Local treatment of cancellous bone grafts with BMP-7 and zoledronate increases both the bone formation rate and bone density: A bone chamber study in rats

Acta Orthopaedica

Volumn 82, Issue 2, 2011, Pages 228-233

  Belfrage, Ola ^a   Flivik, Gunnar ^a   Sundberg, Martin ^a   Kesteris, Uldis ^a   Tägil, Magnus ^a  

^a LUND UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

RECOMBINANT OSTEOGENIC PROTEIN 1; ZOLEDRONIC ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOSYNTHESIS; BONE ALLOGRAFT; BONE CONDUCTION; BONE DENSITY; BONE REMODELING; CANCELLOUS BONE; CANCELLOUS BONE GRAFT; CATABOLISM; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; FEMALE; HISTOPATHOLOGY; MALE; MORPHOMETRICS; NONHUMAN; OSSIFICATION; RAT; TIBIA; TIBIA FRACTURE;

ANIMALS; BONE DENSITY; BONE DENSITY CONSERVATION AGENTS; BONE MORPHOGENETIC PROTEIN 7; BONE TRANSPLANTATION; DIFFUSION CHAMBERS, CULTURE; DIPHOSPHONATES; FEMALE; HUMANS; IMIDAZOLES; OSTEOGENESIS; RATS; RATS, SPRAGUE-DAWLEY; TRANSPLANTATION, AUTOLOGOUS;

EID: 79953814937     PISSN: 17453674     EISSN: 17453682     Source Type: Journal    
DOI: 10.3109/17453674.2011.566138     Document Type: Article

References (24)

1. Aspenberg P, Wang J S. A new bone chamber used for measuring osteoconduction in rats. Eur J Exp Musculoskel Res 1993; 2: 69-74.
2. Aspenberg P, Åstrand J. Bone allografts pretreated with a bisphosphonate are not resorbed. Acta Orthop Scand 2002; 73 (1): 20-3. (Pubitemid 34218817)
3. Baas J, Elmengaard B, Jensen T B, Jakobsen T, Andersen N T, Soballe K. The effect of pretreating morselized allograft bone with rhBMP-2 and/or pamidronate on the fixation of porous Ti and HA-coated implants. Biomaterials 2008; 29 (19): 2915-22.
4. Burchardt H. The biology of bone graft repair. Clin Orthop 1983; (174): 28-42. (Pubitemid 13122171)
5. Carter D R, Spengler D M. Mechanical properties and composition of cortical bone. Clin Orthop 1978; (135): 192-217. (Pubitemid 9046475)
6. Harding A K, Aspenberg P, Kataoka M, Bylski D, Tägil M. Manipulating the anabolic and catabolic response in bone graft remodeling: synergism by a combination of local BMP-7 and a single systemic dosis of zoledronate. J Orthop Res 2008; 26 (9): 1245-9.
7. Iwata K, Li J, Follet H, Phipps R J, Burr D B. Bisphosphonates suppress periosteal osteoblast activity independently of resorption in rat femur and tibia. Bone 2006; 39 (5): 1053-8. (Pubitemid 44528380)
8. Jakobsen T, Kold S, Bechtold J E, Elmengaard B, Soballe K. Local alendronate increases fixation of implants inserted with bone compaction: 12-week canine study. J Orthop Res 2007; 25 (4): 432-41. (Pubitemid 46542029)
9. Jeppsson C, Åstrand J, Tägil M, Aspenberg P. A combination of bisphosphonate and BMP additives in impacted bone allografts. Acta Orthop Scand 2003; 74 (4): 483-9. (Pubitemid 37108471)
10. Kärrholm J, Hourigan P, Timperley J, Razaznejad R. Mixing bone graft with OP-1 does not improve cup or stem fixation in revision surgery of the hip: 5-year follow-up of 10 acetabular and 11 femoral study cases and 40 control cases. Acta Orthop 2006; 77 (1): 39-48. (Pubitemid 43879153)
11. Linder L. Cancellous impaction grafting in the human femur: histological and radiographic observations in 6 autopsy femurs and 8 biopsies. Acta Orthop Scand 2000; 71 (6): 543-52.
12. Little D G, Ramachandran M, Schindeler A. The anabolic and catabolic responses in bone repair. J Bone Joint Surg (Br) 2007; 89 (4): 425-33. (Pubitemid 46851119)
13. McGee M A, Findlay D M, Howie D W, Carbone A, Ward P, Stamenkov R, Page T T, Bruce W J, Wildenauer C I, Toth C. The use of OP-1 in femoral impaction grafting in a sheep model. J Orthop Res 2004; 22 (5): 1008-15. (Pubitemid 39149165)
14. Merz W A, Schenk R K. A quantitative histological study on bone formation in human cancellous bone. Acta Anat (Basel) 1970; 76 (1): 1-15.
15. Okamoto M, Murai J, Yoshikawa H, Tsumaki N. Bone morphogenetic proteins in bone stimulate osteoclasts and osteoblasts during bone development. JBMR 2006; 21 (7): 1022-33. (Pubitemid 43962831)
16. Ornstein E, Franzen H, Johnsson R, Stefansdottir A, Sundberg M, Tägil M. Five-year follow-up of socket movements and loosening after revision with impacted morselized allograft bone and cement: a radiostereometric and radiographic analysis. J Arthroplasty 2006; 21 (7): 975-84. (Pubitemid 44485412)
17. Ornstein E, Linder L, Ranstam J, Lewold S, Eisler T, Torper M. Femoral impaction bone grafting with the Exeter stem - the Swedish experience: survivorship analysis of 1305 revisions performed between 1989 and 2002. J Bone Joint Surg (Br) 2009; 91 (4): 441-6.
18. Parks N L, Engh G A. The Ranawat Award. Histology of nine structural bone grafts used in total knee arthroplasty. Clin Orthop 1997; (345): 17-23.
19. Rabenda V, Mertens R, Fabri V, Vanoverloop J, Sumkay F, Vannecke C, Deswaef A, Verpooten G A, Reginster J Y. Adherence to bisphosphonates therapy and hip fracture risk in osteoporotic women. Osteoporos Int 2008; 19: 811-8.
20. Rogers M J, Gordon S, Benford H L, Coxon F P, Luckman S P, Monkkonen J, Frith J C. Cellular and molecular mechanisms of action of bisphosphonates. Cancer (12 Suppl) 2000; 88: 2961-78. (Pubitemid 30413179)
21. Schindeler A, Little D G. Bisphosphonate action: revelations and deceptions from in vitro studies. J Pharm Sci 2007; 96 (8): 1872-8. (Pubitemid 47280088)
22. Tägil M, Jeppsson C, Wang J S, Aspenberg P. No augmentation of morselized and impacted bone graft by OP-1 in a weight-bearing model. Acta Orthop Scand 2003; 74 (6): 742-8. (Pubitemid 38067879)
23. Tägil M, Aspenberg P, Åstrand J. Systemic zoledronate precoating of a bone graft reduces bone resorption during remodeling. Acta Orthop 2006; 77 (1): 23-6. (Pubitemid 43879150)
24. van der Donk S, Buma P, Slooff T J, Gardeniers J W, Schreurs B W. Incorporation of morselized bone grafts: a study of 24 acetabular biopsy specimens. Clin Orthop 2002; (396): 131-41. (Pubitemid 34207964)