메뉴 건너뛰기




Volumn 34, Issue 5, 2006, Pages 848-854

The role of CYP2A and CYP2E1 in the metabolism of 3-methylindole in primary cultured porcine hepatocytes

Author keywords

[No Author keywords available]

Indexed keywords

3 HYDROXY 3 METHYLOXINDOLE; 3 METHYLOXINDOLE; 4 METHYLPYRAZOLE; 4 NITROPHENOL HYDROXYLASE; COUMARIN 7 HYDROXYLASE; CYTOCHROME P450 2A; CYTOCHROME P450 2E1; CYTOCHROME P450 INHIBITOR; ENZYME; INDOLE DERIVATIVE; ISOENZYME; SKATOLE; UNCLASSIFIED DRUG;

EID: 33645810602     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.105.008128     Document Type: Article
Times cited : (26)

References (41)
  • 1
    • 0031950111 scopus 로고    scopus 로고
    • Chlorzoxazone 6-hydroxylase and p-nitrophenol hydroxylase as the most suitable activities for assaying cytochrome P450 2E1 in cynomolgus monkey liver
    • Amato G, Longo V, Mazzaccaro A, and Gervasi PG (1998) Chlorzoxazone 6-hydroxylase and p-nitrophenol hydroxylase as the most suitable activities for assaying cytochrome P450 2E1 in cynomolgus monkey liver. Drug Metab Dispos 26:483-489.
    • (1998) Drug Metab Dispos , vol.26 , pp. 483-489
    • Amato, G.1    Longo, V.2    Mazzaccaro, A.3    Gervasi, P.G.4
  • 2
    • 58149322606 scopus 로고    scopus 로고
    • Investigation of factors responsible for the development of boar taint
    • Babol J, Squires EJ, and Gullett EA (1996) Investigation of factors responsible for the development of boar taint. Food Res Int 28:573-581.
    • (1996) Food Res Int , vol.28 , pp. 573-581
    • Babol, J.1    Squires, E.J.2    Gullett, E.A.3
  • 3
    • 0032013471 scopus 로고    scopus 로고
    • Hepatic metabolism of skatole in pigs by cytochrome P4502E1
    • Babol J, Squires EJ, and Lundstrom K (1998) Hepatic metabolism of skatole in pigs by cytochrome P4502E1. J Anim Sci 76:822-828.
    • (1998) J Anim Sci , vol.76 , pp. 822-828
    • Babol, J.1    Squires, E.J.2    Lundstrom, K.3
  • 4
    • 0012918014 scopus 로고    scopus 로고
    • Identification of selected metabolites of skatole in plasma and urine from pigs
    • Bæk C, Hansen-Møller J, Friis C, Cornett C, and Hansen SH (1997) Identification of selected metabolites of skatole in plasma and urine from pigs. J Agric Food Chem 45:2332-2340.
    • (1997) J Agric Food Chem , vol.45 , pp. 2332-2340
    • Bæk, C.1    Hansen-Møller, J.2    Friis, C.3    Cornett, C.4    Hansen, S.H.5
  • 6
    • 0009872383 scopus 로고    scopus 로고
    • Boar taint in entire male pigs - A review
    • Bonneau M (1997) Boar taint in entire male pigs - a review. Pig News Inf 18:15-18.
    • (1997) Pig News Inf , vol.18 , pp. 15-18
    • Bonneau, M.1
  • 7
    • 0039440136 scopus 로고
    • Physiological aspects of androstenone and skatole formation in the boar - A review with experimental data
    • Claus R, Weiler U, and Herzog A (1994) Physiological aspects of androstenone and skatole formation in the boar - a review with experimental data. Meat Sci 38:289-305.
    • (1994) Meat Sci , vol.38 , pp. 289-305
    • Claus, R.1    Weiler, U.2    Herzog, A.3
  • 8
    • 0030894106 scopus 로고    scopus 로고
    • Biotransformation of chlorzoxazone by hepatic microsomes from humans and ten other mammalian species
    • Court MH, Von Moltke LL, Shader RI, and Greenblatt DJ (1997) Biotransformation of chlorzoxazone by hepatic microsomes from humans and ten other mammalian species. Biopharm Drug Dispos 18:213-226.
