A dissociated glucocorticoid receptor modulator reduces airway hyperresponsiveness and inflammation in a mouse model of asthma

Journal of Immunology

Volumn 188, Issue 7, 2012, Pages 3478-3487

  Reber, Laurent L ^a,g   Daubeuf, François ^a   Plantinga, Maud ^b,c   De Cauwer, Lode ^c,d   Gerlo, Sarah ^c,d   Waelput, Wim ^b,e   Van Calenbergh, Serge ^d   Tavernier, Jan ^c,d   Haegeman, Guy ^d   Lambrecht, Bart N ^b,c,f   Frossard, Nelly ^a   De Bosscherx, Karolien ^c,d  

^a UNIVERSITÉ DE STRASBOURG   (France)

^b GHENT UNIVERSITY HOSPITAL   (Belgium)

^c DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^d GHENT UNIVERSITY   (Belgium)

^e UNIVERSITY HOSPITAL BRUSSELS   (Belgium)

^f ERASMUS MEDICAL CENTER   (Netherlands)

^g STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (4 ACETOXYPHENYL) 2 CHLORO N ETHYLMETHYLAMMONIUM CHLORIDE; ANTIINFLAMMATORY AGENT; COLLAGEN; DEXAMETHASONE; EOTAXIN; GAMMA INTERFERON; GLUCOCORTICOID RECEPTOR; I KAPPA B ALPHA; IMMUNOGLOBULIN E; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2A; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 17; INTERLEUKIN 4; INTERLEUKIN 5; LEUCINE ZIPPER PROTEIN; MONOCYTE CHEMOTACTIC PROTEIN 1; MUCIN 5AC; MUCIN 5B; OVALBUMIN; RANTES; STAT6 PROTEIN; TRANSCRIPTION FACTOR FOXP3; TRANSCRIPTION FACTOR RELA; UNCLASSIFIED DRUG;

AIRWAY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ASTHMA; B LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL INFILTRATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOTOXIC T LYMPHOCYTE; DENDRITIC CELL; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG MEGADOSE; EOSINOPHIL; GENE; GOBLET CELL; GOBLET CELL METAPLASIA; KIDNEY MASS; LIVER WEIGHT; LUNG LAVAGE; MACROPHAGE; MAPK PHOSPHATASE 1 GENE; MAST CELL; MOUSE; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; RESPIRATORY TRACT ALLERGY; SPLEEN WEIGHT; TH17 CELL; TH2 CELL; TRANSACTIVATION; WEIGHT REDUCTION;

ANIMALS; ANTI-ASTHMATIC AGENTS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ASTHMA; BRONCHIAL HYPERREACTIVITY; BRONCHOALVEOLAR LAVAGE FLUID; CYTOKINES; DEXAMETHASONE; DISEASE MODELS, ANIMAL; DRUG EVALUATION, PRECLINICAL; DUAL SPECIFICITY PHOSPHATASE 1; ENZYME INDUCTION; GENE EXPRESSION REGULATION; GOBLET CELLS; INFLAMMATION; LEUKOCYTES; LUNG; MAST CELLS; METAPLASIA; MICE; MICE, INBRED BALB C; OVALBUMIN; QUATERNARY AMMONIUM COMPOUNDS; RECEPTORS, GLUCOCORTICOID; STAT6 TRANSCRIPTION FACTOR; TRANSCRIPTIONAL ACTIVATION;

EID: 84859390611     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1004227     Document Type: Article

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