Cochlear pharmacokinetics with local inner ear drug delivery using a three-dimensional finite-element computer model

Audiology and Neurotology

Volumn 12, Issue 1, 2007, Pages 37-48

  Plontke, Stefan K ^a   Siedow, Norbert ^b   Wegener, Raimund ^b   Zenner, Hans Peter ^a   Salt, Alec N ^c  

^a UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

^b FRAUNHOFER INSTITUTE FOR INDUSTRIAL MATHEMATICS ITWM   (Germany)

^c WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Computer simulations; Drug delivery; Inner ear; Intratympanic; Modeling; Pharmacokinetics

Indexed keywords

METHYLPREDNISOLONE SODIUM SUCCINATE;

ANALYTICAL PARAMETERS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; COCHLEA; COCHLEA FENESTRA; COMPUTER MODEL; COMPUTER SIMULATION; CONCENTRATION PROCESS; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG DIFFUSION; DRUG DISTRIBUTION; ENDOLYMPH; FINITE ELEMENT ANALYSIS; GEOMETRY; GUINEA PIG; INNER EAR DISEASE; INTERMETHOD COMPARISON; NONHUMAN; PHARMACOKINETICS; PRIORITY JOURNAL; THREE DIMENSIONAL IMAGING;

EID: 33845713390     PISSN: 14203030     EISSN: 14219700     Source Type: Journal    
DOI: 10.1159/000097246     Document Type: Article

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