    • (1997) Biopharm Drug Dispos , vol.18 , pp. 213-226
    • Court, M.H.1    Von Moltke, L.L.2    Shader, R.I.3    Greenblatt, D.J.4
  • 9
    • 0032853327 scopus 로고    scopus 로고
    • Identification of phase 1 metabolites of 3-methylindole produced by pig liver microsomes
    • Diaz GJ, Skordos KW, Yost GS, and Squires EJ (1999) Identification of phase 1 metabolites of 3-methylindole produced by pig liver microsomes. Drug Metab Dispos 27:1150-1156.
    • (1999) Drug Metab Dispos , vol.27 , pp. 1150-1156
    • Diaz, G.J.1    Skordos, K.W.2    Yost, G.S.3    Squires, E.J.4
  • 10
    • 0034119438 scopus 로고    scopus 로고
    • Metabolism of 3-methylindole by porcine liver microsomes: Responsible cytochrome P450 enzymes
    • Diaz GJ and Squires EJ (2000a) Metabolism of 3-methylindole by porcine liver microsomes: responsible cytochrome P450 enzymes. Toxicol Sci 55:284-292.
    • (2000) Toxicol Sci , vol.55 , pp. 284-292
    • Diaz, G.J.1    Squires, E.J.2
  • 11
    • 0034113567 scopus 로고    scopus 로고
    • Role of aldehyde oxidase in the hepatic in vitro metabolism of 3-methylindole in pigs
    • Diaz GJ and Squires EJ (2000b) Role of aldehyde oxidase in the hepatic in vitro metabolism of 3-methylindole in pigs. J Agric Food Chem 48:833-837.
    • (2000) J Agric Food Chem , vol.48 , pp. 833-837
    • Diaz, G.J.1    Squires, E.J.2
  • 12
    • 0038171278 scopus 로고    scopus 로고
    • Phase II in vitro metabolism of 3-methylindole metabolites in porcine liver
    • Diaz GJ and Squires EJ (2003) Phase II in vitro metabolism of 3-methylindole metabolites in porcine liver. Xenobiotica 33:485-498.
    • (2003) Xenobiotica , vol.33 , pp. 485-498
    • Diaz, G.J.1    Squires, E.J.2
  • 13
    • 0000260054 scopus 로고    scopus 로고
    • The coumarin 7-hydroxylation microassay in living hepatic cells in culture
    • Donato MT, Castell JV, and Gómez-Lechón MJ (1998a) The coumarin 7-hydroxylation microassay in living hepatic cells in culture. Altern Lab Anim 26:213-223.
    • (1998) Altern Lab Anim , vol.26 , pp. 213-223
    • Donato, M.T.1    Castell, J.V.2    Gómez-Lechón, M.J.3
  • 14
    • 0031910343 scopus 로고    scopus 로고
    • Human hepatocyte growth factor down-regulates the expression of cytochrome P450 isozymes in human hepatocytes in primary culture
    • Donato MT, Gómez-Lechón MJ, Jover R, Nakamura T, and Castell JV (1998b) Human hepatocyte growth factor down-regulates the expression of cytochrome P450 isozymes in human hepatocytes in primary culture. J Pharmacol Exp Ther 284:760-767.
    • (1998) J Pharmacol Exp Ther , vol.284 , pp. 760-767
    • Donato, M.T.1    Gómez-Lechón, M.J.2    Jover, R.3    Nakamura, T.4    Castell, J.V.5
  • 15
    • 0037140383 scopus 로고    scopus 로고
    • Cytochrome P450IIe1 (CYP2E1) is induced by skatole and this induction is blocked by androstenone in isolated pig hepatocytes
    • Doran E, Whittington FW, Wood JD, and McGivan JD (2002) Cytochrome P450IIe1 (CYP2E1) is induced by skatole and this induction is blocked by androstenone in isolated pig hepatocytes. Chem-Biol Interact 140:81-92.
