-
1
-
-
0036875352
-
Differential effect of Bcl-xl over-expression on cell death of the monocytic leukemia cell line U937
-
Abdelhaleem M. Differential effect of Bcl-xl over-expression on cell death of the monocytic leukemia cell line U937. Anticancer Res. 2002, 22:3911-3915.
-
(2002)
Anticancer Res.
, vol.22
, pp. 3911-3915
-
-
Abdelhaleem, M.1
-
2
-
-
0034875172
-
Involvement of protein kinase C-delta in DNA damage-induced apoptosis
-
Basu A., Woolard M.D., Johnson C.L. Involvement of protein kinase C-delta in DNA damage-induced apoptosis. Cell Death Differ. 2001, 8:899-908.
-
(2001)
Cell Death Differ.
, vol.8
, pp. 899-908
-
-
Basu, A.1
Woolard, M.D.2
Johnson, C.L.3
-
3
-
-
21444459918
-
P2Y2 nucleotide receptors enhance alpha-secretase-dependent amyloid precursor protein processing
-
Camden J.M., Schrader A.M., Camden R.E., Gonzalez F.A., Erb L., Seye C.I., Weisman G.A. P2Y2 nucleotide receptors enhance alpha-secretase-dependent amyloid precursor protein processing. J. Biol. Chem. 2005, 280:18696-18702.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 18696-18702
-
-
Camden, J.M.1
Schrader, A.M.2
Camden, R.E.3
Gonzalez, F.A.4
Erb, L.5
Seye, C.I.6
Weisman, G.A.7
-
4
-
-
0030921730
-
Increased secretion of the amino-terminal fragment of amyloid precursor protein in brains of rats with a constitutive up-regulation of protein kinase C
-
Caputi A., Barindelli S., Pastorino L., Cimino M., Buxbaum J.D., Cattabeni F., Di Luca M. Increased secretion of the amino-terminal fragment of amyloid precursor protein in brains of rats with a constitutive up-regulation of protein kinase C. J. Neurochem. 1997, 68:2523-2529.
-
(1997)
J. Neurochem.
, vol.68
, pp. 2523-2529
-
-
Caputi, A.1
Barindelli, S.2
Pastorino, L.3
Cimino, M.4
Buxbaum, J.D.5
Cattabeni, F.6
Di Luca, M.7
-
5
-
-
0029379605
-
Processing of the beta-amyloid precursor protein and its regulation in Alzheimer's disease
-
Checler F. Processing of the beta-amyloid precursor protein and its regulation in Alzheimer's disease. J. Neurochem. 1995, 65:1431-1444.
-
(1995)
J. Neurochem.
, vol.65
, pp. 1431-1444
-
-
Checler, F.1
-
6
-
-
57549101895
-
Enhanced generation of Alzheimer's amyloid-beta following chronic exposure to phorbol ester correlates with differential effects on alpha and epsilon isozymes of protein kinase C
-
da Cruz e Silva O.A., Rebelo S., Vieira S.I., Gandy S., da Cruz e Silva E.F., Greengard P. Enhanced generation of Alzheimer's amyloid-beta following chronic exposure to phorbol ester correlates with differential effects on alpha and epsilon isozymes of protein kinase C. J. Neurochem. 2009, 108:319-330.
-
(2009)
J. Neurochem.
, vol.108
, pp. 319-330
-
-
da Cruz e Silva, O.A.1
Rebelo, S.2
Vieira, S.I.3
Gandy, S.4
da Cruz e Silva, E.F.5
Greengard, P.6
-
7
-
-
0031952526
-
Regulation of secretion of Alzheimer amyloid precursor protein by the mitogen-activated protein kinase cascade
-
Desdouits-Magnen J., Desdouits F., Takeda S., Syu L.J., Saltiel A.R., Buxbaum J.D., Czernik A.J., Nairn A.C., Greengard P. Regulation of secretion of Alzheimer amyloid precursor protein by the mitogen-activated protein kinase cascade. J. Neurochem. 1998, 70:524-530.
-
(1998)
J. Neurochem.
, vol.70
, pp. 524-530
-
-
Desdouits-Magnen, J.1
Desdouits, F.2
Takeda, S.3
Syu, L.J.4
Saltiel, A.R.5
Buxbaum, J.D.6
Czernik, A.J.7
Nairn, A.C.8
Greengard, P.9
-
8
-
-
0025295039
-
Cleavage of amyloid beta peptide during constitutive processing of its precursor
-
Esch F.S., Keim P.S., Beattie E.C., Blacher R.W., Culwell A.R., Oltersdorf T., McClure D., Ward P.J. Cleavage of amyloid beta peptide during constitutive processing of its precursor. Science 1990, 248:1122-1124.
