Synthesis, characterization of calcium phosphates/polyurethane composites for weight-bearing implants

Journal of Biomedical Materials Research - Part B Applied Biomaterials

Volumn 100 B, Issue 1, 2012, Pages 32-40

  Yoshii, Toshitaka ^a,b,c   Dumas, Jerald E ^a,b   Okawa, Atsushi ^c   Spengler, Dan M ^a   Guelcher, Scott A ^a,b  

^a VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^b VANDERBILT UNIVERSITY   (United States)

^c TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

calcium phosphate; osteoconductive; polyurethane; resorbable; weight bearing

Indexed keywords

BIOMECHANICAL TESTING; BONE DEFECT; CELL VIABILITY; CELLULAR INFILTRATION; CELLULAR RESPONSE; CT IMAGE; GRAFT MATERIALS; HISTOLOGICAL EXAMINATION; HISTOLOGICAL SECTION; IN-VITRO; IN-VIVO; INFLAMMATORY RESPONSE; MICROCOMPUTED TOMOGRAPHY; ORTHOPAEDIC IMPLANTS; OSTEOBLASTIC CELLS; OSTEOCONDUCTIVE; RESORBABLE; TRICALCIUM PHOSPHATES; WEIGHT-BEARING;

AMINO ACIDS; BIOMECHANICS; CALCIUM; CALCIUM PHOSPHATE; CELL CULTURE; CELLS; COMPUTERIZED TOMOGRAPHY; DEFECTS; FRACTURE MECHANICS; HYDROXYAPATITE; IMPLANTS (SURGICAL); MECHANICAL PROPERTIES; POLYURETHANES; TOMOGRAPHY;

BEARINGS (MACHINE PARTS);

CALCIUM PHOSPHATE; HYDROXYAPATITE; POLYURETHAN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOCOMPATIBILITY; BIOMECHANICS; CELL PROLIFERATION; CELL VIABILITY; COMPOSITE GRAFT; DEGRADATION; FEMUR; HISTOPATHOLOGY; IMPLANT; IN VITRO STUDY; IN VIVO STUDY; MICRO-COMPUTED TOMOGRAPHY; NANOFABRICATION; NONHUMAN; OSTEOBLAST; PARTICLE SIZE; RAT; SYNTHESIS; WEIGHT BEARING IMPLANT; X RAY;

ANIMALS; BONE SUBSTITUTES; CALCIUM PHOSPHATES; CELL LINE; DURAPATITE; FEMUR; MALE; MATERIALS TESTING; MICE; POLYURETHANES; RATS; RATS, SPRAGUE-DAWLEY; X-RAY MICROTOMOGRAPHY;

EID: 82955237419     PISSN: 15524973     EISSN: 15524981     Source Type: Journal    
DOI: 10.1002/jbm.b.31917     Document Type: Article

References (47)