    • (2002) Chem-Biol Interact , vol.140 , pp. 81-92
    • Doran, E.1    Whittington, F.W.2    Wood, J.D.3    McGivan, J.D.4
  • 16
    • 0035044205 scopus 로고    scopus 로고
    • Bioactivation and cytotoxicity of 1,1-dichloro-2,2,2,trifluoroethane (HCFC-123) in isolated rat hepatocytes
    • Ferrara R, Zanovello A, Bortolato S, White IN, and Manno M (2001) Bioactivation and cytotoxicity of 1,1-dichloro-2,2,2,trifluoroethane (HCFC-123) in isolated rat hepatocytes. Pharmacol Toxicol 88:192-197.
    • (2001) Pharmacol Toxicol , vol.88 , pp. 192-197
    • Ferrara, R.1    Zanovello, A.2    Bortolato, S.3    White, I.N.4    Manno, M.5
  • 18
    • 0041672111 scopus 로고
    • Is boar-taint related to sex differences or polymorphism of skatole metabolism?
    • 1995 Sept 25-27; Milton Keynes, UK. Meat and Livestock Commission, UK
    • Friis C (1995) Is boar-taint related to sex differences or polymorphism of skatole metabolism?, in Proceedings of the EAAP Working Group: Production and Utilization of Meat from Entire Male Pigs; 1995 Sept 25-27; Milton Keynes, UK. Meat and Livestock Commission, UK.
    • (1995) Proceedings of the EAAP Working Group: Production and Utilization of Meat from Entire Male Pigs
    • Friis, C.1
  • 19
    • 0024538329 scopus 로고
    • Inhibition of 3-methylindole bioactivation by the cytochrome P-450 suicide substrates 1-aminobenzotriazole and alpha-methylbenzylaminobenzotriazole
    • Huijzer JC, Adams JD, Jaw J, and Yost GS (1989) Inhibition of 3-methylindole bioactivation by the cytochrome P-450 suicide substrates 1-aminobenzotriazole and alpha-methylbenzylaminobenzotriazole. Drug Metab Dispos 17:37-42.
    • (1989) Drug Metab Dispos , vol.17 , pp. 37-42
    • Huijzer, J.C.1    Adams, J.D.2    Jaw, J.3    Yost, G.S.4
  • 20
    • 17744417087 scopus 로고    scopus 로고
    • The detection of cytochrome P450 2E1 and its catalytic activity in rat testis
    • Jiang Y, Kuo CL, Pernecky SJ, and Piper WN (1998) The detection of cytochrome P450 2E1 and its catalytic activity in rat testis. Biochem Biophys Res Commun 246:578-583.
    • (1998) Biochem Biophys Res Commun , vol.246 , pp. 578-583
    • Jiang, Y.1    Kuo, C.L.2    Pernecky, S.J.3    Piper, W.N.4
  • 22
    • 0034950482 scopus 로고    scopus 로고
    • Selective dehydrogenation/oxygenation of 3-methylindole by cytochrome P450 enzymes
    • Lanza DL and Yost GS (2001) Selective dehydrogenation/oxygenation of 3-methylindole by cytochrome P450 enzymes. Drug Metab Dispos 29:950-953.
    • (2001) Drug Metab Dispos , vol.29 , pp. 950-953
    • Lanza, D.L.1    Yost, G.S.2
  • 23
    • 1442310959 scopus 로고    scopus 로고
    • Molecular cloning and functional analysis of porcine SULT1A1 gene and its variant: A single mutation SULT1A1 causes a significant decrease in sulfation activity
    • Lin Z, Lou Y, and Squires EJ (2004) Molecular cloning and functional analysis of porcine SULT1A1 gene and its variant: a single mutation SULT1A1 causes a significant decrease in sulfation activity. Mamm Genome 15:218-226.
    • (2004) Mamm Genome , vol.15 , pp. 218-226
    • Lin, Z.1    Lou, Y.2    Squires, E.J.3
  • 24
    • 0020531983 scopus 로고
    • Ketoconazole blocks adrenal steroidogenesis by inhibiting cytochrome P450-dependent enzymes
    • Loose DS, Kan PB, Hirst MA, Marcus RA, and Feldman D (1983) Ketoconazole blocks adrenal steroidogenesis by inhibiting cytochrome P450-dependent enzymes. J Clin Investig 71:1495-1499.