-
(1990)
Science
, vol.248
, pp. 1122-1124
-
-
Esch, F.S.1
Keim, P.S.2
Beattie, E.C.3
Blacher, R.W.4
Culwell, A.R.5
Oltersdorf, T.6
McClure, D.7
Ward, P.J.8
-
9
-
-
3342934646
-
Therapeutic effects of PKC activators in Alzheimer's disease transgenic mice
-
Etcheberrigaray R., Tan M., Dewachter I., Kuiperi C., Van der Auwera I., Wera S., Qiao L., Bank B., Nelson T.J., Kozikowski A.P., Van Leuven F., Alkon D.L. Therapeutic effects of PKC activators in Alzheimer's disease transgenic mice. Proc. Natl. Acad. Sci. U.S.A. 2004, 101:11141-11146.
-
(2004)
Proc. Natl. Acad. Sci. U.S.A.
, vol.101
, pp. 11141-11146
-
-
Etcheberrigaray, R.1
Tan, M.2
Dewachter, I.3
Kuiperi, C.4
Van der Auwera, I.5
Wera, S.6
Qiao, L.7
Bank, B.8
Nelson, T.J.9
Kozikowski, A.P.10
Van Leuven, F.11
Alkon, D.L.12
-
10
-
-
0030068094
-
Activation of K+ channels and suppression of neuronal activity by secreted beta-amyloid-precursor protein
-
Furukawa K., Barger S.W., Blalock E.M., Mattson M.P. Activation of K+ channels and suppression of neuronal activity by secreted beta-amyloid-precursor protein. Nature 1996, 379:74-78.
-
(1996)
Nature
, vol.379
, pp. 74-78
-
-
Furukawa, K.1
Barger, S.W.2
Blalock, E.M.3
Mattson, M.P.4
-
11
-
-
0032007292
-
Overexpression of protein kinase C isoform epsilon but not delta in human interleukin-3-dependent cells suppresses apoptosis and induces bcl-2 expression
-
Gubina E., Rinaudo M.S., Szallasi Z., Blumberg P.M., Mufson R.A. Overexpression of protein kinase C isoform epsilon but not delta in human interleukin-3-dependent cells suppresses apoptosis and induces bcl-2 expression. Blood 1998, 91:823-829.
-
(1998)
Blood
, vol.91
, pp. 823-829
-
-
Gubina, E.1
Rinaudo, M.S.2
Szallasi, Z.3
Blumberg, P.M.4
Mufson, R.A.5
-
12
-
-
0026646604
-
Amyloid beta-peptide is produced by cultured cells during normal metabolism
-
Haass C., Schlossmacher M.G., Hung A.Y., Vigo-Pelfrey C., Mellon A., Ostaszewski B.L., Lieberburg I., Koo E.H., Schenk D., Teplow D.B., Selkoe D.J. Amyloid beta-peptide is produced by cultured cells during normal metabolism. Nature 1992, 359:322-325.
-
(1992)
Nature
, vol.359
, pp. 322-325
-
-
Haass, C.1
Schlossmacher, M.G.2
Hung, A.Y.3
Vigo-Pelfrey, C.4
Mellon, A.5
Ostaszewski, B.L.6
Lieberburg, I.7
Koo, E.H.8
Schenk, D.9
Teplow, D.B.10
Selkoe, D.J.11
-
13
-
-
0037135111
-
The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics
-
Hardy J., Selkoe D.J. The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 2002, 297:353-356.
-
(2002)
Science
, vol.297
, pp. 353-356
-
-
Hardy, J.1
Selkoe, D.J.2
-
14
-
-
0347693127
-
Suppression of protein kinase Calpha triggers apoptosis through down-regulation of Bcl-xL in a rat hepatic epithelial cell line
-
Hsieh Y.C., Jao H.C., Yang R.C., Hsu H.K., Hsu C. Suppression of protein kinase Calpha triggers apoptosis through down-regulation of Bcl-xL in a rat hepatic epithelial cell line. Shock 2003, 19:582-587.
-
(2003)
Shock
, vol.19
, pp. 582-587
-
-
Hsieh, Y.C.1
Jao, H.C.2
Yang, R.C.3
Hsu, H.K.4
Hsu, C.5
-
15
-
-
0034966403
-
Closing in on the amyloid cascade: recent insights into the cell biology of Alzheimer's disease
-
Huse J.T., Doms R.W. Closing in on the amyloid cascade: recent insights into the cell biology of Alzheimer's disease. Mol. Neurobiol. 2000, 22:81-98.
