Role of Y 2 receptors in the regulation of gastric tone in rats

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 302, Issue 7, 2012, Pages

  Janssen, P ^a   Verschueren, S ^a   Rotondo, A ^a   Tack, J ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

BIIE0246; Gastric accommodation; Intragastric pressure; JNJ31020028; PYY 3 36

Indexed keywords

JNJ 31020028; N [2 [1,2 DIHYDRO 3,5(4H) DIOXO 1,2 DIPHENYL 1,2,4 TRIAZOL 4 YL]ETHYL] N2 [[1 [2 [4 [5,11 DIHYDRO 6(6H) OXODIBENZ[B,E]AZEPIN 11 YL] 1 PIPERAZINYL] 2 OXOETHYL]CYCLOPENTYL]ACETYL]ARGININAMIDE; N [4 [4 [2 (DIETHYLAMINO) 2 OXO 1 PHENYLETHYL]PIPERAZIN 1 YL] 3 FLUOROPHENYL] 2 PYRIDIN 3 YLBENZAMIDE; NEUROPEPTIDE Y RECEPTOR ANTAGONIST; NEUROPEPTIDE Y2 RECEPTOR; PEPTIDE YY [3-36]; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; NONHUMAN; NUTRIENT; PRIORITY JOURNAL; RAT; SMOOTH MUSCLE TONE; STATISTICAL SIGNIFICANCE; STOMACH MUSCLE; STOMACH PRESSURE; VAGOTOMY;

ANIMALS; ARGININE; BENZAMIDES; BENZAZEPINES; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION; MALE; MUSCLE TONUS; PEPTIDE YY; PIPERAZINES; RATS; RATS, WISTAR; RECEPTORS, GASTROINTESTINAL HORMONE; STOMACH;

EID: 84859449205     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00404.2011     Document Type: Article

References (57)

