A novel mathematical model quantifying drug release from lipid implants

Journal of Controlled Release

Volumn 128, Issue 3, 2008, Pages 233-240

  Siepmann, F ^a   Herrmann, S ^b   Winter, G ^b   Siepmann, J ^a  

^a UNIV LILLE   (France)

^b UNIVERSITY OF MUNICH   (Germany)

Author keywords

Diffusion; Drug release mechanism; Implant; Mathematical modeling; Protein

Indexed keywords

DIFFUSION; IMPLANTS (SURGICAL); LIPIDS; MATHEMATICAL MODELS; PARAMETER ESTIMATION; PROTEINS;

DRUG RELEASE MECHANISM; DRUG STABILIZERS; LIPID IMPLANTS;

DRUG PRODUCTS;

EXCIPIENT; GAMMA INTERFERON; MACROGOL; TRISTEARIN;

ARTICLE; CONTROLLED DRUG RELEASE; DIFFUSION COEFFICIENT; IMPLANT; LEACHING; MATHEMATICAL MODEL; MATHEMATICS; PRECIPITATION; PRIORITY JOURNAL; SOLUBILITY; TIMED DRUG RELEASE;

BETA-CYCLODEXTRINS; DIFFUSION; DRUG IMPLANTS; EXCIPIENTS; INTERFERON-ALPHA; KINETICS; MODELS, CHEMICAL; POLYETHYLENE GLYCOLS; REPRODUCIBILITY OF RESULTS; SOLUBILITY; TECHNOLOGY, PHARMACEUTICAL; TRIGLYCERIDES; WATER;

EID: 44649126048     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2008.03.009     Document Type: Article

References (26)

1. Setter S.M., Levien T.L., Iltz J.L., Odegard P.S., Neumiller J.J., Baker D.E., and Campbell R.K. Inhaled dry powder insulin for the treatment of diabetes mellitus. Clin. Ther. 29 (2007) 795-813
2. Ravivarapu H.B., Burton K., and DeLuca P.P. Polymer and microsphere blending to alter the release of a peptide from PLGA microspheres. Eur. J. Pharm. Biopharm. 50 (2000) 263-270
3. Clavreul A., Sindji L., Aubert-Pouessel A., Benoit J.P., Menei P., and Montero-Menei C.N. Effect of GDNF-releasing biodegradable microspheres on the function and the survival of intrastriatal fetal ventral mesencephalic cell grafts. Eur. J. Pharm. Biopharm. 63 (2006) 221-228
4. Brunner A., Maeder K., and Goepferich A. PH and osmotic pressure inside biodegradable microspheres during erosion. Pharm. Res. 16 (1999) 847-853
5. Li L., and Schwendeman S.P. Mapping neutral microclimate pH in PLGA microspheres. J. Control. Release 101 (2005) 163-173
6. Lucke A., and Goepferich A. Acylation of peptides by lactic acid solutions. Eur. J. Pharm. Biopharm. 55 (2003) 27-33
7. Na D.H., Youn Y.S., Lee S.D., Son M.W., Kim W.B., DeLuca P.P., and Lee K.C. Monitoring of peptide acylation inside degrading PLGA microspheres by capillary electrophoresis and MALDI-TOF mass spectrometry. J. Control. Release 92 (2003) 291-299
8. Wang P.Y. Lipids as excipient in sustained release insulin implants. Int. J. Pharm. 54 (1989) 223-230
9. Mohl S., and Winter G. Continuous release of rh-interferon α-2a from triglyceride matrices. J. Control. Release 97 (2004) 67-78
10. Ho E.A., Vassileva V., Allen C., and Piquette-Miller M. In vitro and in vivo characterization of a novel biocompatible polymer-lipid implant system for the sustained delivery of paclitaxel. J. Control. Release 104 (2005) 181-191
11. Koennings S., Garcion E., Faisant N., Menei P., Benoit J.P., and Goepferich A. In vitro investigation of lipid implants as a controlled release system for interleukin-18. Int. J. Pharm. 314 (2006) 145-152
12. Opdebeeck J.P., and Tucker I.G. A cholesterol implant used as a delivery system to immunize mice with bovine serum albumin. J. Control. Release 23 (1993) 271-279
13. Yamagata Y., Iga K., and Ogawa Y. Novel sustained-release dosage forms of proteins using polyglycerol esters of fatty acids. J. Control. Release 63 (2000) 319-329
14. Guse C., Koennings S., Maschke A., Hacker M., Becker C., Schreiner S., Blunk T., Spruss T., and Goepferich A. Biocompatibility and erosion behavior of implants made of triglycerides and blends with cholesterol and phospholipids. Int. J. Pharm. 314 (2006) 153-160
15. Walduck A.K., Opdebeeck J.P., Benson H.E., and Prankerd R. Biodegradable implants for the delivery of veterinary vaccines: design, manufacture and antibody responses in sheep. J. Control. Release 51 (1998) 269-280
16. Wang P.Y. Prolonged release of insulin by cholesterol-matrix implant. Diabetes 36 (1987) 1068-1072
17. Wang P.Y. Palmitic acid as an excipient in implants for sustained release of insulin. Biomaterials 12 (1991) 57-62
18. Guse C., Koennings S., Kreye F., Siepmann F., Goepferich A., and Siepmann J. Drug release from lipid-based implants: elucidation of the underlying mass transport mechanisms. Int. J. Pharm. 314 (2006) 137-144
19. Herrmann S., Winter G., Mohl S., Siepmann F., and Siepmann J. Mechanisms controlling protein release from lipidic implants: effects of PEG addition. J. Control. Release 118 (2007) 161-168
20. Herrmann S., Mohl S., Siepmann F., Siepmann J., and Winter G. New insight into the role of polyethylene glycol acting as protein release modifier in lipidic implants. Pharm. Res. 24 (2007) 1527-1537
21. Nag A., Mitra G., and Ghosh P.C. A colorimetric assay for estimation of polyethylene glycol and polyethylene glycolated protein using ammonium ferrothiocyanate. Anal. Biochem. 237 (1996) 224-231
22. Basappa C., Pramila R., Narasimha D., and Divakar S.A. A modified colorimetric method for the estimation of b-cyclodextrin using phenolphthalein. Int. J. Food Sci. Technol. 33 (1998) 517-520
23. In: Crank J. (Ed). The Mathematics of Diffusion. 2nd ed. (1975), Clarendon Press, Oxford
24. In: Vergnaud J.M. (Ed). Liquid Transport Processes in Polymeric Materials (1991), Prentice-Hall, Englewood Cliffs
25. In: Vergnaud J.M. (Ed). Controlled Drug Release of Oral Dosage Forms (1993), Ellis Horwood, Chichester
26. In: Smith G.D. (Ed). Numerical Solution of Partial Differential Equations: Finite Difference Methods (1985), Clarendon Press, Oxford