Hiding the evidence: Two strategies for innate immune evasion by hemorrhagic fever viruses

Current Opinion in Virology

Volumn 2, Issue 2, 2012, Pages 151-156

  Hastie, Kathryn M ^a   Bale, Shridhar ^a   Kimberlin, Christopher R ^a,b   Saphire, Erica Ollmann ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DOUBLE STRANDED RNA; NONSTRUCTURAL PROTEIN 1; VIRUS PROTEIN;

ARENAVIRUS; ARTICLE; CRYSTAL STRUCTURE; EBOLA VIRUS; HEMORRHAGIC FEVER; IMMUNE EVASION; IMMUNE RESPONSE; INNATE IMMUNITY; LASSA VIRUS; MOLECULAR RECOGNITION; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; RNA STRUCTURE;

EID: 84859481301     PISSN: 18796257     EISSN: 18796265     Source Type: Journal    
DOI: 10.1016/j.coviro.2012.01.003     Document Type: Review

References (49)

1. M. Yoneyama, M. Kikuchi, T. Natsukawa, N. Shinobu, T. Imaizumi, M. Miyagishi, K. Taira, S. Akira, and T. Fujita The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses Nat Immunol 5 2004 730 737 (Pubitemid 39023305)
2. J. Andrejeva, K.S. Childs, D.F. Young, T.S. Carlos, N. Stock, S. Goodbourn, and R.E. Randall The V proteins of paramyxoviruses bind the IFN-inducible RNA helicase, MDA-5, and inhibit its activation of the IFN-beta promoter Proc Natl Acad Sci U S A 101 2004 17264 17269 (Pubitemid 39627808)
3. C.F. Basler, X. Wang, E. Muhlberger, V. Volchkov, J. Paragas, H.D. Klenk, A. Garcia-Sastre, and P. Palese The Ebola virus VP35 protein functions as a type I IFN antagonist Proc Natl Acad Sci U S A 97 2000 12289 12294
4. L. Martinez-Sobrido, P. Giannakas, B. Cubitt, A. Garcia-Sastre, and J.C. de la Torre Differential inhibition of type I interferon induction by Arenavirus nucleoproteins J Virol 81 2007 12696 12703 (Pubitemid 350085885)
5. L. Martinez-Sobrido, E.I. Zuniga, D. Rosario, A. Garcia-Sastre, and J.C. de la Torre Inhibition of the type I interferon response by the nucleoprotein of the prototypic arenavirus lymphocytic choriomeningitis virus J Virol 80 2006 9192 9199 (Pubitemid 44359991)
6. S. Baize, E.M. Leroy, M.C. Georges-Courbot, M. Capron, J. Lansoud-Soukate, P. Debre, S.P. Fisher-Hoch, J.B. McCormick, and A.J. Georges Defective humoral responses and extensive intravascular apoptosis are associated with fatal outcome in Ebola virus-infected patients Nat Med 5 1999 423 426 (Pubitemid 29180581)
7. L.M. Branco, M.L. Boisen, K.G. Andersen, J.N. Grove, L.M. Moses, I.J. Muncy, L.A. Henderson, J.S. Schieffellin, J.E. Robinson, J.J. Bangura, and D.S. Grant Lassa hemorrhagic fever in a late term pregnancy from northern Sierra Leone with a positive maternal outcome: case report Virol J 8 2011 404
8. J.N. Grove, L.M. Branco, M.L. Boisen, I.J. Muncy, L.A. Henderson, J.S. Schieffellin, J.E. Robinson, J.J. Bangura, M. Fonnie, R.J. Schoepp, and L.E. Hensley Capacity building permitting comprehensive monitoring of a severe case of Lassa hemorrhagic fever in Sierra Leone with a positive outcome: case report Virol J 8 2011 314
