메뉴 건너뛰기




Volumn 103, Issue 6, 2004, Pages 2196-2204

Activated protein C inhibits bronchial hyperresponsiveness and Th2 cytokine expression in mice

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATED PROTEIN C; CYTOKINE; GLUCOCORTICOID; IMMUNOGLOBULIN E; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NUCLEAR PROTEIN; OVALBUMIN; STAT6 PROTEIN; TH2 CYTOKINE; UNCLASSIFIED DRUG;

EID: 12144291151     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood-2003-06-1980     Document Type: Article
Times cited : (91)

References (41)
  • 1
    • 0002917945 scopus 로고    scopus 로고
    • Epidemiologic trends
    • Barnes PJ, Grunstein MM, Leff AR, Woolcock AJ, eds. Philadelphia, PA: Lippincott Raven
    • Burney PGJ. Epidemiologic trends. In: Barnes PJ, Grunstein MM, Leff AR, Woolcock AJ, eds. Asthma. Philadelphia, PA: Lippincott Raven; 1997:35-47.
    • (1997) Asthma , pp. 35-47
    • Burney, P.G.J.1
  • 3
    • 0033604599 scopus 로고    scopus 로고
    • Therapeutic strategies for allergic diseases
    • Barnes PJ. Therapeutic strategies for allergic diseases. Nature. 1999;402:B31-B37.
    • (1999) Nature , vol.402
    • Barnes, P.J.1
  • 4
    • 1542278045 scopus 로고    scopus 로고
    • The need for new therapy
    • Hansel TT, Barnes PJ, eds. Basel, Switzerland: Karger
    • Barnes PJ, Hansel TT. The need for new therapy. In: Hansel TT, Barnes PJ, eds. New drugs for asthma, allergy and COPD. Basel, Switzerland: Karger;2001:2-5.
    • (2001) New Drugs for Asthma, Allergy and COPD , pp. 2-5
    • Barnes, P.J.1    Hansel, T.T.2
  • 5
  • 7
    • 0031861489 scopus 로고    scopus 로고
    • Protein C anticoagulant system in patients with interstitial lung disease
    • Kobayashi H, Gabazza EC, Taguchi O, et al. Protein C anticoagulant system in patients with interstitial lung disease. Am J Respir Crit Care Med. 1998;157:1850-1854.
    • (1998) Am J Respir Crit Care Med , vol.157 , pp. 1850-1854
    • Kobayashi, H.1    Gabazza, E.C.2    Taguchi, O.3
  • 8
    • 20244382519 scopus 로고    scopus 로고
    • Decreased protein C activation is associated with abnormal collagen turnover in the intraalveolar space of patients with interstitial lung disease
    • Yasui H, Gabazza EC, Taguchi O, et al. Decreased protein C activation is associated with abnormal collagen turnover in the intraalveolar space of patients with interstitial lung disease. Clin Appl Thromb Hemost. 2000;6:202-205.
    • (2000) Clin Appl Thromb Hemost , vol.6 , pp. 202-205
    • Yasui, H.1    Gabazza, E.C.2    Taguchi, O.3
  • 10
    • 0034955797 scopus 로고    scopus 로고
    • Intratracheal administration of activated protein c inhibits bleomycin-induced lung fibrosis in the mouse
    • Yasui H, Gabazza EC, Tamaki S, et al. Intratracheal administration of activated protein c inhibits bleomycin-induced lung fibrosis in the mouse. Am J Respir Crit Care Med. 2001;163:1660-1668.
    • (2001) Am J Respir Crit Care Med , vol.163 , pp. 1660-1668
    • Yasui, H.1    Gabazza, E.C.2    Tamaki, S.3
  • 11
    • 0037086296 scopus 로고    scopus 로고
    • Bleomycin-induced lung fibrosis: The authors should have used another method to induce pulmonary lesions resembling human idiopathic pulmonary fibrosis
    • Gabazza EC, Taguchi O, Adachi Y. Bleomycin-induced lung fibrosis: the authors should have used another method to induce pulmonary lesions resembling human idiopathic pulmonary fibrosis [letter]. Am J Respir Crit Care Med. 2002;165:845-846.
    • (2002) Am J Respir Crit Care Med , vol.165 , pp. 845-846
    • Gabazza, E.C.1    Taguchi, O.2    Adachi, Y.3
  • 12
    • 0035826096 scopus 로고    scopus 로고
    • Efficacy and safety of recombinant human activated protein C for severe sepsis
    • Bernard GR, Vincent JL, Laterre PF, et al. Efficacy and safety of recombinant human activated protein C for severe sepsis. N Engl J Med. 2001;344:699-709.
