Imaging vascular endothelial growth factor (VEGF) receptors in turpentine-induced sterile thigh abscesses with radiolabeled single-chain VEGF

Journal of Nuclear Medicine

Volumn 50, Issue 12, 2009, Pages 2058-2063

  Levashova, Zoia ^a   Backer, Marina ^b   Backer, Joseph M ^b   Blankenberg, Francis G ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b SIBTECH INC   (United States)

Author keywords

Angiogenesis; Inflammation; Musculoskeletal system; SPECT; VEGF

Indexed keywords

RADIOPHARMACEUTICAL AGENT; SINGLE CHAIN VASCULAR ENDOTHELIAL GROWTH FACTOR TC 99M; TURPENTINE; UNCLASSIFIED DRUG; VASCULOTROPIN RECEPTOR; CARBOCYANINE; CY5.5 CYANINE DYE; FLUORESCENT DYE; TECHNETIUM COMPLEX;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; CELL INFILTRATION; CONTROLLED STUDY; DRUG UPTAKE; FLUORESCENCE IMAGING; IMMUNOHISTOCHEMISTRY; ISOTOPE LABELING; MACROPHAGE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; SOFT TISSUE INFLAMMATION; SWISS WEBSTER MOUSE; ANIMAL; CHEMICALLY INDUCED DISORDER; CHEMISTRY; INFLAMMATION; INTRAMUSCULAR DRUG ADMINISTRATION; METABOLISM; METHODOLOGY; MOLECULAR IMAGING; PATHOLOGY; REPRODUCIBILITY; SCINTISCANNING; THIGH;

ANIMALS; CARBOCYANINES; FLUORESCENT DYES; INFLAMMATION; INJECTIONS, INTRAMUSCULAR; ISOTOPE LABELING; MALE; MICE; MOLECULAR IMAGING; ORGANOTECHNETIUM COMPOUNDS; RECEPTORS, VASCULAR ENDOTHELIAL GROWTH FACTOR; REPRODUCIBILITY OF RESULTS; THIGH; TURPENTINE;

EID: 73349132018     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: 10.2967/jnumed.109.068023     Document Type: Article

References (25)

1. Carmeliet P. Angiogenesis in health and disease. Nat Med. 2003;9:653-660.
2. Walsh DA. Pathophysiological mechanisms of angiogenesis. Adv Clin Chem. 2007;44:188-212.
3. Halin C, Detmar M. Inflammation, angiogenesis, and lymphangiogenesis. Methods Enzymol. 2008;445:2-20.
4. Roscoe WA, Welsh ME, Carter DE, Karlik SJ. VEGF and angiogenesis in acute and chronic MOG(35-55) peptide induced EAE. J Neuroimmunol. 2009;209:6-15.
5. Medzhitov R. Origin and physiological roles of inflammation. Nature. 2008;454:428-435.
6. Frantz S, Vincent KA, Feron O, Kelly RA. Innate immunity and angiogenesis. Circ Res. 2005;96:15-26.
7. Costa C, Incio J, Soares R. Angiogenesis and chronic inflammation: cause or consequence? Angiogenesis. 2007;10:149-166.
8. Danese S, Dejana E, Fiocchi C. Immune regulation by microvascular endothelial cells: directing innate and adaptive immunity, coagulation, and inflammation. J Immunol. 2007;178:6017-6022.
9. Prandini N. Nuclear medicine imaging of bone infections. Nucl Med Commun. 2006;27:633-644.
10. El-Maghraby TAF, Moustafa HM, Pauwels EKJ. Nuclear medicine methods for evaluation of skeletal infection among other diagnostic modalities. Q J Nucl Med Mol Imaging. 2006;50:167-192.
11. Goldsmith SJ, Vallabhajosula S. Clinically proven radiopharmaceuticals for infection imaging: mechanisms and applications. Semin Nucl Med. 2009;39:2-10.
12. Graves JE, Nunley K, Heffernan MP. Off-label uses of biologics in dermatology: rituximab, omalizumab, infliximab, etanercept, adalimumab, efalizumab, and alefacept (part 2 of 2). J Am Acad Dermatol. 2007;56:e55-e79.
13. Khanna R, Smith MJ. Utilization and costs of medical services and prescription medications for rheumatoid arthritis among recipients covered by a state Medicaid program: a retrospective, cross-sectional, descriptive, database analysis. Clin Ther. 2007;29:2456-2467.
14. Bickston SJ, Waters HC, Dabbous O, Tang BI, Rahman M. Administrative claims analysis of all-cause annual costs of care and resource utilization by age category for ulcerative colitis patients. J Manag Care Pharm. 2008;14:352-362.
15. Backer MV, Levashova Z, Patel V, et al. Molecular imaging of VEGF receptors in angiogenic vasculature with single-chain VEGF-based probes. Nat Med. 2007;13:504-509.
16. Levashova Z, Backer M, Backer JM, Blankenberg FG. Direct site-specific labeling of the Cys-tag moiety in scVEGF with technetium 99m. Bioconjug Chem. 2008;19:1049-1054.
17. Backer MV, Levashova Z, Levenson R, Blankenberg FG, Backer JM. Cysteine-containing fusion tag for site-specific conjugation of therapeutic and imaging agents to targeting proteins. Methods Mol Biol. 2008;494:275-294.
18. Blankenberg FG, Tait JF, Blankenberg TA, Post AM, Strauss HW. Imaging macrophages and the apoptosis of granulocytes in a rodent model of subacute and chronic abscesses with radiolabeled monocyte chemotactic peptide-1 and annexin V. Eur J Nucl Med. 2001;28:1384-1393.
19. 99mTc]tricine: a useful precursor complex for the radiolabeling of hydrazinonicotinate protein conjugates. Bioconjug Chem. 1995;6:635-638.
20. Tang XN, Wang Q, Koike MA, et al. Monitoring the protective effects of minocycline treatment with radiolabeled annexin V in an experimental model of focal cerebral ischemia. J Nucl Med. 2007;48:1822-1828.
21. Yoo SA, Kwok SK, Kim WU. Proinflammatory role of vascular endothelial growth factor in the pathogenesis of rheumatoid arthritis: prospects for therapeutic intervention. Mediators Inflamm. February 10, 2009 [Epub ahead of print].
22. Clavel G, Bessis N, Lemeiter D, et al. Angiogenesis markers (VEGF, soluble receptor of VEGF and angiopoietin-1) in very early arthritis and their association with inflammation and joint destruction. Clin Immunol. 2007;124:158-164.
23. Varoga D, Paulsen F, Mentlein R, et al. TLR-2-mediated induction of vascular endothelial growth factor (VEGF) in cartilage in septic joint disease. J Pathol. 2006;210:315-324.
24. Bonnet CS, Walsh DA. Osteoarthritis, angiogenesis and inflammation. Rheumatology. 2005;44:7-16.
25. Tanaka E, Aoyama J, Miyauchi M, et al. Vascular endothelial growth factor plays an important autocrine/paracrine role in the progression of osteoarthritis. Histochem Cell Biol. 2005;123:275-281.