A novel method to assess gastric accommodation and peristaltic motility in conscious rats

Scandinavian Journal of Gastroenterology

Volumn 43, Issue 1, 2008, Pages 34-43

  Janssen, Pieter ^a,c   Nielsen, Maria Astin ^a   Hirsch, Ika ^a   Svensson, David ^a   Gillberg, Per Göran ^a,b   Hultin, Leif ^a  

^a ASTRAZENECA R AND D   (Sweden)

^b UPPSALA UNIVERSITY   (Sweden)

^c NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Gastric accommodation; Gastric peristalsis; Intragastric pressure; Motility; Stomach; X ray

Indexed keywords

ARGININE; MOLSIDOMINE; N(G) NITROARGININE METHYL ESTER;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CATHETER; CONSCIOUSNESS; CONTROLLED STUDY; FEMALE; FLUOROSCOPY; INFUSION; NONHUMAN; PRESSURE MEASUREMENT; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; SPRAGUE DAWLEY RAT; STOMACH ACCOMODATION; STOMACH DISTENSION; STOMACH EMPTYING; STOMACH FUNCTION; STOMACH MOTILITY; STOMACH PRESSURE; STRAIN DIFFERENCE; TEST MEAL; WISTAR KYOTO RAT;

EID: 37549008764     PISSN: 00365521     EISSN: 15027708     Source Type: Journal    
DOI: 10.1080/00365520701580066     Document Type: Article

References (36)

