메뉴 건너뛰기




Volumn 6, Issue 5, 2012, Pages 834-845

The roles of different porcine cytochrome P450 enzymes and cytochrome b5A in skatole metabolism

Author keywords

3 methylindole; boar taint; cytochrome b5A; cytochrome P450; skatole

Indexed keywords

CYTOCHROME B5; CYTOCHROME P450; ISOPROTEIN; SKATOLE;

EID: 84859322283     PISSN: 17517311     EISSN: 1751732X     Source Type: Journal    
DOI: 10.1017/S1751731111002175     Document Type: Conference Paper
Times cited : (43)

References (35)
  • 1
    • 84859293691 scopus 로고
    • Absorption from the gastrointestinal tract and liver turnover of skatole
    • (ed. M Bonneau) INRA Editions, Paris
    • Agergaard N and Laue A 1992. Absorption from the gastrointestinal tract and liver turnover of skatole. In Measurement and prevention of boar taint in entire male pigs (ed. M Bonneau), pp. 15-16. INRA Editions, Paris.
    • (1992) Measurement and Prevention of Boar Taint in Entire Male Pigs , pp. 15-16
    • Agergaard, N.1    Laue, A.2
  • 3
    • 0032011701 scopus 로고    scopus 로고
    • Relationship between oxidation and conjugation metabolism of skatole in pig liver and concentrations of skatole in fat
    • Babol J, Squires EJ and Lundström K 1998. Relationship between oxidation and conjugation metabolism of skatole in pig liver and concentrations of skatole in fat. Journal of Animal Science 76, 829-838.
    • (1998) Journal of Animal Science , vol.76 , pp. 829-838
    • Babol, J.1    Squires, E.J.2    Lundström, K.3
  • 5
    • 0023085594 scopus 로고
    • Emerging models in the USA: Swine, woodchucks and the hairless guinea pig
    • (ed. J Kawamata and EC Melby) Alan R. Liss, New York
    • Balk MW 1987. Emerging models in the USA: swine, woodchucks and the hairless guinea pig. In Animal models: assessing the scope of their use in biomedical research (ed. J Kawamata and EC Melby), pp. 311-326. Alan R. Liss, New York.
    • (1987) Animal Models: Assessing the Scope of Their Use in Biomedical Research , pp. 311-326
    • Balk, M.W.1
  • 6
    • 0030935086 scopus 로고    scopus 로고
    • Use of in vitro and in vivo data to estimate the likelihood of metabolic pharmacokinetic interactions
    • Bertz RJ and Granneman GR 1997. Use of in vitro and in vivo data to estimate the likelihood of metabolic pharmacokinetic interactions. Clinical Pharmacoki-netics 32, 210-258.
    • (1997) Clinical Pharmacoki-netics , vol.32 , pp. 210-258
    • Bertz, R.J.1    Granneman, G.R.2
  • 7
    • 59849095112 scopus 로고    scopus 로고
    • The role of porcine cytochrome b5A and cytochrome b5B in the regulation of cytochrome P45017A1 activities
    • Billen MJ and Squires EJ 2009. The role of porcine cytochrome b5A and cytochrome b5B in the regulation of cytochrome P45017A1 activities. Journal of Steroid Biochemistry and Molecular Biology 113, 98-104.
    • (2009) Journal of Steroid Biochemistry and Molecular Biology , vol.113 , pp. 98-104
    • Billen, M.J.1    Squires, E.J.2
  • 8
    • 0000772486 scopus 로고
    • Compounds responsible for boar taint, with special emphasis on androstenone: A review
    • Bonneau M 1982. Compounds responsible for boar taint, with special emphasis on androstenone: a review. Livestock Production Science 9, 687-707.
    • (1982) Livestock Production Science , vol.9 , pp. 687-707
    • Bonneau, M.1
  • 9
    • 4444242339 scopus 로고
    • Entire males vs castrates for pork production-financial benefits to the producer
    • de Lange CFand Squires EJ 1995. Entire males vs castrates for pork production-financial benefits to the producer. Ontario Swine Research Review, 41-44.
    • (1995) Ontario Swine Research Review , pp. 41-44
    • De Lange, C.F.1    Squires, E.J.2
  • 10
    • 0034119438 scopus 로고    scopus 로고
    • Metabolism of 3-methylindole by porcine liver micro-somes: Responsible cytochrome P450 enzymes
    • Diaz GJ and Squires EJ 2000a. Metabolism of 3-methylindole by porcine liver micro-somes: responsible cytochrome P450 enzymes. Toxicological Sciences 55, 284-292.
    • (2000) Toxicological Sciences , vol.55 , pp. 284-292
    • Diaz, G.J.1    Squires, E.J.2
  • 11
    • 0034113567 scopus 로고    scopus 로고
    • Role of aldehyde oxidase in the hepatic in vitro metabolism of 3-methylindole in pigs
