Round window delivery of dexamethasone ameliorates local and remote hearing loss produced by cochlear implantation into the second turn of the guinea pig cochlea

Hearing Research

Volumn 265, Issue 1-2, 2010, Pages 25-29

  Eastwood, Hayden ^a   Chang, Andrew ^a,b   Kel, Gordana ^a   Sly, David ^a   Richardson, Rachael ^a,c   O'Leary, Stephen J ^a,b,c  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b ROYAL VICTORIAN EYE AND EAR HOSPITAL   (Australia)

^c BIONIC EAR INSTITUTE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

DEXAMETHASONE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUDITORY THRESHOLD; BRAIN DEPTH RECORDING; BREATHING RATE; COCHLEA PROSTHESIS; CONTROLLED STUDY; EAR SURGERY; EVOKED BRAIN STEM AUDITORY RESPONSE; GUINEA PIG; HEARING LOSS; HEARING TEST; HISTOPATHOLOGY; NONHUMAN; PRIORITY JOURNAL;

ACOUSTIC STIMULATION; ANIMALS; AUDITORY THRESHOLD; COCHLEAR IMPLANTATION; DEXAMETHASONE; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; EVOKED POTENTIALS, AUDITORY, BRAIN STEM; GLUCOCORTICOIDS; GUINEA PIGS; HEARING LOSS; ROUND WINDOW, EAR; TIME FACTORS;

EID: 77952884927     PISSN: 03785955     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.heares.2010.03.006     Document Type: Article

References (20)

1. Chang A., Eastwood H., Sly D., James D., Richardson R., O'Leary S. Factors influencing the efficacy of round window dexamethasone protection of residual hearing post-cochlear implant surgery. Hear. Res. 2009, 255:67-72.
2. Duan M., Bjelke B., Fridberger A., Counter S.A., Klason T., Skjonsberg A., Herrlin P., Borg E., Laurell G. Imaging of the guinea pig cochlea following round window gadolinium application. Neuroreport 2004, 15:1927-1930.
3. Eshraghi A.A., Adil E., He J., Graves R., Balkany T.J., Van De Water T.R. Local dexamethasone therapy conserves hearing in an animal model of electrode insertion trauma-induced hearing loss. Otol. Neurotol. 2007, 28:842-849.
4. Gantz B.J., Turner C., Gfeller K.E., Lowder M.W. Preservation of hearing in cochlear implant surgery: advantages of combined electrical and acoustical speech processing. Laryngoscope 2005, 115:796-802.
5. Greenwood D.D. Comparing octaves, frequency ranges, and cochlear-map curvature across species. Hear. Res. 1996, 94:157-162.
6. Gstoettner W.K., Helbig S., Maier N., Kiefer J., Radeloff A., Adunka O.F. Ipsilateral electric acoustic stimulation of the auditory system: results of long-term hearing preservation. Audiol. Neurootol. 2006, 11(Suppl. 1):49-56.
7. Gstoettner W.K., Van De Heyning P., O'Connor A.F., Morera C., Sainz M., Vermeire K., McDonald S., Cavalle L., Helbig S., Valdecasas J.G., Anderson I., Adunka O.F. Electric acoustic stimulation of the auditory system: results of a multi-centre investigation. Acta Otolaryngol. 2008, 1-8.
8. Hargunani C.A., Kempton J.B., DeGagne J.M., Trune D.R. Intratympanic injection of dexamethasone: time course of inner ear distribution and conversion to its active form. Otol. Neurotol. 2006, 27:564-569.
9. James D.P., Eastwood H., Richardson R.T., O'Leary S.J. Effects of round window dexamethasone on residual hearing in a Guinea pig model of cochlear implantation. Audiol. Neurootol. 2008, 13:86-96.
10. Jolly C., Garnham C., Mirzadeh H., Truy E., Martini A., Kiefer J., Braun S. Electrode features for hearing preservation and drug delivery strategies. Adv. Otorhinolaryngol. 2010, 67:28-42.
11. Maini S., Lisnichuk H., Eastwood H., Pinder D., James D., Richardson R.T., Chang A., Connolly T., Sly D., Kel G., O'Leary S.J. Targeted therapy of the inner ear. Audiol. Neurootol. 2009, 14:402-410.
12. Mikulec A.A., Plontke S.K., Hartsock J.J., Salt A.N. Entry of substances into perilymph through the bone of the otic capsule after intratympanic applications in guinea pigs: implications for local drug delivery in humans. Otol. Neurotol. 2009, 30:131-138.
13. Palmer A.R., Shackleton T.M. Variation in the phase of response to low-frequency pure tones in the guinea pig auditory nerve as functions of stimulus level and frequency. J. Assoc. Res. Otolaryngol. 2009, 10:233-250.
14. Salt A.N. Simulation of methods for drug delivery to the cochlear fluids. Adv. Otorhinolaryngol. 2002, 59:140-148.
15. Salt A.N., Plontke S.K. Local inner-ear drug delivery and pharmacokinetics. Drug Discov. Today 2005, 10:1299-1306.
16. Salt A.N., Plontke S.K. Principles of local drug delivery to the inner ear. Audiol. Neurootol. 2009, 14:350-360.
17. Salt A.N., Kellner C., Hale S. Contamination of perilymph sampled from the basal cochlear turn with cerebrospinal fluid. Hear. Res. 2003, 182:24-33.
18. Vivero R.J., Joseph D.E., Angeli S., He J., Chen S., Eshraghi A.A., Balkany T.J., Van de Water T.R. Dexamethasone base conserves hearing from electrode trauma-induced hearing loss. Laryngoscope 2008, 118:2028-2035.
19. Woodson E.A., Reiss L.A., Turner C.W., Gfeller K., Gantz B.J. The hybrid cochlear implant: a review. Adv. Otorhinolaryngol. 2010, 67:125-134.
20. Zou J., Pyykko I., Counter S.A., Klason T., Bretlau P., Bjelke B. In vivo observation of dynamic perilymph formation using 4.7T MRI with gadolinium as a tracer. Acta Otolaryngol. 2003, 123:910-915.