9. A. Sanchez, M. Lukwiya, D. Bausch, S. Mahanty, A.J. Sanchez, K.D. Wagoner, and P.E. Rollin Analysis of human peripheral blood samples from fatal and nonfatal cases of Ebola (Sudan) hemorrhagic fever: cellular responses, virus load, and nitric oxide levels J Virol 78 2004 10370 10377 (Pubitemid 39258362)
10. H. Schmitz, B. Kohler, T. Laue, C. Drosten, and P.J. Veldkamp Monitoring of clinical and laboratory data in two cases of imported Lassa fever Microbes Infect 4 2002 43 50 (Pubitemid 34127990)
11. J.S. Towner, P.E. Rollin, D.G. Bausch, A. Sanchez, S.M. Crary, M. Vincent, W.F. Lee, C.F. Spiropoulou, T.G. Ksiazek, M. Lukwiya, and F. Kaducu Rapid diagnosis of Ebola hemorrhagic fever by reverse transcription-PCR in an outbreak setting and assessment of patient viral load as a predictor of outcome J Virol 78 2004 4330 4341 (Pubitemid 38437236)
12. B.H. Harcourt, A. Sanchez, and M.K. Offermann Ebola virus inhibits induction of genes by double-stranded RNA in endothelial cells Virology 252 1998 179 188 (Pubitemid 28564143)
13. B.H. Harcourt, A. Sanchez, and M.K. Offermann Ebola virus selectively inhibits responses to interferons, but not to interleukin-1beta, in endothelial cells J Virol 73 1999 3491 3496 (Pubitemid 29135747)
14. A. Sanchez, and T.W. Geisbert Filoviridae Marburg and Ebola Viruses 2007 Lippincott-Raven Philadelphia
15. J.S. Towner, T.K. Sealy, M.L. Khristova, C.G. Albarino, S. Conlan, S.A. Reeder, P.L. Quan, W.I. Lipkin, R. Downing, J.W. Tappero, and S. Okware Newly discovered Ebola virus associated with hemorrhagic fever outbreak in Uganda PLoS Pathog 4 2008 e1000212
16. C.F. Basler, A. Mikulasova, L. Martinez-Sobrido, J. Paragas, E. Muhlberger, M. Bray, H.D. Klenk, P. Palese, and A. Garcia-Sastre The Ebola virus VP35 protein inhibits activation of interferon regulatory factor 3 J Virol 77 2003 7945 7956 (Pubitemid 36792791)
17. Z. Feng, M. Cerveny, Z. Yan, and B. He The VP35 protein of Ebola virus inhibits the antiviral effect mediated by double-stranded RNA-dependent protein kinase PKR J Virol 81 2007 182 192 (Pubitemid 44975159)
18. M. Schumann, T. Gantke, and E. Muhlberger Ebola virus VP35 antagonizes PKR activity through its c-terminal interferon inhibitory domain J Virol 83 2009 8993 8997
19. J. Haasnoot, W. de Vries, E.J. Geutjes, M. Prins, P. de Haan, and B. Berkhout The Ebola virus VP35 protein is a suppressor of RNA silencing PLoS Pathog 3 2007 e86
20. W.B. Cardenas, Y.M. Loo, M. Gale Jr., A.L. Hartman, C.R. Kimberlin, L. Martinez-Sobrido, E.O. Saphire, and C.F. Basler Ebola virus VP35 protein binds double-stranded RNA and inhibits alpha/beta interferon production induced by RIG-I signaling J Virol 80 2006 5168 5178
21. A.L. Hartman, J.S. Towner, and S.T. Nichol A C-terminal basic amino acid motif of Zaire Ebolavirus VP35 is essential for type I interferon antagonism and displays high identity with the RNA-binding domain of another interferon antagonist, the ns1 protein of influenza a virus Virology 328 2004 177 184 (Pubitemid 39349467)
22. D.W. Leung, N.D. Ginder, D.B. Fulton, J. Nix, C.F. Basler, R.B. Honzatko, and G.K. Amarasinghe Structure of the Ebola VP35 interferon inhibitory domain Proc Natl Acad Sci U S A 106 2009 411 416