    • (1983) J Clin Investig , vol.71 , pp. 1495-1499
    • Loose, D.S.1    Kan, P.B.2    Hirst, M.A.3    Marcus, R.A.4    Feldman, D.5
  • 25
    • 0028343838 scopus 로고
    • A 13-week toxicologic and pathologic evaluation of prolonged cytochromes P450 inhibition by 1-aminobenzotriazole in male rats
    • Meschter CL, Mico BA, Mortillo M, Feldman D, Garland WA, Riley JA, and Kaufman LS (1994) A 13-week toxicologic and pathologic evaluation of prolonged cytochromes P450 inhibition by 1-aminobenzotriazole in male rats. Fundam Appl Toxicol 22:369-381.
    • (1994) Fundam Appl Toxicol , vol.22 , pp. 369-381
    • Meschter, C.L.1    Mico, B.A.2    Mortillo, M.3    Feldman, D.4    Garland, W.A.5    Riley, J.A.6    Kaufman, L.S.7
  • 26
    • 0036908849 scopus 로고    scopus 로고
    • Inhibition of the microsomal metabolism of 1,8-cineole in the common brushtail possum (Trichosurus vulpecula) by terpenes and other chemicals
    • Pass GJ and McLean S (2002) Inhibition of the microsomal metabolism of 1,8-cineole in the common brushtail possum (Trichosurus vulpecula) by terpenes and other chemicals. Xenobiotica 32:1109-1126.
    • (2002) Xenobiotica , vol.32 , pp. 1109-1126
    • Pass, G.J.1    McLean, S.2
  • 27
    • 0036784267 scopus 로고    scopus 로고
    • Preclinical activity of ketoconazole in combination with calcitriol or the vitamin D analogue EB 1089 in prostate cancer cells
    • Peehl DM, Seto E, Hsu J, and Feldman D (2002) Preclinical activity of ketoconazole in combination with calcitriol or the vitamin D analogue EB 1089 in prostate cancer cells. J Urol 168:1583-1588.
    • (2002) J Urol , vol.168 , pp. 1583-1588
    • Peehl, D.M.1    Seto, E.2    Hsu, J.3    Feldman, D.4
  • 29
    • 0027546823 scopus 로고
    • Plasma levels of several androgens and estrogens from birth to puberty in male domestic pigs
    • Schwarzenberger F, Toole GS, Christie HL, and Raeside JI (1993) Plasma levels of several androgens and estrogens from birth to puberty in male domestic pigs. Acta Endocrinol 128:173-177.
    • (1993) Acta Endocrinol , vol.128 , pp. 173-177
    • Schwarzenberger, F.1    Toole, G.S.2    Christie, H.L.3    Raeside, J.I.4
  • 30
    • 0033866924 scopus 로고    scopus 로고
    • Inhibition of cytochrome P450 2A6 increases nicotine's oral bioavailability and decreases smoking
    • Sellers EM, Kaplan HL, and Tyndale RF (2000) Inhibition of cytochrome P450 2A6 increases nicotine's oral bioavailability and decreases smoking. Clin Pharmacol Ther 68:35-43.
    • (2000) Clin Pharmacol Ther , vol.68 , pp. 35-43
    • Sellers, E.M.1    Kaplan, H.L.2    Tyndale, R.F.3
  • 33
    • 0036351423 scopus 로고    scopus 로고
    • Loss of cell anchorage triggers apoptosis (anoikis) in primary mouse hepatocytes
    • Smets FN, Chen Y, Wang L, and Soriano HE (2002) Loss of cell anchorage triggers apoptosis (anoikis) in primary mouse hepatocytes. Mol Genet Metab 75:344-352.