    • Diaz GJ and Squires EJ 2000b. Role of aldehyde oxidase in the hepatic in vitro metabolism of 3-methylindole in pigs. Journal of Agricultural Food and Chemistry 48, 833-837.
    • (2000) Journal of Agricultural Food and Chemistry , vol.48 , pp. 833-837
    • Diaz, G.J.1    Squires, E.J.2
  • 12
    • 0032853327 scopus 로고    scopus 로고
    • Identification of phase i metabolites of 3-methylindole produced by pig liver microsomes
    • Diaz GJ, Skordos KW, Yost GS and Squires EJ 1999. Identification of phase I metabolites of 3-methylindole produced by pig liver microsomes. Drug Metabolism and Disposition 27, 1150-1156.
    • (1999) Drug Metabolism and Disposition , vol.27 , pp. 1150-1156
    • Diaz, G.J.1    Skordos, K.W.2    Yost, G.S.3    Squires, E.J.4
  • 13
    • 0642365314 scopus 로고
    • Disposition of skatole in male and female pigs
    • Tours, France 26-29 September
    • Friis C 1993. Disposition of skatole in male and female pigs. Proceedings of the 5th European ISSX Meeting, Tours, France, 26-29 September, 133p.
    • (1993) Proceedings of the 5th European ISSX Meeting , pp. 133
    • Friis, C.1
  • 15
    • 0002233286 scopus 로고    scopus 로고
    • Microbial production of skatole in the digestive tract of entire male pigs
    • (ed. WK Jensen) Danish Meat Research Institute, Roskilde, Denmark
    • Jensen BB and Jensen MT 1998. Microbial production of skatole in the digestive tract of entire male pigs. In Skatole and boar taint (ed. WK Jensen), pp. 41-75. Danish Meat Research Institute, Roskilde, Denmark.
    • (1998) Skatole and Boar Taint , pp. 41-75
    • Jensen, B.B.1    Jensen, M.T.2
  • 16
    • 0023512987 scopus 로고
    • Comparative metabolism in food-producing animals: Programs sponsored by the center for veterinary medicine
    • Juskevich JC 1987. Comparative metabolism in food-producing animals: programs sponsored by the center for veterinary medicine. Drug Metabolism Reviews 18, 345-362.
    • (1987) Drug Metabolism Reviews , vol.18 , pp. 345-362
    • Juskevich, J.C.1
  • 17
    • 24744447463 scopus 로고    scopus 로고
    • Cloning of six full-length cDNAs encoding pig cytochrome p450 enzymes and gene expression of these enzymes in the liver and kidney
    • Kojima M and Morozumi T 2004. Cloning of six full-length cDNAs encoding pig cytochrome p450 enzymes and gene expression of these enzymes in the liver and kidney. Journal of Health Science 50, 518-529.
    • (2004) Journal of Health Science , vol.50 , pp. 518-529
    • Kojima, M.1    Morozumi, T.2
  • 18
    • 0013212389 scopus 로고    scopus 로고
    • In vitro approaches for studying the inhibition of drug-metabolizing enzymes and identifying the drug-metabolizing enzymes responsible for the metabolism of drugs
    • (ed. AD Rodrigues) Marcel Dekker, New York
    • Madan A, Usuki E, Burton LA, Ogilvie WB and Parkinson A 2002. In vitro approaches for studying the inhibition of drug-metabolizing enzymes and identifying the drug-metabolizing enzymes responsible for the metabolism of drugs. In Drugs and the pharmaceutical sciences: drug-drug interactions (ed. AD Rodrigues), pp. 217-294. Marcel Dekker, New York.
    • (2002) Drugs and the Pharmaceutical Sciences: Drug-drug Interactions , pp. 217-294
    • Madan, A.1    Usuki, E.2    Burton, L.A.3    Ogilvie, W.B.4    Parkinson, A.5
  • 19
    • 77349086874 scopus 로고    scopus 로고
    • Porcine CYP2A19, CYP2E1 and CYP1A2 forms are responsible for skatole biotransformation in the reconstituted system
    • Matal J, Matuskova Z, Tunkova A, Anzenbacherová E and Anzenbacher P 2009. Porcine CYP2A19, CYP2E1 and CYP1A2 forms are responsible for skatole biotransformation in the reconstituted system. Neuroendocrinology Letters 30 (suppl. 1), 36-40.
    • (2009) Neuroendocrinology Letters , vol.30 , Issue.SUPPL. 1 , pp. 36-40
    • Matal, J.1    Matuskova, Z.2    Tunkova, A.3    Anzenbacherová, E.4    Anzenbacher, P.5
  • 20
    • 77954890052 scopus 로고    scopus 로고
    • Deletion of microsomal cytochrome b5 profoundly affects hepatic and extrahepatic drug metabolism
    • McLaughlin LA, Ronseaux S, Finn RD, Henderson CL and Wolf CR 2010. Deletion of microsomal cytochrome b5 profoundly affects hepatic and extrahepatic drug metabolism. Molecular Pharmacology 78, 269-278.