23. D.W. Leung, K.C. Prins, D.M. Borek, M. Farahbakhsh, J.M. Tufariello, P. Ramanan, J.C. Nix, L.A. Helgeson, Z. Otwinowski, R.B. Honzatko, and C.F. Basler Structural basis for dsRNA recognition and interferon antagonism by Ebola VP35 Nat Struct Mol Biol 17 2010 165 172
24. C.R. Kimberlin, Z.A. Bornholdt, S. Li, V.L. Woods Jr., I.J. MacRae, and E.O. Saphire Ebolavirus VP35 uses a bimodal strategy to bind dsRNA for innate immune suppression Proc Natl Acad Sci U S A 107 2010 314 319
25. D.W. Leung, R.S. Shabman, M. Farahbakhsh, K.C. Prins, D.M. Borek, T. Wang, E. Muhlberger, C.F. Basler, and G.K. Amarasinghe Structural and functional characterization of Reston Ebola virus VP35 interferon inhibitory domain J Mol Biol 399 2010 347 357
26. A.L. Hartman, J.E. Dover, J.S. Towner, and S.T. Nichol Reverse genetic generation of recombinant Zaire Ebola viruses containing disrupted IRF-3 inhibitory domains results in attenuated virus growth in vitro and higher levels of IRF-3 activation without inhibiting viral transcription or replication J Virol 80 2006 6430 6440 (Pubitemid 43927446)
27. D. Luo, S.C. Ding, A. Vela, A. Kohlway, B.D. Lindenbach, and A.M. Pyle Structural insights into RNA recognition by RIG-I Cell 147 2011 409 422
28. F. Jiang, A. Ramanathan, M.T. Miller, G.Q. Tang, M. Gale Jr., S.S. Patel, and J. Marcotrigiano Structural basis of RNA recognition and activation by innate immune receptor RIG-I Nature 479 2011 423 427
29. C. Lu, C.T. Ranjith-Kumar, L. Hao, C.C. Kao, and P. Li Crystal structure of Rig-I C-terminal domain bound to blunt-ended double-strand RNA without 5′ triphosphate Nucleic Acids Res 39 2011 1565 1575
30. C. Lu, H. Xu, C.T. Ranjith-Kumar, M.T. Brooks, T.Y. Hou, F. Hu, A.B. Herr, R.K. Strong, C.C. Kao, and P. Li The structural basis of 5′ triphosphate double-stranded RNA recognition by RIG-I C-terminal domain Structure 18 2010 1032 1043
31. Z.A. Bornholdt, and B.V. Prasad X-ray structure of NS1 from a highly pathogenic H5N1 influenza virus Nature 456 2008 985 988
32. A. Cheng, S.M. Wong, and Y.A. Yuan Structural basis for dsRNA recognition by NS1 protein of influenza a virus Cell Res 19 2009 187 195
33. S. Baize, P. Marianneau, P. Loth, S. Reynard, A. Journeaux, M. Chevallier, N. Tordo, V. Deubel, and H. Contamin Early and strong immune responses are associated with control of viral replication and recovery in Lassa virus-infected cynomolgus monkeys J Virol 83 2009 5890 5903
34. R. Carrion Jr., K. Brasky, K. Mansfield, C. Johnson, M. Gonzales, A. Ticer, I. Lukashevich, S. Tardif, and J. Patterson Lassa virus infection in experimentally infected marmosets: liver pathology and immunophenotypic alterations in target tissues J Virol 81 2007 6482 6490 (Pubitemid 46878053)
35. M.M. Djavani, O.R. Crasta, J.C. Zapata, Z. Fei, O. Folkerts, B. Sobral, M. Swindells, J. Bryant, H. Davis, C.D. Pauza, and I.S. Lukashevich Early blood profiles of virus infection in a monkey model for Lassa fever J Virol 81 2007 7960 7973 (Pubitemid 47101481)
