Slower gastric emptying in high-fat diet induced obese rats is associated with attenuated plasma ghrelin and elevated plasma leptin and cholecystokinin concentrations

Regulatory Peptides

Volumn 171, Issue 1-3, 2011, Pages 53-57

  Li, Jie ^a   Ma, Weiwei ^b   Wang, Shuran ^a  

^a HARBIN MEDICAL UNIVERSITY   (China)

^b CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

Diet induced obesity; Gastric emptying; Gastrointestinal transit; Gut hormones

Indexed keywords

CHOLECYSTOKININ; GASTROINTESTINAL HORMONE; GHRELIN; LEPTIN; PEPTIDE YY;

ADIPOSE TISSUE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CALORIC INTAKE; CONTROLLED STUDY; DIET RESTRICTION; DISEASE ASSOCIATION; GASTROINTESTINAL TRANSIT; HORMONE ACTION; HORMONE BLOOD LEVEL; LIPID DIET; MALE; NONHUMAN; OBESITY; PRIORITY JOURNAL; RAT; STOMACH EMPTYING;

ANIMALS; CHOLECYSTOKININ; DIET, HIGH-FAT; GASTRIC EMPTYING; GHRELIN; LEPTIN; MALE; OBESITY; RATS; RATS, SPRAGUE-DAWLEY;

RATTUS;

EID: 80051811345     PISSN: 01670115     EISSN: 18731686     Source Type: Journal    
DOI: 10.1016/j.regpep.2011.07.004     Document Type: Article

References (48)