    • (2002) Mol Genet Metab , vol.75 , pp. 344-352
    • Smets, F.N.1    Chen, Y.2    Wang, L.3    Soriano, H.E.4
  • 34
    • 0030048628 scopus 로고    scopus 로고
    • Identification of beta-glucuronidase-resistant diastereomeric glucuronides of 3-hydroxy-3-methyloxindole formed during 3-methylindole metabolism in goats
    • Smith DJ, Appleton ML, Carlson JR, and Yost GS (1996) Identification of beta-glucuronidase-resistant diastereomeric glucuronides of 3-hydroxy-3- methyloxindole formed during 3-methylindole metabolism in goats. Drug Metab Dispos 24:119-125.
    • (1996) Drug Metab Dispos , vol.24 , pp. 119-125
    • Smith, D.J.1    Appleton, M.L.2    Carlson, J.R.3    Yost, G.S.4
  • 36
    • 33645819895 scopus 로고    scopus 로고
    • Boar taint
    • (Jensen WK, Devine C, and Dikeman M eds) article 9, Academic Press, Oxford
    • Squires EJ and Bonneau M (2004) Boar taint, in Control Encyclopedia of Meat Sciences (Jensen WK, Devine C, and Dikeman M eds) article 9, Academic Press, Oxford.
    • (2004) Control Encyclopedia of Meat Sciences
    • Squires, E.J.1    Bonneau, M.2
  • 37
    • 0031230797 scopus 로고    scopus 로고
    • Relationship between cytochrome P4502E1 in liver and levels of skatole and its metabolites in intact male pigs
    • Squires EJ and Lundström K (1997) Relationship between cytochrome P4502E1 in liver and levels of skatole and its metabolites in intact male pigs. J Anim Sci 75:2506-2511.
    • (1997) J Anim Sci , vol.75 , pp. 2506-2511
    • Squires, E.J.1    Lundström, K.2
  • 38
    • 0029875880 scopus 로고    scopus 로고
    • Metabolism of 3-methylindole by vaccinia-expressed P450 enzymes: Correlation of 3-methyleneindolenine formation and protein-binding
    • Thornton-Manning J, Appleton ML, Gonzalez FJ, and Yost GS (1996) Metabolism of 3-methylindole by vaccinia-expressed P450 enzymes: correlation of 3-methyleneindolenine formation and protein-binding. J Pharmacol Exp Ther 276:21-29.
    • (1996) J Pharmacol Exp Ther , vol.276 , pp. 21-29
    • Thornton-Manning, J.1    Appleton, M.L.2    Gonzalez, F.J.3    Yost, G.S.4
  • 39
    • 0031957833 scopus 로고    scopus 로고
    • Oxidation of methyl- and ethyl-tertiarybutyl ethers in rat liver microsomes: Role of the cytochrome P450 isoforms
    • Turini A, Amato G, Longo V, and Gervasi PG (1998) Oxidation of methyl- and ethyl-tertiarybutyl ethers in rat liver microsomes: role of the cytochrome P450 isoforms. Arch Toxicol 72:207-214.
    • (1998) Arch Toxicol , vol.72 , pp. 207-214
    • Turini, A.1    Amato, G.2    Longo, V.3    Gervasi, P.G.4
  • 40
    • 0024416367 scopus 로고
    • Mechanisms of 3-methylindole pneumotoxicity
    • Yost GS (1989) Mechanisms of 3-methylindole pneumotoxicity. Chem Res Toxicol 2:273-279.
    • (1989) Chem Res Toxicol , vol.2 , pp. 273-279
    • Yost, G.S.1
  • 41
    • 0035024678 scopus 로고    scopus 로고
    • Evaluation of methoxsalen, tranylcypromine and tryptamine as specific and selective CYP2A6 inhibitors in vitro
    • Zhang W, Kilicarslan T, Tyndale RF, and Sellers EM (2001) Evaluation of methoxsalen, tranylcypromine and tryptamine as specific and selective CYP2A6 inhibitors in vitro. Drug Metab Dispos 26:897-902.
    • (2001) Drug Metab Dispos , vol.26 , pp. 897-902
    • Zhang, W.1    Kilicarslan, T.2    Tyndale, R.F.3    Sellers, E.M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.