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Volumn 5, Issue 3, 2012, Pages 351-354

Metformin and cancer stem cells: Old drug, new targets

Author keywords

[No Author keywords available]

Indexed keywords

(1 BUTYLAMINO 3 METHYLBUTYL)(1 PYRROLIDINYL) KETONE; DOXORUBICIN; ERLOTINIB; GEMCITABINE; MAMMALIAN TARGET OF RAPAMYCIN; METFORMIN; RAPAMYCIN;

EID: 84859461497     PISSN: 19406207     EISSN: 19406215     Source Type: Journal    
DOI: 10.1158/1940-6207.CAPR-12-0026     Document Type: Review
Times cited : (52)

References (33)
  • 2
    • 52549087785 scopus 로고    scopus 로고
    • Cancer stem cells in solid tumours: Accumulating evidence and unresolved questions
    • Visvader JE, Lindeman GJ. Cancer stem cells in solid tumours: accumulating evidence and unresolved questions. Nat Rev Cancer 2008; 8:755-68.
    • (2008) Nat Rev Cancer , vol.8 , pp. 755-768
    • Visvader, J.E.1    Lindeman, G.J.2
  • 4
    • 34548455927 scopus 로고    scopus 로고
    • Distinct Populations of Cancer Stem Cells Determine Tumor Growth and Metastatic Activity in Human Pancreatic Cancer
    • DOI 10.1016/j.stem.2007.06.002, PII S1934590907000665
    • Hermann PC, Huber SL, Herrler T, Aicher A, Ellwart JW, Guba M, et al. Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer. Cell Stem Cell 2007;1:313-23. (Pubitemid 47355323)
    • (2007) Cell Stem Cell , vol.1 , Issue.3 , pp. 313-323
    • Hermann, P.C.1    Huber, S.L.2    Herrler, T.3    Aicher, A.4    Ellwart, J.W.5    Guba, M.6    Bruns, C.J.7    Heeschen, C.8
  • 6
    • 77749292153 scopus 로고    scopus 로고
    • Prognostic significance of tumorigenic cells with mesenchymal features in pancreatic adenocarcinoma
    • Rasheed ZA, Yang J, Wang Q, Kowalski J, Freed I, Murter C, et al. Prognostic significance of tumorigenic cells with mesenchymal features in pancreatic adenocarcinoma. J Natl Cancer Inst 2010;102: 340-51.
    • (2010) J Natl Cancer Inst , vol.102 , pp. 340-351
    • Rasheed, Z.A.1    Yang, J.2    Wang, Q.3    Kowalski, J.4    Freed, I.5    Murter, C.6
  • 7
    • 33845317573 scopus 로고    scopus 로고
    • Glioma stem cells promote radioresistance by preferential activation of the DNA damage response
    • DOI 10.1038/nature05236, PII NATURE05236
    • Bao S, Wu Q, McLendon RE, Hao Y, Shi Q, Hjelmeland AB, et al. Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature 2006;444:756-60. (Pubitemid 44949604)
    • (2006) Nature , vol.444 , Issue.7120 , pp. 756-760
    • Bao, S.1    Wu, Q.2    McLendon, R.E.3    Hao, Y.4    Shi, Q.5    Hjelmeland, A.B.6    Dewhirst, M.W.7    Bigner, D.D.8    Rich, J.N.9
  • 8
    • 49149107236 scopus 로고    scopus 로고
    • Colorectal cancer stem cells are enriched in xenogeneic tumors following chemotherapy
    • Dylla SJ, Beviglia L, Park IK, Chartier C, Raval J, Ngan L, et al. Colorectal cancer stem cells are enriched in xenogeneic tumors following chemotherapy. PLoS One 2008;3:e2428.
    • (2008) PLoS One , vol.3
    • Dylla, S.J.1    Beviglia, L.2    Park, I.K.3    Chartier, C.4    Raval, J.5    Ngan, L.6
  • 11
    • 33745307617 scopus 로고    scopus 로고
    • Ras, PI(3)K and mTOR signalling controls tumour cell growth
    • DOI 10.1038/nature04869, PII NATURE04869
    • Shaw RJ, Cantley LC. Ras, PI(3)K and mTOR signalling controls tumour cell growth. Nature 2006;441:424-30. (Pubitemid 44050136)
    • (2006) Nature , vol.441 , Issue.7092 , pp. 424-430
    • Shaw, R.J.1    Cantley, L.C.2
  • 12
    • 28844433635 scopus 로고    scopus 로고
    • Medicine: The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin
    • DOI 10.1126/science.1120781
    • Shaw RJ, Lamia KA, Vasquez D, Koo SH, Bardeesy N, Depinho RA, et al. The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin. Science 2005;310:1642-6. (Pubitemid 41780780)
    • (2005) Science , vol.310 , Issue.5754 , pp. 1642-1646
    • Shaw, R.J.1    Lamia, K.A.2    Vasquez, D.3    Koo, S.-H.4    Bardeesy, N.5    DePinho, R.A.6    Montminy, M.7    Cantley, L.C.8
  • 15
    • 33646376411 scopus 로고    scopus 로고
    • Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells
    • DOI 10.1038/nature04703, PII NATURE04703
    • Yilmaz OH, Valdez R, Theisen BK, Guo W, Ferguson DO, Wu H, et al. Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells. Nature 2006;441:475-82. (Pubitemid 44050144)
    • (2006) Nature , vol.441 , Issue.7092 , pp. 475-482
    • Yilmaz, O.H.1    Valdez, R.2    Theisen, B.K.3    Guo, W.4    Ferguson, D.O.5    Wu, H.6    Morrison, S.J.7
  • 17
    • 77956401999 scopus 로고    scopus 로고
    • Metformin and other biguanides in oncology: Advancing the research agenda