1. Kojima M., Hosoda H., Kangawa K. Purification and distribution of ghrelin: the natural endogenous ligand for the growth hormone secretagogue receptor. Horm Res 2001, 56(Suppl. 1):93-97.
2. Cummings D.E., Weigle D.S., Frayo R.S., Breen P.A., Ma M.K., Dellinger E.P., Purnell J.Q. Plasma ghrelin levels after diet-induced weight loss or gastric bypass surgery. N Engl J Med 2002, 346:1623-1630.
3. Levin F., Edholm T., Schmidt P.T., Gryback P., Jacobsson H., Degerblad M., Hoybye C., Holst J.J., Rehfeld J.F., Hellstrom P.M., Naslund E. Ghrelin stimulates gastric emptying and hunger in normal-weight humans. J Clin Endocrinol Metab 2006, 91:3296-3302.
4. Adrian T.E., Ferri G.L., Bacarese-Hamilton A.J., Fuessl H.S., Polak J.M., Bloom S.R. Human distribution and release of a putative new gut hormone, peptide YY. Gastroenterology 1985, 89:1070-1077.
5. Chen Y.F., Chey W.Y., Chang T.M., Lee K.Y. Duodenal acidification releases cholecystokinin. Am J Physiol 1985, 249:G29-G33.
6. Allen J.M., Fitzpatrick M.L., Yeats J.C., Darcy K., Adrian T.E., Bloom S.R. Effects of peptide YY and neuropeptide Y on gastric emptying in man. Digestion 1984, 30:255-262.
7. Borovicka J., Kreiss C., Asal K., Remy B., Mettraux C., Wells A., Read N.W., Jansen J.B., D'Amato M., Delaloye A.B., Fried M., Schwizer W. Role of cholecystokinin as a regulator of solid and liquid gastric emptying in humans. Am J Physiol 1996, 271:G448-G453.
8. Nguyen N.Q., Fraser R.J., Bryant L.K., Chapman M.J., Wishart J., Holloway R.H., Butler R., Horowitz M. The relationship between gastric emptying, plasma cholecystokinin, and peptide YY in critically ill patients. Crit Care 2007, 11:R132.
9. MacIntosh C.G., Andrews J.M., Jones K.L., Wishart J.M., Morris H.A., Jansen J.B., Morley J.E., Horowitz M., Chapman I.M. Effects of age on concentrations of plasma cholecystokinin, glucagon-like peptide 1, and peptide YY and their relation to appetite and pyloric motility. Am J Clin Nutr 1999, 69:999-1006.
10. Rayner C.K., Park H.S., Doran S.M., Chapman I.M., Horowitz M. Effects of cholecystokinin on appetite and pyloric motility during physiological hyperglycemia. Am J Physiol Gastrointest Liver Physiol 2000, 278:G98-G104.
11. Batterham R.L., Cowley M.A., Small C.J., Herzog H., Cohen M.A., Dakin C.L., Wren A.M., Brynes A.E., Low M.J., Ghatei M.A., Cone R.D., Bloom S.R. Gut hormone PYY(3-36) physiologically inhibits food intake. Nature 2002, 418:650-654.
12. Schwizer W., Borovicka J., Kunz P., Fraser R., Kreiss C., D'Amato M., Crelier G., Boesiger P., Fried M. Role of cholecystokinin in the regulation of liquid gastric emptying and gastric motility in humans: studies with the CCK antagonist loxiglumide. Gut 1997, 41:500-504.
13. Zhang Y., Proenca R., Maffei M., Barone M., Leopold L., Friedman J.M. Positional cloning of the mouse obese gene and its human homologue. Nature 1994, 372:425-432.
14. Lostao M.P., Urdaneta E., Martinez-Anso E., Barber A., Martinez J.A. Presence of leptin receptors in rat small intestine and leptin effect on sugar absorption. FEBS Lett 1998, 423:302-306.
15. Kiely J.M., Noh J.H., Graewin S.J., Pitt H.A., Swartz-Basile D.A. Altered intestinal motility in leptin-deficient obese mice. J Surg Res 2005, 124:98-103.
16. Levin B.E., Triscari J., Sullivan A.C. Relationship between sympathetic activity and diet-induced obesity in two rat strains. Am J Physiol 1983, 245:R364-R371.
17. Li J., Wang S., Zhang N., Li Z., Li R., Li C. Effects of changing dietary fat content on plasma gut hormone concentrations in diet-induced obese and diet-resistant rats. Br J Nutr 2011, 105:879-886.
18. Zhao D., Wang S.R., Ma W.W., Liu L.J., Sun C.H. Alpha1-macroglobulin: a potential obesity-related factor in serum. Med Sci Monit 2008, 14:BR57-BR61.
19. Amira S., Soufane S., Gharzouli K. Effect of sodium fluoride on gastric emptying and intestinal transit in mice. Exp Toxicol Pathol 2005, 57:59-64.
20. Dupont W.D., Plummer W.D. Power and sample size calculations. A review and computer program. Control Clin Trials 1990, 11:116-128.
21. Asakawa A., Inui A., Ueno N., Makino S., Uemoto M., Fujino M.A., Kasuga M. Ob/ob mice as a model of delayed gastric emptying. J Diabetes Complications 2003, 17:27-28.
22. Levin B.E., Keesey R.E. Defense of differing body weight set points in diet-induced obese and resistant rats. Am J Physiol 1998, 274:R412-R419.
23. Basilisco G., Camboni G., Bozzani A., Vita P., Doldi S., Bianchi P.A. Orocecal transit delay in obese patients. Dig Dis Sci 1989, 34:509-512.
24. Horowitz M., Collins P.J., Shearman D.J. Effect of increasing the caloric/osmotic content of the liquid component of a mixed solid and liquid meal on gastric emptying in obese subjects. Hum Nutr Clin Nutr 1986, 40:51-56.
25. Wisen O., Johansson C. Gastrointestinal function in obesity: motility, secretion, and absorption following a liquid test meal. Metabolism 1992, 41:390-395.