1. Giannoudis PV, Dinopoulos H, Tsiridis E,. Bone substitutes: An update. Injury 2005; 36 (Suppl 3): S20-S27.
2. Buckwalter JA, Glimcher MJ, Cooper RR, Recker R,. Bone biology. I. Structure, blood supply, cells, matrix, and mineralization. Instr Course Lect 1996; 45: 371-386.
3. Sammarco VJ, Chang L,. Modern issues in bone graft substitutes and advances in bone tissue technology. Foot Ankle Clinics North Am 2002; 7: 19-41.
4. Kotani S, Fujita Y, Kitsugi T, Nakamura T, Yamamuro T, Ohtsuki C, Kokubo T,. Bone bonding mechanism of beta-tricalcium phosphate. J Biomed Mater Res 1991; 25: 1303-1315.
5. Neo M, Kotani S, Fujita Y, Nakamura T, Yamamuro T, Bando Y, Ohtsuki C, Kokubo T,. Differences in ceramic-bone interface between surface-active ceramics and resorbable ceramics: A study by scanning and transmission electron microscopy. J Biomed Mater Res 1992; 26: 255-267.
6. Chim H, Gosain AK,. Biomaterials in craniofacial surgery experimental studies and clinical application. J Craniofac Surg 2009; 20: 29-33.
7. Moreira-Gonzalez A, Jackson IT, Miyawaki T, Barakat K, DiNick V,. Clinical outcome in cranioplasty: Critical review in long-term follow-up. J Craniofac Surg 2003; 14: 144-153.
8. Khan Y, Yaszemski MJ, Mikos AG, Laurencin CT,. Tissue engineering of bone: Material and matrix considerations. J Bone Joint Surg Am 2008; 90 (Suppl 1): 36-42. (Pubitemid 351329119)
9. Rezwan K, Chen QZ, Blaker JJ, Boccaccini AR,. Biodegradable and bioactive porous polymer/inorganic composite scaffolds for bone tissue engineering. Biomaterials 2006; 27: 3413-3431.
10. Johnson AJ, Herschler BA,. A review of the mechanical behavior of CaP and CaP/polymer composites for applications in bone replacement and repair. Acta Biomater 2011; 7: 16-30.
11. Cai X, Tong H, Shen X, Chen W, Yan J, Hu J,. Preparation and characterization of homogeneous chitosan-polylactic acid/hydroxyapatite nanocomposite for bone tissue engineering and evaluation of its mechanical properties. Acta Biomaterialia 2009; 5: 2693-2703.
12. Hasegawa S, Ishii S, Tamura J, Furukawa T, Neo M, Matsusue Y, Shikinami Y, Okuno M, Nakamura T,. A 5-7 year in vivo study of high-strength hydroxyapatite/poly(l-lactide) composite rods for the internal fixation of bone fractures. Biomaterials 2006; 27: 1327-1332. (Pubitemid 41739557)
13. Ishii S, Tamura J, Furukawa T, Nakamura T, Matsusue Y, Shikinami Y, Okuno M,. Long-term study of high-strength hydroxyapatite/poly(L-lactide) composite rods for the internal fixation of bone fractures: A 2-4-year follow-up study in rabbits. J Biomed Mater Res Part B: Appl Biomater 2003; 66: 539-547. (Pubitemid 37517126)
14. Shikinami Y, Okuno M,. Bioresorbable devices made of forged composites of hydroxyapatite (HA) particles and poly-lactide (PLLA). I. Basic characteristics. Biomaterials 1999; 20: 859-877. (Pubitemid 29184767)
15. Shikinami Y, Matsusue Y, Nakamura T,. The complete process of bioresorption and bone replacement using devices made of forged composites of raw hydroxyapatite particles/poly l-lactide (F-u-HA/PLLA). Biomaterials 2005; 26: 5542-5551. (Pubitemid 40592141)
16. Zhang JY, Beckman EJ, Piesco NP, Agarwal S,. A new peptide-based urethane polymer: Synthesis, biodegradation, and potential to support cell growth in vitro. Biomaterials 2000; 21: 1247-1258. (Pubitemid 30195722)
17. Han J, Chen B, Ye L, Zhang A-y, Zhang J, Feng Z-G,. Synthesis and characterization of biodegradable polyurethane based on poly(ε- caprolactone) and L-lysine ethyl ester diisocyanate. Frontiers Mater Sci China 2009; 3: 25-32.
18. Guelcher SA, Srinivasan A, Dumas JE, Didier JE, McBride S, Hollinger JO,. Synthesis, mechanical properties, biocompatibility, and biodegradation of polyurethane networks from lysine polyisocyanates. Biomaterials 2008; 29: 1762-1775.
19. Dumas JE, Davis T, Holt GE, Yoshii T, Perrien DS, Nyman JS, Boyce T, Guelcher SA,. Synthesis, characterization, and remodeling of weight-bearing allograft bone/polyurethane composites in the rabbit. Acta Biomater 2010; 6: 2394-2406.
20. Dumas JE, Zienkiewicz K, Tanner SA, Prieto EM, Bhattacharyya S, Guelcher SA,. Synthesis and characterization of an injectable allograft bone/polymer composite bone void filler with tunable mechanical properties. Tissue Eng Part A 2010; 16: 2505-2518.
21. Bonzani IC, Adhikari R, Houshyar S, Mayadunne R, Gunatillake P, Stevens MM,. Synthesis of two-component injectable polyurethanes for bone tissue engineering. Biomaterials 2007; 28: 423-433. (Pubitemid 44602225)
22. Adhikari R, Gunatillake PA, Griffiths I, Tatai L, Wickramaratna M, Houshyar S, Moore T, Mayadunne RTM, Field J, McGee M, et al. Biodegradable injectable polyurethanes: Synthesis and evaluation for orthopaedic applications. Biomaterials 2008; 29: 3762-3770.
