Injectable reactive biocomposites for bone healing in critical-size rabbit calvarial defects

Biomedical Materials

Volumn 7, Issue 2, 2012, Pages

  Dumas, Jerald E ^a,b,e   Brownbaer, Pamela B ^c   Prieto, Edna M ^a,b   Guda, Teja ^c,d   Hale, Robert G ^c   Wenke, Joseph C ^c   Guelcher, Scott A ^a,b  

^a VANDERBILT UNIVERSITY   (United States)

^b VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^c US ARMY INSTITUTE OF SURGICAL RESEARCH   (United States)

^d The University of Texas at San Antonio   (United States)

^e Emory University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; DEFECTS; TISSUE;

BIO-COMPOSITES; BONE DEFECT; BONE FORMATION; BONE HEALING; CALVARIAL DEFECTS; COMPLEX DEFECTS; CRANIOFACIAL; ELASTOMERIC SOLIDS; FILTER PRESSING; HEALING PROCESS; INJECTABILITY; LOCAL DELIVERY; LOW YIELD STRESS; MECHANICAL INTEGRITY; RECOMBINANT HUMAN BONE MORPHOGENETIC PROTEIN-2 (RHBMP-2); RHBMP-2; TISSUE REGENERATION; TUMOR ABLATION;

BONE;

BIOMATERIAL; BONE CEMENT; CALCIUM PHOSPHATE; ELASTOMER; LYSINE; POLYURETHAN; RECOMBINANT BONE MORPHOGENETIC PROTEIN 2;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE ALLOGRAFT; COMPOSITE MATERIAL; COMPRESSIVE STRENGTH; CONTROLLED STUDY; EXPERIMENTAL RABBIT; FLOW KINETICS; MATERIALS TESTING; MECHANICAL STRESS; NONHUMAN; OSSIFICATION; SKULL DEFECT; SKULL RADIOGRAPHY; STRESS STRAIN RELATIONSHIP; VISCOSITY; WOUND HEALING; YOUNG MODULUS; ANIMAL; BONE PROSTHESIS; BONE REGENERATION; FRACTURE HEALING; INJECTION; METHODOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; RABBIT; SKULL FRACTURE; TISSUE REGENERATION; TREATMENT OUTCOME;

ORYCTOLAGUS CUNICULUS;

ANIMALS; BONE REGENERATION; BONE SUBSTITUTES; FRACTURE HEALING; GUIDED TISSUE REGENERATION; INJECTIONS; POLYURETHANES; RABBITS; SKULL FRACTURES; TREATMENT OUTCOME;

EID: 84859396017     PISSN: 17486041     EISSN: 1748605X     Source Type: Journal    
DOI: 10.1088/1748-6041/7/2/024112     Document Type: Article

References (63)