26. Lee H.M., Wang G., Englander E.W., Kojima M., Greeley G.H. Ghrelin, a new gastrointestinal endocrine peptide that stimulates insulin secretion: enteric distribution, ontogeny, influence of endocrine, and dietary manipulations. Endocrinology 2002, 143:185-190.
27. Zheng J., Dobner A., Babygirija R., Ludwig K., Takahashi T. Effects of repeated restraint stress on gastric motility in rats. Am J Physiol Regul Integr Comp Physiol 2009, 296:R1358-R1365.
28. Charoenthongtrakul S., Giuliana D., Longo K.A., Govek E.K., Nolan A., Gagne S., Morgan K., Hixon J., Flynn N., Murphy B.J., Hernandez A.S., Li J., Tino J.A., Gordon D.A., DiStefano P.S., Geddes B.J. Enhanced gastrointestinal motility with orally active ghrelin receptor agonists. J Pharmacol Exp Ther 2009, 329:1178-1186.
29. Liddle R.A., Goldfine I.D., Rosen M.S., Taplitz R.A., Williams J.A. Cholecystokinin bioactivity in human plasma. Molecular forms, responses to feeding, and relationship to gallbladder contraction. J Clin Invest 1985, 75:1144-1152.
30. Covasa M., Marcuson J.K., Ritter R.C. Diminished satiation in rats exposed to elevated levels of endogenous or exogenous cholecystokinin. Am J Physiol Regul Integr Comp Physiol 2001, 280:R331-R337.
31. Covasa M., Ritter R.C. Adaptation to high-fat diet reduces inhibition of gastric emptying by CCK and intestinal oleate. Am J Physiol Regul Integr Comp Physiol 2000, 278:R166-R170.
32. French S.J., Murray B., Rumsey R.D., Fadzlin R., Read N.W. Adaptation to high-fat diets: effects on eating behaviour and plasma cholecystokinin. Br J Nutr 1995, 73:179-189.
33. How J.M., Fam B.C., Verberne A.J., Sartor D.M. High-fat diet is associated with blunted splanchnic sympathoinhibitory responses to gastric leptin and cholecystokinin: implications for circulatory control. Am J Physiol Heart Circ Physiol 2011, 300:H961-H967.
34. Sodowski K., Zwirska-Korczala K., Kuka D., Kukla M., Budziszewska P., Czuba B., Wloch A., Cnota W., Bielanski W., Brzozowski T., Rehfeld J.F., Zdun R., Konturek P.C. Basal and postprandial gut peptides affecting food intake in lean and obese pregnant women. J Physiol Pharmacol 2007, 58(Suppl. 1):37-52.
35. Lo C.M., King A., Samuelson L.C., Kindel T.L., Rider T., Jandacek R.J., Raybould H.E., Woods S.C., Tso P. Cholecystokinin knockout mice are resistant to high-fat diet-induced obesity. Gastroenterology 2010, 138:1997-2005.
36. Savage A.P., Adrian T.E., Carolan G., Chatterjee V.K., Bloom S.R. Effects of peptide YY (PYY) on mouth to caecum intestinal transit time and on the rate of gastric emptying in healthy volunteers. Gut 1987, 28:166-170.
37. le Roux C.W., Batterham R.L., Aylwin S.J., Patterson M., Borg C.M., Wynne K.J., Kent A., Vincent R.P., Gardiner J., Ghatei M.A., Bloom S.R. Attenuated peptide YY release in obese subjects is associated with reduced satiety. Endocrinology 2006, 147:3-8.
38. Korner J., Bessler M., Cirilo L.J., Conwell I.M., Daud A., Restuccia N.L., Wardlaw S.L. Effects of Roux-en-Y gastric bypass surgery on fasting and postprandial concentrations of plasma ghrelin, peptide YY, and insulin. J Clin Endocrinol Metab 2005, 90:359-365.
39. Stock S., Leichner P., Wong A.C., Ghatei M.A., Kieffer T.J., Bloom S.R., Chanoine J.P. Ghrelin, peptide YY, glucose-dependent insulinotropic polypeptide, and hunger responses to a mixed meal in anorexic, obese, and control female adolescents. J Clin Endocrinol Metab 2005, 90:2161-2168.
40. Maljaars P.W., Peters H.P., Mela D.J., Masclee A.A. Ileal brake: a sensible food target for appetite control. A review. Physiol Behav 2008, 95:271-281.
41. Murphy K.G., Bloom S.R. Gut hormones and the regulation of energy homeostasis. Nature 2006, 444:854-859.
42. Buyse M., Ovesjo M.L., Goiot H., Guilmeau S., Peranzi G., Moizo L., Walker F., Lewin M.J., Meister B., Bado A. Expression and regulation of leptin receptor proteins in afferent and efferent neurons of the vagus nerve. Eur J Neurosci 2001, 14:64-72.
43. Gaige S., Abysique A., Bouvier M. Effects of leptin on cat intestinal vagal mechanoreceptors. J Physiol 2002, 543:679-689.
44. Martinez V., Barrachina M.D., Wang L., Tache Y. Intracerebroventricular leptin inhibits gastric emptying of a solid nutrient meal in rats. Neuroreport 1999, 10:3217-3221.
45. Cunningham K.M., Daly J., Horowitz M., Read N.W. Gastrointestinal adaptation to diets of differing fat composition in human volunteers. Gut 1991, 32:483-486.
46. Horowitz M., Cunningham K.M., Wishart J.M., Jones K.L., Read N.W. The effect of short-term dietary supplementation with glucose on gastric emptying of glucose and fructose and oral glucose tolerance in normal subjects. Diabetologia 1996, 39:481-486.
47. Tschop M., Smiley D.L., Heiman M.L. Ghrelin induces adiposity in rodents. Nature 2000, 407:908-913.
48. Reeves P.G., Nielsen F.H., Fahey G.C. AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. J Nutr 1993, 123:1939-1951.