메뉴 건너뛰기




Volumn 29, Issue 2, 2012, Pages 379-391

L-3-n-butylphthalide reduces tau phosphorylation and improves cognitive deficits in AβPP/PS1-alzheimer's transgenic mice

Author keywords

Alzheimer's disease; amyloid ; CDK 5; GSK 3 ; L 3 n butylphthalide; tau

Indexed keywords

3 BUTYLPHTHALIDE; AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; BETA ACTIN; CYCLIN DEPENDENT KINASE; GLYCOGEN SYNTHASE KINASE 3BETA; PRESENILIN 1; SERINE; TAU PROTEIN; THREONINE;

EID: 84859398030     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-2011-111577     Document Type: Article
Times cited : (75)

References (41)
  • 1
    • 0028267440 scopus 로고
    • Normal and abnormal biology of the β-amyloid precursor protein
    • Selkoe DJ (1994) Normal and abnormal biology of the beta-amyloid precursor protein. Annu Rev Neurosci 17, 489-517. (Pubitemid 24117040)
    • (1994) Annual Review of Neuroscience , vol.17 , pp. 489-517
    • Selkoe, D.J.1
  • 2
    • 0028986916 scopus 로고
    • Beta-amyloid fibrils induce tau phosphorylation and loss of microtubule binding
    • Busciglio J, Lorenzo A, Yeh J, Yankner BA (1995) beta-amyloid fibrils induce tau phosphorylation and loss of microtubule binding. Neuron 14, 879-888.
    • (1995) Neuron , vol.14 , pp. 879-888
    • Busciglio, J.1    Lorenzo, A.2    Yeh, J.3    Yankner, B.A.4
  • 3
    • 33751557958 scopus 로고    scopus 로고
    • Caspase-3- and calpain-mediated tau cleavage are differentially prevented by estrogen and testosterone in beta-amyloid-treated hippocampal neurons
    • DOI 10.1016/j.neuroscience.2006.09.012, PII S0306452206012401
    • Park SY, Tournell C, Sinjoanu RC, Ferreira A (2007) Caspase-3-and calpain-mediated tau cleavage are differentially prevented by estrogen and testosterone in beta-amyloid-treated hippocampal neurons. Neuroscience 144, 119-127. (Pubitemid 44841997)
    • (2007) Neuroscience , vol.144 , Issue.1 , pp. 119-127
    • Park, S.-Y.1    Tournell, C.2    Sinjoanu, R.C.3    Ferreira, A.4
  • 4
    • 33646198145 scopus 로고    scopus 로고
    • Tau therapeutic strategies for the treatment of Alzheimer's disease
    • Churcher I (2006) Tau therapeutic strategies for the treatment of Alzheimer's disease. Curr Top Med Chem 6, 579-595.
    • (2006) Curr Top Med Chem , vol.6 , pp. 579-595
    • Churcher, I.1
  • 5
    • 0027058857 scopus 로고
    • Modulation of the dynamic instability of tubulin assembly by the microtubule-associated protein tau
    • Drechsel DN, Hyman AA, Cobb MH, Kirschner MW (1992) Modulation of the dynamic instability of tubulin assembly by the microtubule-associated protein tau. Mol Biol Cell 3, 1141-1154. (Pubitemid 23088964)
    • (1992) Molecular Biology of the Cell , vol.3 , Issue.10 , pp. 1141-1154
    • Drechsel, D.N.1    Hyman, A.A.2    Cobb, M.H.3    Kirschner, M.W.4
  • 7
    • 70349638299 scopus 로고    scopus 로고
    • Advances in tau-focused drug discovery for Alzheimer's disease and related tauopathies
    • Brunden KR, Trojanowski JQ, Lee VM (2009) Advances in tau-focused drug discovery for Alzheimer's disease and related tauopathies. Nat Rev Drug Discov 8, 783-793.
    • (2009) Nat Rev Drug Discov , vol.8 , pp. 783-793
    • Brunden, K.R.1    Trojanowski, J.Q.2    Lee, V.M.3
  • 8
    • 61849088424 scopus 로고    scopus 로고
    • Tau phosphoryla-tion: The therapeutic challenge for neurodegenerative disease
    • Hanger DP, Anderton BH, Noble W (2009) Tau phosphoryla-tion: The therapeutic challenge for neurodegenerative disease. Trends Mol Med 15, 112-119.
