TGF-β1-mediated fibrosis and ion channel remodeling are key mechanisms in producing the sinus node dysfunction associated with SCN5A deficiency and aging

Circulation: Arrhythmia and Electrophysiology

Volumn 4, Issue 3, 2011, Pages 397-406

  Hao, Xiaojin ^a   Zhang, Yanmin ^d   Zhang, Xinzhao ^b   Nirmalan, Mahesh ^a   Davies, Laura ^a   Konstantinou, Dimitrios ^a   Yin, Fei ^a   Dobrzynski, Halina ^a   Wang, Xin ^a,c   Grace, Andrew ^d   Zhang, Henggui ^b   Boyett, Mark ^a   Huang, Christopher L H ^d   Lei, Ming ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b Microsystems Engineering Centre   (United Kingdom)

^c Faculty of Life Sciences   (United Kingdom)

^d UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Aging; Ion channels; Nav1.5 protein; Remodeling; Sinoatrial node

Indexed keywords

COLLAGEN; RECOMBINANT ANTIBODY; SODIUM CHANNEL NAV1.5; SODIUM CHANNEL NAV1.5 E3 ANTIBODY; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG; VIMENTIN; RNA; SODIUM CHANNEL; SODIUM CHANNEL PROTEIN TYPE 5 SUBUNIT ALPHA;

AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHANNEL GATING; COLLAGEN SYNTHESIS; COMPUTER SIMULATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE ASSOCIATION; FIBROBLAST; HEART MUSCLE CELL; HEART MUSCLE FIBROSIS; HEART RATE VARIABILITY; HUMAN; HUMAN CELL; ION CHANNEL REMODELING; MOUSE; NONHUMAN; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR DOWN REGULATION; RECEPTOR UPREGULATION; SINOATRIAL CONDUCTION; SINUS NODE DYSFUNCTION; SODIUM CHANNEL NAV1.5 DEFICIENCY; SODIUM CHANNELOPATHY; ANIMAL; CELL CULTURE; COMPARATIVE STUDY; DISEASE MODEL; GENETICS; HEART; HEART MUSCLE; HEART MUSCLE CONDUCTION SYSTEM; IMMUNOHISTOCHEMISTRY; METABOLISM; MOUSE MUTANT; MUTATION; PATHOLOGY; PATHOPHYSIOLOGY; POLYMERASE CHAIN REACTION; PRENATAL DEVELOPMENT; SICK SINUS SYNDROME; SINUS NODE;

AGING; ANIMALS; CELLS, CULTURED; COMPUTER SIMULATION; DISEASE MODELS, ANIMAL; HEART; HEART CONDUCTION SYSTEM; HUMANS; IMMUNOHISTOCHEMISTRY; ION CHANNEL GATING; MICE; MICE, KNOCKOUT; MUTATION; MYOCARDIUM; MYOCYTES, CARDIAC; POLYMERASE CHAIN REACTION; RNA; SICK SINUS SYNDROME; SINOATRIAL NODE; SODIUM CHANNELS;

EID: 80052317310     PISSN: 19413149     EISSN: 19413084     Source Type: Journal    
DOI: 10.1161/CIRCEP.110.960807     Document Type: Article

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