1. Abbott CR, Monteiro M, Small CJ, Sajedi A, Smith KL, Parkinson JR, Ghatei MA, Bloom SR. The inhibitory effects of peripheral administration of peptide YY(3-36) and glucagon-like peptide-1 on food intake are attenuated by ablation of the vagal-brainstem-hypothalamic pathway. Brain Res 1044: 127-131, 2005.
2. Adrian TE, Ferri GL, Bacarese-Hamilton AJ, Fuessl HS, Polak JM, Bloom SR. Human distribution and release of a putative new gut hormone, peptide YY. Gastroenterology 89: 1070-1077, 1985.
3. Adrian TE, Savage AP, Sagor GR, Allen JM, Bacarese-Hamilton AJ, Tatemoto K, Polak JM, Bloom SR. Effect of peptide YY on gastric, pancreatic, and biliary function in humans. Gastroenterology 89: 494-499, 1985.
4. Azpiroz F, Malagelada JR. Vagally mediated gastric relaxation induced by intestinal nutrients in the dog. Am J Physiol Gastrointest Liver Physiol 251: G727-G735, 1986.
5. Azpiroz F, Malagelada JR. Importance of vagal input in maintaining gastric tone in the dog. J Physiol 384: 511-524, 1987.
6. Ballantyne GH. Peptide YY(1-36) and peptide YY(3-36): Part I. Distribution, release and actions. Obes Surg 16: 651-658, 2006.
7. Batterham RL, Cohen MA, Ellis SM, Le Roux CW, Withers DJ, Frost GS, Ghatei MA, Bloom SR. Inhibition of food intake in obese subjects by peptide YY3-36. N Engl J Med 349: 941-948, 2003.
8. Batterham RL, Cowley M, Small CJ, Herzoh H, Cohen M, Dakin C, Wren A, Brynes A, Low M, Ghatei MA, Cone R, Bloom S. Gut hormone PYY(3-36) physiologically inhibits food intake. Nature 418: 650-654, 2002.
9. Batterham RL, Ffytche DH, Rosenthal JM, Zelaya FO, Barker GJ, Withers DJ, Williams SC. PYY modulation of cortical and hypothalamic brain areas predicts feeding behaviour in humans. Nature 450: 106-109, 2007.
10. Challis BG, Pinnock SB, Coll AP, Carter RN, Dickson SL, O'Rahilly S. Acute effects of PYY3-36 on food intake and hypothalamic neuropeptide expression in the mouse. Biochem Biophys Res Commun 311: 915-919, 2003.
11. Chandarana K, Batterham R. Peptide YY. Curr Opin Endocrinol Diabetes Obes 15: 65-72, 2008.
12. Chelikani PK, Haver AC, Reeve JR Jr, Keire DA, Reidelberger RD. Daily, intermittent intravenous infusion of peptide YY(3-36) reduces daily food intake and adiposity in rats. Am J Physiol Regul Integr Comp Physiol 290: R298-R305, 2006.
13. Chelikani PK, Haver AC, Reidelberger RD. Comparison of the inhibitory effects of PYY(3-36) and PYY(1-36) on gastric emptying in rats. Am J Physiol Regul Integr Comp Physiol 287: R1064-R1070, 2004.
14. Chelikani PK, Haver AC, Reidelberger RD. Intravenous infusion of peptide YY(3-36) potently inhibits food intake in rats. Endocrinology 146: 879-888, 2005.
15. Cuche G, Cuber JC, Malbert CH. Ileal short-chain fatty acids inhibit gastric motility by a humoral pathway. Am J Physiol Gastrointest Liver Physiol 279: G925-G930, 2000.
16. De Ponti F, Azpiroz F, Malagelada JR. Reflex gastric relaxation in response to distention of the duodenum. Am J Physiol Gastrointest Liver Physiol 252: G595-G601, 1987.
17. De Ponti F, Giaroni C, Cosentino M, Lecchini S, Frigo G. Adrenergic mechanisms in the control of gastrointestinal motility: from basic science to clinical applications. Pharmacol Ther 69: 59-78, 1996.
18. Degen L, Oesch S, Casanova M, Graf S, Ketterer S, Drewe J, Beglinger C. Effect of peptide YY3-36 on food intake in humans. Gastroenterology 129: 1430-1436, 2005.
19. el Sharkawy TY, Morgan KG, Szurszewski JH. Intracellular electrical activity of canine and human gastric smooth muscle. J Physiol 279: 291-307, 1978.
20. Fox-Threlkeld JA, Daniel EE, Christinck F, Woskowska Z, Cipris S, McDonald TJ. Peptide YY stimulates circular muscle contractions of the isolated perfused canine ileum by inhibiting nitric oxide release and enhancing acetylcholine release. Peptides 14: 1171-1178, 1993.