    • (2009) Trends Mol Med , vol.15 , pp. 112-119
    • Hanger, D.P.1    Anderton, B.H.2    Noble, W.3
  • 9
    • 25844458239 scopus 로고    scopus 로고
    • Current advances on different kinases involved in tau phosphorylation, and implications in Alzheimer's disease and tauopathies
    • DOI 10.2174/1567205052772713
    • Ferrer I, Gomez-Isla T, Puig B, Freixes M, Ribé E, Dalfó E, Avila J (2005) Current advances on different kinases involved in tau phosphorylation, and implications in Alzheimer's disease and tauopathies. Curr Alzheimer Res 2, 3-18. (Pubitemid 41389255)
    • (2005) Current Alzheimer Research , vol.2 , Issue.1 , pp. 3-18
    • Ferrer, I.1    Gomez-Isla, T.2    Puig, B.3    Freixes, M.4    Ribe, E.5    Dalfo, E.6    Avila, J.7
  • 10
    • 0035863188 scopus 로고    scopus 로고
    • Decreased nuclear β-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3β conditional transgenic mice
    • DOI 10.1093/emboj/20.1.27
    • Lucas JJ, Hernández F, Gómez-Ramos P, Morán MA, Hen R, Avila J (2001) Decreased nuclear beta-catenin, tau hyperphos-phorylation and neurodegeneration in GSK-3beta conditional transgenic mice. EMBO J 20, 27-39. (Pubitemid 32099099)
    • (2001) EMBO Journal , vol.20 , Issue.1-2 , pp. 27-39
    • Lucas, J.J.1    Hernandez, F.2    Gomez-Ramos, P.3    Moran, M.A.4    Hen, R.5    Avila, J.6
  • 11
    • 0032578024 scopus 로고    scopus 로고
    • Accumulation of cyclin-dependent kinase 5 (cdk5) in neurons with early stages of Alzheimer's disease neurofibrillary degeneration
    • DOI 10.1016/S0006-8993(98)00296-0, PII S0006899398002960
    • Pei JJ, Grundke-Iqbal I, Iqbal K, Bogdanovic N, Winblad B, Cowburn RF (1998) Accumulation of cyclin-dependent kinase 5 (cdk5) in neurons with early stages of Alzheimer's disease neurofibrillary degeneration. Brain Res 797, 267-277. (Pubitemid 28332739)
    • (1998) Brain Research , vol.797 , Issue.2 , pp. 267-277
    • Pei, J.-J.1    Grundke-Iqbal, I.2    Iqbal, K.3    Bogdanovic, N.4    Winblad, B.5    Cowburn, R.F.6
  • 12
    • 33749826587 scopus 로고    scopus 로고
    • P25/cyclin-dependent kinase 5 induces production and intraneuronal accumulation of amyloid β in vivo
    • DOI 10.1523/JNEUROSCI.3133-06.2006
    • Cruz JC, Kim D, Moy LY, Dobbin MM, Sun X, Bronson RT, Tsai LH (2006) p25/cyclin-dependent kinase 5 induces production and intraneuronal accumulation of amyloid beta in vivo. J Neurosci 26, 10536-10541. (Pubitemid 44564604)
    • (2006) Journal of Neuroscience , vol.26 , Issue.41 , pp. 10536-10541
    • Cruz, J.C.1    Kim, D.2    Moy, L.Y.3    Dobbin, M.M.4    Sun, X.5    Bronson, R.T.6    Tsai, L.-H.7
  • 13
    • 0038187674 scopus 로고    scopus 로고
    • GSK-3α regulates production of Alzheimer's disease amyloid-β peptides
    • DOI 10.1038/nature01640
    • Phiel CJ, Wilson CA, Lee VMY, Klein PS (2003) GSK-3a regulated production of Alzheimer's disease amyloid-fj peptides. Nature 423, 435-439. (Pubitemid 36626994)
    • (2003) Nature , vol.423 , Issue.6938 , pp. 435-439
    • Phiel, C.J.1    Wilson, C.A.2    Lee, V.M.-Y.3    Klein, P.S.4
  • 16
    • 34248560915 scopus 로고    scopus 로고
    • L-3-N-butylphthalide improves cognitive impairment induced by chronic cerebral hypoperfusion in rats
    • DOI 10.1124/jpet.106.118760
    • Peng Y, Xu SF, Chen GQ, Wang L, Feng YP, Wang XL (2007) L-3-n-Butylphthalide improves cognitive impairment induced by chronic cerebral hypoperfusion in rats. J Pharma col Exp Ther 321, 902-910. (Pubitemid 46762705)
    • (2007) Journal of Pharmacology and Experimental Therapeutics , vol.321 , Issue.3 , pp. 902-910
    • Peng, Y.1    Xu, S.2    Chen, G.3    Wang, L.4    Feng, Y.5    Wang, X.6
  • 17
    • 70349617912 scopus 로고    scopus 로고
    • L-3-n-butylphthalide improves cognitive impairment induced by intracerebroventricular infusion of amyloid-fj peptide in rats
    • Peng Y, Xing CH, Xu SF, Lemere CA, Chen GQ, Liu B, Wang L, Feng YP, Wang XL (2009) L-3-n-butylphthalide improves cognitive impairment induced by intracerebroventricular infusion of amyloid-fj peptide in rats. Eur J Pharmacol 621, 38-45.