1. Ueeck B A 2007 Penetrating injuries to the face: delayed versus primary treatment - considerations for delayed treatment J. Oral Maxillofac. Surg. 65 1209-14 (Pubitemid 46755987)
2. Shermak M A, Wong L, Inoue N and Nicol T 2000 Reconstruction of complex cranial wounds with demineralized bone matrix and bilayer artificial skin J. Craniofac. Surg. 11 224-31 (Pubitemid 32007750)
3. Lemperle S M, Calhoun C J, Curran R W and Holmes R E 1998 Bony healing of large cranial and mandibular defects protected from soft-tissue interposition: a comparative study of spontaneous bone regeneration, osteoconduction, and cancellous autografting in dogs Plast. Reconstr. Surg. 101 660-72 (Pubitemid 28113772)
4. Khan Y, Yaszemski M J, Mikos A G and Laurencin C T 2008 Tissue engineering of bone: material and matrix considerations J. Bone Joint Surg. Am. 90 (Suppl. 1) 36-42 (Pubitemid 351329119)
5. Chim H and Gosain A K 2009 Biomaterials in craniofacial surgery experimental studies and clinical application J. Craniofac. Surg. 20 29-33
6. Tessier P 1982 Autogenous bone grafts taken from the calvarium for facial and cranial applications Clin. Plast. Surg. 9 531-8 (Pubitemid 13178620)
7. Wan D C et al 2006 Differential gene expression between juvenile and adult dura mater: a window into what genes play a role in the regeneration of membranous bone Plast. Reconstr. Surg. 118 851-61 (Pubitemid 44412918)
8. Smith D M, Cooper G M, Mooney M P, Marra K G and Losee J E 2008 Bone morphogenetic protein 2 therapy for craniofacial surgery J. Craniofac. Surg. 19 1244-59
9. Lew T A, Walker J A, Wenke J C, Blackbourne L H and Hale R G 2009 Characterization of craniomaxillofacial battle injuries sustained by United States service members in the current conflicts of Iraq and Afghanistan J. Oral Maxillofac. Surg. 68 3-7
10. Kauvar D S, Wolf S E, Wade C E, Cancio L C, Renz E M and Holcomb J B 2006 Burns sustained in combat explosions in operations Iraqi and enduring freedom (OIF/OEF explosion burns) Burns 32 853-7 (Pubitemid 44442613)
11. Schmitz J P, Hollinger J O and Milam S B 1999 Reconstruction of bone using calcium phosphate bone cements: a critical review J. Oral Maxillofac. Surg. 57 1122-6 (Pubitemid 29411633)
12. Elshahat A, Shermak M A, Inoue N, Chao E Y and Manson P 2004 The use of Novabone and Norian in cranioplasty: a comparative study J. Craniofac. Surg. 15 483-9
13. Moghadam H G, Sandor G K, Holmes H H and Clokie C M 2004 Histomorphometric evaluation of bone regeneration using allogeneic and alloplastic bone substitutes J. Oral Maxillofac. Surg. 62 202-13 (Pubitemid 38140681)
14. Clokie C M, Moghadam H, Jackson M T and Sandor G K 2002 Closure of critical sized defects with allogenic and alloplastic bone substitutes J. Craniofac. Surg. 13 111-21 (Pubitemid 34873957)
15. Goldberg C S, Antonyshyn O, Midha R and Fialkov JA 2005 Measuring pulsatile forces on the human cranium J. Craniofac. Surg. 16 134-9 (Pubitemid 40976072)
16. Bohner M 2011 Designing ceramics for injectable bone graft substitutes Injectable Biomaterials: Science and Applications ed BL Vernon (Philadelphia, PA: Woodhead Publishing)
17. Spector J, Luchs J, Mehera B, Greenwald J, Smith L and Longaker M 2001 Expression of bone morphogenetic proteins during membranous bone healing Plast. Reconstr. Surg. 107 124-34 (Pubitemid 32039244)
18. Boerckel J D et al 2011 Effects of protein dose and delivery system on BMP-mediated bone regeneration Biomaterials 32 5241-51
19. Brown K V, Li B, Guda T, Perrien D S, Guelcher S A and Wenke J C 2011 Improving bone formation in a rat femur segmental defect by controlling bone morphogenetic protein-2 release Tissue Eng. A 17 1735-46
20. Smith D M, Afifi A M, Cooper G M, Mooney M P, Marra K G and Losee J E 2008 BMP-2-based repair of large-scale calvarial defects in an experimental model: regenerative surgery in cranioplasty J. Craniofac. Surg. 19 1315-22
