Predictability of drug release from cochlear implants

Journal of Controlled Release

Volumn 159, Issue 1, 2012, Pages 60-68

  Krenzlin, S ^a,b   Vincent, C ^a   Munzke, L ^a,b   Gnansia, D ^c   Siepmann, J ^a,b   Siepmann, F ^a,b  

^a UNIV LILLE   (France)

^b France   (France)

^c Neurelec   (France)

Author keywords

Cochlear implant; Diffusion; Drug release mechanism; Mathematical modeling; Silicone

Indexed keywords

CONTROLLED DRUG DELIVERY SYSTEMS; DEXAMETHASONES; DRUG RELEASE; DRUG RELEASE KINETICS; DRUG RELEASE MECHANISM; FICK'S SECOND LAW; IMPLANT MATRIX; IN-SILICO; INNER EAR; KEY PARAMETERS; MATHEMATICAL MODELING; MATHEMATICAL THEORY; RAPID IDENTIFICATION; SMALL SYSTEMS; THEORETICAL MODELS; THEORETICAL PREDICTION;

COCHLEAR IMPLANTS; COMPUTER SIMULATION; CONTROLLED DRUG DELIVERY; DIFFUSION; FORECASTING; SILICONES; SYSTEMS ANALYSIS;

DRUG PRODUCTS;

DEXAMETHASONE;

ARTICLE; COCHLEA PROSTHESIS; DRUG DELIVERY SYSTEM; DRUG DIFFUSION; DRUG RELEASE; ELECTRODE; MATHEMATICS; PRIORITY JOURNAL; SIMULATION; VALIDITY;

COCHLEAR IMPLANTS; COMPUTER SIMULATION; DEXAMETHASONE; DRUG DELIVERY SYSTEMS; DRUG STABILITY; KINETICS; MODELS, THEORETICAL; PERILYMPH; SILICONES;

EID: 84859515013     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2011.12.032     Document Type: Article

References (44)

