Functional recovery of stepping in rats after a complete neonatal spinal cord transection is not due to regrowth across the lesion site

Neuroscience

Volumn 166, Issue 1, 2010, Pages 23-33

  Tillakaratne, N J K ^a   Guu, J J ^a   de Leon, R D ^b   Bigbee, A J ^c   London, N J ^a   Zhong, H ^a   Ziegler, M D ^a   Joynes, R L ^d   Roy, R R ^a   Edgerton, V R ^a,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b CALIFORNIA STATE UNIVERSITY   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d KENT STATE UNIVERSITY   (United States)

Author keywords

corticospinal; locomotion; retrograde labeling; rubrospinal; spinal cord injury; training

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOMECHANICS; CONTROLLED STUDY; FEMALE; LOCOMOTION; LUMBOSACRAL SPINE; MOTOR PERFORMANCE; NERVE CELL NETWORK; NERVE GROWTH; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PYRAMIDAL TRACT; RAT; RED NUCLEUS; RUBROSPINAL TRACT; SOLEUS MUSCLE; SOMATOSENSORY CORTEX; SPINAL CORD TRANSSECTION; TIBIALIS ANTERIOR MUSCLE; TREADMILL EXERCISE; VESTIBULAR NUCLEUS;

AGE FACTORS; AMIDINES; ANIMALS; ANIMALS, NEWBORN; AXONAL TRANSPORT; BIOTIN; BRAIN STEM; DEXTRANS; DISEASE MODELS, ANIMAL; EFFERENT PATHWAYS; EXERCISE TEST; FEMALE; GROWTH CONES; HERPESVIRUS 1, SUID; LAMENESS, ANIMAL; LOCOMOTION; MOTOR CORTEX; NERVE REGENERATION; NEUROANATOMICAL TRACT-TRACING TECHNIQUES; NEURONAL PLASTICITY; PARALYSIS; RATS; RATS, SPRAGUE-DAWLEY; RECOVERY OF FUNCTION; SPINAL CORD; SPINAL CORD INJURIES; STAINING AND LABELING;

EID: 74449090925     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2009.12.010     Document Type: Article

References (35)