21. Haidar Z S, Hamdy R C and Tabrizian M 2009 Delivery of recombinant bone morphogenetic proteins for bone regeneration and repair: part A. Current challenges in BMP delivery Biotechnol. Lett. 31 1817-24
22. McKay W F, Peckham S M and Badura J M 2007 A comprehensive clinical review of recombinant human bone morphogenetic protein-2 (INFUSE Bone Graft) Int. Orthop. 31 729-34 (Pubitemid 350160311)
23. Carter T G, Brar P S, Tolas A and Beirne O R 2008 Off-Label use of recombinant human bone morphogenetic protein-2 (rhBMP-2) for reconstruction of mandibular bone defects in humans J. Oral Maxillofac. Surg. 66 1417-25 (Pubitemid 351833132)
24. Herford A S and Boyne P J 2008 Reconstruction of mandibular continuity defects with bone morphogenetic protein-2 (rhBMP-2) J. Oral Maxillofac. Surg. 66 616-24 (Pubitemid 351381799)
25. Panetta N J, Gupta D M and Longaker M T 2009 Bone tissue engineering scaffolds of today and tomorrow J. Craniofac. Surg. 20 1531-2
26. Hollister S J et al 2005 Engineering craniofacial scaffolds Orthod. Craniofac. Res. 8 162-73
27. Dumas J E, Zienkiewicz K, Tanner S A, Prieto E M, Bhattacharyya S and Guelcher S 2010 Synthesis and characterization of an injectable allograft bone/polymer composite bone void filler with tunable mechanical properties Tissue Eng. A 16 2505-18
28. Dumas J E et al 2010 Synthesis of allograft bone/polymer composites and evaluation of remodeling in a rabbit femoral condyle model Acta Biomater. 6 2394-406
29. Li J Q and Salovey R 2004 Model filled polymers: the effect of particle size on the rheology of filled poly(methyl methacrylate) composites Polym. Eng. Sci. 44 452-62
30. Baroud G, Cayer E and Bohner M 2005 Rheological characterization of concentrated aqueous beta-tricalcium phosphate suspensions: the effect of liquid-to-powder ratio, milling time, and additives Acta Biomater. 1 357-63 (Pubitemid 43354820)
31. Luvizuto E R et al 2011 The effect of BMP-2 on the osteoconductive properties of beta-tricalcium phosphate in rat calvaria defects Biomaterials 32 3855-61
32. An Y H and Friedman R J 1999 Animal models of bone defect repair Animals Models in Orthopaedic Research ed Y H An and R J Friedman (Boca Raton, FL: CRC Press)
33. Otsu N 1978 A threshold selection method for gray level histogram IEEE Trans. Syst. Man Cybern. SMC-9 62-66
34. Elsalanty M E et al 2008 Recombinant human BMP-2 enhances the effects of materials used for reconstruction of large cranial defects J. Oral Maxillofac. Surg. 66 277-85
35. Bohner M 2000 Calcium orthophosphates in medicine: from ceramics to calcium phosphate cements Injury 31 (Suppl. 4) S-D37-47
36. Lewis G 2007 Percutaneous vertebroplasty and kyphoplasty for the stand-alone augmentation of osteoporosis-induced vertebral compression fractures: present status and future directions J. Biomed. Mater. Res., Appl. Biomater. 81B 371-86 (Pubitemid 46685104)
37. Clarkin O M, Boyd D, Madigan S and Towler M R 2009 Comparison of an experimental bone cement with a commercial control, Hydroset™ J. Mater. Sci., Mater. Med. 20 1563-70
38. Bohner M and Baroud G 2005 Injectability of calcium phosphate pastes Biomaterials 26 1553-63 (Pubitemid 39445378)
39. Cherng A, Takagi S and Chow L C 1997 Effects of hydroxypropyl methylcellulose and other gelling agents on the handling properties of calcium phosphate cement J. Biomed. Mater. Res. 35 273-7 (Pubitemid 27193918)
40. Gilardino M S, Cabiling D S and Bartlett S P 2009 Long-term follow-up experience with carbonated calcium phosphate cement (Norian) for cranioplasty in children and adults Plast. Reconstr. Surg. 123 983-94
41. Aaboe M, Pinholt E M, Schou S and Hjorting-Hansen E 1998 Incomplete bone regeneration of rabbit calvarial defects using different membranes Clin. Oral Implants Res. 9 313-20 (Pubitemid 128658004)
42. Torquato S, Truskett T M and Debenedetti P G 2000 Is random close packing of spheres well defined ? Phys. Rev. Lett. 84 2064-7
