Synthesis and characterization of an injectable allograft bone/polymer composite bone void filler with tunable mechanical properties

Tissue Engineering - Part A

Volumn 16, Issue 8, 2010, Pages 2505-2518

  Dumas, Jerald E ^a,b   Zienkiewicz, Katarzyna ^a,b   Tanner, Shaun A ^a,b   Prieto, Edna M ^a,b   Bhattacharyya, Subha ^c   Guelcher, Scott A ^a,b  

^a VANDERBILT UNIVERSITY   (United States)

^b VANDERBILT UNIVERSITY   (United States)

^c Osteotech Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BEARINGS (MACHINE PARTS); BIOLOGICAL MATERIALS; BONE; BONE CEMENT; CALCIUM; CALCIUM PHOSPHATE; CEMENTS; COMPRESSIVE STRENGTH; DEFECTS; FILLERS; GRAFTS; IMPLANTS (SURGICAL); PHOSPHATES; SEEPAGE; SHEAR DEFORMATION; SOIL MECHANICS;

ATHYMIC; BIOMEDICAL DEVICES; BONE FORMATION; BONE REGENERATION; BONE-PARTICLES; CALCIUM PHOSPHATE BONE CEMENT; CALCIUM PHOSPHATE CEMENT; CELLULAR INFILTRATION; COLLAGEN DEPOSITION; COMPOSITE BONES; DYNAMIC VISCOSITIES; FOOD AND DRUG ADMINISTRATION; IN-SITU; INJECTABLE BIOMATERIALS; OSTEOCONDUCTIVITY; SETTING TIME; SHAPED DEFECTS; SHEAR RATES; SYNTHESIS AND CHARACTERIZATIONS; SYNTHETIC BONE GRAFT MATERIALS; TUNABLE PROPERTIES; TWO-COMPONENT;

MECHANICAL PROPERTIES;

RATTUS;

POLYURETHAN;

ANIMAL; ARTICLE; BONE PROSTHESIS; BONE TRANSPLANTATION; FEMUR FRACTURE; HISTOLOGY; INJECTION; MATERIALS TESTING; METHODOLOGY; NUDE RAT; PATHOLOGY; RAT; SYNTHESIS; TREATMENT OUTCOME;

ANIMALS; BONE DEMINERALIZATION TECHNIQUE; BONE SUBSTITUTES; BONE TRANSPLANTATION; FEMORAL FRACTURES; INJECTIONS; MATERIALS TESTING; POLYURETHANES; RATS; RATS, NUDE; TREATMENT OUTCOME;

EID: 77956064777     PISSN: 19373341     EISSN: 1937335X     Source Type: Journal    
DOI: 10.1089/ten.tea.2009.0672     Document Type: Article

References (39)