    • (2001) N Engl J Med , vol.344 , pp. 699-709
    • Bernard, G.R.1    Vincent, J.L.2    Laterre, P.F.3
  • 13
    • 0034019454 scopus 로고    scopus 로고
    • Role of activated protein C in Helicobacter pylori-associated gastritis
    • Oka S, Gabazza EC, Taguchi Y, et al. Role of activated protein C in Helicobacter pylori-associated gastritis. Infect Immun. 2000;68:2863-2869.
    • (2000) Infect Immun , vol.68 , pp. 2863-2869
    • Oka, S.1    Gabazza, E.C.2    Taguchi, Y.3
  • 14
    • 0038290189 scopus 로고    scopus 로고
    • Activated protein C inhibits the expression of platelet-derived growth factor in the lung
    • Shimizu S, Gabazza EC, Taguchi O, et al. Activated protein C inhibits the expression of platelet-derived growth factor in the lung. Am J Respir Crit Care Med. 2003;167:1416-1426.
    • (2003) Am J Respir Crit Care Med , vol.167 , pp. 1416-1426
    • Shimizu, S.1    Gabazza, E.C.2    Taguchi, O.3
  • 15
    • 0035815747 scopus 로고    scopus 로고
    • Gene expression profile of antithrombotic protein C defines new mechanism modulating inflammation and apoptosis
    • Joyce DE, Gelbert L, Ciaccia A, DeHoff B, Grinnell BW. Gene expression profile of antithrombotic protein C defines new mechanism modulating inflammation and apoptosis. J Biol Chem. 2001;276:11199-11203.
    • (2001) J Biol Chem , vol.276 , pp. 11199-11203
    • Joyce, D.E.1    Gelbert, L.2    Ciaccia, A.3    DeHoff, B.4    Grinnell, B.W.5
  • 16
    • 0028925756 scopus 로고
    • Molecular cloning and expression of murine and bovine endothelial cell protein C/activated protein C receptor (EPCR)
    • Fukudome K, Esmon CT. Molecular cloning and expression of murine and bovine endothelial cell protein C/activated protein C receptor (EPCR). J Biol Chem. 1995;270:5571-5577.
    • (1995) J Biol Chem , vol.270 , pp. 5571-5577
    • Fukudome, K.1    Esmon, C.T.2
  • 17
    • 0032742158 scopus 로고    scopus 로고
    • Endothelial protein C receptor
    • Esmon CT, Xu J, Gu JM, et al. Endothelial protein C receptor. Thromb Haemost. 1999;82:251-258.
    • (1999) Thromb Haemost , vol.82 , pp. 251-258
    • Esmon, C.T.1    Xu, J.2    Gu, J.M.3
  • 18
    • 0031781163 scopus 로고    scopus 로고
    • An improved murine model of asthma: Selective airway inflammation, epithelial lesions and increased methacholine responsiveness following chronic exposure to aerolised allergen
    • Temelkovski J, Hogan SP, Shepherd DP, Foster PS, Kumar RK. An improved murine model of asthma: selective airway inflammation, epithelial lesions and increased methacholine responsiveness following chronic exposure to aerolised allergen. Thorax. 1998;53:849-856.
    • (1998) Thorax , vol.53 , pp. 849-856
    • Temelkovski, J.1    Hogan, S.P.2    Shepherd, D.P.3    Foster, P.S.4    Kumar, R.K.5
  • 19
    • 0030800586 scopus 로고    scopus 로고
    • Non-invasive measurement of airway responsiveness in allergic mice using barometric plethysmography
    • Hamelmann E, Schwarze J, Takeda K, et al. Non-invasive measurement of airway responsiveness in allergic mice using barometric plethysmography. Am J Respir Crit Care Med. 1997;156:766-775.
    • (1997) Am J Respir Crit Care Med , vol.156 , pp. 766-775
    • Hamelmann, E.1    Schwarze, J.2    Takeda, K.3
  • 20
    • 0029808482 scopus 로고    scopus 로고
    • Intracellular demonstration of active TGFbeta1 in B cells and plasma cells of autoimmune mice. IgG-bound TGFbeta1 suppresses neutrophil function and host defense against Staphylococcus aureus infection
    • Caver TE, O'Sullivan FX, Gold LI, Gresham HD. Intracellular demonstration of active TGFbeta1 in B cells and plasma cells of autoimmune mice. IgG-bound TGFbeta1 suppresses neutrophil function and host defense against Staphylococcus aureus infection. J Clin Invest. 1996;8:2496-2506.