1. P.P. Wang, J. Frazier, and H. Brem Local drug delivery to the brain Adv. Drug Del. Rev. 54 2002 987 1013
2. M. Biondi, F. Ungaro, F. Quaglia, and P.A. Netti Controlled drug delivery in tissue engineering Adv. Drug Deliv. Rev. 60 2008 229 242
3. J. Siepmann, F. Siepmann, and A.T. Florence Local controlled drug delivery to the brain: Mathematical modeling of the underlying mass transport mechanisms Int. J. Pharm. 314 2006 101 119
4. S. Juhn Barrier systems in the inner ear Acta Otolaryngol. Suppl. 458 1988 79 83
5. S. Juhn, and L. Rybak Labyrinthine barriers and cochlear homeostasis Acta Otolaryngol. 91 1981 529 534
6. T.M. Connolly, H. Eastwood, G. Kel, H. Lisnichuk, R. Richardson, and S. O'Leary Pre-operative intravenous dexamethasone prevents auditory threshold shift in a Guinea pig model of cochlear implantation Audiol. Neurotol. 16 2011 137 144
7. E.E. Swan, M. Mescher, W. Sewell, S. Tao, and J. Borensetin Inner ear drug delivery for auditory applications Adv. Drug Deliv. Rev. 60 2008 1583 1599
8. A.N. Salt, and S.K. Plontke Local inner-ear drug delivery and pharmacokinetics Drug Discov. Today 10 2005 1299 1306
9. H. Staecker, C. Jolly, and C. Garnham Cochlear implantation: an opportunity for drug development Drug Discov. Today 15 2010 314 321
10. A.N. Salt, D.B. Sirjani, J.J. Hartsock, R.M. Gill, and S.K. Plontke Marker retention in the cochlea following injections through the round window membrane Hear. Res. 232 2007 78 86
11. K. Ohyama, A.N. Salt, and R. Thalmann Volume flow rate of perilymph in the guinea-pig cochlea Hear. Res. 35 1988 119 129
12. S.K. Plontke, T. Biegner, B. Kammerer, U. Delabar, and A.N. Salt Dexamethasone concentration gradients along scala tympani after application to the round window membrane Otol. Neurotol. 29 2008 401 406
13. S.K. Plontke, R. Mynatt, R.M. Gill, S. Borgmann, and A.N. Salt Concentration gradient along the scala tympani after local application of gentamicin to the round window membrane Laryngoscope 117 2007 1191 1198
14. R. Mynatt, S.A. Hale, R.M. Gill, S.K. Plontke, and A.N. Salt Demonstration of a longitudinal concentration gradient along scala tympani by sequential sampling of perilymph from the cochlear apex J. Assoc. Res. Otolaryngol. 7 2006 182 193
15. G.F. Farahmand, H. Mirzadeh, M. Imani, C. Jolly, and M. Farhadi Corticosteroid-releasing cochlear implant: A novel hybrid of biomaterial and drug delivery system J. Biomed. Mater. Res. 94B 2010 388 398
16. H. Eastwood, A. Chang, G. Kel, D. Sly, R. Richardson, and S.J. O'Leary Round window delivery of dexamethasone ameliorates local and remote hearing loss produced by cochlear implantation into the second turn of the guinea pig cochlea Hear. Res. 265 2010 25 29
17. A.A. Eshraghi, E. Adil, J. He, R. Graves, T.J. Balkany, and T.R. Van De Water Local dexamethasone therapy conserves hearing in an animal model of electrode insertion trauma-induced hearing loss Otol. Neurotol. 28 2007 842 849
18. C. Dinh, K. Hoang, S. Haake, S. Chen, S. Angeli, E. Nong, A.A. Eshraghi, T.J. Balkany, and T.R. Van De Water Biopolymer-released dexamethasone prevents tumor necrosis factor [alpha]-induced loss of auditory hair cells in vitro: Implications toward the development of a drug-eluting cochlear implant electrode array Otol. Neurotol. 29 2008 1012 1019
19. L.T. Fan, and S.K. Singh Controlled Release: A Quantitative Treatment 1989 Springer-Verlag Berlin
20. J. Siepmann, and N.A. Peppas Modeling of drug release from delivery systems based on hydroxypropyl methylcellulose (HPMC) Adv. Drug Deliv. Rev. 48 2001 139 157
21. J. Siepmann, and A. Goepferich Mathematical modeling of bioerodible, polymeric drug delivery systems Adv. Drug Deliv. Rev. 48 2001 229 247
22. J. Siepmann, and F. Siepmann Mathematical modeling of drug delivery Int. J. Pharm. 364 2008 328 343
23. F. Kreye, F. Siepmann, A. Zimmer, J.F. Willart, M. Descamps, and J. Siepmann Controlled release implants based on cast lipid blends Eur. J. Pharm. Sci. 43 2011 78 83
24. E. Kaunisto, S. Abrahmsen-Alami, P. Borgquist, A. Larsson, B. Nilsson, and A. Axelsson A mechanistic modelling approach to polymer dissolution using magnetic resonance microimaging J. Control. Release 147 2010 232 241
25. E. Kaunisto, M. Marucci, P. Borgquist, and A. Axelsson Mechanistic modelling of drug release from polymer-coated and swelling and dissolving polymer matrix systems Int. J. Pharm. 418 2011 54 77
26. G. Frenning Modelling drug release from inert matrix systems: From moving-boundary to continuous-field descriptions Int. J. Pharm. 418 2011 88 99
27. M. Grassi, G. Lamberti, S. Cascone, and G. Grassi Mathematical modeling of simultaneous drug release and in vivo absorption Int. J. Pharm. 418 2011 130 141
28. G. Frenning, A. Tunon, and G. Alderborn Modelling of drug release from coated granular pellets J. Control. Release 92 2003 113 123
29. G. Frenning, U. Brohede, and M. Stromme Finite element analysis of the release of slowly dissolving drugs from cylindrical matrix systems J. Control. Release 107 2005 320 329
30. J. Siepmann, and N.A. Peppas Higuchi equation: Derivation, applications, use and misuse Int. J. Pharm. 418 2011 6 12
31. J. Siepmann, and F. Siepmann Mathematical modeling of drug release from lipid dosage forms Int. J. Pharm. 418 2011 42 53
32. J. Siepmann and F. Siepmann, Modeling of diffusion controlled drug delivery, J. Controlled Release, in press, doi: 10.1016./j.jconrel.2011.10.006.
33. F. Siepmann, S. Herrmann, G. Winter, and J. Siepmann A novel mathematical model quantifying drug release from lipid implants J. Control. Release 128 2008 233 240
34. C.-H. Lee, P.P. Bhatt, and Y.W. Chien Effect of excipient on drug release and permeation from silicone-based barrier devices J. Control. Release 43 1997 283 290
35. F. Lecomte, J. Siepmann, M. Walther, R.J. MacRae, and R. Bodmeier Polymer blends used for the aqueous coating of solid dosage forms: importance of the type of plasticizer J. Control. Release 99 2004 1 13
36. M. Igarashi, K. Ohashi, and M. Ishii Morphometric comparison of endolymphatic and perilymphatic spaces in human temporal bones Acta OtoLaryngol. 101 1986 161 164
37. A.N. Salt, and S.K. Plontke Principles of local drug delivery to the inner ear Audiol. Neurootol. 14 2009 350 360
38. S.K. Plontke, and A.N. Salt Quantitative interpretation of corticosteroid pharmacokinetics in inner ear fluids using computer simulations Hear. Res. 182 2003 34 42
39. S.K. Plontke, N. Siedow, H. Hahn, R. Wegener, H.P. Zenner, and A.N. Salt 1D-and 3D-computer simulation for planning and interpretation of pharmacokinetic studies in the inner ear after round window drug delivery ALTEX 21 Suppl. 3 2004 77 85
40. S.K. Plontke, N. Siedow, R. Wegener, H.-P. Zenner, and A.N. Salt Cochlear pharmacokinetics with local inner ear drug delivery using a 3D finite element computer model Audiol. Neurootol. 12 2007 37 48
41. K. Malcolm, D. Woolfson, J. Russell, P. Tallon, L. McAuley, and D. Craig Influence of silicone elastomer solubility and diffusivity on the in vitro release of drugs from intravaginal rings J. Control. Release 90 2003 217 225
42. R.K. Malcolm, S. McCullagh, A. David Woolfson, M. Catney, and P. Tallon A dynamic mechanical method for determining the silicone elastomer solubility of drugs and pharmaceutical excipients in silicone intravaginal drug delivery rings Biomaterials 23 2002 3589 3594
43. J. Crank The Mathematics of Diffusion 2nd Ed 1975 Clarendon Press Oxford 1 7
44. J.M. Vergnaud Controlled Drug Release of Oral Dosage Forms 1993 Ellis Horwood Chichester