-
(2000)
Mol. Neurobiol.
, vol.22
, pp. 81-98
-
-
Huse, J.T.1
Doms, R.W.2
-
16
-
-
0028267440
-
Normal and abnormal biology of the beta-amyloid precursor protein
-
Selkoe D.J. Normal and abnormal biology of the beta-amyloid precursor protein. Annu. Rev. Neurosci. 1994, 17:489-517.
-
(1994)
Annu. Rev. Neurosci.
, vol.17
, pp. 489-517
-
-
Selkoe, D.J.1
-
17
-
-
0030797332
-
Secreted form of beta-amyloid precursor protein shifts the frequency dependency for induction of LTD, and enhances LTP in hippocampal slices
-
Ishida A., Furukawa K., Keller J.N., Mattson M.P. Secreted form of beta-amyloid precursor protein shifts the frequency dependency for induction of LTD, and enhances LTP in hippocampal slices. Neuroreport 1997, 8:2133-2137.
-
(1997)
Neuroreport
, vol.8
, pp. 2133-2137
-
-
Ishida, A.1
Furukawa, K.2
Keller, J.N.3
Mattson, M.P.4
-
18
-
-
3242757474
-
Differential involvement of protein kinase C alpha and epsilon in the regulated secretion of soluble amyloid precursor protein
-
Lanni C., Mazzucchelli M., Porrello E., Govoni S., Racchi M. Differential involvement of protein kinase C alpha and epsilon in the regulated secretion of soluble amyloid precursor protein. Eur. J. Biochem. 2004, 271:3068-3075.
-
(2004)
Eur. J. Biochem.
, vol.271
, pp. 3068-3075
-
-
Lanni, C.1
Mazzucchelli, M.2
Porrello, E.3
Govoni, S.4
Racchi, M.5
-
19
-
-
21244448835
-
Short-term interleukin-1(beta) increases the release of secreted APP(alpha) via MEK1/2-dependent and JNK-dependent alpha-secretase cleavage in neuroglioma U251 cells
-
Ma G., Chen S., Wang X., Ba M., Yang H., Lu G. Short-term interleukin-1(beta) increases the release of secreted APP(alpha) via MEK1/2-dependent and JNK-dependent alpha-secretase cleavage in neuroglioma U251 cells. J. Neurosci. Res. 2005, 80:683-692.
-
(2005)
J. Neurosci. Res.
, vol.80
, pp. 683-692
-
-
Ma, G.1
Chen, S.2
Wang, X.3
Ba, M.4
Yang, H.5
Lu, G.6
-
20
-
-
0030779677
-
Cellular actions of beta-amyloid precursor protein and its soluble and fibrillogenic derivatives
-
Mattson M.P. Cellular actions of beta-amyloid precursor protein and its soluble and fibrillogenic derivatives. Physiol. Rev. 1997, 77:1081-1132.
-
(1997)
Physiol. Rev.
, vol.77
, pp. 1081-1132
-
-
Mattson, M.P.1
-
21
-
-
0032514633
-
Memory-enhancing effects of secreted forms of the beta-amyloid precursor protein in normal and amnestic mice
-
Meziane H., Dodart J.C., Mathis C., Little S., Clemens J., Paul S.M., Ungerer A. Memory-enhancing effects of secreted forms of the beta-amyloid precursor protein in normal and amnestic mice. Proc. Natl. Acad. Sci. U.S.A. 1998, 95:12683-12688.
-
(1998)
Proc. Natl. Acad. Sci. U.S.A.
, vol.95
, pp. 12683-12688
-
-
Meziane, H.1
Dodart, J.C.2
Mathis, C.3
Little, S.4
Clemens, J.5
Paul, S.M.6
Ungerer, A.7
-
22
-
-
0031453010
-
Regulation of amyloid precursor protein catabolism involves the mitogen-activated protein kinase signal transduction pathway
-
Mills J., Laurent Charest D., Lam F., Beyreuther K., Ida N., Pelech S.L., Reiner P.B. Regulation of amyloid precursor protein catabolism involves the mitogen-activated protein kinase signal transduction pathway. J. Neurosci. 1997, 17:9415-9422.