    • (1996) J Clin Invest , vol.8 , pp. 2496-2506
    • Caver, T.E.1    O'Sullivan, F.X.2    Gold, L.I.3    Gresham, H.D.4
  • 21
    • 0032951303 scopus 로고    scopus 로고
    • Acetylcholine-induced endothelium-derived contracting factor in hypoxic pulmonary hypertensive rats
    • Maruyama J, Yokochi A, Maruyama K, Nosaka S. Acetylcholine-induced endothelium-derived contracting factor in hypoxic pulmonary hypertensive rats. J Appl Physiol. 1999;86:1687-1695.
    • (1999) J Appl Physiol , vol.86 , pp. 1687-1695
    • Maruyama, J.1    Yokochi, A.2    Maruyama, K.3    Nosaka, S.4
  • 23
    • 0021100690 scopus 로고
    • Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei
    • Dignam JD, Lebovitz RM, Roeder RG. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res. 1983;11:1475-1489.
    • (1983) Nucleic Acids Res , vol.11 , pp. 1475-1489
    • Dignam, J.D.1    Lebovitz, R.M.2    Roeder, R.G.3
  • 24
    • 0032522489 scopus 로고    scopus 로고
    • Involvement of the IL-2 receptor gamma-chain (gammac) in the control by IL-4 of human monocyte and macrophage proinflammatory mediator production
    • Bonder CS, Dickensheets HL, Finlay-Jones JJ, Donnelly RP, Hart PH. Involvement of the IL-2 receptor gamma-chain (gammac) in the control by IL-4 of human monocyte and macrophage proinflammatory mediator production. J Immunol. 1998;160:4048-4056.
    • (1998) J Immunol , vol.160 , pp. 4048-4056
    • Bonder, C.S.1    Dickensheets, H.L.2    Finlay-Jones, J.J.3    Donnelly, R.P.4    Hart, P.H.5
  • 25
    • 0001606677 scopus 로고    scopus 로고
    • Jak1 expression is required for mediating interleukin-4-induced tyrosine phosphorylation of insulin receptor substrate and Stat6 signaling molecules
    • Chen XH, Patel BK, Wang LM, et al. Jak1 expression is required for mediating interleukin-4-induced tyrosine phosphorylation of insulin receptor substrate and Stat6 signaling molecules. J Biol Chem. 1997;272:6556-6560.
    • (1997) J Biol Chem , vol.272 , pp. 6556-6560
    • Chen, X.H.1    Patel, B.K.2    Wang, L.M.3
  • 26
    • 0032813814 scopus 로고    scopus 로고
    • Thrombin in the airways of asthmatic patients
    • Gabazza EC, Taguchi O, Tamaki S, et al. Thrombin in the airways of asthmatic patients. Lung. 1999;177:253-262.
    • (1999) Lung , vol.177 , pp. 253-262
    • Gabazza, E.C.1    Taguchi, O.2    Tamaki, S.3
  • 27
    • 0034648757 scopus 로고    scopus 로고
    • Thrombin signalling and protease-activated receptors
    • Coughlin SR. Thrombin signalling and protease-activated receptors. Nature. 2000;407:258-264.
    • (2000) Nature , vol.407 , pp. 258-264
    • Coughlin, S.R.1
  • 28
    • 0032793201 scopus 로고    scopus 로고
    • Alpha-Thrombin stimulates contraction of human bronchial rings by activation of protease-activated receptors
    • Hauck RW, Schulz C, Schomig A, Hoffman RK, Panettieri RA Jr. Alpha-Thrombin stimulates contraction of human bronchial rings by activation of protease-activated receptors. Am J Physiol. 1999;1277:L22-L29.
    • (1999) Am J Physiol , vol.1277
    • Hauck, R.W.1    Schulz, C.2    Schomig, A.3    Hoffman, R.K.4    Panettieri Jr., R.A.5
  • 29
    • 10544228517 scopus 로고    scopus 로고
    • Protein C activation in NIDDM patients
    • Gabazza EC, Takeya H, Deguchi H, et al. Protein C activation in NIDDM patients. Diabetologia. 1996;39:1455-1461.
    • (1996) Diabetologia , vol.39 , pp. 1455-1461
    • Gabazza, E.C.1    Takeya, H.2    Deguchi, H.3
  • 30
    • 0027175429 scopus 로고
    • Eosinophil cationic granule proteins impair thrombomodulin function. A potential mechanism for thromboembolism in hypereosinophilic heart disease
    • Slungaard A, Vercellotti GM, Tran T, Gleich GJ, Key NS. Eosinophil cationic granule proteins impair thrombomodulin function. A potential mechanism for thromboembolism in hypereosinophilic heart disease. J Clin Invest. 1993;91:1721-1730.
