Altered sinoatrial node function and intra-atrial conduction in murine gain-of-function Scn5a +/ΔKPQ hearts suggest an overlap syndrome

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 302, Issue 7, 2012, Pages

  Wu, Jingjing ^a,b   Zhang, Yanmin ^c,e   Zhang, Xinzhao ^b   Cheng, Longxian ^a   Lammers, Wim J ^d   Grace, Andrew A ^c   Fraser, James A ^c   Zhang, Henggui ^b   Huang, Christopher L H ^c   Lei, Ming ^a,b  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^d UNITED ARAB EMIRATES UNIVERSITY   (United Arab Emirates)

^e XI'AN JIAOTONG UNIVERSITY   (China)

Author keywords

subunit; Long QT syndrome type 3; Sinus node dysfunction; Sodium channel; Type V; Voltage gated

Indexed keywords

SODIUM CHANNEL NAV1.5;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATRIOVENTRICULAR CONDUCTION; COMPUTER SIMULATION; CONTROLLED STUDY; ELECTROCARDIOGRAPHY; GAIN OF FUNCTION MUTATION; HEART ATRIOVENTRICULAR NODE; HEART ATRIUM CONDUCTION; HEART ELECTROPHYSIOLOGY; HEART RATE; HEART VENTRICLE CONDUCTION; LONG QT SYNDROME; LOSS OF FUNCTION MUTATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; QT INTERVAL; SINOATRIAL CONDUCTION; SINUS ARREST; SINUS BRADYCARDIA; SINUS NODE; SODIUM CURRENT;

ALGORITHMS; ANESTHESIA; ANESTHETICS, DISSOCIATIVE; ANIMALS; ARRHYTHMIAS, CARDIAC; ATRIOVENTRICULAR NODE; COMPUTER SIMULATION; ELECTROCARDIOGRAPHY; ELECTRODES, IMPLANTED; ELECTROPHYSIOLOGICAL PHENOMENA; ETHANOL; HEART; HEART CONDUCTION SYSTEM; KETAMINE; MEMBRANE POTENTIALS; MICE; MICE, KNOCKOUT; SINOATRIAL NODE; SODIUM CHANNELS;

EID: 84859452762     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00357.2011     Document Type: Article

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