    • (2009) Eur J Pharmacol , vol.621 , pp. 38-45
    • Peng, Y.1    Xing, C.H.2    Xu, S.F.3    Lemere, C.A.4    Chen, G.Q.5    Liu, B.6    Wang, L.7    Feng, Y.P.8    Wang, X.L.9
  • 18
    • 64749095664 scopus 로고    scopus 로고
    • Long-term treatment of l-3-n-butylphthalide attenuated neurodegenerative changes in aged rats
    • Ma SP, Xu SF, Liu B, Li J, Feng N, Wang L, Wang XL (2009) Long-term treatment of l-3-n-butylphthalide attenuated neurodegenerative changes in aged rats. Naunyn-Schmied Arch Pharmacol 379, 565-574.
    • (2009) Naunyn-Schmied Arch Pharmacol , vol.379 , pp. 565-574
    • Ma, S.P.1    Xu, S.F.2    Liu, B.3    Li, J.4    Feng, N.5    Wang, L.6    Wang, X.L.7
  • 19
  • 20
    • 78650208071 scopus 로고    scopus 로고
    • L-3-n-butylphthalide regulates amyloid precursor protein processing by PKC and MAPK pathways in SK-N-SH Cells Over-Expressing Wild Type Human APP695
    • Peng Y, Hu YL, Xu SF, Feng N, Wang L, Feng YP, Wang XL (2011) L-3-n-butylphthalide regulates amyloid precursor protein processing by PKC and MAPK pathways in SK-N-SH Cells Over-Expressing Wild Type Human APP695. Neurosci Lett 487, 211-216.
    • (2011) Neurosci Lett , vol.487 , pp. 211-216
    • Peng, Y.1    Hu, Y.L.2    Xu, S.F.3    Feng, N.4    Wang, L.5    Feng, Y.P.6    Wang, X.L.7
  • 21
    • 2542584749 scopus 로고    scopus 로고
    • Progressive age-related development of Alzheimer-like pathology in APP/PS1 mice
    • DOI 10.1002/ana.20101
    • Trinchese F, Liu S, Battaglia F, Walter S, Mathews PM, Arancio O (2004) Progressive age-related development of Alzheimer-like pathology in APP/PS1 mice. Ann Neurol 55, 801-814. (Pubitemid 38702575)
    • (2004) Annals of Neurology , vol.55 , Issue.6 , pp. 801-814
    • Trinchese, F.1    Liu, S.2    Battaglia, F.3    Walter, S.4    Mathews, P.M.5    Arancio, O.6
  • 22
    • 58149268892 scopus 로고    scopus 로고
    • Retinoic acid attenuates beta-amyloid deposition and rescues memory deficits in an Alzheimer's disease transgenic mouse model
    • Ding Y, Qiao A, Wang Z, Goodwin JS, Lee ES, Block ML, Allsbrook M, McDonald MP, Fan GH (2008) Retinoic acid attenuates beta-amyloid deposition and rescues memory deficits in an Alzheimer's disease transgenic mouse model. J Neurosci 28, 11622-11634.