    • (1993) J Clin Invest , vol.91 , pp. 1721-1730
    • Slungaard, A.1    Vercellotti, G.M.2    Tran, T.3    Gleich, G.J.4    Key, N.S.5
  • 31
    • 0037036069 scopus 로고    scopus 로고
    • Activation of endothelial cell protease activated receptor 1 by the protein C pathway
    • Riewald M, Petrovan RJ, Donner A, Mueller BM, Ruf W. Activation of endothelial cell protease activated receptor 1 by the protein C pathway. Science. 2002;296:1880-1882.
    • (2002) Science , vol.296 , pp. 1880-1882
    • Riewald, M.1    Petrovan, R.J.2    Donner, A.3    Mueller, B.M.4    Ruf, W.5
  • 32
    • 0032750835 scopus 로고    scopus 로고
    • Th2 cytokines and GATA-3 in asthma: New insights into the regulation of airway inflammation
    • Ray A, Cohn L. Th2 cytokines and GATA-3 in asthma: new insights into the regulation of airway inflammation. J Clin Invest. 1999;104:985-993.
    • (1999) J Clin Invest , vol.104 , pp. 985-993
    • Ray, A.1    Cohn, L.2
  • 33
    • 15844374279 scopus 로고    scopus 로고
    • Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene
    • Shimoda K, van Deursen J, Sangster MY, et al. Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene. Nature. 1996;380:630-633.
    • (1996) Nature , vol.380 , pp. 630-633
    • Shimoda, K.1    Van Deursen, J.2    Sangster, M.Y.3
  • 35
    • 0032476742 scopus 로고    scopus 로고
    • Essential role of nuclear kappaB in the induction of eosinophilia in allergic airway inflammation
    • Yang L, Cohn L, Zhang DH, Homer R, Ray A, Ray P. Essential role of nuclear kappaB in the induction of eosinophilia in allergic airway inflammation. J Exp Med. 1998;188:1739-1750.
    • (1998) J Exp Med , vol.188 , pp. 1739-1750
    • Yang, L.1    Cohn, L.2    Zhang, D.H.3    Homer, R.4    Ray, A.5    Ray, P.6
  • 36
    • 0028804551 scopus 로고
    • Targeted disruption of the p50 subunit of NF-κB leads to multifocal defects in immune responses
    • Sha WC, Liou HC, Tuomanen EI, Baltimore D. Targeted disruption of the p50 subunit of NF-κB leads to multifocal defects in immune responses. Cell. 1995;80:321-330.
    • (1995) Cell , vol.80 , pp. 321-330
    • Sha, W.C.1    Liou, H.C.2    Tuomanen, E.I.3    Baltimore, D.4
  • 37
    • 0035222187 scopus 로고    scopus 로고
    • A critical role for NF-kappa B in GATA-3 expression and Th2 differentiation in allergic airway inflammation
    • Das J, Chen CH, Yang L, Cohn L, Ray P, Ray A. A critical role for NF-kappa B in GATA-3 expression and Th2 differentiation in allergic airway inflammation. Nat Immunol. 2001;1:45-50.
    • (2001) Nat Immunol , vol.1 , pp. 45-50
    • Das, J.1    Chen, C.H.2    Yang, L.3    Cohn, L.4    Ray, P.5    Ray, A.6
  • 38
    • 0031842614 scopus 로고    scopus 로고
    • Interaction of STAT6 and NF-κB: Direct association and synergistic activation of interleukin-4 induced transcription
    • Shen CH, Stavenezer J. Interaction of STAT6 and NF-κB: direct association and synergistic activation of interleukin-4 induced transcription. Mol Cell Biol. 1998;18:3395-3404.
    • (1998) Mol Cell Biol , vol.18 , pp. 3395-3404
    • Shen, C.H.1    Stavenezer, J.2
  • 39
    • 0345062267 scopus 로고    scopus 로고
    • Functional synergism of STA6 with either NF-κB or PU.1 to mediate IL-4-induced activation of IgE germline gene transcription
    • Stutz AM, Woisetschlager M. Functional synergism of STA6 with either NF-κB or PU.1 to mediate IL-4-induced activation of IgE germline gene transcription. J Immunol. 1999;163:4383-4391.
    • (1999) J Immunol , vol.163 , pp. 4383-4391
    • Stutz, A.M.1    Woisetschlager, M.2
  • 41
    • 0036344597 scopus 로고    scopus 로고
    • Direct effect of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma
    • Kuperman DA, Huang X, Koth LL, et al. Direct effect of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma. Nat Med. 2002;8:885-889.
    • (2002) Nat Med , vol.8 , pp. 885-889
    • Kuperman, D.A.1    Huang, X.2    Koth, L.L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.