21. Goumain M, Voisin T, Lorinet AM, Laburthe M. Identification and distribution of mRNA encoding the Y1, Y2, Y4, and Y5 receptors for peptides of the PP-fold family in the rat intestine and colon. Biochem Biophys Res Commun 247: 52-56, 1998.
22. Greeley GH Jr, Jeng YJ, Gomez G, Hashimoto T, Hill FL, Kern K, Kurosky T, Chuo HF, Thompson JC. Evidence for regulation of peptide-YY release by the proximal gut. Endocrinology 124: 1438-1443, 1989.
23. Grundy D, Gharib-Naseri MK, Hutson D. Plasticity in the gastric inhibitory innervation after immunization against VIP and vagotomy in the ferret. Am J Physiol Gastrointest Liver Physiol 265: G432-G439, 1993.
24. Hakanson R, Vallgren S, Ekelund M, Rehfeld JF, Sundler F. The vagus exerts trophic control of the stomach in the rat. Gastroenterology 86: 28-32, 1984.
25. Hall KE, el Sharkawy TY, Diamant NE. Vagal control of migrating motor complex in the dog. Am J Physiol Gastrointest Liver Physiol 243: G276-G284, 1982.
26. Janssen P, Astin Nielsen M, Hirsch I, Svensson D, Gillberg PG, Hultin L. A novel method to assess gastric accommodation and peristaltic motility in conscious rats. Scand J Gastroenterol 43: 34-43, 2008.
27. Janssen P, Karlsson LK, Nielsen MA, Gillberg PG, Hultin L. Effect of muscarinic and nicotinic receptor antagonism on rat gastric motor activity. Pharmacology 85: 272-279, 2010.
28. Janssen P, Pottel H, Vos R, Tack J. Endogenously released opioids mediate meal-induced gastric relaxation via peripheral mu-opioid receptors. Aliment Pharmacol Ther 33: 607-614, 2011.
29. Janssen P, Prins NH, Moreaux B, Meulemans AL, Lefebvre RA. In vivo characterization of 5-HT1A receptor-mediated gastric relaxation in conscious dogs. Br J Pharmacol 140: 913-920, 2003.
30. Janssen P, Tack J. Intragastric pressure (IGP) during intragastric nutrient drink infusion: a method to objectively discriminate functional dyspeptic (FD) patients with impaired nutrient tolerance and/or gastric accommodation. Gastroenterology 140: S883-S884, 2011.
31. Janssen P, Vanden Berghe P, Verschueren S, Lehmann A, Depoortere I, Tack J. Review article: the role of gastric motility in the control of food intake. Aliment Pharmacol Ther 33: 880-894, 2011.
32. Janssen P, Verschueren S, Huynh Giao L, Vos R, Van Oudenhove L, Tack J. Intragastric pressure during food intake: a physiological and minimally invasive method to assess gastric accommodation. Neurogastroenterol Motil 23: 316-322, 2011.
33. Kindt S, Tack J. Impaired gastric accommodation and its role in dyspepsia. Gut 55: 1685-91, 2006.
34. Koda S, Date Y, Murakami N, Shimbara T, Hanada T, Toshinai K, Niijima A, Furuya M, Inomata N, Osuye K, Nakazato M. The role of the vagal nerve in peripheral PYY3-36-induced feeding reduction in rats. Endocrinology 146: 2369-2375, 2005.
35. Krantis A, Harding RK. Peptide YY induces nerve-mediated responses in the guinea pig intestine. Can J Physiol Pharmacol 69: 1713-1718, 1991.
36. Le Roux CW, Bloom SR. Peptide YY, appetite and food intake. Proc Nutr Soc 64: 213-216, 2005.
37. Li J, Ma W, Wang S. Slower gastric emptying in high-fat diet induced obese rats is associated with attenuated plasma ghrelin and elevated plasma leptin and cholecystokinin concentrations. Regul Pept 171: 53-57, 2011.
38. Lin HC, Zhao XT, Wang L, Wong H. Fat-induced ileal brake in the dog depends on peptide YY. Gastroenterology 110: 1491-1495, 1996.
39. Misra S, Murthy KS, Zhou H, Grider JR. Coexpression of Y1, Y2, and Y4 receptors in smooth muscle coupled to distinct signaling pathways. J Pharmacol Exp Ther 311: 1154-1162, 2004.
40. Moran TH, Smedh U, Kinzig KP, Scott KA, Knipp S, Ladenheim EE. Peptide YY(3-36) inhibits gastric emptying and produces acute reductions in food intake in rhesus monkeys. Am J Physiol Regul Integr Comp Physiol 288: R384-R388, 2005.