    • (2008) J Neurosci , vol.28 , pp. 11622-11634
    • Ding, Y.1    Qiao, A.2    Wang, Z.3    Goodwin, J.S.4    Lee, E.S.5    Block, M.L.6    Allsbrook, M.7    McDonald, M.P.8    Fan, G.H.9
  • 24
    • 0021173996 scopus 로고
    • Developments of a water-maze procedure for studying spatial learning in the rat
    • DOI 10.1016/0165-0270(84)90007-4
    • Morris R (1984) Developments of a water-maze procedure for studying spatial learning in the rat. J Neurosci Meth 11, 47-60. (Pubitemid 14088970)
    • (1984) Journal of Neuroscience Methods , vol.11 , Issue.1 , pp. 47-60
    • Morris, R.1
  • 25
    • 77953750340 scopus 로고    scopus 로고
    • L-3-n-butylphthalide improves cognitive impairment and reduces amyloid-beta in a transgenic model of Alzheimer's disease
    • Peng Y, Sun J, Hon S, Nylander AN, Xia W, Feng Y, Wang X, Lemere CA (2010) L-3-n-butylphthalide improves cognitive impairment and reduces amyloid-beta in a transgenic model of Alzheimer's disease. J Neurosci 30, 8180-8189.
    • (2010) J Neurosci , vol.30 , pp. 8180-8189
    • Peng, Y.1    Sun, J.2    Hon, S.3    Nylander, A.N.4    Xia, W.5    Feng, Y.6    Wang, X.7    Lemere, C.A.8
  • 27
    • 0042334542 scopus 로고    scopus 로고
    • Hyperphosphorylated tau and paired helical filament-like structures in the brains of mice carrying mutant amyloid precursor protein and mutant presenilin-1 transgenes
    • DOI 10.1016/S0969-9961(03)00084-6
    • Kurt MA, Davies DC, Kidd M, Duff K, Howlett DR (2003) Hyperphosphorylated tau and paired helical filament-like structures in the brains of mice carrying mutant amyloid precursor protein and mutant presenilin-1 transgenes. Neurobiol Dis 14, 89-97. (Pubitemid 37103183)
    • (2003) Neurobiology of Disease , vol.14 , Issue.1 , pp. 89-97
    • Kurt, M.A.1    Davies, D.C.2    Kidd, M.3    Duff, K.4    Howlett, D.R.5
  • 28
    • 0032566623 scopus 로고    scopus 로고
    • τ Is phosphorylated by GSK-3 at several sites found in Alzheimer disease and its biological activity markedly inhibited only after it is prephosphorylated by A-kinase
    • DOI 10.1016/S0014-5793(98)01090-4, PII S0014579398010904
    • Wang JZ, Wu Q, Smith A, Grundke-Iqbal I, Iqbal K (1998) Tau is phosphorylated by GSK-3 at several sites found in Alzheimer disease and its biological activity markedly inhibited only after it is prephosphorylated by A-kinase. FEBS Lett 436, 28-34. (Pubitemid 28454601)
    • (1998) FEBS Letters , vol.436 , Issue.1 , pp. 28-34
    • Wang, J.-Z.1    Wu, Q.2    Smith, A.3    Grundke-Iqbal, I.4    Iqbal, K.5
  • 30
    • 0033613199 scopus 로고    scopus 로고
    • Regulation of cyclin-dependent kinase 5 catalytic activity by phosphorylation
    • Sharma P, Sharma M, Amin ND, Albers RW, Pant HC (1999) Regulation of cyclin-dependent kinase 5 catalytic activity by phosphorylation. Proc Natl Acad Sci USA 96, 11156-11560.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 11156-11560
    • Sharma, P.1    Sharma, M.2    Amin, N.D.3    Albers, R.W.4    Pant, H.C.5
  • 32
    • 33746652117 scopus 로고    scopus 로고
    • Alzheimer's disease-like tau neuropathology leads to memory deficits and loss of functional synapses in a novel mutated tau transgenic mouse without any motor deficits
    • DOI 10.2353/ajpath.2006.060002
    • Schindowski K, Bretteville A, Leroy K, Bégard S, Brion JP, Hamdane M, Buée L (2006) Alzheimer's disease-like tau neu-ropathology leads to memory deficits and loss of functional synapses in a novel mutated tau transgenic mouse without any motor deficits. Am J Pathol 169, 599-616. (Pubitemid 44156317)
    • (2006) American Journal of Pathology , vol.169 , Issue.2 , pp. 599-616
    • Schindowski, K.1    Bretteville, A.2    Leroy, K.3    Begard, S.4    Brion, J.-P.5    Hamdane, M.6    Buee, L.7
  • 33
    • 0022365608 scopus 로고
    • The distribution of tau in the mammalian central nervous system
    • DOI 10.1083/jcb.101.4.1371
    • Binder LI, Frankfurter A, Rebhun LI (1985) The distribution of tau in the mammalian central nervous system. J Cell Biol 101, 1371-1378. (Pubitemid 16203754)
    • (1985) Journal of Cell Biology , vol.101 , Issue.4 , pp. 1371-1378
    • Binder, L.I.1    Frankfurter, A.2    Rebhun, L.I.3
  • 35
    • 0026740795 scopus 로고
    • Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease
    • Arriagada PV, Growdon JH, Hedley-Whyte ET, Hyman BT (1992) Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease. Neurology 42, 631-639.