1. Bernstein D.R., Bechard D.E., and Stelzner D.J. Neuritic growth maintained near the lesion site long after spinal cord transection in the newborn rat. Neurosci Lett 26 (1981) 55-60
2. Bryz-Gornia Jr. W.F., and Stelzner D.J. Ascending tract neurons survive spinal cord transection in the neonatal rat. Exp Neurol 93 (1986) 195-210
3. Cai L.L., Fong A.J., Otoshi C.K., Liang Y., Burdick J.W., Roy R.R., and Edgerton V.R. Implications of assist-as-needed robotic step training after a complete spinal cord injury on intrinsic strategies of motor learning. J Neurosci 26 (2006) 10564-10568
4. Cha J., Heng C., Reinkensmeyer D.J., Roy R.R., Edgerton V.R., and de Leon R.D. Locomotor ability in spinal rats is dependent on the amount of activity imposed on the hindlimbs during treadmill training. J Neurotrauma 24 (2007) 1000-1012
5. Commissiong J.W., and Toffano G. Complete spinal cord transection at different postnatal ages: recovery of motor coordination correlated with spinal cord catecholamines. Exp Brain Res 78 (1989) 597-603
6. Cummings J.P., Bernstein D.R., and Stelzner D.J. Further evidence that sparing of function after spinal cord transection in the neonatal rat is not due to axonal generation or regeneration. Exp Neurol 74 (1981) 615-620
7. de Leon R., Hodgson J.A., Roy R.R., and Edgerton V.R. Extensor- and flexor-like modulation within motor pools of the rat hindlimb during treadmill locomotion and swimming. Brain Res 654 (1994) 241-250
8. de Leon R.D., Reinkensmeyer D.J., Timoszyk W.K., London N.J., Roy R.R., and Edgerton V.R. Use of robotics in assessing the adaptive capacity of the rat lumbar spinal cord. Prog Brain Res 137 (2002) 141-149
9. de Leon R.D., Kubasak M.D., Phelps P.E., Timoszyk W.K., Reinkensmeyer D.J., Roy R.R., and Edgerton V.R. Using robotics to teach the spinal cord to walk. Brain Res Brain Res Rev 40 (2002) 267-273
10. Edgerton V.R., Leon R.D., Harkema S.J., Hodgson J.A., London N., Reinkensmeyer D.J., Roy R.R., Talmadge R.J., Tillakaratne N.J., Timoszyk W., and Tobin A. Retraining the injured spinal cord. J Physiol 533 (2001) 15-22
11. Fong A.J., Cai L.L., Otoshi C.K., Reinkensmeyer D.J., Burdick J.W., Roy R.R., and Edgerton V.R. Spinal cord-transected mice learn to step in response to quipazine treatment and robotic training. J Neurosci 25 (2005) 11738-11747
12. Giszter S.F., Kargo W.J., Davies M., and Shibayama M. Fetal transplants rescue axial muscle representations in M1 cortex of neonatally transected rats that develop weight support. J Neurophysiol 80 (1998) 3021-3030
13. Giszter S.F., Davies M.R., and Graziani V. Motor strategies used by rats spinalized at birth to maintain stance in response to imposed perturbations. J Neurophysiol 97 (2007) 2663-2675
14. Gramsbergen A. Normal and abnormal development of motor behavior: lessons from experiments in rats. Neural Plast 8 (2001) 17-29
15. Hase T., Kawaguchi S., Hayashi H., Nishio T., Mizoguchi A., and Nakamura T. Spinal cord repair in neonatal rats: a correlation between axonal regeneration and functional recovery. Eur J Neurosci 15 (2002) 969-974
16. Kao T., Shumsky J.S., Jacob-Vadakot S., Himes B.T., Murray M., and Moxon K.A. Role of the 5-HT2C receptor in improving weight-supported stepping in adult rats spinalized as neonates. Brain Res 1112 (2006) 159-168
17. Kao T., Shumsky J.S., Murray M., and Moxon K.A. Exercise induces cortical plasticity after neonatal spinal cord injury in the rat. J Neurosci 29 (2009) 7549-7557
18. Khristy W., Ali N.J., Bravo A.B., de Leon R., Roy R.R., Zhong H., London N.J., Edgerton V.R., and Tillakaratne N.J. Changes in GABA(A) receptor subunit gamma 2 in extensor and flexor motoneurons and astrocytes after spinal cord transection and motor training. Brain Res 1273 (2009) 9-17
19. Kim D., Adipudi V., Shibayama M., Giszter S., Tessler A., Murray M., and Simansky K.J. Direct agonists for serotonin receptors enhance locomotor function in rats that received neural transplants after neonatal spinal transection. J Neurosci 19 (1999) 6213-6224
20. Kim D., Murray M., and Simansky K.J. The serotonergic 5-HT(2C) agonist m-chlorophenylpiperazine increases weight-supported locomotion without development of tolerance in rats with spinal transections. Exp Neurol 169 (2001) 496-500
21. Kubasak M.D., Hedlund E., Roy R.R., Carpenter E.M., Edgerton V.R., and Phelps P.E. L1 CAM expression is increased surrounding the lesion site in rats with complete spinal cord transection as neonates. Exp Neurol 194 (2005) 363-375
22. Miya D., Giszter S., Mori F., Adipudi V., Tessler A., and Murray M. Fetal transplants alter the development of function after spinal cord transection in newborn rats. J Neurosci 17 (1997) 4856-4872
23. Murray M., Fischer I., Smeraski C., Tessler A., and Giszter S. Towards a definition of recovery of function. J Neurotrauma 21 (2004) 405-413
24. Paxinos G., and Watson C. The rat brain in stereotaxic coordinates (1998), Academic Press, New York
25. Petruska J.C., Ichiyama R.M., Jindrich D.L., Crown E.D., Tansey K.E., Roy R.R., Edgerton V.R., and Mendell L.M. Changes in motoneuron properties and synaptic inputs related to step training after spinal cord transection in rats. J Neurosci 27 (2007) 4460-4471
26. Stelzner D.J., Ershler W.B., and Weber E.D. Effects of spinal transection in neonatal and weanling rats: survival of function. Exp Neurol 46 (1975) 156-177
27. Timoszyk W.K., de Leon R.D., London N., Roy R.R., Edgerton V.R., and Reinkensmeyer D.J. The rat lumbosacral spinal cord adapts to robotic loading applied during stance. J Neurophysiol 88 (2002) 3108-3117
28. Tobias C.A., Shumsky J.S., Shibata M., Tuszynski M.H., Fischer I., Tessler A., and Murray M. Delayed grafting of BDNF and NT-3 producing fibroblasts into the injured spinal cord stimulates sprouting, partially rescues axotomized red nucleus neurons from loss and atrophy, and provides limited regeneration. Exp Neurol 184 (2003) 97-113
29. Wakabayashi Y., Komori H., Kawa-Uchi T., Mochida K., Takahashi M., Qi M., Otake K., and Shinomiya K. Functional recovery and regeneration of descending tracts in rats after spinal cord transection in infancy. Spine 26 (2001) 1215-1222
30. Weber E.D., and Stelzner D.J. Behavioral effects of spinal cord transection in the developing rat. Brain Res 125 (1977) 241-255
31. West M.J. New stereological methods for counting neurons. Neurobiol Aging 14 (1993) 275-285
32. West M.J., Slomianka L., and Gundersen H.J. Unbiased stereological estimation of the total number of neurons in thesubdivisions of the rat hippocampus using the optical fractionator. Anat Rec 231 (1991) 482-497
33. West M.J., Ostergaard K., Andreassen O.A., and Finsen B. Estimation of the number of somatostatin neurons in the striatum: an in situ hybridization study using the optical fractionator method. J Comp Neurol 370 (1996) 11-22
34. Westerga J., and Gramsbergen A. Structural changes of the soleus and the tibialis anterior motoneuron pool during development in the rat. J Comp Neurol 319 (1992) 406-416
35. Williams R.W., and Rakic P. Three-dimensional counting: an accurate and direct method to estimate numbers of cells in sectioned material. J Comp Neurol 278 (1988) 344-352