Tetomilast attenuates elastase-induced pulmonary emphysema through inhibition of oxidative stress in rabbits

Biological and Pharmaceutical Bulletin

Volumn 35, Issue 4, 2012, Pages 494-502

  Baila, Bulin ^a   Ohno, Yasushi ^a   Nagamoto, Hisashi ^c   Kotosai, Kounori ^c   Yabuuchi, Youichi ^c   Funaguchi, Norihiko ^a   Ito, Fumitaka ^a   Endo, Junki ^a   Mori, Hidenori ^a   Takemura, Genzou ^a   Fujiwara, Takako ^b   Fujiwara, Hisayoshi ^a   Minatoguchia, Shinya ^a  

^a GIFU UNIVERSITY   (Japan)

^b KYOTO WOMEN'S UNIVERSITY   (Japan)

^c OTSUKA PHARMACEUTICAL CO LTD   (Japan)

Author keywords

8 hydroxy deoxyguanosine; Chronic obstructive pulmonary disease; Oxidative stress; Tetomilast

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; GLUTATHIONE; KI 67 ANTIGEN; MYELOPEROXIDASE; TETOMILAST;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN EXPRESSION; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CELL COUNT; CELL INFILTRATION; CHRONIC OBSTRUCTIVE LUNG DISEASE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVITY; FORCED EXPIRATORY VOLUME; FORCED VITAL CAPACITY; FUNCTIONAL RESIDUAL CAPACITY; HISTOLOGY; LUNG ALVEOLUS MACROPHAGE; LUNG EMPHYSEMA; LUNG FUNCTION; LUNG PROTECTION; MALE; NONHUMAN; OXIDATIVE STRESS; PROTECTION; RABBIT;

ANIMALS; ANTI-INFLAMMATORY AGENTS; APOPTOSIS; MALE; OXIDATIVE STRESS; PANCREATIC ELASTASE; PNEUMONIA; PULMONARY EMPHYSEMA; RABBITS; THIAZOLES;

EID: 84859453349     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.35.494     Document Type: Article

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