43. Yoshii T, Dumas J E, Okawa A, Spengler D M and Guelcher S A 2012 Synthesis, characterization of calcium phosphates/polyurethane composites for weight-bearing implants J. Biomed. Mater. Res., Appl. Biomater. B 100 32-40
44. Adhikari R et al 2008 Biodegradable injectable polyurethanes: synthesis and evaluation for orthopaedic applications Biomaterials 29 3762-70
45. Malinin T I, Carpenter E M and Temple H T 2007 Particulate bone allograft incorporation in regeneration of osseous defects; importance of particle sizes Open Orthop. J. 1 19-24
46. Hasegawa S et al 2006 A 5-7 year in vivo study of high-strength hydroxyapatite/poly(L-lactide) composite rods for the internal fixation of bone fractures Biomaterials 27 1327-32 (Pubitemid 41739557)
47. Hafeman A E et al 2011 Characterization of the degradation mechanisms of lysine-derived aliphatic poly(ester urethane) scaffolds Biomaterials 32 419-29
48. Li B, Yoshii T, Hafeman A E, Nyman J S, Wenke J C and Guelcher S A 2009 The effects of rhBMP-2 released from biodegradable polyurethane/microsphere composite scaffolds on new bone formation in rat femora Biomaterials 30 6768-79
49. Donath K, Laass M and Gunzl H J 1992 The histopathology of different foreign-body reactions in oral soft tissue and bone tissue Virchows Arch. A, Pathol. Anat. Histopathol. 420 131-7
50. Takaoka K, Koezuka M and Nakahara H 1991 Telopeptide-depleted bovine skin collagen as a carrier for bone morphogenetic protein J. Orthop. Res. 9 902-7
51. Haidar Z S, Hamdy R C and Tabrizian M 2009 Delivery of recombinant bone morphogenetic proteins for bone regeneration and repair: part B. Delivery systems for BMPs in orthopaedic and craniofacial tissue engineering Biotechnol. Lett. 31 1825-35
52. Miyazaki M et al 2009 A porcine collagen-derived matrix as a carrier for recombinant human bone morphogenetic protein-2 enhances spinal fusion in rats Spine J. 9 22-30
53. Sheehan J P, Sheehan J M, Seeherman H, Quigg M and Helm G A 2003 The safety and utility of recombinant human bone morphogenetic protein-2 for cranial procedures in a nonhuman primate model J. Neurosurg. 98 125-30 (Pubitemid 36050455)
54. Kolambkar Y M et al 2011 An alginate-based hybrid system for growth factor delivery in the functional repair of large bone defects Biomaterials 32 65-74
55. Geiger M, Li R H and Friess W 2003 Collagen sponges for bone regeneration with rhBMP-2 Adv. Drug Deliv. Rev. 55 1613-29 (Pubitemid 37420006)
56. Santos M I, Unger R E, Sousa R A, Reis R L and Kirkpatrick C J 2009 Crosstalk between osteoblasts and endothelial cells co-cultured on a polycaprolactone-starch scaffold and the in vitro development of vascularization Biomaterials 30 4407-15
57. Unger R E et al 2007 Tissue-like self-assembly in cocultures of endothelial cells and osteoblasts and the formation of microcapillary-like structures on three-dimensional porous biomaterials Biomaterials 28 3965-76 (Pubitemid 47048370)
58. Szpalski M and Gunzburg R 2005 Recombinant human bone morphogenetic protein-2: a novel osteoinductive alternative to autogenous bone graft? Acta Orthop. Belg. 71 133-48 (Pubitemid 40705128)
59. Jensen E D et al 2010 Bone morphogenic protein 2 directly enhances differentiation of murine osteoclast precursors J. Cell Biochem. 109 672-82
60. Okamoto M, Murai J, Yoshikawa H and Tsumaki N 2006 Bone morphogenetic proteins in bone stimulate osteoclasts and osteoblasts during bone development J. Bone Miner Res. 21 1022-33 (Pubitemid 43962831)
61. Belfrage O, Flivik G, Sundberg M, Kesteris U and Tagil M 2011 Local treatment of cancellous bone grafts with BMP-7 and zoledronate increases both the bone formation rate and bone density Acta Orthop. 82 228-33
62. Schwartz Z et al 1998 Addition of human recombinant bone morphogenetic protein-2 to inactive commercial human demineralized freeze-dried bone allograft makes an effective composite bone inductive implant material J. Periodontol. 69 1337-45
63. McGee M A et al 2004 The use of OP-1 in femoral impaction grafting in a sheep model J. Orthop. Res. 22 1008-15 (Pubitemid 39149165)