    • (2010) Molecular Pharmacology , vol.78 , pp. 269-278
    • McLaughlin, L.A.1    Ronseaux, S.2    Finn, R.D.3    Henderson, C.L.4    Wolf, C.R.5
  • 23
    • 38749123176 scopus 로고    scopus 로고
    • The effect of a c.-8G.T polymorphism on the expression of cytochrome b5A and boar taint in pigs
    • Peacock J, Lou Y, Lundström K and Squires EJ 2008. The effect of a c.-8G.T polymorphism on the expression of cytochrome b5A and boar taint in pigs. Animal Genetics 39, 15-21.
    • (2008) Animal Genetics , vol.39 , pp. 15-21
    • Peacock, J.1    Lou, Y.2    Lundström, K.3    Squires, E.J.4
  • 25
    • 0030834058 scopus 로고    scopus 로고
    • Human cytochrome P450 enzymes: A status report summarizing their reactions, substrates, inducers and inhibitors
    • Rendic S and Carlo FJD 1997. Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers and inhibitors. Drug Metabolism Reviews 29, 413-580.
    • (1997) Drug Metabolism Reviews , vol.29 , pp. 413-580
    • Rendic, S.1    Fjd, C.2
  • 27
    • 34547894694 scopus 로고    scopus 로고
    • Is bupropion a more specific substrate for porcine CYP2E than chlorzoxazone and p-nitrophenol?
    • Skaanlid MTand Friis C 2007. Is bupropion a more specific substrate for porcine CYP2E than chlorzoxazone and p-nitrophenol?. Basic and Clinical Pharmacology and Toxicology 101, 159-162.
    • (2007) Basic and Clinical Pharmacology and Toxicology , vol.101 , pp. 159-162
    • Skaanlid, M.T.1    Friis, C.2
  • 28
    • 0031230797 scopus 로고    scopus 로고
    • Relationship between cytochrome P450IIEI in liver and levels of skatole and its metabolites in intact male pigs
    • Squires EJ and Lundström K 1997. Relationship between cytochrome P450IIEI in liver and levels of skatole and its metabolites in intact male pigs. Journal of Animal Science 75, 2506-2511.
    • (1997) Journal of Animal Science , vol.75 , pp. 2506-2511
    • Squires, E.J.1    Lundström, K.2
  • 29
    • 33645810602 scopus 로고    scopus 로고
    • The role of CYP2A and CYP2E1 in the metabolism of 3-methylindole in primary cultured porcine hepatocytes
    • Terner MA, Gilmore WJ, Lou Y and Squires EJ 2006. The role of CYP2A and CYP2E1 in the metabolism of 3-methylindole in primary cultured porcine hepatocytes. Drug Metabolism and Disposition 34, 848-854.
    • (2006) Drug Metabolism and Disposition , vol.34 , pp. 848-854
    • Terner, M.A.1    Gilmore, W.J.2    Lou, Y.3    Squires, E.J.4
  • 31
    • 0029875880 scopus 로고    scopus 로고
    • Metabolism of 3-methylindole by vaccinia-expressed P450 enzymes: Correlation of 3-methyleneindolenine formation and protein-binding
    • Thornton-Manning J, Appleton ML, Gonzalez FJ and Yost GS 1996. Metabolism of 3-methylindole by vaccinia-expressed P450 enzymes: correlation of 3-methyleneindolenine formation and protein-binding. Pharmacology and Experimental Therapeutics 276, 21-29.
    • (1996) Pharmacology and Experimental Therapeutics , vol.276 , pp. 21-29
    • Thornton-Manning, J.1    Appleton, M.L.2    Gonzalez, F.J.3    Yost, G.S.4
  • 33
    • 77950960669 scopus 로고    scopus 로고
    • Chlorzoxazone metabolism by porcine cytochrome P450 enzymes and the effect of cytochrome b5
    • Wiercinska P and Squires EJ 2010. Chlorzoxazone metabolism by porcine cytochrome P450 enzymes and the effect of cytochrome b5. Drug Metabolism and Disposition 38, 857-862.
    • (2010) Drug Metabolism and Disposition , vol.38 , pp. 857-862
    • Wiercinska, P.1    Squires, E.J.2
  • 34
    • 0030602654 scopus 로고    scopus 로고
    • Requirements for cytochrome b5 in the oxidation of 7-ethoxycoumarin, CLZ, aniline, and N-nitrosodimethylamine by recombinant cytochrome P450 2E1 and by human liver microsomes
    • Yamazaki H, Nakano M, Gillam EMJ, Bell LC, Guengerich FP and Shimada T 1996. Requirements for cytochrome b5 in the oxidation of 7-ethoxycoumarin, CLZ, aniline, and N-nitrosodimethylamine by recombinant cytochrome P450 2E1 and by human liver microsomes. Biochemical Pharmacology 52, 301-309.
    • (1996) Biochemical Pharmacology , vol.52 , pp. 301-309
    • Yamazaki, H.1    Nakano, M.2    Emj, G.3    Bell, L.C.4    Guengerich, F.P.5    Shimada, T.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.