Which hepatocyte will it be? hepatocyte choice for bioartificial liver support systems

Liver Transplantation

Volumn 7, Issue 1, 2001, Pages 2-10

  Tsiaoussis, John ^a   Newsome, Philip Noel ^a   Nelson, Leonard Joseph ^a   Hayes, Peter Clive ^a   Plevris, John Nicholas ^a  

^a ROYAL INFIRMARY OF EDINBURGH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ARTICLE; ARTIFICIAL LIVER; BIOTRANSFORMATION; CELL FUNCTION; CELL IMMORTALIZATION; CELL TYPE; COCULTURE; CONTROLLED STUDY; CULTURE MEDIUM; DETOXIFICATION; DEVELOPED COUNTRY; ENVIRONMENT; HUMAN; HUMAN CELL; LIVER CELL; LIVER CELL CULTURE; LIVER FAILURE; MALIGNANT TRANSFORMATION; MORBIDITY; MORTALITY; NONHUMAN; PRIORITY JOURNAL; XENOGRAFT; ZOONOSIS;

EID: 0035188205     PISSN: 15276465     EISSN: None     Source Type: Journal    
DOI: 10.1053/jlts.2001.20845     Document Type: Article

References (90)

1. High volume plasma exchange in fulminant hepatic failure
2. Hemodiabsorption in the treatment of acute hepatic failure
3. Continuous removal of middle molecules by hemofiltration in patients with acute liver failure
4. Brain edema and portasystemic encephalopathy
5. Cerebral herniation in patients with acute liver failure is correlated with arterial ammonia concentration
6. Neurochemistry of hepatic encephalopathy
7. Hepatic encephalopathy: Molecular mechanisms underlying the clinical syndrome
8. Hepatic encephalopathy: A neurochemical disorder
9. False neurotransmitters and hepatic failure
10. The liver-Anatomy, physiology and biochemistry
11. Drug metabolism in adult rat hepatocytes in primary monolayer culture
12. Activities of cytosolic and microsomal drug oxidases of rat hepatocytes in primary culture
13. Xenotransplantation: Postponed by a millennium?
14. Artificial liver: A forthcoming attraction
15. Improved liver function following treatment with an extracorporeal liver assist device
16. Variant protein patterns in hepatomas and transformed liver cell lines as determined by high resolution two-dimensional gel electrophoresis (2DE)
17. Search for cross-species transmission of porcine endogenous retrovirus in patients treated with living pig tissue
18. Primary hepatocytes outperform Hep G2 cells as the source of biotransformation functions in a bioartificial liver
19. Comparison of porcine hepatocytes with human hepatoma (C3A) cells for use in a bioartificial liver support system
20. Transplantation of highly differentiated immortalized human hepatocytes to treat acute liver failure
21. Characterization of human hepatocyte lines derived from normal liver tissue
22. Prevention of acute liver failure in rats with reversibly immortalized human hepatocytes
23. Assessment of an extracorporeal liver assist device in anhepatic dogs
24. Pilot-controlled trial of the extracorporeal liver assist device in acute liver failure
25. Reversal of fulminant hepatic failure using an extracorporeal liver assist device
26. Clinical experience with an extracorporeal liver assist device
27. Hepatic drug-metabolizing enzymes in primary and secondary tumors of human liver
28. Cultivation and characterization of a new immortalized human hepatocyte cell line, HepZ, for use in an artificial liver support system
29. Immortalization of epithelial-like cells from human liver tissue with SV40 T-antigen gene
30. Development of a bioartificial liver: Properties and function of a hollow-fiber module inoculated with liver cells
31. The use of microcarrier-roller bottle culture for large-scale production of porcine hepatocytes
32. Hepatocytes in cell therapy
33. Isolation and culture of porcine hepatocytes for artificial liver support
34. Immunologic considerations in the use of cultured porcine hepatocytes as a hybrid artificial liver. Antiporcine hepatocyte human serum
35. Xenoantibody response of patients with severe acute liver failure exposed to porcine antigens following treatment with a bioartificial liver
36. Characterization of human xenoreactive active antibodies in liver failure patients exposed to pig hepatocytes after bioartificial liver treatment: An ex vivo model of pig to human xenotransplantation
37. Artificial liver support in acute liver failure
38. Xenografts and retroviruses
39. Infection of human cells by an endogenous retrovirus of pigs
40. Infection by porcine endogenous retrovirus after islet xenotransplantation in SCID mice
41. Influence of human fulminant hepatic failure sera on endogenous retroviral expression in pig hepatocytes
42. Xenotransplantation: A summary of the International Business Communications' Fourth International Congress
43. Recent advances in xenotransplantation
44. Efficacy and current problems with a porcine hepatocyte-based bioartificial liver: Light and shade
45. Extracorporeal support and hepatocyte transplantation in acute liver failure and cirrhosis
46. Loss and recovery of liver regeneration in rats with fulminant hepatic failure