    • (1992) Neurology , vol.42 , pp. 631-639
    • Arriagada, P.V.1    Growdon, J.H.2    Hedley-Whyte, E.T.3    Hyman, B.T.4
  • 37
    • 22744459527 scopus 로고    scopus 로고
    • Pseudo-phosphorylation of tau at Ser202 and Thr205 affects tau filament formation
    • DOI 10.1016/j.molbrainres.2005.04.012, PII S0169328X05001762
    • Rankin CA, Sun Q, Gamblin TC (2005) Pseudo-phosphorylation of tau at Ser202 and Thr205 affects tau filament formation. Brain Res Mol Brain Res 138, 84-93. (Pubitemid 41032932)
    • (2005) Molecular Brain Research , vol.138 , Issue.1 , pp. 84-93
    • Rankin, C.A.1    Sun, Q.2    Gamblin, T.C.3
  • 38
    • 0026501888 scopus 로고
    • Hydrofluoric acid-treated tau PHF proteins display the same biochemical properties as normal tau
    • Greenberg SG, Davies P, Schein JD, Binder LI (1992) Hydrofluoric acid-treated tau PHF proteins display the same biochemical properties as normal tau. J Biol Chem 267, 564-569.
    • (1992) J Biol Chem , vol.267 , pp. 564-569
    • Greenberg, S.G.1    Davies, P.2    Schein, J.D.3    Binder, L.I.4
  • 39
    • 0027421625 scopus 로고
    • Brain proline-directed protein kinase phosphorylates tau on sites that are abnormally phosphorylated in tau associated with Alzheimer's paired helicalfilaments
    • Paudel HK, Lew J, Ali Z, Wang JH (1993) Brain proline-directed protein kinase phosphorylates tau on sites that are abnormally phosphorylated in tau associated with Alzheimer's paired helicalfilaments.J Biol Chem268, 23512-23516.
    • (1993) J Biol Chem , vol.268 , pp. 23512-23516
    • Paudel, H.K.1    Lew, J.2    Ali, Z.3    Wang, J.H.4
  • 40
    • 0037111833 scopus 로고    scopus 로고
    • Tau-mediated cytotoxicity in a pseudohyperphosphorylation model of Alzheimer's disease
    • Fath T, Eidenmüller J, Brandt R (2002) Tau-mediated cytotoxicity in a pseudohyperphosphorylation model of Alzheimer's diseasese. J Neurosci 22, 9733-9741. (Pubitemid 35332856)
    • (2002) Journal of Neuroscience , vol.22 , Issue.22 , pp. 9733-9741
    • Fath, T.1    Eidenmuller, J.2    Brandt, R.3
  • 41
    • 0030937952 scopus 로고    scopus 로고
    • The phosphorylation of tau: A critical stage in neurodevelopment and neurodegenerative process
    • DOI 10.1016/S0306-4522(96)00577-5, PII S0306452296005775
    • Lovestone S, Reynolds CH (1997) The phosphorylation of tau: A critical stage in neurodevelopment and neurodegener-ative processes. Neuroscience 78, 309-324. (Pubitemid 27170324)
    • (1997) Neuroscience , vol.78 , Issue.2 , pp. 309-324
    • Lovestone, S.1    Reynolds, C.H.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.