1. Friedman, CD., Constantino, P.D., Takagi, S., and Chow, L.C. BoneSource™ hydroxyapatite cement: a novel bioma-terial for craniofacial skeletal tissue engineering and reconstruction. J Biomed Mater Res 43, 428, 1998.
2. Chim, H., and Gosain, A.K. Biomaterials in craniofacial surgery experimental studies and clinical application. J Craniofac Surg 20, 29, 2009.
3. Gasparini, G., Boniello, R., Moro, A., Tamburrini, G., Di Rocco, C, and Pelo, S. Cranial reshaping using methyl methacrylate:technical note. J Craniofac Surg 20, 184, 2009.
4. Moreira-Gonzalez, A., Jackson, I.T., Miyawaki, T., Barakat, K., and DiNick, V. Clinical outcome in cranioplasty: critical review in long-term follow-up. J Craniofac Surg 14, 144, 2003.
5. Bohner, M. Calcium orthophosphates in medicine: from ceramics to calcium phosphate cements. Injury 31, S-D37, 2000.
6. Hollier, L.H., and Stal, S. The use of hydroxyapatite cements in craniofacial surgery. Clin Plast Surg 31, 423, 2004.
7. United States Food and Drug Administration Center for Devices and Radiological Health, Manufacturer and User Facility Device Experience Database. Available at www.fda. gov/cdrh/maude.html. Accessed November 5, 2008.
8. Baker, S.B., Weinzweig, J., Kirschner, R.E., and Bartlett, S.P. Applications of a new carbonated calcium phosphate bone cement: early experience in pediatric and adult craniofacial reconstruction. Plast Reconstr Surg 109, 1789, 2002.
9. Goldberg, C.S., Antonyshyn, O., Midha, R., and Fialkov, J.A. Measuring pulsatile forces on the human cranium. J Craniofac Surg 16, 134, 2005.
10. Boyce, T.M., Winterbottom, J.M., Kaes, D.R., Shimp, L.A., and Knaack, D.A. Development of a bone-derived composite implant for skeletal applications. Presented at the Pittsburgh Bone Symposium, Pittsburgh, PA, 2003.
11. Osteotech, Inc. Concerned about the safety of your auto-graft? Eatontown, NJ: Osteotech, Inc., 2006.
12. Bilezikian, J.P., Raisz, L.G., and Rodan, G.A. Principles of Bone Biology. New York: Academic Press, 1996, pp. 1-1398.
13. Market Dynamics: Bone Substitutes and Growth Factors. New York: Datamonitor (DMHC1812), 2002, pp. 118-132.
14. Newton, C.D., and Nunamaker, D.B. Textbook of Small Animal Orthopaedics. Philadelphia: Lippincott, 1985.
15. Hafeman, A., Li, B., Yoshii, T., Zienkiewicz, K., Davidson, J., and Guelcher, S. Injectable biodegradable polyurethane scaffolds with release of platelet-derived growth factor for tissue repair and regeneration. Pharm Res 25, 2387, 2008.
16. Guelcher, S. Biodegradable polyurethanes: synthesis and applications in regenerative medicine. Tissue Eng B 14, 3, 2008.
17. Storey, R.F., Wiggins, J.S., and Puckett, A.D. Hydrolyzable poly(ester-urethane) networks from L-lysine diisocyanate and D,L-lactide/e-caprolactone homo-and copolyester triols. J Polym Sci Part A: Polym Chem 32, 2345, 1994.
18. Skarja, G.A., and Woodhouse, K.A. Structure-property relationships of degradable polyurethane elastomers containing an amino acid-based chain extender. J Appl Polym Sci 75, 1522, 2000.
19. Adhikari, R., Gunatillake, P.A., Griffiths, I., Tatai, L., Wick-ramaratna, M., Houshyar, S., Moore, T., Mayadunne, R.T., Field, J., McGee, M., and Carbone, T. Biodegradable inject-able polyurethanes: synthesis and evaluation for orthopaedic applications. Biomaterials 29, 3762, 2008.
20. Gorna, K., and Gogolewski, S. Preparation, degradation, and calcification of biodegradable polyurethane foams for bone graft substitutes. J Biomed Mater Res 67A, 813, 2003.
21. Vertenten, G., Vlaminck, L., Gorski, T., Schreurs, E., Van Den Broeck, W., Duchateau, L., Schacht, E., and Gasthuys, F. Evaluation of an injectable, photopolymerizable threedi-mensional scaffold based on D,L-lactide and e-caprolactone in a tibial goat model. J Mater Sci Mater Med 19, 2761, 2008.