23. Hasegawa S, Ishii S, Tamura J, Furukawa T, Neo M, Matsusue Y, Shikinami Y, Okuno M, Nakamura T,. A 5-7 year in vivo study of high-strength hydroxyapatite/poly(L-lactide) composite rods for the internal fixation of bone fractures. Biomaterials 2006; 27: 1327-1332. (Pubitemid 41739557)
24. Norman-Taylor FH, Santori N, Villar RN,. The trouble with bone allograft. BMJ 1997; 315: 498.
25. Kunze C, Freier T, Helwig E, Sandner B, Reif D, Wutzler A, Radusch HJ,. Surface modification of tricalcium phosphate for improvement of the interfacial compatibility with biodegradable polymers. Biomaterials 2003; 24: 967-974. (Pubitemid 36020385)
26. Guelcher SA, Patel V, Gallagher KM, Connolly S, Didier JE, Doctor JS, Hollinger JO,. Synthesis and in vitro biocompatibility of injectable polyurethane foam scaffolds. Tissue Eng 2006; 12: 1247-1259. (Pubitemid 44024495)
27. Yang F, Murugan R, Ramakrishna S, Wang X, Ma YX, Wang S,. Fabrication of nano-structured porous PLLA scaffold intended for nerve tissue engineering. Biomaterials 2004; 25: 1891-1900. (Pubitemid 38102264)
28. Ghosh-Choudhury N, Windle JJ, Koop BA, Harris MA, Guerrero DL, Wozney JM, Mundy GR, Harris SE,. Immortalized murine osteoblasts derived from BMP 2-T-antigen expressing transgenic mice. Endocrinology 1996; 137: 331-339. (Pubitemid 26005008)
29. Radin C,. Random close packing of granular matter. J Stat Phys 2008; 131: 567-573.
30. Ehrenfried LM, Farrar D, Cameron RE,. The degradation properties of co-continuous calcium phosphate polyester composites: Insights with synchrotron micro-computer tomography. J R Soc Interface 2010; 7 (Suppl 5): S663-S674.
31. Lin FH, Chen TM, Lin CP, Lee CJ,. The merit of sintered PDLLA/TCP composites in management of bone fracture internal fixation. Artif Organs 1999; 23: 186-194.
32. Ang KC, Leong KF, Chua CK, Chandrasekaran M,. Compressive properties and degradability of poly(epsilon-caprolatone)/hydroxyapatite composites under accelerated hydrolytic degradation. J Biomed Mater Res A 2007; 80: 655-660. (Pubitemid 46239077)
33. Ehrenfried LM, Farrar D, Cameron RE,. Degradation properties of co-continuous calcium-phosphate-polyester composites. Biomacromolecules 2009; 10: 1976-1985.
34. Wiltfang J, Merten HA, Schlegel KA, Schultze-Mosgau S, Kloss FR, Rupprecht S, Kessler P,. Degradation characteristics of alpha and beta tri-calcium-phosphate (TCP) in minipigs. J Biomed Mater Res 2002; 63: 115-121. (Pubitemid 34263854)
35. Heidemann W, Jeschkeit S, Ruffieux K, Fischer JH, Wagner M, Kruger G, Wintermantel E, Gerlach KL,. Degradation of poly(D, L)lactide implants with or without addition of calciumphosphates in vivo. Biomaterials 2001; 22: 2371-2381. (Pubitemid 32672859)
36. Ducheyne P, Radin S, King L,. The effect of calcium phosphate ceramic composition and structure on in vitro behavior. I. Dissolution. J Biomed Mater Res 1993; 27: 25-34. (Pubitemid 23002764)
37. Koerten HK, van der Meulen J,. Degradation of calcium phosphate ceramics. J Biomed Mater Res 1999; 44: 78-86. (Pubitemid 28544088)
38. Kenny SM, Buggy M,. Bone cements and fillers: A review. J Mater Sci Mater Med 2003; 14: 923-938. (Pubitemid 37504967)
39. Leeuwenburgh SC, Wolke JG, Siebers MC, Schoonman J, Jansen JA,. In vitro and in vivo reactivity of porous, electrosprayed calcium phosphate coatings. Biomaterials 2006; 27: 3368-3378.
40. Rush SM,. Bone graft substitutes: osteobiologics. Clinics Podiatric Med Surg 2005; 22: 619-630. (Pubitemid 41423564)
41. Eagan MJ, McAllister DR,. Biology of allograft incorporation. Clinics Sports Med 2009; 28: 203-214.
42. Newton CD, Nunamaker DB.,. Textbook of Small Animal Orthopaedics. Philadelphia. Lippincott: Lippincott; 1985.
43. Yuan H, Li Y, de Bruijn JD, de Groot K, Zhang X,. Tissue responses of calcium phosphate cement: A study in dogs. Biomaterials 2000; 21: 1283-1290. (Pubitemid 30195726)
44. Malinin TI, Carpenter EM, Temple HT,. Particulate bone allograft incorporation in regeneration of osseous defects; importance of particle sizes. Open Orthop J 2007; 1: 19-24.
45. Voor MJ, Arts JJ, Klein SA, Walschot LH, Verdonschot N, Buma P,. Is hydroxyapatite cement an alternative for allograft bone chips in bone grafting procedures? A mechanical and histological study in a rabbit cancellous bone defect model. J Biomed Mater Res B Appl Biomater 2004; 71: 398-407. (Pubitemid 39463778)
46. Muzylak M, Arnett TR, Price JS, Horton MA,. The in vitro effect of pH on osteoclasts and bone resorption in the cat: Implications for the pathogenesis of FORL. J Cell Physiol 2007; 213: 144-150. (Pubitemid 47378802)
47. Winkler T, Hoenig E, Gildenhaar R, Berger G, Fritsch D, Janssen R, Morlock MM, Schilling AF,. Volumetric analysis of osteoclastic bioresorption of calcium phosphate ceramics with different solubilities. Acta Biomater 2010; 6: 4127-4135.