    • Pollak M. Metformin and other biguanides in oncology: advancing the research agenda. Cancer Prev Res 2010;3:1060-5.
    • (2010) Cancer Prev Res , vol.3 , pp. 1060-1065
    • Pollak, M.1
  • 18
    • 77956414137 scopus 로고    scopus 로고
    • Chemoprevention meets glucose control
    • Engelman JA, Cantley LC. Chemoprevention meets glucose control. Cancer Prev Res 2010;3:1049-52.
    • (2010) Cancer Prev Res , vol.3 , pp. 1049-1052
    • Engelman, J.A.1    Cantley, L.C.2
  • 21
  • 23
    • 36348950449 scopus 로고    scopus 로고
    • Metformin inhibits mammalian target of rapamycin-dependent translation initiation in breast cancer cells
    • DOI 10.1158/0008-5472.CAN-07-2310
    • Dowling RJ, Zakikhani M, Fantus IG, Pollak M, Sonenberg N. Metformin inhibits mammalian target of rapamycin-dependent translation initiation in breast cancer cells. Cancer Res 2007;67:10804-12. (Pubitemid 350145909)
    • (2007) Cancer Research , vol.67 , Issue.22 , pp. 10804-10812
    • Dowling, R.J.O.1    Zakikhani, M.2    Fantus, I.G.3    Pollak, M.4    Sonenberg, N.5
  • 24
    • 33751284806 scopus 로고    scopus 로고
    • Metformin is an AMP kinase-dependent growth inhibitor for breast cancer cells
    • DOI 10.1158/0008-5472.CAN-06-1500
    • Zakikhani M, Dowling R, Fantus IG, Sonenberg N, Pollak M. Metformin is an AMP kinase-dependent growth inhibitor for breast cancer cells. Cancer Res 2006;66:10269-73. (Pubitemid 44799743)
    • (2006) Cancer Research , vol.66 , Issue.21 , pp. 10269-10273
    • Zakikhani, M.1    Dowling, R.2    Fantus, I.G.3    Sonenberg, N.4    Pollak, M.5
  • 25
    • 70350236538 scopus 로고    scopus 로고
    • Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission
    • Hirsch HA, Iliopoulos D, Tsichlis PN, Struhl K. Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission. Cancer Res 2009;69: 7507-11.
    • (2009) Cancer Res , vol.69 , pp. 7507-7511
    • Hirsch, H.A.1    Iliopoulos, D.2    Tsichlis, P.N.3    Struhl, K.4
  • 26
    • 79955490053 scopus 로고    scopus 로고
    • Metformin decreases the dose of chemotherapy for prolonging tumor remission in mouse xenografts involving multiple cancer cell types
    • Iliopoulos D, Hirsch HA, Struhl K. Metformin decreases the dose of chemotherapy for prolonging tumor remission in mouse xenografts involving multiple cancer cell types. Cancer Res 2011;71:3196-201.
    • (2011) Cancer Res , vol.71 , pp. 3196-3201
    • Iliopoulos, D.1    Hirsch, H.A.2    Struhl, K.3
  • 27
    • 84859463669 scopus 로고    scopus 로고
    • Metformin inhibits cell proliferation, migration, and invasion by attenuating CSC function mediated by deregulating microRNAs (miRNAs) in pancreatic cancer cells
    • Bao B, Wang Z, Ali S, Ahmad A, Azmi AS, Sarkar SH, et al. Metformin inhibits cell proliferation, migration, and invasion by attenuating CSC function mediated by deregulating microRNAs (miRNAs) in pancreatic cancer cells. Cancer Prev Res 2012;5:361-70.
    • (2012) Cancer Prev Res , vol.5 , pp. 361-370
    • Bao, B.1    Wang, Z.2    Ali, S.3    Ahmad, A.4    Azmi, A.S.5    Sarkar, S.H.6
  • 28
    • 0038143611 scopus 로고    scopus 로고
    • Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells
    • Chambers I, Colby D, Robertson M, Nichols J, Lee S, Tweedie S, et al. Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells. Cell 2003;113:355-64.
    • (2003) Cell , vol.113 , pp. 355-364
    • Chambers, I.1    Colby, D.2    Robertson, M.3    Nichols, J.4    Lee, S.5    Tweedie, S.6
  • 29
    • 0032582513 scopus 로고    scopus 로고
    • Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4
    • DOI 10.1016/S0092-8674(00)81769-9
    • Nichols J, Zevnik B, Anastassiadis K, Niwa H, Klewe-Nebenius D, Chambers I, et al. Formation of pluripotent stemcells in the mammalian embryo depends on the POU transcription factor Oct4. Cell 1998;95: 379-91. (Pubitemid 28507326)
    • (1998) Cell , vol.95 , Issue.3 , pp. 379-391
    • Nichols, J.1    Zevnik, B.2    Anastassiadis, K.3    Niwa, H.4    Klewe-Nebenius, D.5    Chambers, I.6    Scholer, H.7    Smith, A.8
  • 33
    • 73049110243 scopus 로고    scopus 로고
    • The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs
    • Wellner U, Schubert J, Burk UC, Schmalhofer O, Zhu F, Sonntag A, et al. The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs. Nat Cell Biol 2009;11:1487-95.
    • (2009) Nat Cell Biol , vol.11 , pp. 1487-1495
    • Wellner, U.1    Schubert, J.2    Burk, U.C.3    Schmalhofer, O.4    Zhu, F.5    Sonntag, A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.