22. Bennett, S., Connolly, K., Lee, D.R., Jiang, Y., Buck, D., Hollinger, J.O., and Gruskin, E.A. Initial biocompatibility studies of a novel degradable polymeric bone substitute that hardens in situ. Bone 19, 101S, 1996.
23. Hasegawa, S., Ishii, S., Tamura, J., Furukawa, T., Neo, M., Matsusue, Y., Shikinami, Y., Okuno, M., and Nakamura, T. A 5-7 year in vivo study of high-strength hydroxyapatite/poly(L-lactide) composite rods for the internal fixation of bone fractures. Biomaterials 27, 1327, 2006.
24. Malinin, T.I., Carpenter, E.M., and Temple, H.T. Particulate bone allograft incorporation in regeneration of osseous defects; importance of particle sizes. Open Orthop J 1, 19, 2007.
25. Guelcher, S.A., Patel, V., Gallagher, K.M., Connolly, S., Di-dier, J.E., Doctor, J.S., and Hollinger, J.O. Synthesis and in vitro biocompatibility of injectable polyurethane foam scaffolds. Tissue Eng 12, 1247, 2006.
26. Guelcher, S.A., Gallagher, K.M., Srinivasan, A., McBride, S.B., Didier, J.E., Doctor, J.S., and Hollinger, J.O. Synthesis, in vitro degradation, and mechanical properties of two-component poly(ester urethane)urea scaffolds: effects of water and polyol composition. Tissue Eng 13, 2321, 2007.
27. ASTM-International. ASTM D4274-99: Standard Test Method for Testing Polyurethane Raw Materials: Determination of Hydroxyl Numbers of Polyols. Section 8: Plastics. West Con-shohocken, PA: ASTM International, 1999.
28. ASTM-International. ASTM D2572-97: Standard Test Method for Isocyanate Groups in Urethane Materials or Prepolymers. Section 8: Plastics. West Conshohocken, PA: ASTM International, 2000.
29. TM. J Mater Sci Mater Med 20, 1563, 2009.
30. Sperling, L.H. Introduction to Physical Polymer Science, 3rd edition. New York: Wiley-Interscience, 2001.
31. Oertel, G. Polyurethane Handbook, 2nd edition. Berlin: Hanser Gardner Publications, 1994.
32. Baroud, G., Bohner, M., Heini, P., and Steffen, T. Injection biomechanics of bone cements used in vertebroplasty. Biomed Mater Eng 14, 487, 2004.
33. Bohner, M., and Baroud, G. Injectability of calcium phosphate pastes. Biomaterials 26, 1553, 2005.
34. Dumas, J.E., Davis, T.E., Holt, G.E., Yoshii, T., Perrien, D.S., Nyman, J.S., Boyce, T.M., and Guelcher, S.A. Synthesis, Characterization, and Remodeling of Weight-bearing Allo-graft Bone/Polyurethane Composites in the Rabbit. Acta Biomaterialia. In Press. doi:10.1016/j.actbio.2010.01.030.
35. Neuendorf, R.E., Saiz, E., Tomsia, A.P., and Ritchie, R.O. Adhesion between biodegradable polymers and hydroxy-apatite: relevance to synthetic bone-like materials and tissue engineering scaffolds. Acta Biomater 4, 1288, 2008.
36. Lewis, G. Percutaneous vertebroplasty and kyphoplasty for the stand-alone augmentation of osteoporosis-induced vertebral compression fractures: present status and future directions. J Biomed Mater Res Part B: Appl Biomater 81B, 371, 2007.
37. Li, B., Yoshii, T., Hafeman, A.E., Nyman, J.S., Wenke, J.C., and Guelcher, S.A. The effects of rhBMP-2 released from biodegradable polyurethane/microsphere composite scaffolds on new bone formation in rat femora. Biomaterials 30, 6768, 2009.
38. Boyce, T.M., Winterbottom, J.M., Lee, S., Kaes, D.R., Bela-ney, R.M., Shimp, L.A., and Knaack, D. Cellular penetration and bone formation depends upon allograft bone fraction in a loadbearing composite implant. Presented at the Society For Biomaterials 30th Annual Meeting Transactions, Memphis, TN, 2005.
39. Shikinami, Y., and Okuno, M. Bioresorbable devices made of forged composites of hydroxyapatite (HA) particles and poly-L-lactide (PLLA): Part I. Basic characteristics. Biomaterials 20, 859, 1999.