41. Nguyen AD, Herzog H, Sainsbury A. Neuropeptide Y and peptide YY: important regulators of energy metabolism. Curr Opin Endocrinol Diabetes Obes 18: 56-60, 2011.
42. Pappas TN, Debas HT, Chang AM, Taylor IL. Peptide YY release by fatty acids is sufficient to inhibit gastric emptying in dogs. Gastroenterology 91: 1386-1389, 1986.
43. Pironi L, Stanghellini V, Miglioli M, Corinaldesi R, De GR, Ruggeri E, Tosetti C, Poggioli G, Morselli Labate AM, Monetti N. Fat-induced ileal brake in humans: a dose-dependent phenomenon correlated to the plasma levels of peptide YY. Gastroenterology 105: 733-739, 1993.
44. Potter EK, Tripovic D. Modulation of sympathetic neurotransmission by neuropeptide Y Y2 receptors in rats and guinea-pigs. Exp Brain Res 173: 346-352, 2006.
45. Rudnicki M, Rigel DF, McFadden DW. Vagal cooling blocks circulating neuropeptide Y (NPY), peptide YY (PYY), and pancreatic polypeptide (PP) release. J Surg Res 51: 40-45, 1991.
46. Schirra J, Wank U, Arnold R, Goke B, Katschinski M. Effects of glucagon-like peptide-1(7-36)amide on motility and sensation of the proximal stomach in humans. Gut 50: 341-348, 2002.
47. Scott V, Kimura N, Stark JA, Luckman SM. Intravenous peptide YY3-36 and Y2 receptor antagonism in the rat: effects on feeding behaviour. J Neuroendocrinol 17: 452-457, 2005.
48. Shoblock JR, Welty N, Nepomuceno D, Lord B, Aluisio L, Fraser I, Motley ST, Sutton SW, Morton K, Galici R, Atack JR, Dvorak L, Swanson DM, Carruthers NI, Dvorak C, Lovenberg TW, Bonaventure P. In vitro and in vivo characterization of JNJ-31020028 (N-(4-(4-[2-(diethylamino)-2-oxo-1-phenylethyl]piperazin-1-yl)-3-fluorophenyl)-2-pyridin-3-ylbenzamide), a selective brain penetrant small molecule antagonist of the neuropeptide Y Y(2) receptor. Psychopharmacology 208: 265-277, 2010.
49. Spiller RC, Trotman IF, Adrian TE, Bloom SR, Misiewicz JJ, Silk DB. Further characterisation of the 'ileal brake' reflex in man-effect of ileal infusion of partial digests of fat, protein, and starch on jejunal motility and release of neurotensin, enteroglucagon, and peptide YY. Gut 29: 1042-1051, 1988.
50. Straathof JW, Mearadji B, Lamers CB, Masclee AA. Effect of CCK on proximal gastric motor function in humans. Am J Physiol Gastrointest Liver Physiol 274: G939-G944, 1998.
51. Tack J, Demedts I. Role of nitric oxide in the gastric accommodation reflex and in meal induced satiety in humans. Gut 51: 219-224, 2002.
52. Takahashi T, Owyang C. Characterization of vagal pathways mediating gastric accommodation reflex in rats. J Physiol 504: 479-488, 1997.
53. 2depletion. Am J Physiol Gastrointest Liver Physiol 297: G1028-G1034, 2009.
54. Tschöp M, Castaneda TR, Joost HG, Thöne-Reineke C, Ortmann S, Klaus S, Hagan MM, Chandler PC, Oswald KD, Benoit SC, Seeley RJ, Kinzig KP, Moran TH, Beck-Sickinger AG, Koglin N, Rodgers RJ, Blundell JE, Ishii Y, Beattie AH, Holck P, Allison DB, Raun K, Madsen K, Wulff BS, Stidsen CE, Birringer M, Kreuzer OJ, Schindler M, Arndt K, Rudolf K, Mark M, Deng XY, Whitcomb DC, Halem H, Taylor J, Dong J, Datta R, Culler M, Craney S, Flora D, Smiley D, Heiman ML. Physiology: does gut hormone PYY3-36 decrease food intake in rodents? Nature 431: 1038, 2004.
55. Whited KL, Tso P, Raybould HE. Involvement of apolipoprotein A-IV and cholecystokinin1 receptors in exogenous peptide YY3 36-induced stimulation of intestinal feedback. Endocrinology 148: 4695-4703, 2007.
56. Witte AB, Gryback P, Holst JJ, Hilsted L, Hellström PM, Jacobsson H, Schmidt PT. Differential effect of PYY1-36 and PYY3-36 on gastric emptying in man. Regul Pept 158: 57-62, 2009.
57. Zai H, Haga N, Fujino MA, Itoh Z. Effect of peptide YY on gastric motor and secretory activity in vagally innervated and denervated corpus pouch dogs. Regul Pept 61: 181-188, 1996.