-
(1997)
J. Neurosci.
, vol.17
, pp. 9415-9422
-
-
Mills, J.1
Laurent Charest, D.2
Lam, F.3
Beyreuther, K.4
Ida, N.5
Pelech, S.L.6
Reiner, P.B.7
-
23
-
-
0035879075
-
Dishevelled regulates the metabolism of amyloid precursor protein via protein kinase C/mitogen-activated protein kinase and c-Jun terminal kinase
-
Mudher A., Chapman S., Richardson J., Asuni A., Gibb G., Pollard C., Killick R., Iqbal T., Raymond L., Varndell I., Sheppard P., Makoff A., Gower E., Soden P.E., Lewis P., Murphy M., Golde T.E., Rupniak H.T., Anderton B.H., Lovestone S. Dishevelled regulates the metabolism of amyloid precursor protein via protein kinase C/mitogen-activated protein kinase and c-Jun terminal kinase. J. Neurosci. 2001, 21:4987-4995.
-
(2001)
J. Neurosci.
, vol.21
, pp. 4987-4995
-
-
Mudher, A.1
Chapman, S.2
Richardson, J.3
Asuni, A.4
Gibb, G.5
Pollard, C.6
Killick, R.7
Iqbal, T.8
Raymond, L.9
Varndell, I.10
Sheppard, P.11
Makoff, A.12
Gower, E.13
Soden, P.E.14
Lewis, P.15
Murphy, M.16
Golde, T.E.17
Rupniak, H.T.18
Anderton, B.H.19
Lovestone, S.20
more..
-
24
-
-
0026451081
-
Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C
-
Nishizuka Y. Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. Science 1992, 258:607-614.
-
(1992)
Science
, vol.258
, pp. 607-614
-
-
Nishizuka, Y.1
-
25
-
-
0029060391
-
Protein kinase C and lipid signaling for sustained cellular responses
-
Nishizuka Y. Protein kinase C and lipid signaling for sustained cellular responses. FASEB J. 1995, 9:484-496.
-
(1995)
FASEB J.
, vol.9
, pp. 484-496
-
-
Nishizuka, Y.1
-
26
-
-
33745209915
-
ADAM10 activation is required for green tea (-)-epigallocatechin-3-gallate-induced alpha-secretase cleavage of amyloid precursor protein
-
Obregon D.F., Rezai-Zadeh K., Bai Y., Sun N., Hou H., Ehrhart J., Zeng J., Mori T., Arendash G.W., Shytle D., Town T., Tan J. ADAM10 activation is required for green tea (-)-epigallocatechin-3-gallate-induced alpha-secretase cleavage of amyloid precursor protein. J. Biol. Chem. 2006, 281:16419-16427.
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 16419-16427
-
-
Obregon, D.F.1
Rezai-Zadeh, K.2
Bai, Y.3
Sun, N.4
Hou, H.5
Ehrhart, J.6
Zeng, J.7
Mori, T.8
Arendash, G.W.9
Shytle, D.10
Town, T.11
Tan, J.12
-
27
-
-
77953750340
-
L-3-n-Butylphthalide improves cognitive impairment and reduces amyloid-beta in a transgenic model of Alzheimer's disease
-
Peng Y., Sun J., Hon S., Nylander A.N., Xia W., Feng Y., Wang X., Lemere C.A. l-3-n-Butylphthalide improves cognitive impairment and reduces amyloid-beta in a transgenic model of Alzheimer's disease. J. Neurosci. 2010, 30:8180-8189.
-
(2010)
J. Neurosci.
, vol.30
, pp. 8180-8189
-
-
Peng, Y.1
Sun, J.2
Hon, S.3
Nylander, A.N.4
Xia, W.5
Feng, Y.6
Wang, X.7
Lemere, C.A.8
-
28
-
-
40849139194
-
L-3-n-Butylphthalide ameliorates beta-amyloid-induced neuronal toxicity in cultured neuronal cells
-
Peng Y., Xing C.H., Lemere C.A., Chen G.Q., Xu S.F., Wang L., Feng Y.P., Wang X.L. l-3-n-Butylphthalide ameliorates beta-amyloid-induced neuronal toxicity in cultured neuronal cells. Neurosci. Lett. 2008, 434:224-229.
-
(2008)
Neurosci. Lett.
, vol.434
, pp. 224-229
-
-
Peng, Y.1
Xing, C.H.2
Lemere, C.A.3
Chen, G.Q.4
Xu, S.F.5
Wang, L.6
Feng, Y.P.7
Wang, X.L.8
-
29
-
-
70349617912
-
L-3-n-Butylphthalide improves cognitive impairment induced by intracerebroventricular infusion of amyloid-β peptide in rats
-
Peng Y., Xing C.H., Xu S.F., Lemere C.A., Chen G.Q., Liu B., Wang L., Feng Y.P., Wang X.L. l-3-n-Butylphthalide improves cognitive impairment induced by intracerebroventricular infusion of amyloid-β peptide in rats. Eur. J. Pharmacol. 2009, 621:38-45.