36. S.P. Fisher-Hoch, S.W. Mitchell, D.R. Sasso, J.V. Lange, R. Ramsey, and J.B. McCormick Physiological and immunologic disturbances associated with shock in a primate model of Lassa fever J Infect Dis 155 1987 465 474 (Pubitemid 17032803)
37. D.H. Walker, J.B. McCormick, K.M. Johnson, P.A. Webb, G. Komba-Kono, L.H. Elliott, and J.J. Gardner Pathologic and virologic study of fatal Lassa fever in man Am J Pathol 107 1982 349 356 (Pubitemid 12084836)
38. K.M. Johnson, J.B. McCormick, P.A. Webb, E.S. Smith, L.H. Elliott, and I.J. King Clinical virology of Lassa fever in hospitalized patients J Infect Dis 155 1987 456 464 (Pubitemid 17032802)
39. L. Martinez-Sobrido, S. Emonet, P. Giannakas, B. Cubitt, A. Garcia-Sastre, and J.C. de la Torre Identification of amino acid residues critical for the anti-interferon activity of the nucleoprotein of the prototypic arenavirus lymphocytic choriomeningitis virus J Virol 83 2009 11330 11340
40. K.M. Hastie, C.R. Kimberlin, M.A. Zandonatti, I.J. MacRae, and E.O. Saphire Structure of the Lassa virus nucleoprotein reveals a dsRNA-specific 3′ to 5′ exonuclease activity essential for immune suppression Proc Natl Acad Sci U S A 108 2011 2396 2401
41. X. Qi, S. Lan, W. Wang, L.M. Schelde, H. Dong, G.D. Wallat, H. Ly, Y. Liang, and C. Dong Cap binding and immune evasion revealed by Lassa nucleoprotein structure Nature 468 2010 779 783
42. Y. Zuo, and M.P. Deutscher Exoribonuclease superfamilies: structural analysis and phylogenetic distribution Nucleic Acids Res 29 2001 1017 1026 (Pubitemid 32186186)
43. T. Horio, M. Murai, T. Inoue, T. Hamasaki, T. Tanaka, and T. Ohgi Crystal structure of human ISG20, an interferon-induced antiviral ribonuclease FEBS Lett 577 2004 111 116 (Pubitemid 39452369)
44. S. Hamdan, P.D. Carr, S.E. Brown, D.L. Ollis, and N.E. Dixon Structural basis for proofreading during replication of the Escherichia coli chromosome Structure 10 2002 535 546 (Pubitemid 34304232)
45. D.C. Baulcombe, and A. Molnar Crystal structure of P19 - a universal suppressor of RNA silencing Trends Biochem Sci 29 2004 279 281 (Pubitemid 38968756)
46. J.A. Chao, J.H. Lee, B.R. Chapados, E.W. Debler, A. Schneemann, and J.R. Williamson Dual modes of RNA-silencing suppression by flock house virus protein B2 Nat Struct Mol Biol 12 2005 952 957
47. E. Minskaia, T. Hertzig, A.E. Gorbalenya, V. Campanacci, C. Cambillau, B. Canard, and J. Ziebuhr Discovery of an RNA virus 3′→5′ exoribonuclease that is critically involved in coronavirus RNA synthesis Proc Natl Acad Sci U S A 103 2006 5108 5113
48. L.D. Eckerle, M.M. Becker, R.A. Halpin, K. Li, E. Venter, X. Lu, S. Scherbakova, R.L. Graham, R.S. Baric, T.B. Stockwell, and D.J. Spiro Infidelity of SARS-COV NSP14-exonuclease mutant virus replication is revealed by complete genome sequencing PLoS Pathog 6 2010 e1000896
49. N.A. Baker, D. Sept, S. Joseph, M.J. Holst, and J.A. McCammon Electrostatics of nanosystems: application to microtubules and the ribosome Proc Natl Acad Sci U S A 98 2001 10037 10041 (Pubitemid 32802969)