In vivo reactivation by oximes of inhibited blood, brain and peripheral tissue cholinesterase activity following exposure to nerve agents in guinea pigs

Chemico-Biological Interactions

Volumn 187, Issue 1-3, 2010, Pages 207-214

  Shih, Tsung Ming ^a   Skovira, Jacob W ^a   O'Donnell, John C ^a   McDonough, John H ^a  

^a US ARMY MEDICAL RESEARCH INSTITUTE OF CHEMICAL DEFENSE   (United States)

Author keywords

Acetylcholinesterase; Cholinesterase reactivation; Guinea pig; Methoxime; Nerve agents; Oximes

Indexed keywords

1 (4 AMINOCARBONYLPYRIDINIO) 3(2 HYDROXYIMINOMETHYLPYRIDINIO)PROPANE DICHLORIDE MONOHYDRATE; 1 (4 CARBAMOYLPYRIDINIO) 1' (2 HYDROXYIMINOMETHYLPYRIDINIO)DIMETHYL ETHER; 1 [1 (2 HYDROXYIMINOMETHYL 3 METHYL)IMIDAZOLO] 3 (4 CARBAMOYLPYRIDINIUM)PROPANE DICHLORIDE HYDRATE; 1 [2,4 BIS(HYDROXYIMINOMETHYL)PYRIDINIO] 1' (4 CARBAMOYLPYRIDINIO)DIMETHYL ETHER DIIODIDE; 1 [3 (4 AMINOCARBONYLPYRIDINIO)PROPYL] 2 METHYLPYRIDINIUM DICHLORIDE HYDRATE; 1,1' METHYLENEBIS(4 HYDROXYIMINOMETHYLPYRIDINIUM) DICHLORIDE; 2 ETHYL[2 (DIISOPROPYLAMINO)ETHYL]METHYLPHOSPHONOTHIOATE; 2 ISOBUTYL[2 (DIETHYLAMINO)ETHYL]METHYLPHOSPHOTHIOATE; 3 (4 CARBAMOYL 1 PYRIDINO) 1 [2,4 BIS(HYDROXYIMINOMETHYL) 1 PYRIDINO]PROPANE DICHLORIDE HYDRATE; BIS(4 TERT BUTYL 1 PYRIDINIOMETHYL) ETHER; CARBOXIME; CHOLINESTERASE; CHOLINESTERASE REACTIVATOR; CYCLOSARIN; ICD 3805; ICD 585; ICS 4157; ICS 692; ORGANOPHOSPHORUS COMPOUND; OXIME DERIVATIVE; PRALIDOXIME; SARIN; TRIMEDOXIME; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BLOOD; BRAIN; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENCY; DRUG SENSITIVITY; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME REACTIVATION; GUINEA PIG; IN VIVO STUDY; LD 50; MALE; NONHUMAN; SURVIVAL RATE; TISSUE LEVEL; TOXICITY TESTING;

ANIMALIA; CAVIA;

EID: 77955508878     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbi.2010.03.006     Document Type: Article

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