47. Alternatives to liver transplantation: From hepatocyte transplantation to tissue-engineered organs
48. Clinical experience with a bioartificial liver in the treatment of severe liver failure. A phase I clinical trial
49. The Hepatix extracorporeal liver assist device: Initial clinical experience
50. Hepatocyte culture between three dimensionally arranged biomatrix-coated independent artificial capillary systems and sinusoidal endothelial cell co-culture compartments
51. A novel full-scale flat membrane bioreactor utilizing porcine hepatocytes: Cell viability and tissue-specific functions
52. Towards serum-free, chemically defined media for mammalian cell culture
53. Monolayer culture of hepatocytes
54. Liver regeneration: Molecular mechanisms of growth control
55. Improved function of microencapsulated hepatocytes in a hybrid bioartificial liver support system
56. Characterization of the three-compartment gel-entrapment porcine hepatocyte bioartificial liver
57. Hepatocytes entrapped in collagen gel following 14 days of storage at 4 degrees C: Preservation of hybrid artificial liver
58. Design of hepatocyte-specific extracellular matrices for hybrid artificial liver
59. Bioartificial liver support system using porcine hepatocytes entrapped in a three-dimensional hollow fiber module with collagen gel: An evaluation in the swine acute liver failure model
60. Morphogenetic events in mixed cultures of rat hepatocytes and nonparenchymal cells maintained in biological matrices in the presence of hepatocyte growth factor and epidermal growth factor
61. Functional activity of isolated pig hepatocytes attached to different extracellular matrix substrates. Implication for application of pig hepatocytes in a bioartificial liver
62. In vitro characterization of porcine hepatocyte function
63. The peroxisome proliferators are hepatocyte mitogens in chemically-defined media: Glucocorticoid-induced PPAR alpha is linked to peroxisome proliferator mitogenesis
64. Glutathione replenishment capacity is lower in isolated perivenous than in periportal hepatocytes
65. Urea synthesis in freshly isolated and in cultured periportal and perivenous hepatocytes
66. Digitonin-collagenase perfusion for efficient separation of periportal or perivenous hepatocytes
67. A novel bioreactor design for in vitro reconstruction of in vivo liver characteristics
68. Effect of cell-cell interactions in preservation of cellular phenotype: Cocultivation of hepatocytes and nonparenchymal cells
69. Induction of three-dimensional assembly of human liver cells by simulated microgravity
70. Growing tissues in microgravity
71. Formation of porcine hepatocyte spheroids for use in a bioartificial liver
72. Extended liver-specific functions of porcine hepatocyte spheroids entrapped in collagen gel
73. Survival and function of hepatocytes on a novel three-dimensional synthetic biodegradable polymer scaffold with an intrinsic network of channels
74. Support of the acutely failing liver: State of the art
75. Establishment of a human hepatocyte line derived from primary culture in a collagen gel sandwich culture system
76. Three-dimensional in vitro cell culture leads to a marked upregulation of cell function in human hepatocyte cell lines-An important tool for the development of a bioartificial liver machine
77. Improved hepatocyte in vitro maintenance in a culture model with woven multicompartment capillary systems: Electron microscopy studies
78. Isolation and cryopreservation of human hepatocytes
79. Long-term maintenance of drug-metabolizing enzyme activities in rat hepatocytes after cryopreservation
80. Optimization of cryo-preservation procedures for rat and human hepatocytes
81. Insights into the cryoprotective mechanism of dimethyl sulfoxide for phospholipid bilayers
82. Survival and function of isolated hepatocytes after cryopreservation
83. Cryopreservation of cynomolgus monkey (Macaca fascicularis) hepatocytes for subsequent culture and protein synthesis studies
84. Characterization of cryopreserved rat liver parenchymal cells by metabolism of diagnostic substrates and activities of related enzymes
85. Preservation of the rate and profile of xenobiotic metabolism in rat hepatocytes stored in liquid nitrogen
86. An improved ex vivo method of primary porcine hepatocyte isolation for use in bioartificial liver systems
87. In vitro evaluation of a novel bioreactor based on an integral oxygenator and a spirally wound nonwoven polyester matrix for hepatocyte culture as small aggregates
88. Evaluation of a novel bioartificial liver in rats with complete liver ischemia: Treatment efficacy and species-specific alpha-GST detection to monitor hepatocyte viability
89. Development of a hybrid bioartificial liver
90. Hybrid liver support system in a short term application on hepatectomized pigs