lee BH, Lee KH, Yoon DH, Kim UJ, Hwang YS, Park SK, et al: Effects of methylprednisolone on the neural conduction of the motor evoked potentials in spinal cord injured rats. J Korean Med Sci 20:132-138, 2005
32. Lee JHT, Tigchelaar S, Liu J, Stammers AMT, Streijger F, Tetzlaff W, et al: Lack of neuroprotective effects of simvastatin and minocycline in a model of cervical spinal cord injury. Exp Neurol 225:219-230, 2010
33. Letzen BS, Liu C, Thakor NV, Gearhart JD, All AH, Kerr CL: MicroRNA expression profiling of oligodendrocyte differentiation from human embryonic stem cells. PLoS ONE 5:e10480, 2010
34. Maier IC, Baumann K, Thallmair M, Weinmann O, Scholl J, Schwab ME: Constraint-induced movement therapy in the adult rat after unilateral corticospinal tract injury. J Neurosci 28:9386-9403, 2008
35. Martinez M, Brezun JM, Zennou-Azogui Y, Baril N, Xerri C: Sensorimotor training promotes functional recovery and somatosensory cortical map reactivation following cervical spinal cord injury. Eur J Neurosci 30:2356-2367, 2009
36. Maybhate A, Hu C, Bazley FA, Yu Q, Thakor NV, Kerr C, et al: Potential long-term benefits of acute hypothermia after spinal cord injury: assessments with somatosensory-evoked potentials. Crit Care Med [epub ahead of print], 2011
37. Metz GA, Curt A, van de Meent H, Klusman I, Schwab ME, Dietz V: Validation of the weight-drop contusion model in rats: a comparative study of human spinal cord injury. J Neurotrauma 17:1-17, 2000 (Pubitemid 30075612)
38. Midha R, Fehlings MG, Tator CH, Saint-Cyr JA, Guha A: Assessment of spinal cord injury by counting corticospinal and rubrospinal neurons. Brain Res 410:299-308, 1987 (Pubitemid 17083324)
39. Murray M, Goldberger ME: Restitution of function and collateral sprouting in the cat spinal cord: the partially hemisected animal. J Comp Neurol 158:19-36, 1974
40. Pearse DD, Lo TP Jr, Cho KS, Lynch MP, Garg MS, Marcillo AE, et al: Histopathological and behavioral characterization of a novel cervical spinal cord displacement contusion injury in the rat. J Neurotrauma 22:680-702, 2005 (Pubitemid 40840383)
41. Pettersson LG, Alstermark B, Blagovechtchenski E, Isa T, Sasaski S: Skilled digit movements in feline and primate-recovery after selective spinal cord lesions. Acta Physiol (Oxf) 189:141-154, 2007 (Pubitemid 46148325)
42. Raineteau O, Fouad K, Bareyre FM, Schwab ME: Reorganization of descending motor tracts in the rat spinal cord. Eur J Neurosci 16:1761-1771, 2002 (Pubitemid 35370709)
43. Raineteau O, Schwab ME: Plasticity of motor systems after incomplete spinal cord injury. Nat Rev Neurosci 2:263-273, 2001 (Pubitemid 33673067)
44. Ruitenberg MJ, Plant GW, Hamers FP, Wortel J, Blits B, Dijkhuizen PA, et al: Ex vivo adenoviral vector-mediated neurotrophin gene transfer to olfactory ensheathing glia: effects on rubrospinal tract regeneration, lesion size, and functional recovery after implantation in the injured rat spinal cord. J Neurosci 23:7045-7058, 2003 (Pubitemid 36975870)
45. Sandrow-Feinberg HR, Izzi J, Shumsky JS, Zhukareva V, Houle JD: Forced exercise as a rehabilitation strategy after unilateral cervical spinal cord contusion injury. J Neurotrauma 26:721- 731, 2009
46. Sandrow-Feinberg HR, Zhukareva V, Santi L, Miller K, Shumsky JS, Baker DP, et al: PEGylated interferon-beta modulates the acute inflammatory response and recovery when combined with forced exercise following cervical spinal contusion injury. Exp Neurol 223:439-451, 2010
47. Saporta S, Makoui AS, Willing AE, Daadi M, Cahill DW, Sanberg PR: Functional recovery after complete contusion injury to the spinal cord and transplantation of human neuroteratocarcinoma neurons in rats. J Neurosurg 97 (1 Suppl):63-68, 2002 (Pubitemid 34686602)
48. Soblosky JS, Song JH, Dinh DH: Graded unilateral cervical spinal cord injury in the rat: evaluation of forelimb recovery and histological effects. Behav Brain Res 119:1-13, 2001 (Pubitemid 32063349)
49. Thomas SL, Gorassini MA: Increases in corticospinal tract function by treadmill training after incomplete spinal cord injury. J Neurophysiol 94:2844-2855, 2005 (Pubitemid 41327380)
50. Tillakaratne NJK, Guu JJ, de Leon RD, Bigbee AJ, London NJ, Zhong H, et al: Functional recovery of stepping in rats after a complete neonatal spinal cord transection is not due to regrowth across the lesion site. Neuroscience 166:23-33, 2010
51. Wang X, Smith GM, Xu XM: Preferential and bidirectional labeling of the rubrospinal tract with adenovirus-GFP for monitoring normal and injured axons. J Neurotrauma 28:635-647, 2011
52. Wang XY, Li XL, Hong SQ, Xi-Yang YB, Wang TH: Electroacupuncture induced spinal plasticity is linked to multiple gene expressions in dorsal root deafferented rats. J Mol Neurosci 37:97-110, 2009
53. Weidner N, Ner A, Salimi N, Tuszynski MH: Spontaneous corticospinal axonal plasticity and functional recovery after adult central nervous system injury. Proc Natl Acad Sci U S A 98:3513-3518, 2001 (Pubitemid 32220876)
54. Yip PK, Wong LF, Sears TA, Yáñez-Muñoz RJ, McMahon SB: Cortical overexpression of neuronal calcium sensor-1 induces functional plasticity in spinal cord following unilateral pyramidal tract injury in rat. PLoS Biol 8:e1000399, 2010
55. Young W: Spinal cord contusion models. Prog Brain Res 137:231-255, 2002
56. Zhang Y, Xiong Y, Mahmood A, Meng Y, Liu Z, Qu C, et al: Sprouting of corticospinal tract axons from the contralateral hemisphere into the denervated side of the spinal cord is associated with functional recovery in adult rat after traumatic brain injury and erythropoietin treatment. Brain Res 1353:249-257, 2010