-
(2009)
Eur. J. Pharmacol.
, vol.621
, pp. 38-45
-
-
Peng, Y.1
Xing, C.H.2
Xu, S.F.3
Lemere, C.A.4
Chen, G.Q.5
Liu, B.6
Wang, L.7
Feng, Y.P.8
Wang, X.L.9
-
30
-
-
34248560915
-
L-3-n-Butylphthalide improves cognitive impairment induced by chronic cerebral hypoperfusion in rats
-
Peng Y., Xu S.F., Chen G.Q., Wang L., Feng Y.P., Wang X.L. l-3-n-Butylphthalide improves cognitive impairment induced by chronic cerebral hypoperfusion in rats. J. Pharmacol. Exp. Ther. 2007, 321:902-910.
-
(2007)
J. Pharmacol. Exp. Ther.
, vol.321
, pp. 902-910
-
-
Peng, Y.1
Xu, S.F.2
Chen, G.Q.3
Wang, L.4
Feng, Y.P.5
Wang, X.L.6
-
31
-
-
34248535284
-
Effect of l-3-n-utylphthalide on cerebral infarct volume in the transient cerebral ischemia rats
-
Peng Y., Xu S.F., Wang L., Feng Y.P., Wang X.L. Effect of l-3-n-utylphthalide on cerebral infarct volume in the transient cerebral ischemia rats. Chin. New Drug 2005, 14:420-423.
-
(2005)
Chin. New Drug
, vol.14
, pp. 420-423
-
-
Peng, Y.1
Xu, S.F.2
Wang, L.3
Feng, Y.P.4
Wang, X.L.5
-
32
-
-
2542468786
-
Antiplatelet and antithrombotic activity of l-3-n-butylphthalide in rats
-
Peng Y., Zeng X., Feng Y., Wang X.L. Antiplatelet and antithrombotic activity of l-3-n-butylphthalide in rats. J. Cardiovasc. Pharmacol. 2004, 43:876-881.
-
(2004)
J. Cardiovasc. Pharmacol.
, vol.43
, pp. 876-881
-
-
Peng, Y.1
Zeng, X.2
Feng, Y.3
Wang, X.L.4
-
33
-
-
0037222109
-
Role of protein kinase Calpha in the regulated secretion of the amyloid precursor protein
-
Racchi M., Mazzucchelli M., Pascale A., Sironi M., Govoni S. Role of protein kinase Calpha in the regulated secretion of the amyloid precursor protein. Mol. Psychiatry 2003, 8:209-216.
-
(2003)
Mol. Psychiatry
, vol.8
, pp. 209-216
-
-
Racchi, M.1
Mazzucchelli, M.2
Pascale, A.3
Sironi, M.4
Govoni, S.5
-
34
-
-
0035319002
-
Protein kinase Ca and b1 isoforms are regulators of asecretory proteolytic processing of amyloid precursor protein in vivo
-
RoBner S., Mendla K., Schliebs R., Bigl V. Protein kinase Ca and b1 isoforms are regulators of asecretory proteolytic processing of amyloid precursor protein in vivo. Eur. J. Neurosci. 2001, 13:1644-1648.
-
(2001)
Eur. J. Neurosci.
, vol.13
, pp. 1644-1648
-
-
RoBner, S.1
Mendla, K.2
Schliebs, R.3
Bigl, V.4
-
35
-
-
0032566717
-
A functional role for mitochondrial protein kinase Calpha in Bcl2 phosphorylation and suppression of apoptosis
-
Ruvolo P.P., Deng X., Carr B.K., May W.S. A functional role for mitochondrial protein kinase Calpha in Bcl2 phosphorylation and suppression of apoptosis. J. Biol. Chem. 1998, 273:25436-25442.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 25436-25442
-
-
Ruvolo, P.P.1
Deng, X.2
Carr, B.K.3
May, W.S.4
-
36
-
-
0031574345
-
Amyloid precursor protein potentiates the neurotrophic activity of NGF
-
Wallace W.C., Akar C.A., Lyons W.E. Amyloid precursor protein potentiates the neurotrophic activity of NGF. Brain Res. Mol. Brain Res. 1997, 52:201-212.
-
(1997)
Brain Res. Mol. Brain Res.
, vol.52
, pp. 201-212
-
-
Wallace, W.C.1
Akar, C.A.2
Lyons, W.E.3
|