1. Takahashi T, Owyang C. Characterization of vagal pathways mediating gastric accommodation reflex in rats. J Physiol 1997;504:479-88.
2. Azpiroz F, Malagelada JR. Importance of vagal input in maintaining gastric tone in the dog. J Physiol 1987;384:511-24.
3. Dixit D, Zarate N, Liu LW, Boreham DR, Huizinga JD. Interstitial cells of Cajal and adaptive relaxation in the mouse stomach. Am J Physiol Gastrointest Liver Physiol 2006;291:G1129-36.
4. Desai KM, Zembowicz A, Sessa WC, Vane JR. Nitroxergic nerves mediate vagally induced relaxation in the isolated stomach of the guinea pig. Natl Acad Sci USA 1991;88:11490-4.
5. Kuiken SD, Samsom M, Camilleri M, Mullan BP, Burton DD, Kost LJ, et al. Development of a test to measure gastric accommodation in humans. Am J Physiol Gastrointest Liver Physiol 1999;277:G1217-21.
6. Lee KJ, Vos R, Janssens J, Tack J. Differences in the sensorimotor response to distension between the proximal and distal stomach in humans. Gut 2004;53:938-43.
7. Mayer EA. The physiology of gastric storage and emptying. In: Johnson LR. Physiol of the gastrointestinal tract. New York: Rave Press; 1994. pp 929-76.
8. Bisschops R, Tack J. Dysaccommodation of the stomach: therapeutic nirvana. Neurogastroenterol Motil 2007;19:85-93.
9. Urbain JL, Vekemans MC, Parkman H, Van CJ, Mayeur SM, Van dMV, et al. Dynamic antral scintigraphy to characterize gastric antral motility in functional dyspepsia. J Nucl Med 1995;36:1579-86.
10. Stanghellini V, De PF, De GR, Barbara G, Tosetti C, Corinaldesi R. New developments in the treatment of functional dyspepsia. Drugs 2003;63:869-92.
11. Astin Nielsen M, Bayati A, Mattsson H. Wistar Kyoto rats have impaired gastric accommodation compared to Sprague Dawley rats due to increased gastric vagal cholinergic tone. Scand J Gastroenterol 2006;41:773-81.
12. Mattsson H, Arani Z, Astin M, Bayati A, Overstreet DH, Lehmann A. Altered neuroendocrine response and gastric dysmotility in the Flinders Sensitive Line rat. Neurogastroenterol Motil 2005;17:166-74.
13. Tsuchida D, Fukuda H, Koda K, Miyazaki M, Pappas TN, Takahashi T. Central effect of mu-opioid agonists on antral motility in conscious rats. Brain Res 2004;1024:244-50.
14. Wang XY, Lammers WJ, Bercik P, Huizinga JD. Lack of pyloric interstitial cells of Cajal explains distinct peristaltic motor patterns in stomach and small intestine. Am J Physiol Gastrointest Liver Physiol 2005;289:539-49.
15. Nakade Y, Tsuchida D, Fukuda H, Iwa M, Pappas TN, Takahashi T. Restraint stress augments postprandial gastric contractions but impairs antropyloric coordination in conscious rats. Am J Physiol Regul Integr Comp Physiol 2006;290:616-24.
16. Parkman HP, Trate DM, Knight LC, Brown KL, Maurer AH, Fisher RS. Cholinergic effects on human gastric motility. Gut 1999;45:346-54.
17. Madsen JL, Rasmussen SL, Linnet J, Fuglsang S, Rumessen JJ. Effect of sustained-release isosorbide dinitrate on postprandial gastric emptying and gastroduodenal motility in healthy humans. J Int Med Res 2004;32:351-8.
18. Madsen JL, Sondergaard SB, Fuglsang S, Rumessen JJ, Graff J. Effect of sildenafil on gastric emptying and postprandial frequency of antral contractions in healthy humans. Scand J Gastroenterol 2004;39:629-33.
19. Su YC, Vozzo R, Doran S, Leelakusolvong S, Rayner CK, Chapman IM, et al. Effects of the nitric oxide synthase inhibitor NG-nitro-L-arginine methyl ester (L-NAME) on antropyloroduodenal motility and appetite in response to intraduodenal lipid infusion in humans. Scand J Gastroenterol 2001;36:948-54.
20. Holle GE, Steinbach E, Wunsch E, Holst JJ. Effect of 17-norleucine-VIP on gastroduodenal motility relative to serum VIP concentration and blockade of NOS. Am J Physiol 1995;269:584-90.
21. Ishiguchi T, Nishioka S, Takahashi T. Inhibitory neural pathway regulating gastric emptying in rats. J Auton Nerv Syst 2000;79:45-51.
22. Konturek JW, Thor P, Domschke W. Effects of nitric oxide on antral motility and gastric emptying in humans. Eur J Gastroenterol Hepatol 1995;7:97-102.
23. Glasgow I, Mattar K, Krantis A. Rat gastroduodenal motility in vivo: involvement of NO and ATP in spontaneous motor activity. Am J Physiol 1998;275:889-96.
24. Tack J, Piessevaux H, Coulie B, Caenepeel P, Janssens J. Role of impaired gastric accommodation to a meal in functional dyspepsia. Gastroenterology 1998;115:1346-52.
25. Lunding JA, Tefera S, Bayati A, Helge Gilja O, Mattsson H, Hausken T, Berstad A. Pressure-induced gastric accommodation studied with a new distension paradigm. Abnormally low accommodation rate in patients with functional dyspepsia. Scand J Gastroenterol 2006;41:544-52.
26. Paterson CA, Anvari M, Tougas G, Huizinga JD. Nitrergic and cholinergic vagal pathways involved in the regulation of canine proximal gastric tone: an in vivo study. Neurogastroenterol Motil 2000;12:301-6.
27. Sarnelli G, Sifrim D, Janssens J, Tack J. Influence of sildenafil on gastric sensorimotor function in humans. Am J Physiol Gastrointest Liver Physiol 2004;287:988-92.
28. Kuiken SD, Vergeer M, Heisterkamp SH, Tytgat GN, Boeckxstaens GE. Role of nitric oxide in gastric motor and sensory functions in healthy subjects. Gut 2002;51:212-8.
29. Azpiroz F, Malagelada JR. Importance of vagal input in maintaining gastric tone in the dog. J Physiol 1987;384:511-24.
30. Crema F, Moro E, Nardelli G, de Ponti F, Frigo G, Crema A. Role of tachykininergic and cholinergic pathways in modulating canine gastric tone and compliance in vivo. Pharmacol Res 2002;45:341-7.
31. Bruley des Varannes S, Parys V, Ropert A, Chayvialle JA, Roze C, Galmiche JP. Erythromycin enhances fasting and postprandial proximal gastric tone in humans. Gastroenterology 1995;109:32-9.
32. Lidums I, Hebbard GS, Holloway RH. Effect of atropine on proximal gastric motor and sensory function in normal subjects. Gut 2000;47:30-6.
33. Kortezova NI, Shikova LI, Milusheva EA, Itzev DE, Bagaev VA, Mizhorkova ZN. Muscarinic modulation of nitrergic neurotransmission in guinea-pig gastric fundus. Neurogastroenterol Motil 2004;16:155-65.
34. Takeuchi T, Toyoshima M, Mukai K, Hagi K, Matsui M, Nakajima H, et al. Involvement of M(2) muscarinic receptors in relaxant response of circular muscle of mouse gastric antrum. Neurogastroenterol Motil 2006;18:226-33.
35. Calatayud S, Garcia-Zaragoza E, Hernandez C, Quintana E, Felipo V, Esplugues JV, et al. Downregulation of nNOS and synthesis of PGs associated with endotoxin-induced delay in gastric emptying. Am J Physiol Gastrointest Liver Physiol 2002;283:1360-7.
36. Schoonjans R, Van Vlem B, Van Heddeghem N, Vandamme W, Vanholder R, Lameire N, et al. The 13C-octanoic acid breath test: validation of a new noninvasive method of measuring gastric emptying in rats. Neurogastroenterol Motil 2002;14:287-93.